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Willy Brodus Uwan
Perbedaan prevalensi infeksi helicobacter pylori antara etnis Tionghoa dan Dayak dengan sindrom dispepsia = The differences in prevalence of helicobacter pylori infection between Chinese and Dayaknese with dyspeptic syndrome
"[ABSTRAK
Latar Belakang : Risiko infeksi Helicobacter pylori (H.pylori) dikaitkan dengan
banyak faktor yang terkait dengan pejamu-agen-lingkungan. Etnis adalah salah
satu faktor dari pejamu yang banyak diteliti di luar negeri. Prevalensi infeksi
H.pylori didapatkan lebih tinggi pada etnis tertentu seperti misalnya di China.
Berdasarkan teori Migrasi dan teori Transmisi diduga infeksi H.pylori akan
dibawa oleh penduduk yang bermigrasi dari daerah dengan prevalensi tinggi ke
tempat tujuan migrasi. Etnis Tionghoa di Kalimantan Barat berasal dari daerah
China Selatan dimana prevalensi infeksi H.pylori tinggi. Diperkirakan ada
perbedaan angka prevalensi infeksi H.pylori pada etnis Tionghoa dibandingkan
pada etnis asli Kalimantan Barat, yaitu etnis Dayak.
Tujuan : Untuk mengetahui perbedaan angka prevalensi, karakteristik
epidemiologis dan gambaran hasil pemeriksaan endoskopi pada subjek etnis
Tionghoa dan Dayak dengan sindrom dispepsia.
Metode : Penelitian ini adalah studi potong lintang untuk mengetahui perbedaan
angka prevalensi infeksi H.pylori. Penelitian dilakukan di RSU Santo Antonius
Pontianak dari bulan Desember 2014 sampai Juni 2015 dengan metode
pengambilan sampel secara consecutive sampling. Angka prevalensi infeksi
H.pylori disajikan dalam angka persentase, sedangkan perbedaan karakteristik
epidemiologis dan perbedaan gambaran hasil pemeriksaan endoskopi pada etnis
Tionghoa dan Dayak dianalisis dengan analisis bivariat menggunakan chi-square
dengan tingkat kemaknaan (p) = 0,05.
Hasil : Dari 203 subjek yang diteliti, terdiri dari 102 subjek etnis Tionghoa dan
101 subjek etnis Dayak didapatkan angka prevalensi H.pylori sebesar 40,8%.
Prevalensi pada etnis Tionghoa didapatkan lebih tinggi dibanding etnis Dayak,
berturut-turut sebesar 48,0% dan 33,7%. Tidak ada perbedaan karakteristik
epidemiologis dan temuan hasil pemeriksaan endoskopi pada kedua kelompok
etnis.
Simpulan : Terdapat perbedaan angka prevalensi infeksi H.pylori pada etnis
Tionghoa (48,0%) dibanding etnis Dayak (33,7%). Tidak ada perbedaan
karakteristik epidemiologis dan gambaran hasil pemeriksaan endoskopi pada
kedua kelompok etnis.
ABSTRACT
Background : Helicobacter pylori (H. pylori) infection risk is associated with
many factors related to host-agent-environment matter. Ethnicity is one of the host
factors which was the most studied factor overseas. The prevalence of H. pylori
infection was found higher in certain ethnic such among Chinese. Based on
migration and transmission theory, it was suspected that H. pylori infection were
transmitted by people migrating from areas with a high prevalence of infection to
the destination area. Chinese in West Borneo are originated from South China
region where the prevalence of H. pylori infection is high. It is estimated that
there are differences in the prevalence of H. pylori infection among Chinese
compared to the native people of West Borneo, the Dayaknese.
Objective: To determine the differences in the prevalence, epidemiological
characteristics and endoscopic finding between Chinese and Dayaknese with
dyspeptic syndrome.
Methods: This study was a cross-sectional study to determine the differences in
the prevalence of H. pylori infection. The study was conducted at St. Antonius
General Hospital Pontianak from December 2014 to June 2015 with consecutive
sampling method. H.pylori infection prevalence is presented in percentage
numbers, while the epidemiological characteristics and endoscopic finding
differences among Chinese and Dayaknese were analyzed by bivariate analysis
using the chi-square with significance value (p) = 0.05.
Results : From a total of 203 subjects in this study, consisted of 102 Chinese
subjects and 101 Dayaknese subjects, the prevalence of H.pylori infection was
40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0%
and 33.7%, respectively. There is no difference in the epidemiological
characteristics and endoscopic findings in both ethnic groups.
Conclusions : The prevalence of H. pylori infection among the Chinese (48.0%)
is higher than among Dayaknese (33.7%). There is no difference in the
epidemiological characteristics and endoscopic finding among both ethnic groups.;Background : Helicobacter pylori (H. pylori) infection risk is associated with
many factors related to host-agent-environment matter. Ethnicity is one of the host
factors which was the most studied factor overseas. The prevalence of H. pylori
infection was found higher in certain ethnic such among Chinese. Based on
migration and transmission theory, it was suspected that H. pylori infection were
transmitted by people migrating from areas with a high prevalence of infection to
the destination area. Chinese in West Borneo are originated from South China
region where the prevalence of H. pylori infection is high. It is estimated that
there are differences in the prevalence of H. pylori infection among Chinese
compared to the native people of West Borneo, the Dayaknese.
Objective: To determine the differences in the prevalence, epidemiological
characteristics and endoscopic finding between Chinese and Dayaknese with
dyspeptic syndrome.
Methods: This study was a cross-sectional study to determine the differences in
the prevalence of H. pylori infection. The study was conducted at St. Antonius
General Hospital Pontianak from December 2014 to June 2015 with consecutive
sampling method. H.pylori infection prevalence is presented in percentage
numbers, while the epidemiological characteristics and endoscopic finding
differences among Chinese and Dayaknese were analyzed by bivariate analysis
using the chi-square with significance value (p) = 0.05.
Results : From a total of 203 subjects in this study, consisted of 102 Chinese
subjects and 101 Dayaknese subjects, the prevalence of H.pylori infection was
40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0%
and 33.7%, respectively. There is no difference in the epidemiological
characteristics and endoscopic findings in both ethnic groups.
Conclusions : The prevalence of H. pylori infection among the Chinese (48.0%)
is higher than among Dayaknese (33.7%). There is no difference in the
epidemiological characteristics and endoscopic finding among both ethnic groups.;Background : Helicobacter pylori (H. pylori) infection risk is associated with
many factors related to host-agent-environment matter. Ethnicity is one of the host
factors which was the most studied factor overseas. The prevalence of H. pylori
infection was found higher in certain ethnic such among Chinese. Based on
migration and transmission theory, it was suspected that H. pylori infection were
transmitted by people migrating from areas with a high prevalence of infection to
the destination area. Chinese in West Borneo are originated from South China
region where the prevalence of H. pylori infection is high. It is estimated that
there are differences in the prevalence of H. pylori infection among Chinese
compared to the native people of West Borneo, the Dayaknese.
Objective: To determine the differences in the prevalence, epidemiological
characteristics and endoscopic finding between Chinese and Dayaknese with
dyspeptic syndrome.
Methods: This study was a cross-sectional study to determine the differences in
the prevalence of H. pylori infection. The study was conducted at St. Antonius
General Hospital Pontianak from December 2014 to June 2015 with consecutive
sampling method. H.pylori infection prevalence is presented in percentage
numbers, while the epidemiological characteristics and endoscopic finding
differences among Chinese and Dayaknese were analyzed by bivariate analysis
using the chi-square with significance value (p) = 0.05.
Results : From a total of 203 subjects in this study, consisted of 102 Chinese
subjects and 101 Dayaknese subjects, the prevalence of H.pylori infection was
40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0%
and 33.7%, respectively. There is no difference in the epidemiological
characteristics and endoscopic findings in both ethnic groups.
Conclusions : The prevalence of H. pylori infection among the Chinese (48.0%)
is higher than among Dayaknese (33.7%). There is no difference in the
epidemiological characteristics and endoscopic finding among both ethnic groups., Background : Helicobacter pylori (H. pylori) infection risk is associated with
many factors related to host-agent-environment matter. Ethnicity is one of the host
factors which was the most studied factor overseas. The prevalence of H. pylori
infection was found higher in certain ethnic such among Chinese. Based on
migration and transmission theory, it was suspected that H. pylori infection were
transmitted by people migrating from areas with a high prevalence of infection to
the destination area. Chinese in West Borneo are originated from South China
region where the prevalence of H. pylori infection is high. It is estimated that
there are differences in the prevalence of H. pylori infection among Chinese
compared to the native people of West Borneo, the Dayaknese.
Objective: To determine the differences in the prevalence, epidemiological
characteristics and endoscopic finding between Chinese and Dayaknese with
dyspeptic syndrome.
Methods: This study was a cross-sectional study to determine the differences in
the prevalence of H. pylori infection. The study was conducted at St. Antonius
General Hospital Pontianak from December 2014 to June 2015 with consecutive
sampling method. H.pylori infection prevalence is presented in percentage
numbers, while the epidemiological characteristics and endoscopic finding
differences among Chinese and Dayaknese were analyzed by bivariate analysis
using the chi-square with significance value (p) = 0.05.
Results : From a total of 203 subjects in this study, consisted of 102 Chinese
subjects and 101 Dayaknese subjects, the prevalence of H.pylori infection was
40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0%
and 33.7%, respectively. There is no difference in the epidemiological
characteristics and endoscopic findings in both ethnic groups.
Conclusions : The prevalence of H. pylori infection among the Chinese (48.0%)
is higher than among Dayaknese (33.7%). There is no difference in the
epidemiological characteristics and endoscopic finding among both ethnic groups.]"
2015
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Chyntia Olivia Maurine Jasirwan
Korelasi rasio firmicutes/bacteroidetes dengan nilai Controlled Attenuation Parameter (CAP) dan Transient Elastography (TE) pada pasien Non Alcoholic Fatty Liver Disease (NAFLD) = The correlation of Firmicutes/Bacteroidetes ratio with Controlled Attenuation Parameter (CAP) and Transient Elastography (TE) in Non Alcoholic-Fatty Liver Patients
"Latar Belakang: Non alcoholic fatty liver disease (NAFLD) merupakan kondisi perlemakan hati yang merupakan salah satu faktor risiko karsinoma hepatoselular (KSH). NAFLD melibatkan berbagai faktor dalam patogenesisnya, salah satunya mikrobiota saluran cerna. Disbiosis mikrobiota saluran cerna dianggap sebagai faktor utama dalam peristiwa disregulasi sistem imun dan inflamasi pada patogenesis NAFLD.
Tujuan: Studi ini bertujuan untuk melihat profil dan konfigurasi mikrobiota saluran cerna pasien dengan NAFLD dan pengaruhnya terhadap nilai kondisi fibrosis dan stratosis hati yang tercermin dalam nilai controlled attenuation parameter (CAP) dan transient elastography (TE).
Metode: Dilakukan studi potong lintang analitik terhadap 37 pasien dengan NAFLD yang memenuhi kriteria inklusi di Rumah Sakit Cipto Mangunkusumo pada Desember 2018 hingga Maret 2019. Dilakukan anamnesis, wawancara food recall, pemeriksaan fisik, pemeriksaan laboratorium, pemeriksaan CAP-TE, dan pengambilan sampel feses pada pasien subjek penelitian. Mikrobiota saluran cerna disekuensing dengan Next-Generation Sequencing (NGS) platform Miseq (Illumina).
Hasil: NAFLD lebih dominan pada wanita dan penderita penyakit sindrom metabolik. Firmicutes, Bacteroidetes, dan Proteobacteria berturut-turut merupakan filum dengan proporsi terbesar. Disbiosis mikrobiaota saluran cerna didapatkan pada separuh dari sampel subjek penelitian. Rasio Firmicutes/Bacteroidetes (RFB) pada setiap pasien berbeda-beda dan tidak berkorelasi secara signifikan terhadap variabel sindrom metabolik. Diversitas mikrobiota saluran cerna didapatkan menurun pada pasien NAFLD dengan trigliserida tinggi dan obesitas sentral.
Simpulan: Sejumlah mikrobiota saluran cerna pada tingkat taksonomi yang berbeda memiliki korelasi positif maupun negatif terhadap fibrosis dan steatosis.
Background: Non alcoholic fatty liver disease (NAFLD) is fatty liver condition that can lead to hepatocellular carcinoma (HCC). NAFLD is multifactorial component in its pathogenesis, one of which is gut microbiota. Dysbiosis of gut microbiota is considered as main factor in the dysregulation of immune system and inflammatory condition in the pathogenesis of NAFLD.
Aim: This study aim to investigate the profile and configuration of gut microbiota in patient with NAFLD dan its correelation withfibrosis and steatosis condition as reflected in controlled attenuation parameter (CAP) dan transient elastography (TE) value.
Method: cross sectional study was done upon 37 NAFLD patients in Cipto Mangunkusumo National General Hospital from December 2018 to March 2019. All subjects undergone food recall examination, physical and laboratory examination, CAP-TE value measurement, and fecal sample examination. The gut microbiota was investigated through 16s RNA sequensing by Next-Generation Sequencing (NGS) platform Miseq (Illumina).
Result: NAFLD was predominant in female subjects and those with metabolic syndrome. Firmicutes, Bacteroidetes, dan Proteobacteria was the predominant phylum consecutively. Dysbiosis was appeared in half of the study subjects. The Ratio of Firmicutes/Bacteroidetes was different in each patients and has no significnat correlation with metabolic syndrome variables. The diversity of gut microbiota was decresed in NAFLD patients with high tryglicerides and central obesity.
Conclusion: Certain gut microbiota at different taxonomy level have positive and negative correlation with fibrosis and steatosis."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
T55584
UI - Tesis Membership  Universitas Indonesia Library
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Chyntia Olivia Maurine Jasirwan
Korelasi Rasio Firmicutes/Bacteroidetes dengan Nilai Controlled Attenuation Parameter (CAP) dan Transient Elastography (TE) pada Pasien Non Alcoholic Fatty Liver Disease (NAFLD) = The Correlation of Firmicutes/Bacteroidetes Ratio with Controlled Attenuation Parameter (CAP) and Transient Elastography (TE) in Non Alcoholic-Fatty Liver Patients
"

Latar Belakang: Non alcoholic fatty liver disease (NAFLD) merupakan kondisi perlemakan hati yang merupakan salah satu faktor risiko karsinoma hepatoselular (KSH). NAFLD melibatkan berbagai faktor dalam patogenesisnya, salah satunya mikrobiota saluran cerna. Disbiosis mikrobiota saluran cerna dianggap sebagai faktor utama dalam peristiwa disregulasi sistem imun dan inflamasi pada patogenesis NAFLD.

Tujuan: Studi ini bertujuan untuk melihat profil dan konfigurasi mikrobiota saluran cerna pasien dengan NAFLD dan pengaruhnya terhadap nilai kondisi fibrosis dan stratosis hati yang tercermin dalam nilai controlled attenuation parameter (CAP) dan transient elastography (TE).

Metode: Dilakukan studi potong lintang analitik terhadap 37 pasien dengan NAFLD yang memenuhi kriteria inklusi di Rumah Sakit Cipto Mangunkusumo pada Desember 2018 hingga Maret 2019. Dilakukan anamnesis, wawancara food recall, pemeriksaan fisik, pemeriksaan laboratorium, pemeriksaan CAP-TE, dan pengambilan sampel feses pada pasien subjek penelitian. Mikrobiota saluran cerna disekuensing dengan Next-Generation Sequencing (NGS) platform Miseq (Illumina).

Hasil: NAFLD lebih dominan pada wanita dan penderita penyakit sindrom metabolik. Firmicutes, Bacteroidetes, dan Proteobacteria berturut-turut merupakan filum dengan proporsi terbesar. Disbiosis mikrobiaota saluran cerna didapatkan pada separuh dari sampel subjek penelitian. Rasio Firmicutes/Bacteroidetes (RFB) pada setiap pasien berbeda-beda dan tidak berkorelasi secara signifikan terhadap variabel sindrom metabolik. Diversitas mikrobiota saluran cerna didapatkan menurun pada pasien NAFLD dengan trigliserida tinggi dan obesitas sentral.

Simpulan: Sejumlah mikrobiota saluran cerna pada tingkat taksonomi yang berbeda memiliki korelasi positif maupun negatif terhadap fibrosis dan steatosis.

Background: Non alcoholic fatty liver disease (NAFLD) is fatty liver condition that can lead to hepatocellular carcinoma (HCC). NAFLD is multifactorial component in its pathogenesis, one of which is gut microbiota. Dysbiosis of gut microbiota is considered as main factor in the dysregulation of immune system  and inflammatory condition in the pathogenesis of NAFLD.

Aim: This study aim to investigate the profile and configuration of gut microbiota in patient with NAFLD dan its correelation withfibrosis and steatosis condition as reflected in controlled attenuation parameter (CAP) dan transient elastography (TE) value.

Method: cross sectional study was done upon 37 NAFLD patients in Cipto Mangunkusumo National General Hospital from December 2018 to March 2019. All subjects undergone food recall examination, physical and laboratory examination, CAP-TE value measurement, and fecal sample examination. The gut microbiota was investigated through 16s RNA sequensing by Next-Generation Sequencing (NGS) platform Miseq (Illumina).

Result: NAFLD was predominant in female subjects and those with metabolic syndrome. Firmicutes, Bacteroidetes, dan Proteobacteria was the predominant phylum consecutively. Dysbiosis was appeared in half of the study subjects. The Ratio of Firmicutes/Bacteroidetes was different in each patients and has no significnat correlation with metabolic syndrome variables. The diversity of gut microbiota was decresed in NAFLD patients with high tryglicerides and central obesity.

Conclusion: Certain gut microbiota at different taxonomy level have positive and negative correlation with fibrosis and steeatosis.

"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Nababan, Saut Horas Hatoguan
Proporsihdan prediksi mortalitas dalam perawatanp Sirosis Hati dengan dekompensasi akut di RS Cipto Mangunkusumo = Proportion and prediction of In-hospital mortality in acutely decompensated liver cirrhosis at Cipto Mangunkusumo Hospital.
"Latar Belakang: Sirosis hati dengan dekompensasi akut merupakan masalah
kesehatan dengan beban biaya yang besar dan berpengaruh negatif terhadap
produktivitas dan kualitas hidup. Belum diketahui sepenuhnya prediktor mortalitas
dalam perawatan pasien sirosis hati dekompensasi akut di Indonesia.
Tujuan: Mengetahui proporsi dan prediktor mortalitas dalam perawatan pasien
sirosis hati dekompensasi akut di Rumah Sakit Cipto Mangunkusumo (RSCM).
Metode: Studi kohort retrospektif berbasis data rekam medis pasien sirosis hati
dekompensasi akut di RSCM (2016-2019). Analisis bivariat dan multivariat regresi
logistik dilakukan untuk mengidentifikasi prediktor mortalitas dalam perawatan.
Dua sistem skor dikembangkan berdasarkan identifikasi faktor-faktor tersebut.
Hasil: 241 pasien dianalisis, sebagian besar adalah laki-laki (74,3%), menderita
hepatitis B (38,6%) dan Child-Pugh B dan C (40% dan 38%). Perdarahan saluran
cerna ditemukan pada 171 pasien (70,95%) dan 29 pasien (12,03%) meninggal
dalam perawatan. Prediktor independen mortalitas dalam perawatan adalah usia
(adjusted OR:1,09 [1,03–1,14]; p=0,001), infeksi bakterial (adjusted OR: 6,25
[2,31–16,92]; p<0,001), kadar bilirubin total (adjusted OR: 3,01 [1,85– 4,89];
p<0,001) dan kadar kreatinin (adjusted OR: 2,70 [1,20–6,05]; p=0,016). Skor
logistik dan aditif untuk prediksi mortalitas dalam perawatan memiliki nilai
AUROC masing-masing 0,89 dan 0,86.
Simpulan: Proporsi mortalitas dalam perawatan pasien sirosis hati dekompensasi
akut di RSCM adalah 12,03%. Prediktor independen dari mortalitas dalam
perawatan antara lain usia, adanya infeksi bakterial, kadar bilirubin dan kreatinin.
Telah dikembangkan sistem skor prediksi mortalitas dalam perawatan pasien sirosis
hati dekompensasi akut.
Background: Acutely decompensated liver cirrhosis is associated with a high
medical cost and negatively affects productivity and quality of life. Data on the
predictors of in-hospital mortality in acutely decompensated liver cirrhosis patients
in Indonesia is still limited.
Objective: To determine the proportion and predictors of in-hospital mortality in
acutely decompensated liver cirrhosis patients at Cipto Mangunkusumo Hospital.
Methods: Retrospective cohort study using the hospital database of acutely
decompensated liver cirrhosis at Cipto Mangunkusumo Hospital (2016-2019).
Bivariate and multivariate logistic regression analyses were performed to identify
predictors of in-hospital mortality. Two scoring systems were developed based on
the identified factors.
Results: 241 patients were analyzed, mostly male (74,3%), suffering from hepatitis
B (38.6%) and Child-Pugh B and C (40% and 38%). Gastrointestinal bleeding was
found in 171 patients (70,95%) and 29 patients (12,03%) died during
hospitalization. The independent predictors of in-hospital mortality were age
(adjusted OR: 1,09 [1,03-1,14]; p = 0,001), bacterial infection (adjusted OR: 6,25
[2,31-16,92]; p <0,001), total bilirubin levels (adjusted OR: 3,01 [1,85-4,89]; p
<0,001) and creatinine levels (adjusted OR: 2,70 [1,20-6,05]; p = 0,016). The
logistic and additive scoring system for predicting in-hospital mortality had
AUROC values of 0,89 and 0,86, respectively.
Conclusion: The proportion of in-hospital mortality in acutely decompensated liver
cirrhosis at Cipto Mangunkusumo Hospital was 12,03%. The independent
predictors of in-hospital mortality were age, bacterial infection, bilirubin, and
creatinine levels. The in-hospital mortality prediction scoring systems have been
developed for acutely decompensated liver cirrhosis."
Depok: Fakultas Kedokteran Universitas Indonesia, 2020
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library