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"Tujuan Pengobatan untuk eradikasi H pylori dengan kombinasi PPI dan Amoksisilin 1000 mg atau Clarithromycin 500 mg yang diberikan 2 kali sehari selama 2 minggu telah terbukti efektif. Kebanyakan penelitian menyebutkan bahwa pengobatan 7 dan 10 hari sama efektif. Tujuan dari penelitian ini adalah untuk membandingkan terapi eradikasi H pylori selama 5 dan 7 hari. Metode Penelitian ini dilakukan secara prospektif pada 60 pasien yang terinfeksi H pylori, pemeriksaan dilakukan dengan endoskopi dan biopsi saluran cerna bagian atas di 6 (enam) rumah sakit di Indonesia. Diagnosis H pylori ditegakkan berdasarkan pada 2 pemeriksaan rapid urea test (Pronto Dry) dan pemeriksaan histopatologi atau adanya urea breath test (UBT) yang positif. Kemudian secara terbuka pasien akan dibagi menjadi 2 kelompok, kelompok pertama mendapatkan pengobatan oral amoksisilin 1000 mg 2 kali sehari, clarithromycin oral 500 mg 2 kali sehari, rabeprazole 10 mg 2 kali sehari selama 5 hari dan kelompok kedua mendapatkan pengobatan oral amoksisilin 1000 mg 2 kali sehari, clarithromycin oral 500 mg 2 kali sehari, rabeprazole 10 mg 2 kali sehari selama 7 hari. Empat minggu kemudian, pasien dievaluasi dengan UBT untuk memastikan keberadaan H pylori. Hasil Pada penelitian ini didapatkan 60 pasien yang terdiri dari 42 laki-laki dan 18 perempuan dengan rata-rata (usia+SD) 47.63+13.93 tahun, rentang usia 21-74 tahun. Kelompok pengobatan 5 hari terdiri dari 25 (41,7%) pasien dan kelompok pengobatan 7 hari terdiri dari 35 (58.3%) pasien. Setelah kelompok pengobatan 5 hari didapatkan 18 (72%) pasien H Pylori negatif, dan setelah pengobatan 7 hari didapatkan 32 (91.4%) pasien H Pylori negatif. Kegagalan eradikasi ditemukan pada kelompok pengobatan 5 hari sebesar 7 (28%) pasien dan pada kelompok pengobatan 7 hari sebesar 3 (8.6%) (p=0,077). Kesimpulan Penelitian ini menunjukkan bahwa eradikasi H pylori dengan pengobatan tripel dengan rabeprazole pada kelompok 7 hari masih lebih baik daripada kelompok pengobatan 5 hari. Perbedaan yang tidak bermakna secara statistik ini mungkin karena jumlah sampel tidak mencukupi.

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Aim A combination of PPI and 1000 mg amoxicillin/500 mg clarithromycin twice daily for 2 weeks has been proven effective in the eradication of H. pylori. Most studies suggested that treatment for 7 and 10 days may be equally effective. Few data are available on the effi cacy of 5-day triple therapy. Aim of this study was to compare 5-day and 7-day rabeprazole triple therapy for eradication of H. pylori infection. Methods We prospectively studied 60 consecutive H. pylori-infected patients who came to hospitals in six centres in Indonesia and who underwent upper endoscopy and biopsy. H. pylori infection was confi rmed if two rapid urease tests (Pronto Dry) and histology or urea breath test were positive. Patients were assigned to either an open-labelled 5-day or 7-day course of oral amoxicillin 1000 mg b.i.d., clarithromycin 500 mg b.i.d., and rabeprazole 10 mg b.i.d. (RAC).Four weeks after therapy, all patients had a repeated UBT for evaluation of the presence of H. pylori. Results Of the 60 patients (42 males and 18 females) with mean age (± SD) 47.63 ± 13.93 years, range 21?74 years, 25 patients (41.7%) had 5-day treatment and 35 patients (58.3%) had 7-day treatment. With 5-day treatment, 18 patients (72%) and with 7-day treatment 32 patients (91.4%) became negative for H. pylori infection. The eradication failure was found on 7 patients (28.0%) in 5-day reatment and 3 patients (8.6%) in 7-day treatment. Conclusions The study showed that the eradication of H. pylori infection by triple rabeprazole-based treatment in 7-day is still better than in 5-day."

"[ABSTRAKLatar Belakang : Risiko infeksi Helicobacter pylori (H.pylori) dikaitkan denganbanyak faktor yang terkait dengan pejamu-agen-lingkungan. Etnis adalah salahsatu faktor dari pejamu yang banyak diteliti di luar negeri. Prevalensi infeksiH.pylori didapatkan lebih tinggi pada etnis tertentu seperti misalnya di China.Berdasarkan teori Migrasi dan teori Transmisi diduga infeksi H.pylori akandibawa oleh penduduk yang bermigrasi dari daerah dengan prevalensi tinggi ketempat tujuan migrasi. Etnis Tionghoa di Kalimantan Barat berasal dari daerahChina Selatan dimana prevalensi infeksi H.pylori tinggi. Diperkirakan adaperbedaan angka prevalensi infeksi H.pylori pada etnis Tionghoa dibandingkanpada etnis asli Kalimantan Barat, yaitu etnis Dayak.Tujuan : Untuk mengetahui perbedaan angka prevalensi, karakteristikepidemiologis dan gambaran hasil pemeriksaan endoskopi pada subjek etnisTionghoa dan Dayak dengan sindrom dispepsia.Metode : Penelitian ini adalah studi potong lintang untuk mengetahui perbedaanangka prevalensi infeksi H.pylori. Penelitian dilakukan di RSU Santo AntoniusPontianak dari bulan Desember 2014 sampai Juni 2015 dengan metodepengambilan sampel secara consecutive sampling. Angka prevalensi infeksiH.pylori disajikan dalam angka persentase, sedangkan perbedaan karakteristikepidemiologis dan perbedaan gambaran hasil pemeriksaan endoskopi pada etnisTionghoa dan Dayak dianalisis dengan analisis bivariat menggunakan chi-squaredengan tingkat kemaknaan (p) = 0,05.Hasil : Dari 203 subjek yang diteliti, terdiri dari 102 subjek etnis Tionghoa dan101 subjek etnis Dayak didapatkan angka prevalensi H.pylori sebesar 40,8%.Prevalensi pada etnis Tionghoa didapatkan lebih tinggi dibanding etnis Dayak,berturut-turut sebesar 48,0% dan 33,7%. Tidak ada perbedaan karakteristikepidemiologis dan temuan hasil pemeriksaan endoskopi pada kedua kelompoketnis.Simpulan : Terdapat perbedaan angka prevalensi infeksi H.pylori pada etnisTionghoa (48,0%) dibanding etnis Dayak (33,7%). Tidak ada perbedaankarakteristik epidemiologis dan gambaran hasil pemeriksaan endoskopi padakedua kelompok etnis.

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ABSTRACTBackground : Helicobacter pylori (H. pylori) infection risk is associated withmany factors related to host-agent-environment matter. Ethnicity is one of the hostfactors which was the most studied factor overseas. The prevalence of H. pyloriinfection was found higher in certain ethnic such among Chinese. Based onmigration and transmission theory, it was suspected that H. pylori infection weretransmitted by people migrating from areas with a high prevalence of infection tothe destination area. Chinese in West Borneo are originated from South Chinaregion where the prevalence of H. pylori infection is high. It is estimated thatthere are differences in the prevalence of H. pylori infection among Chinesecompared to the native people of West Borneo, the Dayaknese.Objective: To determine the differences in the prevalence, epidemiologicalcharacteristics and endoscopic finding between Chinese and Dayaknese withdyspeptic syndrome.Methods: This study was a cross-sectional study to determine the differences inthe prevalence of H. pylori infection. The study was conducted at St. AntoniusGeneral Hospital Pontianak from December 2014 to June 2015 with consecutivesampling method. H.pylori infection prevalence is presented in percentagenumbers, while the epidemiological characteristics and endoscopic findingdifferences among Chinese and Dayaknese were analyzed by bivariate analysisusing the chi-square with significance value (p) = 0.05.Results : From a total of 203 subjects in this study, consisted of 102 Chinesesubjects and 101 Dayaknese subjects, the prevalence of H.pylori infection was40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0%and 33.7%, respectively. There is no difference in the epidemiologicalcharacteristics and endoscopic findings in both ethnic groups.Conclusions : The prevalence of H. pylori infection among the Chinese (48.0%)is higher than among Dayaknese (33.7%). There is no difference in theepidemiological characteristics and endoscopic finding among both ethnic groups.;Background : Helicobacter pylori (H. pylori) infection risk is associated withmany factors related to host-agent-environment matter. Ethnicity is one of the hostfactors which was the most studied factor overseas. The prevalence of H. pyloriinfection was found higher in certain ethnic such among Chinese. Based onmigration and transmission theory, it was suspected that H. pylori infection weretransmitted by people migrating from areas with a high prevalence of infection tothe destination area. Chinese in West Borneo are originated from South Chinaregion where the prevalence of H. pylori infection is high. It is estimated thatthere are differences in the prevalence of H. pylori infection among Chinesecompared to the native people of West Borneo, the Dayaknese.Objective: To determine the differences in the prevalence, epidemiologicalcharacteristics and endoscopic finding between Chinese and Dayaknese withdyspeptic syndrome.Methods: This study was a cross-sectional study to determine the differences inthe prevalence of H. pylori infection. The study was conducted at St. AntoniusGeneral Hospital Pontianak from December 2014 to June 2015 with consecutivesampling method. H.pylori infection prevalence is presented in percentagenumbers, while the epidemiological characteristics and endoscopic findingdifferences among Chinese and Dayaknese were analyzed by bivariate analysisusing the chi-square with significance value (p) = 0.05.Results : From a total of 203 subjects in this study, consisted of 102 Chinesesubjects and 101 Dayaknese subjects, the prevalence of H.pylori infection was40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0%and 33.7%, respectively. There is no difference in the epidemiologicalcharacteristics and endoscopic findings in both ethnic groups.Conclusions : The prevalence of H. pylori infection among the Chinese (48.0%)is higher than among Dayaknese (33.7%). There is no difference in theepidemiological characteristics and endoscopic finding among both ethnic groups.;Background : Helicobacter pylori (H. pylori) infection risk is associated withmany factors related to host-agent-environment matter. Ethnicity is one of the hostfactors which was the most studied factor overseas. The prevalence of H. pyloriinfection was found higher in certain ethnic such among Chinese. Based onmigration and transmission theory, it was suspected that H. pylori infection weretransmitted by people migrating from areas with a high prevalence of infection tothe destination area. Chinese in West Borneo are originated from South Chinaregion where the prevalence of H. pylori infection is high. It is estimated thatthere are differences in the prevalence of H. pylori infection among Chinesecompared to the native people of West Borneo, the Dayaknese.Objective: To determine the differences in the prevalence, epidemiologicalcharacteristics and endoscopic finding between Chinese and Dayaknese withdyspeptic syndrome.Methods: This study was a cross-sectional study to determine the differences inthe prevalence of H. pylori infection. The study was conducted at St. AntoniusGeneral Hospital Pontianak from December 2014 to June 2015 with consecutivesampling method. H.pylori infection prevalence is presented in percentagenumbers, while the epidemiological characteristics and endoscopic findingdifferences among Chinese and Dayaknese were analyzed by bivariate analysisusing the chi-square with significance value (p) = 0.05.Results : From a total of 203 subjects in this study, consisted of 102 Chinesesubjects and 101 Dayaknese subjects, the prevalence of H.pylori infection was40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0%and 33.7%, respectively. There is no difference in the epidemiologicalcharacteristics and endoscopic findings in both ethnic groups.Conclusions : The prevalence of H. pylori infection among the Chinese (48.0%)is higher than among Dayaknese (33.7%). There is no difference in theepidemiological characteristics and endoscopic finding among both ethnic groups., Background : Helicobacter pylori (H. pylori) infection risk is associated withmany factors related to host-agent-environment matter. Ethnicity is one of the hostfactors which was the most studied factor overseas. The prevalence of H. pyloriinfection was found higher in certain ethnic such among Chinese. Based onmigration and transmission theory, it was suspected that H. pylori infection weretransmitted by people migrating from areas with a high prevalence of infection tothe destination area. Chinese in West Borneo are originated from South Chinaregion where the prevalence of H. pylori infection is high. It is estimated thatthere are differences in the prevalence of H. pylori infection among Chinesecompared to the native people of West Borneo, the Dayaknese.Objective: To determine the differences in the prevalence, epidemiologicalcharacteristics and endoscopic finding between Chinese and Dayaknese withdyspeptic syndrome.Methods: This study was a cross-sectional study to determine the differences inthe prevalence of H. pylori infection. The study was conducted at St. AntoniusGeneral Hospital Pontianak from December 2014 to June 2015 with consecutivesampling method. H.pylori infection prevalence is presented in percentagenumbers, while the epidemiological characteristics and endoscopic findingdifferences among Chinese and Dayaknese were analyzed by bivariate analysisusing the chi-square with significance value (p) = 0.05.Results : From a total of 203 subjects in this study, consisted of 102 Chinesesubjects and 101 Dayaknese subjects, the prevalence of H.pylori infection was40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0%and 33.7%, respectively. There is no difference in the epidemiologicalcharacteristics and endoscopic findings in both ethnic groups.Conclusions : The prevalence of H. pylori infection among the Chinese (48.0%)is higher than among Dayaknese (33.7%). There is no difference in theepidemiological characteristics and endoscopic finding among both ethnic groups.]"

"Kami melaporkan sebuah kasus seorang laki-laki, 72 tahun, etnis Tionghoa dengan keluhan utama buangair besar berwarna hitam lembek. Pemeriksaan fisik menunjukkan warna pucat pada konjungtiva palpebrayang dikonfirmasi dengan hasil hitung darah lengkap. Pemeriksaan gastroduodenoskopi menemukan adanyaulkus berukuran 3 mm di antrum (Forrest stage III). Infeksi H. pylori dinyatakan positif berdasarkan limametode berbeda (urinary antibody tests, rapid urease test, kultur, histologi dan imunohistokimia). Analisisdengan sequencing berbasis polymerase chain reaction didapatkan bahwa pasien terinfeksi oleh strainberjenis East-Asian-type cagA dan vacA s1m1. Analisis lanjutan dengan menggunakan tujuh housekeepinggen mengkonfirmasikan bahwa strain tersebut tergolong dalam kelompok hspEAsia. Pasien diberikan infusintravena kontinyu pompa proton inhibitor dan standar triple therapy regimens untuk terapi eradikasi H. pylori.We reported a male, 72 yo, Chinese ethnic with chief complaint black mushy defecation. Physical examinationrevealed pale on conjunctival palpebra which confirmed as anemia on complete blood count. Gastroduodenoscopyrevealed a 3 mm ulcer at the antrum (Forrest stage III). H. pylori infection was positive based on five differenttest methods (urinary antibody tests, rapid urease test, culture, histology ad immunohistochemistry). Usedpolymerase chain reaction-based sequencing, we found the patient infected by CagA producing, East-Asian-typecagA and vacA s1m1-strain. Further analysis using 7 housekeeping genes confirmed that the strain categorizedin to hspEAsia group. The patient was given continuous intravenous infusions of proton pump inhibitor andstandard triple therapy regimens eradication of H. pylori."

"Helicobacter pylori (H.pylori) infection is still a big issue in gastroenterology field. Its relationship with gastrointestinal malignancies now is widely known and the extra-gastrointestinal manifestation of this epidemic bring new problems. Although the prevalence is decreasing in develop countries, the resistance rate of some strains to standard therapy needs more attention and new strategies. Recent epidemiology studies revealed that H.pylori infection is a specific population disease. Many trials and meta analyses revealed new evidence and horizons in the management of this infection. This review update and highligted pathophysiology, clinical aspects, and new epidemiology data on H.pylori infection which is published in the last five years"

"Helicobacter pylori is a globally significant pathogen that infects half of the population of the world. Its recognition enabled the development of new therapeutic and preventative strategies for serious health conditions such as gastric cancer, of which it is the major causative agent. Providing a broad overview of the current understanding of this pathogen and emphasizing its world health impacts, this book explores a range of topics including virulence factors, vaccine development and obstacles, epidemiology, antibiotic resistance and the role of Nod receptors, with a foreword by Barry Marshall, the Nobel Laureate and co-discoverer of H. pylori. It is an essential resource for researchers, students and medics in infectious and Helicobacter-associated diseases."

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Latar belakang: Prevalensi infeksi Helicobacter pylori pada anak di Indonesia 8%- 52%. Gejala dominan pada anak dengan infeksi H. pylori adalah refluks gastroesofageal yang mengganggu kualitas hidup (penyakit refluks gastroesofageal/PRGE), yang secara definitf di diagnosis dengan pemeriksaan esofagogastroduodenoskopi (EGD). Untuk mengetahui infeksi dilakukan uji Rapid Urease Test (RUT) pada saat bedside, namun uji ini belum diketahui akurasinya Tujuan: Mendapatkan proporsi positif RUT pada biopsi lambung dibandingkan real-time PCR. Selain itu ingin diketahui karakteristik gambaran klinis, demografi, dan hubungan faktor risiko pada anak PRGE yang menjalani prosedur EGD. Metode: Penelitian potong lintang pada 46 anak dengan PRGE di RSCM dan RS MMC. Semua subyek menjalani RUT, real-time PCR dan histopatologi. Hasil: Anak perempuan berusia lebih dari 10-18 tahun dengan tingkat pendidikan orangtua rendah mendominasi karakteristik subyek penelitian ini. Nyeri perut lebih dari 3 bulan, anemia, status nutrisi, orangtua dispepsia dan kepadatan kapling rumah pada penelitian ini tidak terbukti sebagai faktor risiko terhadap terjadinya PRGE. Namun, pola makan tidak teratur dan komsumsi makan berempah memengaruhi terjadinya gastropati pada lambung anak (p < 0,05). Proporsi positif RUT; 2,2% dan real-time PCR; 8,7%. Kesimpulan: Hasil negatif pada pemeriksaan RUT tidak menyingkirkan terjadinya infeksi H. pylori, terutama pada pasien dalam terapi proton pump inhibitor (PPI). Pemeriksaan lanjutan menggunakan real-time PCR dianjurkan untuk mendukung diagnosis ini.

 

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Background: The prevalence of detected Helicobacter pylori infection of children in Indonesia was 8%-52%. Gastroesophageal reflux was the dominant symptom and might be attributable to H. pylori infection which reduced quality of life. Current definitive diagnosis was using esophagogastroduodenoscopy (EGD). Rapid Urease Test (RUT) was used in bedside setting for H. pylori detection, however its accuracy was still unkown. Objectives: This study was done to determine the positive proportion of RUT on gastric biopsy specimens and real-time PCR. Moreover, this study explored the characteristics of clinical and demographic features, and examined the risk factors in children with GERD (gastroesophageal reflux disease) who underwent diagnostic EGD. Methods: This is a cross-sectional study on 46 children diagnosed as GERD, admitted to the RSCM and MMC Hospital. All subject underwent RUT, real-time PCR and histopathology examination. Results: Most subjects are girls, more than 10-18 years with low parental education dominated the proportion of subject included in this study. According to abdominal pain more than 3 months, anemia, nutritional status, parental dyspepsia and crowded household were not proven to be risk factors for increase of GERD. However, irregular feeding habit and consumption of spicy foods were be associated with gastropathy in child’s gastric mucosa (p < 0,05). The positive proportion of RUT was 2.2% and real-time PCR was 8.7%. Conclusion: The negative result of RUT could not rule out of H. pylori infection, especially in patients with proton pump inhibitor (PPI) therapy. Further examination using real-time PCR is needed to support the diagnosis.

 

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"Latar Belakang: Infeksi Helicobacter pylori merupakan infeksi kronis bakterial yang berhubungan dengan penyakit gastroduodenal. Berdasarkan konsensus Bangkok, pemeriksaan diagnostik infeksi H.pylori hendaknya dilakukan pada semua pasien dispepsia kronis. Urea breath test (UBT) merupakan pemeriksaan referens non-invasif dengan biaya cukup mahal. Rapid test antigen feses merupakan pemeriksaan yang praktis dengan biaya lebih terjangkau. Penelitian ini bertujuan mengevaluasi peran diagnostik rapid test antigen H.pylori dalam feses terhadap UBT pada pasien dispepsia. Metode: Penelitian ini merupakan uji potong lintang terhadap pasien dispepsia di RSUPN Cipto Mangunkusumo selama bulan Agustus-Oktober 2018. Sebanyak 70 subjek diambil secara consecutive sampling dan dilakukan pemeriksaan rapid test SD Bioline H.pylori Ag^® dan Urea [¹³C] Breath Test Kit-Heliforce^®. Hasil: Rerata usia subjek penelitian adalah 46,2 ± 14,23 tahun (18-70 tahun) dan terdapat 17,14% subjek positif terinfeksi H.pylori berdasarkan hasil UBT. Sensitivitas, spesifisitas, nilai prediksi positif, dan nilai prediksi negatif rapid test secara berurutan adalah 41,67%, 100%, 100%, dan 89,23%. Simpulan: Rapid test antigen H.pylori dalam feses memiliki sensitvitas yang kurang baik tetapi memiliki spesifisitas, NPP, dan NPN yang cukup baik; praktis digunakan; dan harganya jauh lebih terjangkau sehingga masih dapat dipertimbangkan untuk digunakan pada daerah dengan keterbatasan ekonomi dan fasilitas.

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Background: Helicobacter pylori infection is a chronic bacterial infection associated with gastroduodenal diseases. Based on the Bangkok consensus, a diagnostic test of H.pylori infection should be carried out in all patients with chronic dyspepsia. Urea breath test (UBT) is a non-invasive reference test with a fairly expensive cost. Stool antigen rapid test is a practical test with a more affordable cost. We aimed to evaluate the diagnostic role of the H.pylori stool antigen rapid test against UBT in dyspeptic patients.

Methods: This was a cross-sectional study of dyspeptic patients at RSUPN Cipto Mangunkusumo during August-October 2018. A total of 70 subjects were taken by consecutive sampling method and tested with rapid test SD Bioline H.pylori Ag^® and Urea [¹³C] Breath Test Kit-Heliforce^®.

Results: The mean age of the subjects was 46.2 ± 14.23 years (18-70 years) and there were 17.14% subjects positively infected with H.pylori based on UBT results. Sensitivity, specificity, positive predictive value, and negative predictive value of the rapid test were 41.67%, 100%, 100%, and 89.23% respectively.

Conclusion: Helicobacter pylori stool antigen rapid test had poor sensitivity but had a good specificity, PPV, and NPV; practical use; and more affordable price so that it could still be considered to be used in areas with economic and facilities limitations."

"Latar Belakang: Prevalensi infeksi Helicobacter pylori yang masih tinggi di beberapa negara. Penelitian di Guang Zhou terjadi penurunan seroprevalensi infeksi Helicobacter pylori antara tahun 1993 2003 dari 62 5 menjadi 47. Studi prevalensi di salah satu RS swasta Jakarta menunjukkan penurunan prevalensi infeksi Helicobacter pylori dari 12 5 di tahun 1998 menjadi 2 9 di tahun 2005 Perlunya diketahui seroprevalensi dikomunitas saat ini apakah sesuai dengan penurunan yang terjadi pada penelitian berbasis rumah sakit dan faktor faktor yang mempengaruhi infeksi Helicobacter pylori di masyarakat. Tujuan: Mengetahui seroprevalensi dan faktor faktor sosiodemografis yang berhubungan dengan infeksi Helicobacter pylori. Metode: Studi potong lintang terhadap 111 pasien dispepsia yang berobat di Puskesmas Kelurahan Kalibaru Jakarta Utara Januari-Februari 2015. Dilakukan analisa bivariat untuk mengetahui hubungan faktor faktor dengan infeksi Helicobacter pylori menggunakan uji chi square dan uji T tidak berpasangan serta alternatifnya. Analisa multivariat menggunakan uji regresi logistik. Hasil dan Pembahasan: Pada 111 pasien dewasa dengan keluhan dispepsia yang berobat ke Puskesmas Kelurahan Kalibaru didapatkan seroprevalensi Helicobacter pylori sebesar 22 5 95 IK 14 8 30 2. Usia tidak berhubungan dengan infeksi Helicobacter pylori p 0 270. Semakin tinggi tingkat sosial ekonomi semakin rendah rasio odds infeksi Helicobacter pylori OR 0 2 95 IK 0 02-1 71. Semakin tinggi indeks kepadatan penduduk semakin tinggi rasio odds infeksi Helicobacter pylori OR 1 2 95 IK 0 37-4 49. Semakin rendah clean water index semakin tinggi rasio odds infeksi Helicobacter pylori OR 1 5 95 IK 0 57-4 04. Semakin rendah status sanitasi semakin tinggi rasio odds infeksi Helicobacter pylori OR 2 5 95 IK 1 01-6 19. Kesimpulan: Seroprevalensi Helicobacter pylori pada pasien dispepsia kelurahan Kalibaru sebesr 22 5 95 IK 14 8 30 2. Didapatkan hubungan antara sanitasi lingkungan dengan Helicobacter pylori.

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Background: The prevalence of Helicobacter pylori infection in some countries remains high. Study in Guang Zhou showed a decrease in seroprevalence of Helicobacter pylori from 62 5 in 1993 to 47 in 2003. Prevalence studies in one of the private hospitals in Jakarta showed a decrease in the prevalence of Helicobacter pylori infection from 12 5 in 1998 to 2 9 in 2005. It is important to know the seroprevalence in community nowadays and its related factors in society.

Objective: To identify seroprevalence of Helicobacter pylori infection and its socio demogrphic related factors.

Method: A cross sectional study in 111 patients with dyspepsia who got treatment in Kalibaru Primary Health Care in North Jakarta from January to February 2015. A bivariate analysis was done to know relationship between Helicobacter pylori infection and its related factors using chi square unpaired t test and their alternatives. Multivariate analysis was done using logistic regression test.

Result: Seroprevalence of Helicobacter pylori of 111 dyspepsia patients who get treatment in Kalibaru Primary Helath Care in this study was 22 5 95 CI 14 8 30 2. There is no relationship between age and Helicobacter pylori infection p 0 270 Higher socio economic class was related to lower risk Helicobacter pylori infection OR 0 2 95 IK 0 02-1 71. Higher crowding index was related to higher risk Helicobacter pylori infection OR 1 2 95 IK 0 37-4 49. Lower clean water index was related to higher risk Helicobacter pylori infection OR 1 5 95 IK 0 57-4 04. Lower sanitation status was related to higher risk Helicobacter pylori infection OR 2 5 95 IK 1 01-6 19.

Conclusion: Seroprevalence of Helicobacter pylori infection in patient with dyspepsia in Kalibaru village was 22 5 95 CI 14 8 30 2. There is a relation between sanitation and Helicobacter pylori infection. "

"Dyspepsia is a common complain in clinical practice. Correlation between helicobacter pylori (H. pylori) and functional dyspepsia had been reported in many studies, but studies that analyzed the severity of dyspepsia and H. pylori were limited and the result were controversial. This study is about to know the correlation between the severity of dyspepsia and H. pylori infection. A retrospective descriptive analysis to patients with dyspepsia at Permata Bunda Hospital, Medan was done in 2010-2014. Simple random sampling was done to get 44 patient with dyspepsia, 22 are H. pylori positive and 22 patients are H. pylori negative. The severity of dyspepsia assessed with porto alegre dyspeptic symptoms questionnaire (PADYQ) scoring instrument. Univariate and bivariate analysis (Chi-square and spearman correlation) were done using SPSS version 22. Epigastric pain is teh most common symptom in dyspepsia patients. There is a correlation between ulcer type dyspepsia and H. pylori infection (p=0.030), while dysmotility type and mixed type were not correlated. The severity of epigastric pain has significant positive correlation with H. pylori (r=0.386;p=0.01), while the severity of other symptoms such as nausea, vomit, and abdominal bloating have negative correlation with H.pylori. Dyspepsia total scoring is significantly lower in H. pylori positive than in H.pylori negative (p=0.033). There is a positive correlation between the severity of nausea, vamit, and abdominal bloating and H.pylori infection, and correlation between lower dyspepsia total scoring and H.pylori pain."