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"ABSTRAK Latar belakang : Penelitian ini merupakan studi awal untuk mengukur kapasitasdifusi paru DLCO-SB ipada pasien PPOK di RSUP Persahabatan Jakarta untukmengetahui prevalens penurunan nilai DLCO pada pasien PPOK.Metode : Penelitian ini menggunakan desain studi potong lintang (cross sectional study) pada pasien PPOK yang berkunjung di Poliklinik Asma-PPOK RSUPPersahabatan Jakarta. Dilakukan uji spirometri dan DLCO pada pasien PPOKyang diambil secara konsekutif antara bulan Mei-Juli 2015. Komorbiditas jugadicatat.Hasil : Uji Spirometri and DLCO dilakukan pada 65 subjek didapatkan 7 subjek (10,8%) termasuk kedalam PPOK Grup A, 19 subjek (29,2%) PPOK Grup B, 21subjek (32,3%) PPOK grup C dan 18 subjek (27,7%) PPOK grup D. rerata usia64,15 (45-89) tahun;rerata VEP1% 46,05%, rerata nilai DLCO 19,42ml/menit/mmHg dan rerata DLCO % adalah 72.00%. prevalens penurunanDLCO pasien PPOK adalah 56,92% (37/65 subjek) sedangkan 28 subjek dengannilai DLCO normal. Ditemukan 15 subjek (23,07%) dengan penurunan ringan, 18subjek (27.69%) penurunan sedang dan 4 subjek (6,15%) dengan penurunan berat.Ditemukan 47 subjek (72,3%) memiliki komorbid. Terdapat hubungan bermaknaantara grup PPOK, derajat spirometri, VEP1, IMT dan komorbiditas dengan nilaihasil uji DLCO. Tidak terdapat hubungan bermakna antara nilai DLCO denganjenis kelamin, umur, riwayat merokok, Indeks Brinkmann, obstruksi-restriksi danlama terdiagnosis PPOK.Kesimpulan : Proporsi penurunan nilai DLCO pada pasien PPOK adalah 56,92%. Terdapat hubungan bermakna antara grup PPOK, derajat spirometri,VEP1, IMT dan riwayat TB dengan nilai hasil uji DLCO. Tidak terdapathubungan bermakna antara nilai DLCO dengan jenis kelamin, umur, riwayatmerokok, Indeks Brinkmann, obstruksi-restriksi, komorbid dan lama terdiagnosisPPOK.ABSTRACT Background and the aim of study : This is a preliminary study to measureDLCO-SB in COPD patients in Persahabatan Hospital. The aim of the study is toknow the magnitude of disturbance in diffusing capacity of the lung in COPDpatients.Methods : This was a cross sectional study in which COPD patients attending COPD-Asthma clinic in Persahabatan Hospital Jakarta were performed spirometryand DLCO-SB consecutively between May 2015?July 2015. Comorbiditiesconditions were also recorded.Results : Spirometry and DLCO-SB measurement were conducted on 65 COPDsubjects of which 7 subjects (10.8%) were COPD Group A, 19 subjects (29.2%)were Group B, 21 subjects (32.3%) were COPD group C and 18 subjects (27.7%)were COPD group D. The mean age was 64.15 (45-89); mean FEV1% was46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO%was 72.00%. The prevalence of decreasing in diffusing capacity of the lung inCOPD patients was 56.92% (37 subjects) While 28 subjects were normal. Therewere 15 subjects (23.07%) with mild decrease in DLCO, 18 subjects (27.69%)were moderate decrease and 4 subjects (6.15%) with severe decrease. 47 subjects(72.3%) had comorbid conditions. There was significant correlation between grupCOPD, GOLD COPD grade, VEP1, BMI and comorbidities with magnitude ofdecreasing DLCO value. There was no correlation between DLCO value with sex,smoking history, Brinkmann index, age, obstruction-mix criteria, length of COPDperiod. Conclusion : The proportion of decreasing in DLCO in COPD patients are56.92%. There is significant correlation among the group of COPD, GOLDCOPD grade, VEP1, BMI and previous TB history with magnitude of decreasingDLCO value. There is no correlation between DLCO value with sex, smokinghistory, brinkmann index, age, obstruction-mix criteria, comorbidities and lengthof COPD period. ;Background and the aim of study : This is a preliminary study to measureDLCO-SB in COPD patients in Persahabatan Hospital. The aim of the study is toknow the magnitude of disturbance in diffusing capacity of the lung in COPDpatients.Methods : This was a cross sectional study in which COPD patients attending COPD-Asthma clinic in Persahabatan Hospital Jakarta were performed spirometryand DLCO-SB consecutively between May 2015?July 2015. Comorbiditiesconditions were also recorded.Results : Spirometry and DLCO-SB measurement were conducted on 65 COPDsubjects of which 7 subjects (10.8%) were COPD Group A, 19 subjects (29.2%)were Group B, 21 subjects (32.3%) were COPD group C and 18 subjects (27.7%)were COPD group D. The mean age was 64.15 (45-89); mean FEV1% was46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO%was 72.00%. The prevalence of decreasing in diffusing capacity of the lung inCOPD patients was 56.92% (37 subjects) While 28 subjects were normal. Therewere 15 subjects (23.07%) with mild decrease in DLCO, 18 subjects (27.69%)were moderate decrease and 4 subjects (6.15%) with severe decrease. 47 subjects(72.3%) had comorbid conditions. There was significant correlation between grupCOPD, GOLD COPD grade, VEP1, BMI and comorbidities with magnitude ofdecreasing DLCO value. There was no correlation between DLCO value with sex,smoking history, Brinkmann index, age, obstruction-mix criteria, length of COPDperiod. Conclusion : The proportion of decreasing in DLCO in COPD patients are56.92%. There is significant correlation among the group of COPD, GOLDCOPD grade, VEP1, BMI and previous TB history with magnitude of decreasingDLCO value. There is no correlation between DLCO value with sex, smokinghistory, brinkmann index, age, obstruction-mix criteria, comorbidities and lengthof COPD period. ;Background and the aim of study : This is a preliminary study to measureDLCO-SB in COPD patients in Persahabatan Hospital. The aim of the study is toknow the magnitude of disturbance in diffusing capacity of the lung in COPDpatients.Methods : This was a cross sectional study in which COPD patients attending COPD-Asthma clinic in Persahabatan Hospital Jakarta were performed spirometryand DLCO-SB consecutively between May 2015?July 2015. Comorbiditiesconditions were also recorded.Results : Spirometry and DLCO-SB measurement were conducted on 65 COPDsubjects of which 7 subjects (10.8%) were COPD Group A, 19 subjects (29.2%)were Group B, 21 subjects (32.3%) were COPD group C and 18 subjects (27.7%)were COPD group D. The mean age was 64.15 (45-89); mean FEV1% was46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO%was 72.00%. The prevalence of decreasing in diffusing capacity of the lung inCOPD patients was 56.92% (37 subjects) While 28 subjects were normal. Therewere 15 subjects (23.07%) with mild decrease in DLCO, 18 subjects (27.69%)were moderate decrease and 4 subjects (6.15%) with severe decrease. 47 subjects(72.3%) had comorbid conditions. There was significant correlation between grupCOPD, GOLD COPD grade, VEP1, BMI and comorbidities with magnitude ofdecreasing DLCO value. There was no correlation between DLCO value with sex,smoking history, Brinkmann index, age, obstruction-mix criteria, length of COPDperiod. Conclusion : The proportion of decreasing in DLCO in COPD patients are56.92%. There is significant correlation among the group of COPD, GOLDCOPD grade, VEP1, BMI and previous TB history with magnitude of decreasingDLCO value. There is no correlation between DLCO value with sex, smokinghistory, brinkmann index, age, obstruction-mix criteria, comorbidities and lengthof COPD period. "

"Tingginya jumlah perokok aktif di kalangan pelajar. Merokok adalah penyebabnya dari beberapa kondisi keluhan pernafasan dan faktor risiko untuk beberapa kasus: fungsi paru-paru. Inkonsistensi antara dampak negatif merokok dan prevalensi tingkat merokok yang tinggi membuat penelitian tentang hubungan antara kebiasaan merokok dan Keluhan gejala pernafasan dan fungsi paru perlu dilakukan.Tujuan: Mengetahui hubungan antara kebiasaan merokok dengan fungsi dan gejala paru-paru pernapasan pada siswa di Depok.Metode: Penelitian ini menggunakan metode potong lintang dengan instrumen kuesioner penelitian dan alat uji. Kuesioner yang digunakan terdiri dari ATS. daftar pertanyaan (American Thoracic Society) untuk gejala pernapasan dan kuesioner Indeks Brinkman untuk kebiasaan merokok. Alat uji yang digunakan adalah spirometer merek EasyOne® Airspirometer. Penelitian ini diikuti oleh 116 siswa laki-laki perokok aktif di Depok. Data yang telah diperoleh dianalisis menggunakan uji non parametrik Mann-Whitney, T-test independen, dan korelasi bivariat Spearman. Hasil: Hasil analisis statistik dari 116 subjek menunjukkan mayoritas siswa adalah perokok aktif di Depok masih dalam kategori kebiasaan merokok ringan (96,56%) dan memiliki keluhan gejala pernafasan (74,14%). Ada siswa yang perokok aktif mengalami gangguan fungsi paru sebanyak 15,5%. Namun, secara statistik tidak ditemukanhubungan yang signifikan antara kebiasaan merokok pada mahasiswa perokok dengan keluhan gejala pernapasan dan gangguan fungsi paru.

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The high number of active smokers among students. Smoking is the cause of several respiratory conditions and a risk factor in some cases: lung function. The inconsistency between the negative impact of smoking and the prevalence of high smoking rates makes research on the relationship between smoking habits and complaints of respiratory symptoms and lung function necessary.

Objective: To determine the relationship between smoking habits and respiratory lung function and symptoms in students in Depok.

Methods: This study used a cross-sectional method with research questionnaire instruments and test equipment. The questionnaire used consisted of ATS. questionnaire (American Thoracic Society) for respiratory symptoms and a Brinkman Index questionnaire for smoking. The test equipment used is the EasyOne® Air brand spirometer spirometer. This study was followed by 116 male students who were active smokers in Depok. The data obtained were analyzed using the Mann-Whitney non-parametric test, independent T-test, and Spearman bivariate correlation. Results: The results of statistical analysis of 116 subjects showed that the majority of students were active smokers in Depok who were still in the category of light smoking habits (96.56%) and had complaints of respiratory symptoms (74.14%). There are students who are active smokers have lung function disorders as much as 15.5%. However, statistically not found There is a significant relationship between smoking habits in student smokers with complaints of respiratory symptoms and impaired lung function.

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"Kebiasaan merokok masih menjadi masalah global dan juga di Indonesia. Rokok mengandung senyawa dan unsur yang berbahaya bagi kesehatan, salah satunya adalah nikotin. Nikotin memiliki efek ketergantungan pada penggunanya karena paparan jangka panjang dapat menyebabkan desensitisasi reseptor asetilkoin nikotinat. Tingkat dan lama paparan nikotin dari rokok akan mempengaruhi tingkat ketergantungan nikotin. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat kebiasaan merokok dengan tingkat ketergantungan nikotin pada perokok aktif di Depok. Penelitian ini merupakan penelitian cross sectional dengan instrumen penelitian angket. Kuesioner yang digunakan terdiri dari kuesioner tentang faktor-faktor yang mempengaruhi (usia, IMT, latar belakang pendidikan, uang saku, kebiasaan merokok keluarga, dan lingkungan sosial), kuesioner tentang tingkat kebiasaan merokok (diukur dengan indeks Brinkman), dan Fagerstorm/ Kuesioner FTND (melihat tingkat ketergantungan). nikotin). Penelitian ini diikuti oleh 124 mahasiswa perokok aktif di Depok. Penelitian ini menemukan bahwa semakin tinggi indeks Brinkman subjek, semakin tinggi skor Fagerstorm (p < 0,001, r = 0,420). Selain itu, penelitian ini menemukan hubungan antara umur (p = 0,009, r = 0,223), uang saku (p = 0,003, r = 0,261), dan latar belakang pendidikan (p = 0,042) dengan derajat kebiasaan merokok, serta uang jajan ( p = 0,005, r = 0,249) dengan tingkat ketergantungan nikotin. Hasil ini menunjukkan adanya hubungan yang signifikan dengan kekuatan korelasi sedang antara derajat kebiasaan merokok dengan tingkat ketergantungan nikotin.Smoking habits are still a global problem and also in Indonesia. Cigarettes contain compounds and elements that are harmful to health, one of which is nicotine. Nicotine has a dependent effect on its users because long-term exposure can cause desensitization of nicotinic acetylcoin receptors. The level and duration of nicotine exposure from cigarettes will affect the level of nicotine dependence. This study aims to determine the relationship between the level of smoking habits with the level of nicotine dependence on active smokers in Depok. This research is a cross sectional study with a questionnaire research instrument. The questionnaire used consisted of a questionnaire about the influencing factors (age, BMI, educational background, pocket money, family smoking habits, and social environment), a questionnaire about the level of smoking habits (measured by the Brinkman index), and the Fagerstorm/FTND Questionnaire. (see dependency level). nicotine). This study was followed by 124 students who are active smokers in Depok. This study found that the higher the subject's Brinkman index, the higher the Fagerstorm score (p < 0.001, r = 0.420). In addition, this study found a relationship between age (p = 0.009, r = 0.223), pocket money (p = 0.003, r = 0.261), and educational background (p = 0.042) with the degree of smoking habit, and pocket money (p = 0.005, r = 0.249) with the level of nicotine dependence. These results indicate a significant relationship with moderate strength of correlation between the degree of smoking habit and the level of nicotine dependence."

"Metode : Penelitian ini adalah penelitian potong lintang yang bersifat deksriptif analitik untuk mengetahui proporsi rinitis alergi pada pasien asma periode Agustus sampai Oktober 2014. Pasien asma yang datang ke poliklinik Asma dinilai derajat asma dan derajat kontrol asma dengan menggunakan Asthma Control Test (ACT). Jika terdapat minimal 2 gejala rinitis alergi maka dilakukan pemeriksaan nasoendoskopi dan uji cukit kulit. Dari uji cukit kulit, apabila terdapat jenis alergen positif maka didapatkan proporsi rinitis alergi.Hasil. Dari 185 pasien asma yang memiliki dua atau lebih gejala rinitis alergi dan dilanjutkan dengan pemeriksaan nasoendoskopi serta uji cukit kulit adalah 67 orang. Didapatkan proporsi rinitis alergi pada pasien asma 54 orang (29,2%). Data karakteristik pasien asma meliputi jenis kelamin perempuan 77,3% lebih banyak dibandingkan laki-laki 22,7% dengan median usia 52 tahun. Hampir semua pasien menggunakan pembayaran BPJS 94,1% dengan riwayat alergi sebanyak 44,9%. Proporsi derajat asma stabil terbanyak persisten sedang 101 orang (54,6%) dan derajat asma terkontrol adalah terkontrol sebagian 47,0%. Dari sebaran gejala rinitis alergi yang terbanyak adalah bersin 46,5%, rinore 28,6%, dan hidung tersumbat 26,5%. Pada pemeriksaan nasoendoskopi, terdapat kelainan 28,6% dengan terbanyak septum deviasi 56,6%, konka pucat 50,9% dan konka edema 22,6%. Pemeriksaan uji cukit kulit 67 orang, didapatkan 54 orang positif dengan jenis alergen terbanyak positif adalah tungau debu rumah 38,8%. Proporsi derajat rinitis alergi sesuai kriteria ARIA terbanyak intermiten ringan dan persisten ringan 46,3%. Terdapat hubungan yang bermakna antara derajat rinitis alergi dengan derajat asma (p = 0,035). Hubungan antara derajat rinitis alergi dengan derajat kontrol asma juga bermakna (p = 0,006).Kesimpulan. Proporsi rinitis alergi pada pasien asma adalah 29,2% dengan jenis alergen terbanyak berdasarkan uji cukit kulit adalah tungau debu rumah. Terdapat hubungan bermakna antara derajat rinitis alergi dengan derajat asma dan derajat kontrol asma.

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Introduction : Asthma and rhinitis are two different entities are anatomical, physiological and clinical management but located in one airway. United Airway Disease (UAD) have hypothesized that inflammation of the upper and lower respiratory tract both a manifestation of a process of inflammation in the airways and this hypothesis is supported by evidence arising from the systemic relationship of the upper and lower respiratory tract. World Health Organization (WHO) issued a guidance entitled Allergic Rhinitis and it's Impact on Asthma (ARIA) 2001 which provides a comprehensive overview of the pathophysiology, diagnosis and treatment of allergic rhinitis in asthma patients. This study aims to knowthe allergic rhinitis proportion on those patients and related factors at Persahabatan Hospital.Methods : This is a cross-sectional study based on the descriptive and analytical to find out the allergic rhinitis proportion in asthma patients at the period August to October 2014. Those who came to asthma clinic evaluated for the degree of asthma control test (ACT). If there are at least two allergic rhinitis symptoms, nasoendoscopy examination and skin prick test should be done and if there is type of positive from skin prick test, the allergic rhinis proportion obtained.Results : From 185 asthma patients who participate, have two or more allergic rhinitis symptoms and have joined nasoendoscopy examination and skin prick test are 67 person. It is found that the allergic rhinitis proportion in asthma patients are 54 (29,2%) the characteristics data of asthma patients include female (77,3%) and more than male (22,7%) with a median age of 52 years. Almost all patients use BPJS payment (94,1%) with the allergic history (44,9%).. The proportion of the highest degree persistent stable asthma are 101 person (54,6%) and the degree of asthma control which is partially controlled is 47,0%. From the distribution of the most allergic rhinitis symptoms are sneezing (46,5%), rhinorrhea (28,6%) and nasal congestion (26,5%). In the nasoendoscopy examination, there are abnormalities (28,6%) with septum deviation (56,6%), pale turbinate (50,9%) and concha edema (22,6%). Examination of the skin prick test from 67 person, 54 person are positive with the most type of allergen caused by house dust mites (38,8%). The proportion of the allergic rhinitis degree based on ARIA criteria, mild intermittent and mild persistent (46,3%). There is a significant correlation between the degree of allergic rhinitis with the asthma degree (p = 0,035). The corellation between the degree of allergic rhinitis with the degree of asthma control was also significant (p = 0,006).Conclusion : The allergic rhinitis proportion in asthma patients is 29,2% and based on the skin prick test, the most type of allergensare the house dust mites. There is a significant association between the degree of allergic rhinitis with the asthma degree and the degree of asthma control."

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Latar Belakang: Dampak merokok masih menjadi permasalahan besar di Dunia meskipun penggunaan rokok merupakan salah satu penyebab kematian terbesar yang dapat dicegah. Salah satu zat yang berbahaya dari merokok adalah karbon monoksida, sayangnya belum dilakukan penelitian antara tingkatan karbon monoksida perokok rokok putih dengan rokok kretek pada mahasiswa di Indonesia

Tujuan: Mengetahui perbandingan kadar CO ekspirasi pada mahasiswa laki-laki perokok rokok putih dan kretek di universitas di Depok

Metode: Penelitian ini menggunakan desain studi Potong-Lintang dengan 108 sampel yang dibagi menjadi dua kelompok perokok putih dan perokok kretek dengan teknik pengambilan sampel consecutive. Subyek melakukan tes CO ekspirasi dan mengisi kuesioner yang berhubungan dengan kebiasaan merokok dan faktor-faktor lainnya.

Hasil: Penelitian mendapatkan hasil karbon monoksida ekspirasi pada perokok rokok putih 13,9 ± 8,36 ppm dan kretek sebesar 13,18 ± 8,79 ppm, sementara hasil uji statistik pilihan tipe rokok terhadap karbon monoksida sebesar 0,663. Sementara terdapat faktor lainnya yang berpengaruh terhadap CO ekspirasi subyek yaitu Indeks Brinkman dengan p<0,001 dengan korelasi lemah, sementara terdapat faktor yang berpengaruh terhadap pilihan tipe rokok yaitu uang saku dengan nilai p 0,023 dan umur dengan nilai 0,015.

Kesimpulan: Tidak terdapat hubungan bermakna secara statistik antara rerata perokok putih atau perokok kretek dengan kadar karbon monoksida ekspirasi pada subyek, hal tersebut mungkin dikarenakan pengaruh yang lebih signifikan oleh jumlah rokok yang dikonsumsi (IB). Melihat tren di Indonesia rokok kretek relatif lebih murah dibandingkan rokok putih, maka uang saku menjadi salah satu faktor yang menentukan pilihan rokok putih atau kretek pada mahasiswa di Depok.

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Background: The impact of smoking is still a big problem in the world although the use of cigarettes is one of the biggest causes of death that can be prevented. One of the harmful substances of smoking is carbon monoxide, unfortunately research has not been conducted between the levels of carbon monoxide smokers of regular cigarettes or clove cigarettes to college students  in Indonesia

Objective: The aim of this study is to determine the relationship of expiratory CO levels in smoking  male students of regular and clove cigarettes at universities in Depok

Methods: This study uses a cross-sectional study design with 108 samples divided into two groups of white cigarette smokers and clove cigarette smokers with consecutive sampling technique. Subjects took the expiratory CO test and filled out questionnaires related to smoking and other factors.

Results: The study found expiratory carbon monoxide results in regular cigarette smokers at 13.9 ± 8.36 ppm and clove cigarette  at 13.18 ± 8.79 ppm, while the statistical test results of the choice of cigarette types on carbon monoxide amounted to 0.663. While there are other factors that influence subjects CO expiration, such as the Brinkman Index with p <0.001 and a weak correlation result, however there are factors that influence the choice of cigarette type, namely pocket money with a p value of 0.023 and age with a value of 0.015

Conclusion: There was no statistically significant relationship between the average of white cigarette smokers or clove cigarette smokers with expiratory carbon monoxide levels in subjects, this might be due to a more significant effect on the number of cigarettes consumed (BI). Seeing the trend in Indonesia that kretek cigarettes are relatively cheaper than white cigarettes, pocket money is one of the factors that determine the choice of white or kretek cigarettes for college students in Depok.

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"Latar Belakang: Merokok adalah masalah kesehatan yang persisten di Indonesia. Penelitian mengenai dampak merokok terhadap kadar FeNO pada mahasiswa sudah dilakukan sebelumnya, namun tidak pernah dilakukan di Indonesia. Jumlah perokok dan perokok remaja di Indonesia sangat ekstensif, sehingga pengetahuan mengenai akibat merokok pada subjek ini sangat dibutuhkan, salah satunya adalah mengenai kadar FeNO pada mahasiswa yang merokok di Indonesia. Selain itu, dibutuhkan juga penelitian mengenai alasan merokok , karena alasan merokok berhubungan dengan metode pemberhentian merokok yang lebih efektif. Tujuan: Penelitian ini bertujuan untuk melihat hubungan antara kebiasaan merokok dengan kadar nitrit oksida yang dihembuskan dan untuk mengetahui faktor-faktor yang memengaruhi kebiasaan merokok pada mahasiswa di Depok. Metode: Penelitian ini merupakan studi potong lintang pada 124 subjek yang dilakukan wawancara dan dengan 30 subjek di antaranya dipilih untuk tes kadar FeNO. Hasil: Dari hasil penelitian yang dilakukan, korelasi kebiasaan merokok dengan kadar FeNO sebesar -,12 dan dengan kemaknaan statistika sebesar ,524. Sementara itu, alasan paling umum dari merokok yang ditemukan adalah penghilang stress dan untuk menimbulkan kesenangan. Kesimpulan: Tidak ditemukan korelasi antara kebiasaan merokok dengan FeNO. Penghilang stress dan kesenangan pada merokok tmenjadi faktor yang paling memengaruhi kebiasaan merokok pada subjek.

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Background: Smoking is a nationwide, persistent, health problem in Indonesia. Researches about the impact of smoking to the FeNO rate of college students have been conducted, but not one of them have been done in Indonesia. The amount of smokers and teenage smokers in Indonesia are extensive, thus created this need of understanding of the implications of smoking, which one of them is to understand the FeNO level on college smokers. This also created the need for the understanding of reasons of smoking, as the understanding of reasons of smoking correlates to a more effective smoking cessation attempt. Objective: The study aimed to determine the relationship between smoking habit and exhaled nitric oxide level and to understand more about the reasons for smoking in college students in Depok. Methods: The study is conducted by using both analytical and descriptive cross-sectional study. We interviewed 124 subjects, which on 30 of them are chosen for the FeNO level test. Result: Based on the conducted studies, the correlation coefficient between smoking habit and FeNo level are,-12 with data significance of ,524. The most prominent reason for smoking is to relieve stress and to incite pleasure of smoking. Conclussion: There is no correlation found between smoking habit and exhaled nitric oxide among subjects. Stress relieving and pleasure from smoking are factors that have the most influence in the smoking habit of subjects. "

"ABSTRAKLatar Belakang: Prevalens PPOK memiliki kecenderungan meningkat, penyebab utama morbiditas dan mortalitas di seluruh dunia. Eksaserbasi dan beberapa penyakit komorbid menyebakan disabilitas yang berdampak pada kualitas hidup pasien PPOK. Kualitas hidup yang baik adalah tujuan utama dalam penatalaksanaan pasien PPOK. Tujuan penelitian ini mengetahui hubungan CAT dan SGRQ dalam menilai kualitas hidup pasien PPOK yang dikontrol dengan indeks BODE melalui pengukuran selama 6 bulan.Metode: Penelitian ini merupakan studi prospektif terhadap 49 pasien PPOK stabil yang memenuhi kriteria inklusi melalui pengukuran pada 0, 3 dan 6 bulan di poliklinik Asma dan PPOK RS Persahabatan. Pasien PPOK stabil dilakukan pemeriksaan spirometri, pengukuran IMT, pengisian kuesioner CAT dan SGRQ, skala sesak mMRC dan uji jalan 6 menit.Hasil: 49 pasien PPOK stabil pada awal evaluasi terdiri dari 5 orang pasien PPOK derajat I, 16 orang pasien PPOK derajat II, 21 pasien PPOK derajat III dan 7 pasien derajat. Kelompok usia 48-81 tahun dengan median 69 tahun dan rerata 67,04 ± 8,86. Riwayat merokok dari 49 pasien laki-laki terdiri dari 30 pasien memiliki indeks Brinkman (IB) berat, 12 pasien dengan IB sedang dan 7 pasien IB ringan. Komorbid terbanyak adalah penyakit kardiovaskuler (40%). CAT memiliki korelasi yang sangat kuat dengan SGRQ (r=0,89, p<0,0001) dan korelasi yang kuat dengan indeks BODE (r=0,65, p<0,0001). SGRQ memiliki korelasi yang kuat dengan indeks BODE (r=0,69, p<0,0001).Kesimpulan: CAT dapat digunakan dengan baik untuk menilai kualitas hidup pasien PPOK seperti SGRQ. Korelasi CAT dengan SGRQ sangat kuat dan kuat dengan indek BODE tetapi SGRQ masih sedikit lebih baik dibandingkan CAT dalam memprediksi tingkat angka tahan hidup atau prognostik pasien PPOK.

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ABSTRACTBackground: COPD has been increase in prevalence, a leading cause of morbidity and mortality worldwide. Exacerbation of COPD and some comorbid disease cause disability with impact on related quality of life (HRQoL). A good quality of life is major goal in management of COPD patients. The purpose of this study was to determine the correlation of any CAT, SGRQ and BODE index to estimate the quality of life in COPD patients.Methods: The study was conducted with prospective study in 49 stable mild to very severe degree of COPD patients with repeated measurements in 0, 3 and 6 months at Asthma and COPD clinic Persahabatan Hospital. Stable COPD patients performed spirometry, measured BMI, fill out CAT and SGRQ questionnaire, MMRC dyspnea score and 6 minute walking testResults: Forty nine COPD patients consist of 5 COPD patients of stage I, 16 patients of stage II, 21 patients of stage III and 7 patients of stage IV had been evaluated for 6 months. The median is 69 years (48;81) and mean 67,04 ± 8,86. Smoking history of patient consist of severe degree in 30 patients, 12 patients of moderate, and 7 patients of mild Brinkman index The most comorbid is cardiovascular disease (40%). A patient was die at the end evaluation. The CAT correlates very well with SGRQ (r=0.89, p<0.0001) and well with BODE index (r=0.65, p<0.0001). The SGRQ correlates well with BODE index (r=0.69, p<0.0001).Conclusion: The CAT could be as reliable tools in predicting HRQoL as SGRQ. The CAT correlates very well with SGRQ and well with BODE index, but SGRQ is a bit better to predict survival COPD patient or prognostic patient than CAT."

"ABSTRAKLatar belakang penelitian : Polisi Lalu Lintas yang bekerja di daerah lalu lintas yang padat terpajan emisi kendaraan selama bertahun-tahun. Banyak penelitian melaporkan pajanan asap, bahan kimia dan partikel dalam emisi akan merusak faal paru. Belum ada data mengenai faal paru polisi lalu lintas di Wilayah Jakarta SelatanMetode penelitian :Penelitian ini merupakan bagian dari penelitian besar di Wilayah Jakarta, Bogor, Depok, Tangerang dan Bekasi (JABODTABEK) dengan desain cross-sectional untuk menentukan faal paru polisi lalu lintas dan faktor-faktor yang mempengaruhi. Penelitian ini dilakukan pada polisi lalu lintas di Wilayah Jakarta Selatan pada bulan Oktober-November 2012 dengan teknik pengambilan total sampling. Wawancara menggunakan Kuesioner Pneumobile Project Indonesia, dilakukan pemeriksaan uji faal paru, foto toraks dan pengukuran CO ekshalasi. Data dianalisis secara deskriptif dan multivariat dengan menggunakan SPSS versi 17.Hasil penelitian : Pada penelitian ini kami menemukan sebanyak 181 subjek penelitian sesuai dengan kriteria inklusi, kelompok umur terbanyak 41-50 tahun (35,4%), status gizi kelebihan berat badan (54,1%) dan perokok ringan (33,1). Sebanyak 9 subjek ditemukan kelainan faal paru dengan rincian 5 obstruksi ringan dan 4 restriksi ringan. Gambaran kelainan foto toraks ditemukan sebanyak 5 subjek. Nilai kadar CO ekshalasi didapatkan dengan rerata 14,0 ± 8,5. Analisis yang dilakukan pada penelitian ini tidak didapatkan hubungan bermakna secara statisitik antara faktor usia, status gizi, merokok, masa kerja, pemakaian APD dan kualitas udara dengan faal paru.Kesimpulan: Terdapat kelainan faal paru pada 9 (5%) polisi lalu lintas di Wilayah Jakarta Selatan. Tidak terdapat hubungan yang bermakna secara statistik antara gambaran faal paru dengan semua faktor-faktor yang diteliti.

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ABSTRACTBackground: Traffic policemen working in the busy traffic signal areas get exposed to the vehicular missions for years together. Many studies have reported exposure to smoke, chemicals and particles in emissions will damage lung function. Since there were no data available on the parameters of traffic police personnel of South Jakarta.Methods: This study is part of a major research area Jakarta, Bogor, Depok, Tangerang and Bekasi (JABODETABEK) with cross-sectional study to determine the pulmonary function of traffic police and the factors that influenc. The study was conducted traffic policemen in South Jakarta Regional in Oktober-November 2012. Interview using Kuesioner Pneumobile Project Indonesia, Pulmonary function test, Chest X-ray and CO exhaled. The data were analyze using descriptive and multivariate processed to look at the relationship between variables with SPSS version 17.Results: In this study we found as many as 181 subjects the inclusion criteria with predominant age group between 41-50 years old (35,4%), over weight (54,1%) and mild smoker (33,1%). A total of nine subjects with pulmonary function abnormalities details mild obstruction 5 and 4 mild restriction.Chest X-ray abnormality was found by 5 subjects. Levels of CO exhalation values ​​obtained with a mean 14.0 ± 8.5. The analysis conducted in this study found no significant relationship between the statistics of age, nutritional status, smoking, length of service, use of mask and air quality index with lung function.Conclusion: There pulmonary function abnormalities in 9 (5%) of traffic police in the area of South Jakarta. There was no statistically significant association between lung function overview with all the factors studied."

"Latar belakang: Laju penurunan VEP1 dan VEP1/KVP pada pasien PPOK dari beberapa data yang ada menunjukkan penurunan yang lebih tajam dibandingkan normal, namun untuk penelitian yang dilakukan selama 1 tahun belum pernah diperbarui di RSUP Persahabatan. Penelitian ini mencoba untuk mengetahui laju penurunan nilai VEP1, VEP1/KVP pada pasien PPOK setelah 1 tahun pengobatan. Metode: Penelitian kohort retrospektif ini dilakukan untuk mengukur laju penurunan nilai VEP1, VEP1/KVP pasien PPOK di klinik Asma PPOK RSUP Persahabatan setelah pengobatan selama 1 tahun. Hasil: Laju penurunan nilai VEP1 setelah 1 tahun pengobatan adalah sebesar 121,53 120ml/tahun sedangkan laju penurunan nilai VEP1/KVP setelah 1 tahun pengobatan adalah sebesar 2,75 0,47 p10 80,6, derajat GOLD 2 64,5 , mengkonsumsi LABACs 64,5 dan usia terdiagnosis ≥60 tahun 64,5 . Laju penurunan VEP1 lebih banyak terjadi pada kelompok D 110ml/tahun sedangkan laju penurunan VEP1/KVP lebih banyak terjadi pada kelompok B 3,29. Kesimpulan: Pada penelitian ini diketahui sebagian besar pasien mengalami laju penurunan VEP1 dan VEP1/KVP yang bermakna secara statistik dan sebagian kecil yang mengalami kenaikan meskipun tidak bermakna secara statistik. Tidak didapatkan hubungan yang berbeda bermakna baik antara jenis kelamin, usia, keluhan respirasi, riwayat merokok, IB, jenis rokok, komorbid, tingkat pendidikan, usia terdiagnosis, IMT, kelompok A-B dan C-D, kelompok A-C dan B-D, riwayat eksaserbasi, CAT, derajat obstruksi dan pemberian terapi LABACs dengan laju penurunan nilai VEP1 dan VEP1/KVP. Kata kunci: Penurunan fungsi paru, PPOK.

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Background: The rate of decline in FEV1 and FEV1/FVC in COPD patients from some of the available data shows more decline than normal, but for a 1 year study has not been updated in Persahabatan Hospital. This study attempted to determine the rate of FEV1 and FEV1/FVC decline in COPD patients after 1 year treatment.

Methods: This retrospective cohort study was conducted to measure the rate of FEV1 and FEV1/FVC decline in COPD patients at Asthma COPD Clinic Persahabatan Hospital after 1 year treatment.

Results: The rate of decline in FEV1 after 1 year treatment was 121.53 120ml/year while the rate of decline in FEV1/FVC after 1 year treatment was 2.75 0.47 p 10 80.6 , GOLD 2 64.5 , with LABACs treatment 64.5 and diagnosed ge;60 years 64.5 . The rate of decline in FEV1 was more prevalent in group D 110ml/year while the rate of decline in FEV1/FVC was more prevalent in group B 3.29.

Conclusions: In this study most patients have a statistically significant rate of decline in FEV1 and FEV1/FVC, however a small proportion of patients experienced increases in FEV1 and FEV1/FVC although it does not reach statistical treshhold. No significant differences are found between sex, age, respiratory complaints, smoking history, BI, type of cigarette, comorbid, educational level, diagnosed age, BMI, AB and CD group, AC and BD group, history of exacerbations, CAT, obstruction and treatment of LABACs with rate of decline in VEP1 and VEP1 / KVP. "

"Latar Belakang : Asma merupakan penyakit inflamasi kronik saluran napas dengan fungsi bersihan mukosilier yang menurun, maka itu bentuk matur dari spora Aspergillus fumigatus bisa tumbuh dan membuat sensitisasi Aspergillus yang merupakan kondisi awal aspergillosis paru pada asma dan dapat berkembang menjadi Allergic Bronchopulmonary Aspergillosis (ABPA). Penegakkan diagnosis aspergillosis paru didapatkan jika reaksi hipersensitisasi terhadap antigen A.fumigatus positif.Metode : Penelitian ini menggunakan metode potong lintang pada 86 pasien asma yang berobat ke RSUP Persahabatan dengan nilai Asthma Control Test (ACT) ≤ 24. Subjek penelitian dibagi 2 kelompok berdasarkan sensitisasi Aspergillus. Penilaian aspergillosis paru menggunakan pemeriksaan Imunoglobulin E (IgE) spesifik A.fumigatus. Kriteria diagnosis ABPA yang digunakan pada penelitian ini menggunakan kriteria International Society of Human and Animal Mycology (ISHAM) yaitu dua kriteria obligatory (IgE spesifik A.fumigatus dan IgE total) serta 3 kriteria tambahan (IgG spesifik A.fumigatus, eosinofil total, gambaran foto toraks). Pemeriksaan fungsi paru dilakukan pada penelitian ini termasuk spirometri, kapasitas difusi paru karbon monoksida (DLCO) dan nitrit oksida udara ekspirasi (FeNO).Hasil : Proporsi pasien asma tidak terkontrol yang memiliki aspergillosis paru didapatkan 3,5% (3/86) sedangkan proporsi ABPA didapatkan 1,1% (1/86). Terdapat faktor-faktor yang memengaruhi aspergillosis paru pada asma tidak terkontrol, diantaranya adalah nilai IMT (p=0,77), riwayat merokok (p=0,86) dan riwayat TB paru (p=0,03).. Karakteristik imunologi didapatkan nilai median IgE total pada subjek dengan aspergillosis paru 465(22-1690) IU/ml dan nilai median hitung total eosinofil 380 (0-770) sel/µl. Dari penilaian spirometri pada subjek aspergillosis paru didapatkan nilai median KVP 1630(950-2150) ml, nilai rerata KVP%prediksi 70±33,71%, nilai VEP1 1150(470-1240) ml, nilai median VEP1% prediksi 54(24-76)%, nilai rerata VEP1/KVP 59,33±14,57)% serta nilai rerata DLCO 84,67±24,66%. Nilai median FeNO pada asma tidak terkontrol dengan aspergillosis paru pada penelitian ini didapatkan 32 (12-45) ppb.Kesimpulan : Penegakkan diagnosis aspergillosis paru pada pasien asma tidak terkontrol harus dilakukan sejak awal, terutama pada pasien dengan riwayat TB  paru. Hal tersebut dapat mencegah aspergillosis paru pada asma tidak terkontrol berkembang menjadi penyakit ABPA serta kerusakan paru yang permanen.

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Background: Asthma is a chronic airway inflammation with decrease of mucocilliary clearance. The mature form of Aspergillus fumigatus spores could grow in this condition and caused an Aspergillus sensitization as an early progression to allergic bronchopulmonary aspergillosis (ABPA). Pulmonary aspergillosis could be diagnosed from a hypersensitivity reaction to the A. fumigatus antigen.

Methods : This cross-sectional study included 86 asthma patients with Asthma Control Test ACT score ≤ 24 and treated at Persahabatan Hospital Jakarta, Indonesia. Pulmonary aspergillosis was examined using specific immunoglobulin E (IgE) assay of A. fumigatus. The ABPA diagnostic in this study used the International Society of Human and Animal Mycology (ISHAM) criteria, which included two obligatory criteria (A. fumigatus-specific IgE and total IgE) and three additional criteria (A. fumigatus-specific IgG, blood eosinophil count, and thoracic x-ray). Lung function were examined using spirometry, diffusing capacity for carbon monoxide (DLCO), and fraction of exhaled nitric oxide (FeNO).

Results: Uncontrolled asthma patients who had pulmonary aspergillosis was 3.5% (3/86) while the proportion of ABPA was 1.1% (1/86).  A history of prior pulmonary tuberculosis (TB) was correlated with aspergillosis in uncontrolled asthma patients (p=0.03). The median value of total IgE and blood eosinophil count in pulmonary aspergillosis subjects was 465 (22-1690) IU/mL and 380 (0-770) cells/µL, respectively. Spirometry results of pulmonary aspergillosis subjects were median FVC 1630 (950-2150) ml, mean predicted FVC% predicted value 70±33.71%, mean FEV1 1150 (470-1240) ml, median predicted FEV1% 54 (24-24)%, mean FEV1/FVC 59.33±14.57%, and mean DLCO 84.67±24.66%. The median FeNO in uncontrolled asthma with pulmonary aspergillosis in this study was 32 (12-45) ppb.

Conclusion: Diagnosis of pulmonary aspergillosis in patients with uncontrolled asthma should be carried out early, especially in patients with a history of pulmonary TB. This would prevent pulmonary aspergillosis in uncontrolled asthma from developing into ABPA disease and permanent lung damage."