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"Monosodium glutamat (MSG) merupakan garam natrium dari glutamat yang merupakan asam amino nonesensial yang dapat bersifat eksitotoksik. Terdapat dugaan bahwa glutamat berpotensi menyebabkan kerusakan oksidatif di hati dengan mekanisme yang sama dengan eksitotoksisitas karena reseptor glutamat juga ditemukan di hati. Penelitian ini bertujuan untuk mengetahui adanya pemulihan kerusakan oksidatif hati tikus setelah pemberian MSG dihentikan. Sebanyak 30 ekor tikus putih (Rattus norvegicus) jantan dewasa dibagi menjadi 3 kelompok: kontrol (akuades), kelompok MSG 4 g/kg dan 6 g/kg. Perlakuan diberikan melalui sonde selama 30 hari. Setiap kelompok kemudian dibagi lagi menjadi 2 berdasarkan waktu mematikannya (hari ke-45, dan hari ke-59). Organ hati diambil untuk pemeriksaan kadar MDA, GSH dan aktivitas spesifik enzim katalase. Kadar MDA meskipun tidak berbeda bermakna pada semua kelompok tetapi cenderung menurun, kadar GSH meningkat dan berbeda bermakna (p=0,017), aktifitas spesifik katalase menurun dan terdapat perbedaan bermakna (p=0,012). Tidak terdapat korelasi antara kadar MDA, GSH, dan aktivitas spesifik enzim katalase pada jaringan hati tikus setelah penghentian pemberian MSG. Penelitian ini menunjukkan bahwa pasca penghentian pemberian MSG dengan dosis 4 gr/kg BB dan 6 gr/kg BB selama 14 dan 28 hari dapat menyebabkan penurunan kadar MDA, peningkatan kadar GSH, dan penurunan aktivitas spesifik enzim katalase jaringan hati tikus. Hal ini mengindikasikan telah terjadi pemulihan kerusakan oksidatif akibat penghentian total pemberian MSG.

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Monosodium glutamate (MSG) is the sodium salt which is can be excitotoxic. Glutamate could potentially cause oxidative damage in the liver by excitotoxicity because glutamate receptors are also found in the liver. This study aims to investigate the oxidative damage recovery rat liver after administration of MSG is stopped. A total of 30 adult male rats (Rattus norvegicus) were divided into 3 groups: control (distilled water), MSG 4 g / kg and the last group MSG 6 g / kg. The treatment is given through a sonde for 30 days. Each group was further divided into two by sacrivised time as follow, day 45, and day 59. The liver was taken for measurement of MDA, GSH levels and the specific activity of catalase. MDA levels although not significantly different in all groups but tend to decline. Different levels of GSH increased significantly (p = 0.017) during recovery, the specific activity of catalase were decline (p=0.012). There was no correlation between MDA, GSH, and specific activity of catalase in the liver after cessation of MSG. This study shows that cessation administration of that certain doses of MSG can lead to decreased levels of MDA, GSH levels, and a decrease in the specific activity of catalase rat liver tissue. This indicates that there was a recovery process of oxidative damage as a result of the cessation of administration of MSG."

"Monosodium glutamat (MSG) adalah garam natrium glutamat yang merupakan asam amino nonessensial yang dapat bersifat eksitotoksik. Terdapat dugaan bahwa glutamat berpotensi menyebabkan peningkatan stres oksidatif di hati dengan mekanisme yang sama dengan eksitotoksisitas karena reseptor glutamat juga ditemukan di hati. Penelitian ini bertujuan untuk mengetahui pengaruh MSG terhadap peningkatan stres oksidatif pada hati tikus (Rattus norvegicus) jantan. Parameter yang diukur adalah kadar MDA, GSH, dan aktivitas spesifik katalase sebagai penanda adanya stres oksidatif. Sebanyak 27 ekor tikus putih (Rattus norvegicus) jantan dibagi dalam 3 kelompok: kelompok kontrol (diberi akuades), kelompok P1A (diberi MSG 4g/KgBB), dan kelompok P2A (diberi MSG 6g/KgBB). Perlakuan diberikan melalui sonde selama 30 hari. Pengambilan sampel hati dilakukan pada hari ke-31. Hasil penelitian menunjukkan terdapat peningkatan kadar MDA pada kelompok perlakuan yang berbeda bermakna dengan kelompok kontrol, p≤0,05, tetapi pada kadar GSH terjadi penurunan yang tidak berbeda bermakna dibandingkan kelompok kontrol, (p≥0,05). Aktivitas spesifik katalase, juga terjadi penurunan yang tidak berbeda bermakna dibandingkan dengan kelompok kontrol, p≥0,05. Penelitian ini menunjukan bahwa pemberian MSG dengan dosis 4g/KgBB dan 6g/KgBB selama 30 hari menyebabkan terjadinya peningkatan stres oksidatif pada hati tikus (Rattus norvegicus) jantan yang ditunjukkan dengan peningkatan kadar MDA.

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Monosodium glutamate (MSG) is the sodium salt of glutamate which is a nonessential amino acid that may cause exicytotoxicity. There are allegations that glutamate could potentially increase an oxidative stress in the rat's liver by the same mechanism with exicytotoxicity because of glutamate receptors are also found in the liver.

This study aims to determine the effect of MSG on oxidative stress in the rat's liver. The level of MDA and GSH were measured as the marker of oxidative stress, and also specific activity of catalase. 27 albino rat's (Rattus norvegicus) were divided into 3 groups: control group (distilled water), and 2 treatment groups, P1A (treated with MSG 4g / KgBW), and P2A (treated with MSG 6g / KgBW). The treatment was carried out for 30 days. On day 31 the liver were collected after euthanasia of the rats.

The results showed there were increased levels of MDA in the treatment groups compare to control significantly, p≤0,05, but the decreased of GSH levels were not significantly different than the control group, (p≥0,05). The specific activity of catalase, also a decreasing but not significantly different compared to control group, p≥0,05.

This study showed that the administration of MSG with a dose of 4g / KgBW and 6g / KgBW for 30 days led to an increased in oxidative stress on the liver of rats (Rattus norvegicus) which is indicated by elevated levels of MDA."