"[
ABSTRAKLatar Belakang: Diare akut adalah masalah umum di negara berkembang seperti
Indonesia; penyakit ini banyak ditemukan dalam praktek sehari-hari dengan angka
morbiditas dan mortalitas yang cukup tinggi. Pada beberapa Rumah Sakit di
Jakarta ditemukan bahwa pasien diare akut dewasa mengalami defisiensi kadar
seng sebesar 69.3%.
Pemberian seng sudah terbukti bermanfaat untuk pengobatan diare akut pada
anak.
Tujuan: Mengetahui dampak suplementasi seng sebagai terapi alternatif /
adjuvant untuk pengobatan diare akut pada pasien dewasa, dengan
membandingkan lama berlangsung dan berat-ringan gejala pada kelompok pasien
yang diberikan dan yang tidak diberikan suplementasi seng.
Metode: Double blind randomized controlled trial dilakukan pada penelitian ini
untuk mengetahui efek suplementasi seng terhadap durasi dan gejala
gastrointestinal pada pasien diare akut rawat inap di RS Pusat Pertamina di Jakarta
selama periode Januari-Desember 2013. Analisis data dilakukan dengan
menggunakan uji chi-square (x2) untuk perbandingan durasi diare dan uji general
linear model (GLM) untuk menilai tren perubahan gejala penyerta diare.
Hasil: Analisis data dari 84 pasien yang dikelola: 30 pasien pria [seng 19,
plasebo 11] dan 54 pasien wanita [seng 23, plasebo 31] ~ (p 0.111)
memperlihatkan pemberian suplementasi seng bermakna mengurangi durasi diare
akut (p 0.027) dan bermakna mengurangi gejala mual (p 0.032). Selain itu ada
tren perbaikan pada sebagian gejala penyerta diare akut, seperti sakit perut,
frekuensi b.a.b., konsistensi feses, gejala muntah, kembung, dan gangguan
aktivitas sehari-hari.
Simpulan: Pemberian suplementasi seng bermakna membuat durasi diare akut
lebih singkat dan bermakna mengurangi gejala mual, serta perbaikan pada
sebagian gejala gastrointestinal.
ABSTRACTBackground: Acute diarrhea is a common problem in developing countries such
as Indonesia; which is found in everyday practice with quite high morbidity and
mortality rate. It was revealed in adult acute diarrhea patients in several hospitals
in Jakarta the levels of zinc deficiency was 69.3%. Zinc has been proven to be
beneficial in the treatment of acute diarrhea in pediatric patients.
Objective: To discover the effectiveness of zinc supplementation as an adjuvant
therapy in acute diarrhea for adult patients by comparing the duration and the
severity of signs and symptoms of acute diarrhea between the zinc and placebo
group.
Methods: A double blind randomized controlled trial is done to find out about
the effect of zinc supplementation to the duration, signs and symptoms on acute
diarrheal in hospitalized adults patients in Pertamina Central Hospital in Jakarta
from January-December 2013. The data is analyzed using chi-square test (x2) for
comparing the duration of diarrhea and general linear model (GLM) to assess
trend changes accompanying symptoms of diarrhea.
Results: Analysis of the data from 84 patients: 30 males [19 zinc, 11 placebo]
and 54 females [23 zinc, 31 placebo] ~ (p 0.111) obtained zinc supplementation
significantly reduced the duration of acute diarrhea (p 0.027) and significantly
reduce the symptoms of nausea (p 0.032). In addition there is trend of
improvement in some acute diarrhea associated symptoms, such as abdominal
pain, frequency of diarrhea, stool consistency, vomiting, bloating, and disruption
of daily activities.
Conclusion: Zinc supplementation significantly reduce the duration of diarrhea,
significantly reduce the symptoms of nausea; besides, improving some symptoms
accompanying acute diarrhea.;Background: Acute diarrhea is a common problem in developing countries such
as Indonesia; which is found in everyday practice with quite high morbidity and
mortality rate. It was revealed in adult acute diarrhea patients in several hospitals
in Jakarta the levels of zinc deficiency was 69.3%. Zinc has been proven to be
beneficial in the treatment of acute diarrhea in pediatric patients.
Objective: To discover the effectiveness of zinc supplementation as an adjuvant
therapy in acute diarrhea for adult patients by comparing the duration and the
severity of signs and symptoms of acute diarrhea between the zinc and placebo
group.
Methods: A double blind randomized controlled trial is done to find out about
the effect of zinc supplementation to the duration, signs and symptoms on acute
diarrheal in hospitalized adults patients in Pertamina Central Hospital in Jakarta
from January-December 2013. The data is analyzed using chi-square test (x2) for
comparing the duration of diarrhea and general linear model (GLM) to assess
trend changes accompanying symptoms of diarrhea.
Results: Analysis of the data from 84 patients: 30 males [19 zinc, 11 placebo]
and 54 females [23 zinc, 31 placebo] ~ (p 0.111) obtained zinc supplementation
significantly reduced the duration of acute diarrhea (p 0.027) and significantly
reduce the symptoms of nausea (p 0.032). In addition there is trend of
improvement in some acute diarrhea associated symptoms, such as abdominal
pain, frequency of diarrhea, stool consistency, vomiting, bloating, and disruption
of daily activities.
Conclusion: Zinc supplementation significantly reduce the duration of diarrhea,
significantly reduce the symptoms of nausea; besides, improving some symptoms
accompanying acute diarrhea., Background: Acute diarrhea is a common problem in developing countries such
as Indonesia; which is found in everyday practice with quite high morbidity and
mortality rate. It was revealed in adult acute diarrhea patients in several hospitals
in Jakarta the levels of zinc deficiency was 69.3%. Zinc has been proven to be
beneficial in the treatment of acute diarrhea in pediatric patients.
Objective: To discover the effectiveness of zinc supplementation as an adjuvant
therapy in acute diarrhea for adult patients by comparing the duration and the
severity of signs and symptoms of acute diarrhea between the zinc and placebo
group.
Methods: A double blind randomized controlled trial is done to find out about
the effect of zinc supplementation to the duration, signs and symptoms on acute
diarrheal in hospitalized adults patients in Pertamina Central Hospital in Jakarta
from January-December 2013. The data is analyzed using chi-square test (x2) for
comparing the duration of diarrhea and general linear model (GLM) to assess
trend changes accompanying symptoms of diarrhea.
Results: Analysis of the data from 84 patients: 30 males [19 zinc, 11 placebo]
and 54 females [23 zinc, 31 placebo] ~ (p 0.111) obtained zinc supplementation
significantly reduced the duration of acute diarrhea (p 0.027) and significantly
reduce the symptoms of nausea (p 0.032). In addition there is trend of
improvement in some acute diarrhea associated symptoms, such as abdominal
pain, frequency of diarrhea, stool consistency, vomiting, bloating, and disruption
of daily activities.
Conclusion: Zinc supplementation significantly reduce the duration of diarrhea,
significantly reduce the symptoms of nausea; besides, improving some symptoms
accompanying acute diarrhea.]"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
