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Trestyawaty
Hubungan laktat ibu dan laktat arteri umbilikalis dengan asidemia janin sebagai prediktor asfiksia neonatorum = Hubungan laktat ibu dan laktat arteri umbilikalis dengan asidemia janin sebagai prediktor asfiksia neonatorum
"Tujuan: Penelitian ini bertujuan menilai hubungan laktat ibu dan laktat arteri umbilikalis dengan asidemia janin.
Metode: Penelitian desain uji diagnostik dengan 42 ibu hamil dengan janin tunggal hidup usia gestasi ≥ 34minggu dengan FDJP < 5 atau kecurigaan asidemia janin di Rumah Sakit Dr. Cipto Mangunkusumo pada bulan November 2012 hingga Februari 2013. Laktat ibu dievaluasi segera saat ditegakkan diagnosis kecurigaan asidemia janin, analisa gas darah dan laktat arteri umbilikalis diambil segera saat bayi lahir. Asidemia janin ditegakkan dengan pH arteri umbilkalis < 7,2. Kadar laktat diukur dengan menggunakan Lactate Pro. Nilai diagnostik laktat ibu dan laktat a.umbilikalis untuk memprediksi asidemia janin diuji dengan metode Receiver Operating Character (ROC).
Hasil: Sebanyak 39 subyek penelitian yang diperoleh data laktat ibu & laktat arteri umbilikalisnya dan 3 subyek penelitian yang diperoleh data laktat ibunya saja. Untuk memprediksi asidemia janin laktat ibu mempunyai akurasi 88.9% (IK 95% 0,791-0,987). Secara statistik terdapat asosiasi antara laktat ibu dengan asidemia janin (p<0,001). Bila kadar laktat ibu ≥ 4,70 mmol/l akan dapat diprediksi akan terjadi asidemia janin sebesar 92%. Sedangkan bila kadar laktat ibu < 4,7 mmol/l maka prediksi tidak akan terjadi asidemia janin sebesar 58,8%. Untuk memprediksi asidemia janin laktat arteri umbilikalis mempunyai akurasi 82,4% (IK 95% 0,660-0,988). Secara statistik terdapat asosiasi antara laktat arteri umbilikalis dengan asidemia janin (p=0,035). Bila kadar laktat arteri umbilikalis ≥ 4,1mmol/l maka akan diprediksi akan terjadi asidemia janin sebesar 88,89%. Sedangkan bila kadar laktat arteri umbilikalis < 4,1mmol/l maka prediksi tidak akan terjadi asidemia janin sebesar 75%. Secara statistik terdapat hubungan antara laktat ibu dengan laktat arteri umbilikalis (p=0,017). Semakin bertambah laktat ibu maka semakin besar laktat arteri umbilikalisnya (r=0,238). Tidak ada hubungan secara statistik antara nilai Apgar dengan laktat ibu (AUC 60,6%), laktat arteri umbilikalis (AUC 65%) dan asidemia janin (AUC 65%). Tidak ada perbedaan nilai AUC antara laktat ibu dan laktat arteri umbilikalis dalam memprediksi asidemia janin (p=0,515).
Kesimpulan: Laktat ibu dan laktat arteri umbilikalis memenuhi standar uji diagnostik yang baik untuk memprediksi kejadian asidemia janin. Laktat ibu dapat memprediksi asidemia janin sebelum bayi lahir.
Objectives: To asses the association among maternal lactate and umbilical arterial lactate with fetal acidemia.
Methods: This was a diagnostic test study, which was held on the 42 pregnant women with a singleton live fetus, gestational age ≥ 34 weeks and modified biophysical profile < 5 or suspected fetal acidemia at Dr. Cipto Mangunkusumo Hospital from November 2012 until February 2013. Maternal lactate was evaluated immediately at the time that the diagnosed of suspected fetal acidemia was established. Blood gas analysis and umbilical arterial lactate were taken immediately when the baby was born. Fetal acidemia is defined as umbilical arterial pH <7.2. Lactate levels were measured using the Lactate Pro. Diagnostic value of maternal lactate and umbilical arterial lactate to predict fetal acidemia was tested by the method of Receiver Operating Character (ROC).
Results: Both maternal and umbilical arterial lactate were obtained from 39 subjects. Maternal lactate only was obtained from 3 subjects. To predict a fetal acidemia, the maternal lactate has an accuracy of 88,9% (CI 95% 0,791- 0,987). There was an association between fetal acidemia and maternal lactate statistically ( p<0.001). If maternal lactate levels ≥ 4.70 mmol / l, it would be predicted that 92% fetal acidemia are occurred. Meanwhile, if maternal lactate levels <4.7 mmol/l then there will be a prediction that 58.8% was no fetal acidemia. To predict a fetal acidemia, the umbilical arterial lactate has an accuracy 82,4% (CI 95% 0,660-0,988). There was an association between fetal acidemia and umbilical arterial lactate statistically (p=0,035). If umbilical arterial lactate levels ≥ 4,1 mmol/l, it would be predicted 88,89% fetal acidemia are occurred, meanwhile if umbilical arterial lactate levels < 4,1 mmol/l then there will be a prediction that 75% was no fetal acidemia. Statistically there was an association between maternal lactate and umbilical arterial lactate (p=0,017). If maternal lactate increased, the umbilical arterial lactate would be increased (r=0.238). Statistically there was no association between Apgar score with maternal lactate (AUC 60.6%), umbilical arterial lactate (AUC 65%) and fetal acidemia (AUC 65%). There is no difference in AUC values between maternal lactate and umbilical arterial lactate in predicting fetal acidemia (p = 0.515).
Conclusion: Maternal lactate and umbilical arterial lactate meet a good standard diagnostic test for predicting the incidence of fetal acidemia. Maternal lactate can predict fetal acidemia before the baby is born."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
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UI - Tugas Akhir  Universitas Indonesia Library
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Astry Susanti
Hubungan volume asupan cairan dan jumlah asupan serat makanan dengan gejala konstipasi pada ibu hamil = The Association between fluid and dietary fiber intake with constipation symptoms in pregnancy
"Latar Belakang : Prevalensi konstipasi pada ibu hamil berkisar 10-40%. Perubahan hormon dan mekanik selama masa kehamilan berpengaruh terhadap saluran cerna. Menurunnya gerakan peristaltik menyebabkan absorpsi cairan di usus besar meningkat sehingga konsistensi feses menjadi semakin padat yang pada akhirnya dapat menimbulkan gejala konstipasi. Hidrasi yang cukup dapat memperbaiki konsistensi feses. Sedangkan konsumsi serat makanan diketahui mampu meningkatkan massa feses sehingga meningkatkan motilitas usus dan memperpendek waktu transit di usus besar.
Tujuan : Mengetahui hubungan asupan volume cairan dan jumlah asupan serat makanan dengan gejala konstipasi pada ibu hamil.
Metode : Penelitian epidemiologis dengan disain potong lintang. Sebanyak 99 subjek yang memenuhi kriteria inklusi dilakukan wawancara, pemeriksaan antropometri, pemeriksaan fisik dan USG. Dilakukan pencatatan minum selama 7 hari, dilanjutkan wawancara food recall 24 jam. Penelitian dilaksanakan di Puskesmas Kecamatan Cempaka Putih pada bulan Maret 2014.
Hasil: Insiden gejala konstipasi pada ibu hamil sebesar 43%. Rerata volume asupan cairan ibu hamil per hari pada penelitian ini adalah 2683+682 ml, sementara median jumlah asupan serat makanan per hari adalah 9,1 (2,9 , 31,4) gram. Terdapat hubungan antara volume asupan cairan dengan gejala konstipasi pada ibu hamil (p 0,008). Tidak terdapat hubungan bermakna antara jumlah asupan serat makanan dengan gejala konstipasi pada ibu hamil (p 0,594). Volume asupan cairan <2600 ml/hari berisiko mengalami gejala konstipasi (RO 3,077; IK 95% : 1,33 , 7,119). Jumlah asupan serat <12,6 gram/hari berisiko mengalami gejala konstipasi (RO 1,28; IK 95% : 0,515-3,182).
Kesimpulan: Volume asupan cairan berhubungan dengan keluhan konstipasi pada ibu hamil, namun tidak ada hubungan bermakna antara jumlah asupan serat makanan dengan keluhan konstipasi pada ibu hamil.
Background: Constipation in the pregnancy ranges about 10-40%. Hormonal and mechanical changes during pregnancy influence the gastrointestinal tract. The decline in peristaltic increase the fluid absorption in the large intestine which makes more solid fecal mass. Sufficient hydration can improve the consistency of feces and dietary fiber known to increase the fecal mass which will improve bowel movements and shortening the transit time in the large intestine.
Objectives: Knowing association of fluid and dietary fiber intake with constipation symptoms in pregnancy.
Methods: This is an epidemiologic cross sectional study, taking place in Puskesmas Kecamatan Cempaka Putih on March 2014. Among 99 subjects who met the inclusion criteria were conducted interviews, antrophometric, physical and ultrasound examination. Seven days consecutive daily fluid intake were recorded, then the 24 hour dietary recall was held to each subject.
Result: The incidens of constipation symptoms in pregnancy ranges 43%. The rates of daily fluid intake volume of pregnant women in this study was 2683+682 ml, and the median of daily dietary fiber intake was 9,1 (2,9 , 31,4) grams. There was association between fluid intake volume with constipation symptoms (p value 0,008) but there was no association between dietary fiber intake with constipation symptoms (p value 0,594). Fluid intake volume lower than 2600 ml/day and dietary fiber intake lower than 12,6 gram/day were having increasing risk for constipation symptoms (OR 3,077; CI 95% : 1,33 , 7,119 and OR 1,28; 95% CI : 0,515 , 3,182, respectively).
Conclusion: There was association between fluid intake volume and constipation symptoms, but there was no association between fiber intake and constipation symptoms in pregnancy. Nevertheless there are higher odds ratio in the pregnant women with lower fluid intake volume or dietary fiber to get constipation symptoms."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tugas Akhir  Universitas Indonesia Library
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Siti Azizah, examiner
Gambaran keluhan subjektif selama kehamilan di Jakarta dan faktor-faktor yang berhubungan = Distribution of subjective symptoms during pregnancy in Jakarta and factors correlated
"[ABSTRAK
Tujuan: Mengetahui gambaran keluhan subjektif selama kehamilan pada populasi di Indonesia, khususnya Jakarta.
Metode: Wanita hamil yang datang ke poliklinik obstetri RSUPN Cipto Mangunkusumo dan RS Fatmawati (n=956), diberikan kuesioner yang berisi pertanyaan mengenai karakteristik dan keluhan subjektif. Sebaran keluhan subjektif selama kehamilan dideskripsikan berdasarkan umur, paritas, pendidikan, sosial ekonomi, keinginan hamil dan riwayat infertilitas.
Hasil: Mual adalah keluhan terbanyak selama trimester pertama (57,5%) dan trimester dua (33,5%), sementara kontraksi (69,3%), nyeri punggung (68,7%) terutama terjadi pada trimester tiga. Terdapat hubungan bermakna antara umur dengan keluhan mual, muntah dan keputihan.Terdapat hubungan bermakna antara paritas dengan keluhan mual, muntah, konstipasi, keputihan dan kontraksi.Terdapat hubungan bermakna antara tingkat pendidikan dengan keluhan mual, muntah, heartburn, hemoroid, keputihan, nyeri punggung dan disfungsi simfisis pubis.Terdapat hubungan bermakna antara tingkat sosial ekonomi dengan keluhan mual, konstipasi, nyeri punggung, disfungsi simfisis pubis dan kontraksi.Terdapat hubungan bermakna antara keinginan hamil dengan keluhan nyeri punggung dan edema tungkai.Terdapat hubungan bermakna antara riwayat infertilitas dengan keluhan nyeri punggung, disfungsi simfisis pubis dan kontraksi.
Kesimpulan: Keluhan utama pada trimester pertama dan dua adalah mual, sementara pada trimester 3 adalah kontraksi. Faktor-faktor seperti umur, paritas, pendidikan, sosial ekonomi, keinginan hamil dan riwayat infertilitas, mempengaruhi sebaran keluhan subjektif selama kehamilan.ABSTRACT Objective: To obtain a description of subjective complaints during pregnancy in the population in Indonesia, especially Jakarta.
Methods: Pregnant women who visited obstetric clinic of Cipto Mangunkusumo and Fatmawati Hospital (n = 956), answered questionnaire containing questions about the characteristics and subjective symptoms. Distribution of subjective symptoms during pregnancy was described based on age, parity, education, socioeconomic status, pregnant desire and history of infertility.
Results: Nausea was the main symptom during first trimester (57,5%) and second trimester (33,5%) of pregnancy, while contraction (69,3%) and backpain (68,7%) were main symptoms during third trimester. There were significant relationships between maternal age and symptoms of nausea, vomiting and vaginal discharge. There were significant relationship between parity and complaints of nausea, vomiting, constipation, vaginal discharge and contraction. There were significant relationship between educational level and complaints of nausea, vomiting, heartburn, hemorrhoid, vaginal discharge, back pain and symphysis pubis dysfunction. There were significant relationship between socioeconomic level with complaints of nausea, constipation, back pain, symphysis pubis dysfunction and contraction. There were significant relationship between pregnant desire and complaints of back pain and extremities edema. There were significant relationship between history of infertility and complaints of back pain, symphysis pubis dysfunction and contraction.
Conclusions: The main symptoms during the first and second trimester was nausea, while the one during the third trimester was contraction. Factors such as age, parity, educational level, socioeconomic status, pregnant desire and history of infertility, affected the distribution of subjective symptoms during pregnancy., Objective: To obtain a description of subjective complaints during pregnancy in the population in Indonesia, especially Jakarta.
Methods: Pregnant women who visited obstetric clinic of Cipto Mangunkusumo and Fatmawati Hospital (n = 956), answered questionnaire containing questions about the characteristics and subjective symptoms. Distribution of subjective symptoms during pregnancy was described based on age, parity, education, socioeconomic status, pregnant desire and history of infertility.
Results: Nausea was the main symptom during first trimester (57,5%) and second trimester (33,5%) of pregnancy, while contraction (69,3%) and backpain (68,7%) were main symptoms during third trimester. There were significant relationships between maternal age and symptoms of nausea, vomiting and vaginal discharge. There were significant relationship between parity and complaints of nausea, vomiting, constipation, vaginal discharge and contraction. There were significant relationship between educational level and complaints of nausea, vomiting, heartburn, hemorrhoid, vaginal discharge, back pain and symphysis pubis dysfunction. There were significant relationship between socioeconomic level with complaints of nausea, constipation, back pain, symphysis pubis dysfunction and contraction. There were significant relationship between pregnant desire and complaints of back pain and extremities edema. There were significant relationship between history of infertility and complaints of back pain, symphysis pubis dysfunction and contraction.
Conclusions: The main symptoms during the first and second trimester was nausea, while the one during the third trimester was contraction. Factors such as age, parity, educational level, socioeconomic status, pregnant desire and history of infertility, affected the distribution of subjective symptoms during pregnancy.]"
Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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Marendra Mahathir
Hubungan kadar albumin dengan keluhan subjektif (gatal, edema tungkai, rasa baal, kesemutan dan nyeri pada pergelangan tangan) pada kehamilan trimester III di Jakarta tahun 2020 = Relationship of albumin levels with subjective complaints (itching, leg edema, numbness, tingling, and pain in the wrist) in third trimester pregnancy in Jakarta 2020
"Latar Belakang: Banyak keluhan subjektif yang timbul pada kehamilan trimester III seperti gatal, edema tungkai, rasa baal, kesemutan dan nyeri pada pergelangan tangan. Keluhan tersebut dapat menyebabkan penurunan kualitas hidup ibu hamil. Selama kehamilan dapat terjadi perubahan kadar albumin yang cukup masif yang diduga berhubungan dengan timbulnya keluhan subjektif tersebut.
Objektif: Mengetahui hubungan kadar albumin dengan keluhan subjektif (gatal, edema tungkai, rasa baal, kesemutan dan nyeri pada pergelangan tangan) pada kehamilan trimester III.
Metode: Ibu hamil trimester III tanpa penyakit penyerta yang kontrol kehamilan di poliklinik antenatal care (ANC) RSCM dan RSIA Anggrek Mas (n=78). Sampel tersebut di kelompokan menjadi sampel dengan keluhan subjektif (n=50) dan tanpa keluhan subjektif (n=28). Selanjutnya dilakukan pemeriksaan kadar serum albumin pada semua subjek penelitian di labolatorium dan dilakukan analisis untuk mencari hubungan variabel tersebut.
Hasil dan Kesimpulan: Kadar albumin di bawah 3.51 g/dl berhubungan bermakna secara statistik dengan keluhan kesemutan (P=0.025) dan edema tungkai (P=0.001) dengan sensitifitas & spesifisitas masing-masing 76% & 55% dan 47% & 92%. Perubahan kadar albumin tidak berhubungan dengan keluhan gatal (mean 3.60 g/dl), rasa baal (mean 3.61 g/dl) dan rasa nyeri pada pergelangan tangan (mean 3.60 g/dl)
Background: There was many of subjective complaints arise in the third trimester of pregnancy such as itching, leg edema, numbness, tingling, and pain in the wrist. These complaints can cause a decrease in the quality of life for pregnant women. During pregnancy, changes in albumin levels are quite massive which is thought to be related to subjective complaints that arise.
Objective: Knowing the asociation beetween albumin serum levels and subjective complaints (itching, leg edema, numbness, tigling and pain in the wrist) during the third trimester of pregnancy
Methods: Third trimester pregnant mother without complication that control their pregnancy in the clinic RSCM and RSIA Anggrek Mas (n=78). These samples are grouped into samples with subjective complaints (n=50) and without subjective complaints (n=28). Furthermore, albumin serum level examination of all subject were performed on laboratory and all the result were analyze to obtain the association between these variables.
Results and Conclusions: Albumin serum levels below 3.51 g/dl were statistically significantly related to numbness complaints (P=0.025) and leg edema (P=0.001) with sensitivity & specificity of 76% & 55% and 47% & 92%, respectively. Changes in albumin levels were not associated with complaints of pain tingling (mean 3.60 g/dl), numbness (mean 3.61 g/dl) and pain in the whirst (mean 3.60 g/dl )."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
T58327
UI - Tesis Membership  Universitas Indonesia Library
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Novan Satya Pamungkas
Elektroakustimulasi untuk mengatasi keluhan mual-muntah pada trimester pertama kehamilan = Electroacustimulation for reducing nausea and vomiting in the first trimester of pregnancy / Novan Satya Pamungkas
"Tujuan
Penelitian ini bertujuan mengetahui manfaat elektroakustimulasi dalam mengatasi keluhan mual dan muntah pada trimester pertama kehamilan.
Metode
Empat puluh pasien dengan emesis gravidarum dibagi ke dalam 2 kelompok secara acak. Kelompok kontrol diberikan vitamin B6 3x30 mg per hari dan kelompok yang ingin diteliti diberikan alat elektroakustimulasi. Derajat keparahan mual dan muntah pasien dinilai pra dan 3 hari pasca perlakuan dengan menggunakan kuesioner PUQE.
Hasil
Penelitian ini diikuti oleh 40 ibu hamil. Tidak didapatkan adanya perbedaan usia kehamilan dan skor PUQE pra perlakuan pada kedua kelompok. 3 hari pasca perlakuan didapatkan pengurangan skor PUQE yang bermakna secara statistik baik pada kelompok vitamin B6 (p= .004) maupun pada kelompok elektroakustimulasi (p= .000). Namun, perubahan skor PUQE pada kedua kelompok tersebut tidak berbeda bermakna scara statistik (p= .286).
Kesimpulan
Elektroakustimulasi efektif untuk mengatasi mual dan muntah pada trimester pertama kehamilan. Tidak terdapat perbedaan efektivitas antara elektroakustimulasi dan vitamin B6 dalam mengatasi mual dan muntah pada trimester pertama kehamilan.
Objective
To evaluate the effectiveness of electroacustimulation in reducing nausea and vomiting in the first trimester of pregnancy.
Study design
Pregnant volunteers with symptoms of nausea and vomiting below 14 weeks of gestation participated in a 3-day clinical trial. Participants were randomly assigned to receive a device for electroacustimulation therapy or vitamin B6 with the dosage of 3 x 30 mg per day. The primary outcome measure was self-recorded symptoms according to PUQE scoring system before and after 3-days treatment.
Results
Fourty pregnant women completed this study. There were no differences between groups in gestational age at entry and PUQE score pre-treatment. After 3 day therapy, there were significant decrease in PUQE score in group receiving B6 (p= .004) and also in electroacustimulation group (p= .000). However, the change in PUQE score was not significantly different between the two groups (p= .286).
Conclusion
Electroacustimulation is effective for reducing nausea and vomiting in first trimester of pregnancy. There were no different in effectivity between vitamin B6 and electroacustimulation for reducing nausea and vomiting in first trimester of pregnancy."
Fakultas Kedokteran Universitas Indonesia, 2013
T33200
UI - Tesis Membership  Universitas Indonesia Library
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Ferry Darmawan
Perbandingan prevalensi periodontitis dan karies dentis, serta pengetahuan, sikap, perilaku kesehatan gigi mulut pada ibu hamil yang mengalami persalinan preterm dengan ibu bersalin spontan di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo = Comparison of the prevalence of periodontitis and dental caries and knowledge attitude and behavior about oral health between women with preterm labor and spontaneous labor in Cipto Mangunkusumo Hospital / Ferry Darmawan
"ABSTRAK
Latar Belakang
Persalinan preterm bukan hanya merupakan masalah kesehatan dengan kejadian yang tinggi (11,1%) tetapi juga penyebab tertinggi (30%) kematian bayi di Indonesia. Faktor risikonya antara lain periodontitis dan kemungkinan karies dentis. Hal ini menunjukkan pentingnya kesehatan gigi dan mulut pada saat kehamilan. Namun, perilaku ibu hamil untuk memeriksakan kesehatan gigi dan mulut masih buruk.
Tujuan
Mengetahui perbandingan prevalensi periodontitis dan karies dentis serta pengetahuan, sikap, perilaku kesehatan gigi mulut antara ibu dengan persalinan preterm dengan persalinan spontan.
Metode
Penelitian ini merupakan penelitian potong lintang dengan pendekatan pengambilan sampel seperti kasus kontrol. Kelompok kasus adalah ibu hamil yang mengalami persalinan preterm dan kelompok kontrol adalah ibu hamil yang yang bersalin spontan. Diagnosis periodontitis berdasarkan kriteria Community Periodontal Index (CPI). Diagnosis karies berdasarkan adanya karies pulpa. Penilaian pengetahuan, sikap, dan perilaku kesehatan gigi dan mulut dengan kuisioner. Karakteristik demografik dan variabel perancu dikontrol dengan analisis multivariat.
Hasil
Didapatkan 182 subjek penelitian yang terdiri dari 83 subjek kasus dan 79 pasien kontrol. Prevalensi periodontitis lebih tinggi pada kelompok persalinan preterm namun tidak bermakna sebagai faktor risiko persalinan preterm (55,4 % vs 54,4 %, p 0,089). Prevalensi karies dentis lebih tinggi pada persalinan preterm namun juga tidak bermakna sebagai faktor risiko persalinan preterm (62.7 % vs 59,5 %, p 0,680.). Tidak didapatkan perbedaan bermakna antara pengetahuan, sikap dan perilaku mengenai kesehatan gigi mulut pada ibu hamil kedua kelompok.
Kesimpulan
Prevalensi periodontitis dan karies dentis pada populasi ini cenderung tinggi. Prevalensi tersebut lebih tinggi pada persalinan preterm namun bukan merupakan faktor risiko persalinan preterm pada populasi ini. Tidak terdapat perbedaan bermakna antara pengetahuan, sikap, dan perilaku kesehatan gigi mulut antara pada ibu hamil yang mengalami persalinan preterm dibandingkan kontrol.
ABSTRACT
Backgrounds
Preterm labor is not only one of health problems with high incidence (11.1%), but also the most cause of perinatal death (30%) in Indonesia. The risk factors are periodontitis and dental caries which assumed. This condition emerges the importance of oral health during pregnancy. However, the behavior of pregnant women for routine oral health evaluation is poor.
Objectives
To compare the prevalence of periodontitis and dental caries, knowledge, attitudes, and behaviors about oral health between women with preterm labor and spontaneous labor.
Methods
This study was a cross sectional study with case-control sampling approach. Case group were pregnant women who experience preterm labor and the control group were women with spontaneous labor. Diagnosis of periodontitis was according to Community Periodontal Index (CPI) criteria. Diagnosis of caries was based on the presence of caries pulp. Assessment of knowledge, attitudes, and behaviors of oral health were using questionnaires. Demographic characteristics and confounding variables were controlled using multivariate analysis.
Results
One hundred and eighty two subjects were obtained, consisted of 83 cases subjects and 79 control subjects. The prevalence of periodontitis was higher but not significant as risk factor for preterm labor (55.4% vs. 54.4%, p 0.089). The prevalence of caries was not significantly different (62.7% vs. 59.5%, p 0.680.). There were no significant differences between knowledge, attitudes and behaviors of oral health in two groups of pregnant women.
Conclusions
Prevalence of periodontitis and dental caries were relatively high. Both prevalences were higher among preterm group, but were not significant risk factors in this population. There were no significant differences between knowledge, attitudes, and behaviors of oral health among preterm group and control."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Adhitya Yudha Maulana
Hubungan Profil Lipid dengan Derajat Inflamasi pada Ibu Hamil = The Relationship between Lipid Profile and Degree of Inflammation in Pregnant Women
"Latar Belakang dan Tujuan: Proses inflamasi tidak dapat dihindari pada kehamilan, namun inflamasi yang berlebihan pada trimester pertama dapat menyebabkan morbiditas ibu dan bayi baru lahir. Penelitian ini bertujuan untuk mengevaluasi hubungan profil lipid dengan derajat inflamasi pada ibu hamil. Metode dan Desain Studi: Studi cross-sectional ini dilakukan dari bulan April hingga Oktober 2022 di Puskesmas Kramat Jati di Jakarta. 98 wanita hamil trimester pertama berusia 20-40 tahun dengan kehamilan intrauterin dimasukkan, sedangkan peserta dengan kondisi medis tertentu dikeluarkan. Pengumpulan data dilakukan melalui anamnesis, pemeriksaan fisik, pemeriksaan USG, dan sampel darah. Analisis data akan melibatkan analisis univariat, bivariat dan multivariat untuk menentukan variabel independen yang paling signifikan. Hasil: Usia rata-rata partisipan adalah 28,39 tahun dan median kehamilan minggu ke-10 ditemukan 29,6% memiliki kadar kolesterol tinggi, 15,3% memiliki kadar trigliserida tinggi, 49% memiliki kadar LDL tinggi, dan 1% memiliki kadar LDL tinggi. rasio /HDL. Sebagian besar (85,7%) responden memiliki hs-CRP yang tinggi, sedangkan kadar CRP yang tinggi hanya ditemukan pada 37,8%. Analisis bivariat menunjukkan hubungan yang signifikan antara CRP dan trigliserida (p=0,026), sedangkan parameter lainnya tidak signifikan. Analisis multivariat menunjukkan hubungan paling signifikan antara CRP dan trigliserida (p=0,017). Studi ini menunjukkan bahwa risiko relatif CRP tertinggi adalah terhadap trigliserida (2,04), diikuti oleh kolesterol total (1,45) dan LDL (1,31). Kesimpulan: Peningkatan kadar trigliserida pada wanita hamil berhubungan dengan kemungkinan peningkatan CRP selama trimester pertama.
Inflammatory processes are inevitable in pregnancy, however excessive inflammation in the first trimester can cause maternal and neonatal morbidity. This study aims to evaluate the relationship between lipid profile and degree of inflammation in pregnant women. Methods and Study Design: This cross-sectional study was conducted from April to October 2022 at Kramat Jati Community Health Center in Jakarta.  98 first trimester pregnant women aged 20-40 years old with an intrauterine pregnancy was included, while participants with certain medical conditions were excluded.  Data was collected through history-taking, physical examination, ultrasound examination, and blood samples. Data analysis will involve univariate, bivariate and multivariate analysis to determine the most significant independent variables. Results: The average age of participants was 28.39 years old and a median of the 10th week of pregnancy found that 29.6% had high cholesterol levels, 15.3% had high triglyceride levels, 49% had high LDL levels, and 1% had a high LDL/HDL ratio. A majority (85.7%) of the respondents had high hs-CRP, while high CRP levels were found only in 37.8%. The bivariate analysis showed a significant relationship between CRP and triglycerides (p=0.026), while the other parameters were not significant. The multivariate analysis was showed the most significant relationship between CRP and triglycerides (p=0.017). This study showed that the highest relative risk of CRP was against triglyceride (2.04), followed by total cholesterol (1.45) and LDL (1.31). Conclusions: Elevated triglyceride level in pregnant women are associated with an increased likelihood of CRP elevation during the first trimester."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2023
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Murthy Mutmainah
Perbandingan Kadar Asam Salisilat Natural dalam Serum dan Urin pada Preeklamsia Awitan Dini dan Awitan Lambat = Comparison of Natural Salicylic Acid Levels in Blood and Urine in Early-Onset and Late-Onset Preeclampsia
"Latar Belakang: Prevalensi preeklamsia dalam kehamilan di Indonesia sebesar 7-10%, Asam asetilsalisilat yang mengandung senyawa aktif asam salisilat diketahui dapat mencegah terjadinya preeklamsia awitan dini terutama bila diberikan sebelum usia kehamilan 16 minggu. Tubuh memiliki asam salisilat natural yang didapatkan dari konsumsi sayuran yang mengandung asam salisilat. Asam salisilat merupakan senyawa aktif yang berperan sebagai anti inflamasi. Penelitian ini bertujuan menilai apakah kejadian preeklamsia dipengaruhi oleh kadar asam salisilat natural serum dan urin.
Metode: Penelitian ini menggunakan disain case-control berpasangan. Subjek adalah pasien hamil dengan preeklamsia awitan dini (PEAD) dibandingkan dengan hamil normotensi 20-34 minggu terdiri atas 35 pasien/kelompok, preeklamsia awitan lambat (PEAL) dibandingkan dengan hamil normotensi 34-40 minggu terdiri atas 39 pasien/ kelompok. Pemeriksaan kadar asam salisilat (SA) dan asam salisilurat (SUA) dalam serum diperiksa dari sampel darah vena, kadar SA dan SUA urin diperiksa dari sampel urin sewaktu yang terkoreksi dengan kadar kreatinin urin, semuanya diperiksa menggunakan kromatografi. Seluruh subjek dilakukan wawancara FFQ (Food Frequent Questionnaire) untuk mengetahui asupan makanan selama hamil. Analisis statistik yangdigunakan adalah uji Mann Whitney .
Hasil: Median usia kehamilan pasien PEAD adalah 31 minggu, kelompok normal adalah 30 minggu. Kadar SUA serum pada PEAD berbeda bermakna dibandingkan hamil normal dengan median 1,43 (min-max 0,001-9,32) vs 0,21 (0,002-15,78) nilai p<0,001. Kadar albumin pada PEAD berbeda bermakna dengan hamil normal median 3 (2,1 – 3,8) vs 3,7 (3,4-4,3) p<0,001. Kadar Asupan protein berbeda bermakna (13% vs 14%,
p<0,001)Kadar serat pangan pada PEAD berbeda bermakna dibandingkan hamil normal (8 gram/hari vs 9,6 g/hari, p<0,001). Kadar SA dalam serum dan urin, SUA urin pada kelompok ini tidak berbeda bermakna.
Median usia kehamilan PEAL dan normotensi adalah 37 minggu. Kadar SA serum dan urin dan SUA serum tidak berbeda bermakna antara kedua kelompok. Kadar albumin pada PEAL berbeda bermakna dengan median (3 (2,4-3,6) vs 3,4 (2,9-4,1) p<0,001).
Simpulan : Tidak terdapat perbedaan bermakna kadar asam salisilat dan asam salisilurat pada serum dan urin pada kehamilan preeklamsia dan normotensi. Kelompok PEAD terdapat kadar SUA serum yang lebih tinggi dan berkorelasi dengan kadar albumin dan asupan protein yang rendah. Asupan serat pangan berhubungan dengan kejadian PEAD, tetapi tidak berhubungan dengan kadar asam salisilat dan asam salisilurat
Background: The prevalence of preeclampsia in pregnancy in Indonesia is 7-10%. Acetylsalicylate which contains the active compound salicylic acid is known to prevent early onset preeclampsia, especially if given before 16 weeks of gestation. The body has natural salicylic acid which is obtained from the consumption of vegetables that contain salicylic acid. Salicylic acid is an active compound that acts as an anti-inflammatory. This study aims to assess whether the incidence of preeclampsia is influenced by the
levels of natural salicylic acid in the blood and urine.
Methods: : A matched case-control was adopted in this study. Subjects were pregnant patients with early onset preeclampsia (EOP) compared to normotensive pregnancies of 20-34 weeks consisting of 35 patients/group, late onset preeclampsia (LOP) compared with normotensive pregnancies of 34-40 weeks consisting of 39 patients/group. Examination of salicylic acid (SA) and salicylic acid (SUA) levels in serum was examined from venous blood samples, urine SA and SUA levels were examined from urine samples while corrected by urine creatinine levels, all were examined using chromatography. . To measure food intake during pregnancy, all subject were interviewed using the FFQ (Food Frequent Questionnaire). The Mann Whitney test was utilized in the statistical analysis.
Objective: The goal of this study is to see if natural blood and urine levels of salicylic acid affect the risk of preeclampsia.
Result :EOP subject had a median gestational age of 31 weeks, while normal group 30 wga. Serum SUA levels in EOP were considerably different from normal pregnant women, with a median of 1.43 (min-max 0.001-9.32) versus 0.21 (0.002-15.78) p value <0.001, while albumin levels in EOP were significantly different from normal pregnant women, with a median of 3 (2.1-3.8) vs. 3.7 (3.4-4.3) p<0.001, and protein intake significantly lower than normal (13 vs 14%, p<0,001).. Dietary fiber in EOP was significantly
different compared to normal pregnancy (8 g/day vs 9.6 g/day, p<0.001) SA levels in serum and urin, as well as urine SUA, were not substantially different in this group.
LOP and normotensive gestational age were both 37 weeks. The levels of SA and SUA in the serum and urine were not substantially different between the two groups. With a median of 3 (2.4-3.6) vs. 3.4, albumin levels in PEAL were substantially different (2.9-4.1).
Conclusion: In preeclampsia and normotensive pregnancies, there was no significant difference in salicylic acid and salicyluric acid levels in blood and urine. The serum SUA levels in the EOP group were greater and associated with low albumin levels and low protein intake. Fiber intake was linked to the development of EOP, but not to salicylic acid levels or salicyluric acid levels."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
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Sandhy Prayudhana
Perbandingan aktifitas antioksidan superoxide dismutase eritrosit, kadar trace elements eritrosit dan indeks eritrosit pada kehamilan normal dan preeklamsia = Comparison between erythrocyte antioxidant superoxide dismutase activity, erythrocyte trace elements and erythrocyte index in normal pregnancy and preeclampsia
"Latar Belakang: Preeklamsia merupakan penyebab utama morbiditas dan mortalitas ibu dan bayi di seluruh dunia. Gejala preeklamsia disebabkan oleh disfungsi endotel maternal. Eritrosit maternal dapat berperan menyebabkan disfungsi endotel maternal melalui gangguan keseimbangan nitric oxide. Stres oksidatif dan trace elements pada eritrosit dicurigai berperan menyebabkan gangguan produksi nitric oxide. Stres oksidatif eritrosit juga dapat mempengaruhi morfologi eritrosit. Tujuan: Penelitian ini membandingkan aktifitas antioksidan superoxide dismutase eritrosit, kadar trace elements eritrosit dan indeks eritrosit pada kehamilan normal dan preeklamsia. Metode: Penelitian ini merupakan studi potong lintang dengan jumlah sampel 20 pasien preeklamsia dan 20 pasien hamil normal yang melakukan kunjungan pada RS Cipto Mangunkusumo, RSUD Kab. Tangerang dan RSUD Koja. Pemeriksaan antioksidan superoxide dismutase eritrosit dengan metode ELISA dan pemeriksaan trace elements eritrosit dengan metode ICP-MS. Data disajikan dalam tabel dan dianalisis dengan uji parametrik yakni uji-t tidak berpasangan bila sebaran normal atau uji Mann-Whitney U bila sebaran tidak normal. Penelitian ini sudah lolos kaji etik dan mendapatkan persetujuan pelaksanaan dari Komite Etik Penelitian Kesehatan FKUI-RSCM.
Hasil: Didapatkan kadar eritrosit preeklamsia dibandingkan kontrol adalah (4,39 ± 0,55 vs 3,84 ± 0,44 juta/ml) (p=0,001), MCV (83,01 ± 8,48 vs 88,53 ± 5,6 fL) (p=0,020), MCH (26,9 ± 3,6 vs 29,6 ± 5,7 pg) (p=0,009) dan MCHC (32,4 ± 1,7 vs 33,4 ± 1,03 %) (p=0,023). Tidak terdapat perbedaan bermakna RDW-CV eritrosit preeklamsia dibandingan kontrol 14,3 (12,5-23,7) vs 14,1 (12-16,2) (p=0,448). Kadar aktifitas SOD eritrosit kelompok preeklamsia dibandingkan kelompok kontrol adalah 35,74 ± 7,97 vs 28,9 ± 6,28 U/ml (p=0,005); Aktifitas SOD/Hb eritrosit kelompok preeklamsia dibandingkan kelompok kontrol adalah 310,8 ± 83,4 vs 257,88 ± 63,1 U/g Hb (p=0,029). Untuk trace elements preeklamsia dibandingkan kontrol adalah : Ferrum (67 (23-82) vs 75 (24-92)) fg/RBC (p=0,033); Cobalt (0,15 (0,05-0,61) vs 0,08(0,02-0,34)) ag/RBC (p=0,027); Selenium (18,5 ± 4,6 vs 21,7 ± 2,8) ag/RBC (p=0,014); Cadmium (0,10 (0,02-0,22) vs 0,33 (0,01-0.14)) (p=0,006) dan Timbal (9,37 ± 4,67 vs 5,6 ± 2,06) ag/RBC (p=0,003). Trace elements eritrosit mangan, nikel, cuprum, seng, arsenik, merkuri dan thalium tidak terdapat perbedaan antara kehamilan preeklamsia dan kontrol.
Background : Preeclampsia is a major cause of maternal and infant morbidity and mortality worldwide. Symptoms of preeclampsia are caused by maternal endothelial dysfunction. Maternal erythrocytes can play a role in causing maternal endothelial dysfunction through impaired nitric oxide balance. Oxidative stress and micro-minerals in erythrocytes are suspected to play a role in causing impaired nitric oxide production. Oxidative stress of erythrocytes can also affect the morphology of erythrocytes. Objective : This study compared the anti-oxidant activity of erythrocyte superoxide dismutase, erythrocyte micro mineral content and erythrocyte index in normal pregnancy and preeclampsia. Methods: This study is a cross-sectional study with a sample of 20 patients with preeclampsia and 20 pregnant patients without preeclampsia who visited Cipto Mangunkusumo Hospital, Kab. Tangerang and hospitals. Koja. Examination of erythrocyte superoxide dismutase antioxidant by ELISA method and micro erythrocyte mineral examination by ICP-MS method. The data are presented in tables and analyzed by parametric test, unpaired t-test if the distribution is normal or the Mann-Whitney U test if the distribution is not normal. This research has passed the ethical review and received implementation approval from the Health Research Ethics Committee of the FKUI-RSCM.
Results: The preeclampsia erythrocyte levels compared to controls were (4.39 ± 0.55 vs 3.84 ± 0.44 million/ml) (p=0.001), MCV (83.01 ± 8.48 vs. 88.53 ± 5 .6 fL) (p=0.020), MCH (26.9 ± 3.6 vs 29.6 ± 5.7 pg) (p=0.009) and MCHC (32.4 ± 1.7 vs 33 ,4 ± 1.03%) (p=0.023). There was no significant difference in RDW-CV of preeclampsia erythrocytes compared to controls 14.3 (12.5-23.7) vs. 14.1 (12-16.2) (p=0.448). SOD activity levels of erythrocytes in the preeclampsia group compared to the control group were 35.74 ± 7.97 vs. 28.9 ± 6.28 U/ml (p=0.005);The erythrocyte SOD/Hb activity of the preeclampsia group compared to the control group was 310.8 ± 83.4 vs. 257.88 ± 63.1U/g Hb (p=0.029). For preeclampsia trace minerals compared to controls were: Ferrum (67 (23-82) vs 75 (24-92)) fg/RBC (p=0.033); Cobalt (0.15 (0.05-0.61) vs. 0.08(0.02-0.34)) ag/RBC (p=0.027); Selenium (18.5 ± 4.6 vs. 21.7 ± 2.8) ag/RBC (p=0.014); Cadmium (0.10 (0.02-0.22) vs. 0.33 (0.01-0.14)) (p=0.006) and Lead (9.37 ± 4.67 vs 5.6 ± 2.06) ag/RBC (p=0.003). The trace elements erythrocyte: manganese, nickel, cuprum, seng, arsenic, mercury and thallium showed no significant difference between the preeclampsia and control groups."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
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Ruth Widhiati Raharjo Putri
Perbandingan Trace elemen dan Kadar Asam Lemak Serum dan Sel Darah Merah pada Preeklamsia Berat dan Normotensi = Comparison of Trace Elements and Fatty Acids Levels in Serum and Red Blood Cells in Severe Preeclampsia and Normotensive
"Ketidakseimbangan trace elemen dan asam lemak berperan dalam terjadinya preeklamsia. Penelitian ini bertujuan untuk mengetahui status trace elemen serum dan eritrosit serta asam lemak pada preeklamsia berat. Desain potong lintang dilakukan pada 40 ibu hamil dalam 2 kelompok, preeklamsia berat dan normotensi. Pengukuran trace elemen dan asam lemak dalam serum dan eritrosit dilakukan dengan menggunakan Inductively Coupled Plasma and Gas Chromatography Mass Spectrometry. Receiver Operating Characteristic (ROC), analisis bivariat dan multivariat dilakukan. Trace elemen yang ditemukan berbeda nyata baik dalam serum maupun dalam eritrosit adalah selenium, besi, cadmium dan timbal (p<0,05). Hampir semua asam lemak eritrosit, ALA, EPA, DHA, omega-3, LA, GLA, DGLA, AA, omega-6 dan asam oleat ditemukan berbeda bermakna. Nilai tertinggi prediksi preeklamsia berat dengan AUC 0,77(IK95%:0,625-0,912) dan sensitifitas 90% serta spesifitas 50% terdapat pada ALA dengan cut off 0,16 amol/RBC yang mewakili asam lemak omega3 dan untuk golongan omega6 terdapat pada LA dengan cut off 54,25 amol/RBC (sensitifitas 85%; spesifitas 75%). Peningkatan risiko preeklamsia tertinggi terdapat pada EPA yang rendah(OR 14,53; IK95% 2,21-95,41) dan AA yang tinggi(OR 7,37; IK95% 1,37-39,7). Pengukuran trace elemen dan asam lemak diperlukan untuk menentukan status nutrisi dan terutama sebagai prediktor preeklamsia. Pengukuran asam lemak pada eritrosit dinilai lebih baik dibandingkan serum.
Imbalance of trace elements and fatty acids plays a role in the occurrence of preeclampsia. The aim of the study was to determine the status of serum and erythrocyte trace elements and fatty acids in severe preeclampsia. Cross-sectional design was performed on 40 pregnant women in 2 groups, severe preeclampsia and normotensive. Measurement of trace elements and fatty acids in serum and erythrocyte was performed using Inductively Coupled Plasma and Gas Chromatography Mass Spectrometry. Receiver Operating Characteristic (ROC), bivariate and multivariate analysis were performed. Trace elements found to be significantly different both in serum and in erythrocyte were Selenium, Iron, Cadmium and Lead (p<0.05). Almost all erythrocyte fatty acids, ALA, EPA, DHA, omega-3, LA, GLA, DGLA, AA, omega-6 and oleic were found to be significantly different. The highest predictive value of severe preeclampsia with an AUC of 0.77(95% CI: 0.625-0.912); a sensitivity of 90% and specificity of 50% was found in ALA with a cut off of 0.16 amol/RBC representing omega3 fatty acids and for the omega6 group in LA with a cut off of 54.25 amol/RBC (85% sensitivity; 75% specificity). The highest increased risk of preeclampsia was found in low EPA (OR 14.53; 95% CI 2.21-95.41) and high AA (OR 7.37; 95% CI 1.37-39.7). Measurement of trace elements and fatty acids is needed to determine nutritional status especially as a predictor of preeclampsia. Erythrocyte fatty acids measurement is considered better than serum. "
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
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