Hasil Pencarian  ::  Simpan CSV :: Kembali

"Lovastatin dapat berfungsi menghambat proses pembentukan kolesterol dalam hati, dengan cara penghambatan secara kompetitif terhadap sintesis enzim 3 hydroxy -3-methylglutaryl-koenzim A reduktase (HMG-KoA reduktase). Penelitian bertujuan untuk melakukan skrining kapang Aspergillus. spp. koleksi University of Indonesia Culture Collection (UICC), fermentasi, dan analisis produksi lovastatin. Hasil skrining lovastatin dari sebanyak 40 biakan Aspergillus spp. koleksi UICC 18 biakan (45%) positif menghasilkan lovastatin dan 22 biakan (55%) negatif. Aspergillus flavus UICC 360 menghasilkan lovastatin tertinggi dibandingkan sepuluh Aspergillus spp. terpilih. Analisis Thin Layer Chromatografy (TLC) menunjukkan nilai Rf sepuluh Aspergillus spp. hampir sama dengan standart. Analisis High Performance Chromatography (HPLC) mengkonfirmasi lovastatin Asp. flavus UICC 360 mempunyai waktu retensi sama dengan standart (13,2 menit).

---

Lovastatin is an acting inhibitor of enzyme 3 hydroxy -3-methylglutaryl-coenzyme A reduktase (HMG-CoA reductase) as competitive inhibitor on biosynthesis of cholesterol. The aims of the research is for the selection, fermentation, and analysis of lovastatin from isolates mold Aspergillus spp. at the University of Indonesia Culture Collection (UICC). The results revealed that out of 40 cultures, 18 cultures (45%) produced lovastatin and 22 cultures (55%) were negative. Aspergillus flavus UICC 360 showed the highest lovastatin production compared of 10 selected cultures. Thin Layer Chromatografy (TLC) analysis amount of 10 Aspergillus spp. have similarity of Rf value compared to the standard. High Performance Chromatography (HPLC) analysis confirmed that lovastatin Aspergillus flavus UICC 360 has the same retention time with the standard (13.2 minutes)."

"Angka Kematian Jemaah Haji Provinsi Jambi Tahun 2017/1438H sebesar 0,84 merupakanyang tertinggi di Indonesia. Sebanyak 22 dari 2609 jemaah haji Provinsi Jambi Tahun2017/1438 H meninggal saat melaksanakan ibadah haji. Riwayat Hipertensi sebelummelaksanakan ibadah haji merupakan faktor risiko kematian saat menunaikan ibadah haji.Penelitianinibertujuan mengetahui hubungan antara riwayat hipertensi sebelum menunaikanibadah haji dengan kematian jemaah haji saat melaksanakan ibadah hai di tanah suci. Desainyang digunakanadalahcross sectional potong lintang .Populasi dalam penelitian ini adalahseluruh jemaah haji Provinsi Jambi Tahun 2017/1438 H. Metode pengambilan sampel yangdigunakan adalah total populasi jemaah haji Provinsi Jambi Tahun 2017/1438 H sebanyak2615 orang. Hasil penelitian menunjukkan hipertensi berpengaruh kepada kematian jemaahhaji asal Provinsi Jambi Tahun 2017/1438 H dengan nilai Prevalence Ratio PR sebesar0,473 95 CI 0,158 ndash; 1,405 setelah di kontrol oleh variabel umur, jenis kelamin,pekerjaan, tingkat pendidikan, Diabetes Melitus, Indeks Massa Tubuh IMT Anemia,Penyakit Infeksi, Penyakit Kardiovaskular dan Penyakit Pernafasan.

---

Mortality Rate Jamaah Haji Jambi Province Year 2017 1438 H by 0.84 is the highest inIndonesia. A total of 22 of the 2609 pilgrims of Jambi Province in 2017 1438 H died whileperforming the pilgrimage. Hypertension history before performing the pilgrimage is a riskfactor of death when performing the pilgrimage. This study aims to determine therelationship between history of hypertension before performing the pilgrimage with the deathof pilgrims when performing worship in the holy land. The design used is cross sectional. Thepopulation in this study is all pilgrims Jambi Province 2017 1438 H. The sampling methodused is the total population of pilgrims Jambi Province in 2017 1438 H as many as 2615people. The results showed that hypertension influenced the death of Hajj pilgrims fromJambi Province in 2017 1438 H with PR value of 0.473 95 CI 0.158 1.405 aftercontrolled by age, sex, occupation, education, diabetes Melitus, Body Mass Index IMT Anemia, Infectious Diseases, Cardiovascular Disease and Respiratory Disease."