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Sutriyo
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Propranolol hydrochloride is antihypertension agent that has a short biological half life of 2-6 hours. Microcapsules of propranolol hydrochloride are prepared by solvent evaporation method using ethylcellulose as a wall material with the drugpolymer ratio 1:1, 1:2, and 1:3 for sustained release oral delivery. The microcapsules were then evaluated by particle size distribution analysis, shape and morphology (SEM), drug content, and dissolution studies. In vitro dissolution was studied using the dissolution apparatus II (paddle) with ...
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Depok: Fakultas Farmasi Universitas Indonesia, 2004
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Artikel Jurnal Universitas Indonesia Library
