Ditemukan 18 dokumen yang sesuai dengan query
Marco Falasca, editor
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This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the ...
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Dordrecht: [Springer, ], 2012
e20417294
eBooks Universitas Indonesia Library
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Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually ...
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New York: Springer, 2012
e20401435
eBooks Universitas Indonesia Library
Andre Kamkin, editor
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The volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways. The book presents not only the latest achievements in the field but also brings the problem closer to the experts in related medical and biological sciences as well as practicing doctors. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different living organs and tissues and allows to predict ...
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Dordrecht: [, Springer], 2012
e20410734
eBooks Universitas Indonesia Library
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Fungi are sessile, highly sensitive organisms that actively compete for environmental resources both above and below the ground. They assess their surroundings, estimate how much energy they need for particular goals, and then realise the optimum variant. They take measures to control certain environmental resources. They perceive themselves and can distinguish between ?self? and ?non-self?. They process and evaluate information and then modify their behaviour accordingly. These highly diverse competences show us that this is ...
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Dordrecht: [Springer, ], 2012
e20417349
eBooks Universitas Indonesia Library
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Main question : G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and ...
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Dordrecht: Springer, 2012
e20417317
eBooks Universitas Indonesia Library
Malay Chatterjee, editor
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This book provides an overview of critical components of cell signaling machinery and its role in epithelial morphogenesis, proliferation, invasions and angiogenesis in human cancer and discusses novel types of protein kinase pathways ...
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New York: [, Springer], 2012
e20417669
eBooks Universitas Indonesia Library
Thomas Decker, editor
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This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat ...
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Wien: [, Springer], 2012
e20418016
eBooks Universitas Indonesia Library
Lones, Michael A., editor
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The 13 revised full papers presented together with 26 extended abstracts were carefully reviewed and selected from numerous submissions. The papers cover a wide range of topics in disciplines related to genetic and epigenetic networks, transcriptomics and gene regulation, signalling pathways and responses, protein structure and metabolic networks, patterning and rhythm generation, neural modelling and neural networks, biomedical modelling and signal processing, information processing and representation, and algorithmic approaches in computational biology ...
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Berlin: [Springer-Verlag, ], 2012
e20410290
eBooks Universitas Indonesia Library
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This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. ...
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Dordrecht: Springer, 2012
e20417396
eBooks Universitas Indonesia Library
Islam, Md. Shahidul
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This volume covers topics ranging from fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It includes discussion of calcium signaling in different mammalian cells, oocytes, zebrafishes and even in plants ...
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Dordrecht: Springer, 2012
e20417505
eBooks Universitas Indonesia Library
