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"Latar Belakang: Penelitian mengenai petanda inflamasi akut terkait pajanan uap las pada pekerja las sudah banyak dilakukan. Akan tetapi, tidak semua penelitian tersebut sepakat terjadi perbedaan jumlah petanda inflamasi akut sesudah terpajan uap las. Penelitian ini ingin mengetahui apakah terjadi perbedaan jumlah petanda inflamasi akut akibat pajanan uap las dengan sel netrofil mukosa hidung sebagai petanda inflamasinya.Metode:Pada penelitian longitudinal ini, 110 pekerja di sebuah perusahaan pembuat knalpot diperiksa jumlah sel netrofil mukosa hidungnya sebelum dan sesudah terpajan uap las serta diukur kadar logam Kromium, Besi, Mangan, dan Aluminium dalam darah pada 40 pekerja diantaranya. Dilakukan pengukuran kadar logam Cr, Fe, Mn, dan Al di lingkungan kerja untuk menilai kadar pajanan.Hasil:Pengukuran lingkungan menunjukkan kadar Kromium, Besi, Mangan, dan Aluminium udara berada di bawah Nilai Ambang Batas. Sel netrofil sediaan apus sebelum dan sesudah terpajan uap las 8 jam sama – sama berjumlah 2 sel/10 lpk (p = 0,233). Pada penelitian ini juga ditemukan kadar dalam darah logam Cr sebesar 1,03 µg/l; logam Fe sebesar 283.787,73 µg/l; logam Mn sebesar 14,96 µg/l; dan logam Al sebesar 25,68 µg/l.Kesimpulan:Tidak ditemukan perbedaan jumlah sel netrofil mukosa hidung yang bermakna secara statistik akibat pajanan uap las.

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Background and Objective: Many studies about acute inflammation marker regarding metal fume exposure have been conducted but not all agree that metal fume exposure will raise acute inflammation response. One of the acute inflammation markers is nasal mucous neutrophil and this study was conducted to investigate the difference of neutrophil count after being exposed to metal fume as acute inflammation response.

Methods: This study used a longitudinal design with 110 welders as subjects. Nasal mucous neutrophil data was collected before and after 8 hours metal fume exposure. Metal fume (i.e. Chromium, Iron, Manganese, and Aluminum) exposure in the work place was measured with AAS while blood metal level in 40 subjects among them was with ICP-MS.

Results: Chromium, Iron, Manganese, and Aluminum fume level in the work place was under Threshold Limit Value while Chromium, Iron, Manganese, and Aluminum blood level was 1,03 µg/l; 283.787,73 µg/l; 14,96 µg/l; and 25,68 µg/l respectively.Neutrophil count before and after 8 hours metal fume exposure didn’t show any difference with statistically significance (p = 0,233)

Conclusions: There was no statistical significant increase of nasal mucous neutrophil regarding metal fume exposure"

"Background : Metal workers in Indonesia are susceptible to metal fume exposure. One of them is exposure to manganese and aluminum metal fumes that can increase the risk of decline in memory function. Nevertheless, the influence of metal exposure from welding fumes containing manganese and aluminum are still not conclusive. This study was conducted to determine differences in memory function between metal workers exposed and not exposed to metal fume. Methods : This research using a cross-sectional study design with a comparative analysis based on differences in exposure to welding fumes. Metal fume exposure is measured by the levels of manganese and aluminum in the air within work environment using Atomic Absorption Spectrophotometer (AAS) and in the blood using Inductive Coupled Plasma Mass Spectrometry (ICP-MS). Subject’s memory function were examined with Rey Osterrieth Complex Figure, the Beck Depression Inventory II, Digit Span Backward. Results : Manganese and aluminum levels are 0,00001 mg/m3 and 0,000016 mg/m3 and it below the threshold value of the environment nationwide. Median scores on memory function welding worker group is 23.75 (4-34) and non-welding workers was 19.5 (7-35) were not statistically different (p = 0.06). The memory function in the group of workers with blood manganese levels above normal {median 26 (4-34)} is higher than normal {median of 20 (5-35)} (p = 0.005). Conclusions : The differences of memory function is obtained in the group of workers by category of blood manganese levels. The median difference of memory function scores did not differ based on worker exposure to welding fumes.

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ABSTRACTBackground : Metal workers in Indonesia are susceptible to metal fume exposure. One of them is exposure to manganese and aluminum metal fumes that can increase the risk of decline in memory function. Nevertheless, the influence of metal exposure from welding fumes containing manganese and aluminum are still not conclusive. This study was conducted to determine differences in memory function between metal workers exposed and not exposed to metal fume. Methods : This research using a cross-sectional study design with a comparative analysis based on differences in exposure to welding fumes. Metal fume exposure is measured by the levels of manganese and aluminum in the air within work environment using Atomic Absorption Spectrophotometer (AAS) and in the blood using Inductive Coupled Plasma Mass Spectrometry (ICP-MS). Subject’s memory function were examined with Rey Osterrieth Complex Figure, the Beck Depression Inventory II, Digit Span Backward. Results : Manganese and aluminum levels are 0,00001 mg/m3 and 0,000016 mg/m3 and it below the threshold value of the environment nationwide. Median scores on memory function welding worker group is 23.75 (4-34) and non-welding workers was 19.5 (7-35) were not statistically different (p = 0.06). The memory function in the group of workers with blood manganese levels above normal {median 26 (4-34)} is higher than normal {median of 20 (5-35)} (p = 0.005). Conclusions : The differences of memory function is obtained in the group of workers by category of blood manganese levels. The median difference of memory function scores did not differ based on worker exposure to welding fumes."