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Ditemukan 4 dokumen yang sesuai dengan query
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Herlina
Gambaran kognitif pasien HIV anak yang telah memperoleh terapi Antitretrovirus = Cognitive profile in HIV infected children on Antiretroviral therapy
"[ABSTRAK
Latar belakang: Pasien HIV anak berisiko tinggi mengalami gangguan
neurokognitif akibat keterlibatan sistem saraf pusat (SSP). Prevalens gangguan
kognitif tersebut berkisar antara 8%-62%. Pemberian ARV menurunkan viral
load di SSP sehingga mencegah penurunan fungsi kognitif. Tujuan penelitian ini
untuk memberikan gambaran fungsi kognitif pasien HIV anak dalam terapi ARV.
Metode: Studi potong lintang dilakukan terhadap pasien HIV anak berusia 5-15
tahun. Penilaian kognitif dilakukan dengan instrumen Wechsler intelligence scale
for children IV (WISC IV). Pemeriksaan elektroensefalografi bertujuan untuk
membuktikan kerusakan akibat keterlibatan SSP pada infeksi HIV.
Hasil: Sembilan puluh pasien HIV anak median usia 9 tahun telah memperoleh
ARV dengan median 69 bulan. Hasil rerata verbal, performance, dan full-scale IQ
(FSIQ) berturut-turut adalah 88,66 (SB 15,69), 85,30 (SB 15,35), dan 85,73 (SB
15,61). Enam puluh tujuh (74,4%) subjek memiliki verbal IQ normal, 56 (62,2%)
performance scale normal, dan 58 (64,4%) FSIQ normal. Hasil EEG abnormal
didapatkan pada 22 subjek (22,4%) dan tidak memiliki hubungan dengan stadium
klinis, usia dan lama pemberian ARV, serta viral load. Stadium HIV
menunjukkan hubungan bermakna dengan komponen verbal scale IQ dan FSIQ
(p=0,042 dan p=0,044). Hasil IQ tidak memiliki hubungan dengan usia pemberian
ARV, lama pemberian ARV, dan viral load.
Simpulan: Pasien HIV anak dalam terapi ARV memiliki rerata IQ abnormal pada
verbal, performance, dan FSIQ. Berdasarkan kategori hasil IQ lebih dari 50%
subjek memiliki IQ normal pada ketiga skala WISC. Studi kohort diperlukan
untuk menilai apakah pemberian ARV lebih dini dan faktor yang memengaruhi
dapat mencegah penurunan fungsi kognitif pasien HIV anakABSTRACT Introduction: Children with HIV infection are at high risk for developing
neurocognitive impairment because of central nervous system (CNS)
involvement. Prevalence of cognitive impairment is reported between 8%-62%.
Decreased viral load due to antiretroviral therapy (ARV) would prevent the
decrease of cognitive function. The aim of this study was to describe cognitive
function in HIV-infected children on ARV.
Method: We conducted cross sectional study of HIV-infected children aged 5-15
years. Wechsler intelligence scale for children IV (WISC-IV) was administered
for assessing cognitive function. Electroencephalograph was performed to prove
abnormalities caused by CNS involvement of HIV infection
Results: Ninety HIV-infected children with median age of 9 years had received
ARV for median of 69 months. The mean (SD) of verbal, performance, and full
scale IQ were 88,66 (SD 15,69), 85,30 (SD 15,35), and 85,73 (SD 15,61)
respectively. Sixty seven subjects (74,4%) had normal verbal IQ, 56 subjects
(62,2%) had normal performance IQ, and 58 subjects (64,4%) had normal FSIQ.
Twenty two children (22,4%) showed EEG abnormality which was not correlated
to clinical stage, onset and duration of ARV, and viral load. Clinical stage of HIV
showed significant association with verbal and FSIQ (p 0,042 and p 0,044). IQ
results did not have association with onset and duration of ARV and viral load.
Conclusion: HIV-infected children on ARV have abnormal mean IQ in verbal,
performance and FSIQ. Based on categorical IQ, most subjects have normal
verbal, performance, and FSIQ. Cohort study is needed to address whether early
ARV can preserve cognitive function.;Introduction: Children with HIV infection are at high risk for developing
neurocognitive impairment because of central nervous system (CNS)
involvement. Prevalence of cognitive impairment is reported between 8%-62%.
Decreased viral load due to antiretroviral therapy (ARV) would prevent the
decrease of cognitive function. The aim of this study was to describe cognitive
function in HIV-infected children on ARV.
Method: We conducted cross sectional study of HIV-infected children aged 5-15
years. Wechsler intelligence scale for children IV (WISC-IV) was administered
for assessing cognitive function. Electroencephalograph was performed to prove
abnormalities caused by CNS involvement of HIV infection
Results: Ninety HIV-infected children with median age of 9 years had received
ARV for median of 69 months. The mean (SD) of verbal, performance, and full
scale IQ were 88,66 (SD 15,69), 85,30 (SD 15,35), and 85,73 (SD 15,61)
respectively. Sixty seven subjects (74,4%) had normal verbal IQ, 56 subjects
(62,2%) had normal performance IQ, and 58 subjects (64,4%) had normal FSIQ.
Twenty two children (22,4%) showed EEG abnormality which was not correlated
to clinical stage, onset and duration of ARV, and viral load. Clinical stage of HIV
showed significant association with verbal and FSIQ (p 0,042 and p 0,044). IQ
results did not have association with onset and duration of ARV and viral load.
Conclusion: HIV-infected children on ARV have abnormal mean IQ in verbal,
performance and FSIQ. Based on categorical IQ, most subjects have normal
verbal, performance, and FSIQ. Cohort study is needed to address whether early
ARV can preserve cognitive function.;Introduction: Children with HIV infection are at high risk for developing
neurocognitive impairment because of central nervous system (CNS)
involvement. Prevalence of cognitive impairment is reported between 8%-62%.
Decreased viral load due to antiretroviral therapy (ARV) would prevent the
decrease of cognitive function. The aim of this study was to describe cognitive
function in HIV-infected children on ARV.
Method: We conducted cross sectional study of HIV-infected children aged 5-15
years. Wechsler intelligence scale for children IV (WISC-IV) was administered
for assessing cognitive function. Electroencephalograph was performed to prove
abnormalities caused by CNS involvement of HIV infection
Results: Ninety HIV-infected children with median age of 9 years had received
ARV for median of 69 months. The mean (SD) of verbal, performance, and full
scale IQ were 88,66 (SD 15,69), 85,30 (SD 15,35), and 85,73 (SD 15,61)
respectively. Sixty seven subjects (74,4%) had normal verbal IQ, 56 subjects
(62,2%) had normal performance IQ, and 58 subjects (64,4%) had normal FSIQ.
Twenty two children (22,4%) showed EEG abnormality which was not correlated
to clinical stage, onset and duration of ARV, and viral load. Clinical stage of HIV
showed significant association with verbal and FSIQ (p 0,042 and p 0,044). IQ
results did not have association with onset and duration of ARV and viral load.
Conclusion: HIV-infected children on ARV have abnormal mean IQ in verbal,
performance and FSIQ. Based on categorical IQ, most subjects have normal
verbal, performance, and FSIQ. Cohort study is needed to address whether early
ARV can preserve cognitive function., Introduction: Children with HIV infection are at high risk for developing
neurocognitive impairment because of central nervous system (CNS)
involvement. Prevalence of cognitive impairment is reported between 8%-62%.
Decreased viral load due to antiretroviral therapy (ARV) would prevent the
decrease of cognitive function. The aim of this study was to describe cognitive
function in HIV-infected children on ARV.
Method: We conducted cross sectional study of HIV-infected children aged 5-15
years. Wechsler intelligence scale for children IV (WISC-IV) was administered
for assessing cognitive function. Electroencephalograph was performed to prove
abnormalities caused by CNS involvement of HIV infection
Results: Ninety HIV-infected children with median age of 9 years had received
ARV for median of 69 months. The mean (SD) of verbal, performance, and full
scale IQ were 88,66 (SD 15,69), 85,30 (SD 15,35), and 85,73 (SD 15,61)
respectively. Sixty seven subjects (74,4%) had normal verbal IQ, 56 subjects
(62,2%) had normal performance IQ, and 58 subjects (64,4%) had normal FSIQ.
Twenty two children (22,4%) showed EEG abnormality which was not correlated
to clinical stage, onset and duration of ARV, and viral load. Clinical stage of HIV
showed significant association with verbal and FSIQ (p 0,042 and p 0,044). IQ
results did not have association with onset and duration of ARV and viral load.
Conclusion: HIV-infected children on ARV have abnormal mean IQ in verbal,
performance and FSIQ. Based on categorical IQ, most subjects have normal
verbal, performance, and FSIQ. Cohort study is needed to address whether early
ARV can preserve cognitive function.]"
Fakultas Kedokteran Universitas Indonesia, 2015
S-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Roy Amardiyanto
Dampak anti retroviral ARV pada HIV anak: kajian pada perubahan nilai intelligence quotient (IQ) dan elektroensefalografi (EEG) = The impact of antiretroviral ARV treatment on HIV-infected children: an evaluation on altered intelligence quotient (IQ) and electroencephalography (EEG) activity
"ABSTRAK
Latar Belakang: Mayoritas anak dengan HIV memiliki masalah fungsi susunan saraf pusat SSP dan neurokognitif walaupun telah mendapatkan ARV. Gangguan fungsi SSP dan neurokognitif perlu dimonitor secara jangka panjang. Tujuan: Mengetahui perubahan IQ dan gambaran EEG pada pasien HIV anak yang telah memperoleh ARV. Metode: Penelitian kohort retrospektif pada 63 anak dengan HIV berusia 7-17 tahun yang telah memperoleh ARV pasca follow-up dalam 3 tahun dilakukan di Rumah Sakit Cipto Mangunkusumo RSCM . Dilakukan anamnesis, tes IQ, dan EEG. Selanjutnya, dinilai perubahan proporsi IQ dan EEG serta hubungan perubahan IQ dengan stadium klinis HIV, penyakit infeksi SSP, jenis ARV, keteraturan minum ARV, dan jenis sekolah. Hasil: Perubahan proporsi IQ normal menjadi abnormal pada verbal scale, performance, dan full-scale adalah 13 20,6 subyek p=0,002 , 12 19 subyek p=0,035 , dan 10 15,9 subyek p=0,039 . Perubahan proporsi verbal, performance, dan full-scale IQ tidak berhubungan dengan stadium HIV, infeksi SSP, keteraturan minum ARV, dan tipe sekolah. Perubahan proporsi EEG normal menjadi abnormal sebanyak 19 subyek 30,2 p=0,003 . Simpulan: Obat anti retroviral jangka panjang tidak memperbaiki IQ dan gambaran EEG pada pasien HIV anak.
ABSTRACT
Background: A majority of HIV-infected children are dealing with central nervous system CNS dysfunction and neurocognitive disorder. CNS dysfunction and neurocognitive disorder need to be monitored in the long-term. Objective: To identify altered IQ and EEG activity in HIV-infected children who had received ARV treatment. Methods: A retrospective cohort study in HIV-infected children aged 7 to 17 years who had received ARV and had 3-year follow up was conducted in Cipto Mangunkusumo Hospital CMH . History taking, IQ test, and EEG was performed. We evaluated changes in IQ proportion, EEG activity and the correlation between altered IQ and HIV infection stages, CNS infection, ARV type, medication adherence and school type. Results: There was an altered proportion of IQ score from normal into abnormal for verbal scale, performance and full scale scores, which occurred in 13 20.6 subjects p=0.002 , 12 19 subjects p=0.035 , and 10 15.9 subjects p=0.039 , respectively; The altered IQ proportion had no correlation with HIV infection stages, CNS infection, medication adherence and school type. The altered proportion of EEG activity was found in 19 30.2 subjects p=0.003 . Conclusion: Long-term ARV does not improve the IQ score and EEG activity in HIV-infected children."
Fakultas Kedokteran Universitas Indonesia, 2018
SP-PDF
UI - Dokumentasi  Universitas Indonesia Library
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Winona Andrari Mardhitiyani
Hubungan latar belakang pengasuh terhadap kepatuhan minum obat antiretroviral pada pasien anak terinfeksi hiv di RSCM = Correlation between caregiver's background and hiv infected children's adherence to antiretroviral therapy in RSCM
"Infeksi Human Immunodeficiency Virus HIV yang menyebabkan AIDS sampai saat ini masih menjadi salah satu penyebab kematian tertinggi di dunia. Pengobatan infeksi HIV kemudian menjadi sangat penting untuk meningkatkan kualitas hidup dari penderita. Pengobatan infeksi HIV pada anak-anak khususnya sering menemui hambatan dalam hal kepatuhan, baik dari anak itu sendiri maupun dari pengasuh. Dalam penelitian ini dianalisis mengenai hubungan latar belakang pengasuh terhadap kepatuhan minum obat anak terinfeksi HIV di RSCM. Desain penelitian yang digunakan adalah cross-sectional dengan jumlah sampel sebesar 94. Pengambilan data menggunakan kuesioner kepatuhan minum obat yang diambil dari Development of Multi-Method Tool to Measure ART Adherence in Resource-Constrained Settings: The South Africa Experience yang diterbitkan oleh Center for Pharmaceutical Management, Management Sciences for Health pada tahun 2007 yang dikembangkan di Afrika Selatan. Hasil yang ditemukan adalah tidak ada hubungan antara tingkat pendidikan, tingkat pendapatan, status pengasuh, dan keterlibatan pada Kelompok Dukungan Sebaya KDS dengan kepatuhan minum obat p >0,05.
Human Immunodeficiency Virus HIV infection causes AIDS, and is still one of the most frequent cause of death in the world. HIV medication then becomes highly important to improve the patients'quality of life, and to expand their life expectancies. HIV medication in children, however, is especially problematic in terms of adherence, whether the problems are from the children themselves or from the caregivers. This research was meant to analyze the correlation between caregiver's background and HIV infected children's adherence in RSCM, a hospital in Jakarta, Indonesia. This research used cross sectional method with 94 caregivers as the sample. The data was collected using an adherence questionnaire that was adapted from Development of Multi Method Tool to Measure ART Adherence in Resource Constrained Settings The South Africa Experience which was published by Center for Pharmaceutical Management, Management Sciences for Health in 2007. This questionnaire was developed in Southern Africa. After collection, the data was analyzed statistically using chi square or Kolmogorov Smirnov if using chi square was not possible. The results reveal that there is no correlation between caregiver's background educational background, income per month, caregiver's relation with the child, and caregiver's involvement in an HIV related support groups and HIV infected children's adherence to antiretroviral therapy p 0,05."
Depok: Fakultas Kedokteran Universitas Indonesia, 2016
S70386
UI - Skripsi Membership  Universitas Indonesia Library
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Tiroy Junita
Hubungan pembukaan status HIV terhadap kepatuhan minum obat pasien anak terinfeksi HIV di RSUPN dr. Cipto Mangunkusumo = Relationship of disclosure and adherence to antiretroviral therapy among HIV infected children in dr. Cipto Mangunkusumo Hospital
"Pembukaan status merupakan faktor penting yang diketahui mempengaruhi kepatuhan minum obat antiretroviral dan telah banyak diteliti di negara-negara dengan beban infeksi HIV tinggi. Penelitian ini bertujuan menganalisis hubungan pembukaan status dengan kepatuhan minum obat pada pasien anak terinfeksi HIV di RSUPN Dr. Cipto Mangunkusumo. Penelitian menggunakan desain potong lintang dengan sampel sebanyak 94 pengasuh dari 101 pasien anak terinfeksi HIV. Pengumpulan data pembukaan status dilakukan melalui kuesioner yang dibuat oleh peneliti, sedangkan data kepatuhan minum obat diambil menggunakan kuesioner yang diadaptasi dari instrumen multimetode yang dikembangkan oleh Gavin Steel, dkk. Penelitian ini menunjukkan sebagian besar pengasuh berjenis kelamin perempuan 89,4 , memiliki pendidikan terakhir SMP-SMA 64,9 , memiliki pendapatan di bawah upah minimum provinsi UMP Jakarta 75,5 , tergabung ke dalam kelompok dukungan sebaya 55,3 , dan bukan orangtua kandung dari pasien anak terinfeksi HIV 51,1 . Sebagian besar pasien anak terinfeksi HIV berusia 7 hingga di bawah 12 tahun 69,3 , berjenis kelamin perempuan 50,5 , menjalani terapi ARV lini 1 66,3 , belum mengalami pembukaan status HIV 71,3 , dan memiliki kepatuhan minum obat sedang 50,5 . Dari uji Chi-square diperoleh bahwa tidak terdapat perbedaan proporsi kepatuhan minum obat antara pasien anak terinfeksi HIV yang telah mengalami pembukaan status dengan yang belum mengalami pembukaan status p 0,367.
Disclosure is an important factor known affecting adherence to antiretroviral therapy that has been extensively studied in high burden countries. This research aims to determine relationship between disclosure and adherence among HIV infeceted children in Dr. Cipto Mangunkusumo Hospital, Indonesia. This research is a cross sectional study with samples of 94 caregivers from 101 HIV infected children. Disclosure data was collected using questionnaire reproduced by researcher, while adherence data was collected using questionnaire adapted from a multi method instrument developed by Gavin Steel, et.al. in West Africa. Demographic data shows that most caregivers are women 89.4 , have middle school education 64.9 , have income less than minimum regional wage of Jakarta 75.5 , join peer group 55.3 , and are not the biological parents of infected children 51.1 . Most children are girls 50.5 , currently in 1st line antiretroviral therapy 66.3 , have not been disclosed 71.3 , dan have moderate level of adherence 50.5 . Statistical analysis using Chi Square shows no relationship between disclosure and adherence among HIV infected children in Dr. Cipto Mangunkusumo Hospital p 0.367."
Depok: Fakultas Kedokteran Universitas Indonesia, 2016
S70345
UI - Skripsi Membership  Universitas Indonesia Library