Hasil Pencarian  ::  Simpan CSV :: Kembali

"Penelitian dengan rancangan pre-post test mengambil subyek dengan riwayat hiperkolesterolemia (yang satu tahun lalu mendapat konseling gizi sebanyak lima kali selama enam minggu). Pada subyek dilakukan wawancara satu kali mengenai asupan status gizi ; nutrisi dan aktivitas fisik, pemeriksaan status gizi (IMT, lingkar pinggang) serta kadar kolesterol LDL serum. Data yang didapat dibandingkan dengan data subyek satu tahun yang lalu. Wawancara asupan nutrisi menggunakan metode food recall 1 x 24 jam dan zat gizi yang dinilai meliputi kalori, protein, karbohidrat, lemak, kolesterol, serat dan fitosterol. Uji statistik yang digunakan adalah uji t berpasangan jika data berdistribusi normal dan Wilcoxon, jika data berdistribusi tidak normal. Tingkat kemaknaan yang digunakan p < 0, 05. 0,26 g menjadi 0,21 ± 0,18 g. Aktivitas fisikjuga meningkat. Dari rata-rata 7, 15 ± 1, 30 menjadi 8, 11 ± 1, 0. Peningkatan total indeks aktivitas fisik ini diduga menyebabkan menjadi tidak signifikan peningkatan nilai rerata IMT,yaitu dari rata-rata 26, 21 ± 4, 34 kg/m menjadi 26, 57± 4, 56 kg/m. Sedangkan pada lingkar pinggang terjadi peningkatan yang bermakna dari rata-rata 85, 37 ± 7, 61 em menjadi 89, 16 ± 6, 68 em. Peningkatan asupan kalori, lemak dan kolesterol menyebabkan meningkatnya kadar kolesterol LDL subyek penelitian sebesar 7,31 %. Dari rata-rata 151, 53 ± 24,81 mg/dl, menjadi 160,45 ± 27, 01 mg/dl. Tapi peningkatan ini tidak signifikan.

---

Pre-post test design study to subjects with history of hypercholesterolemia. Subjects was exposed to nutrition counseling for six weeks a year ago. The subject was interviewed one time concerning nutrition intake and physical activity, examination to nutritional status and serum cholesterol LDL JeveL The result is comparing to the subject data one year ago. Interview of nutrient intake using 1x24 hours food recall method, and the nutrient which are significant but increase in carbohydrate> protein, fat, cholesterol and fiber were significant. Phitosteroi is decrease significantly from median 0,26 g to 0.21 ± 0.18 g. Unexpected increase occurred in subjects' total index of physical activity. From average of7.!5 ± 1.30 to 8.11 ± 1.0. This increase in physical activity total index assumed to have been the cause of ineensement IMT average rate to be insignificant, that is from average of26.21 ± 4.34 kg/m to 26.57 ± 4.56 kg!m While on subjects'waist circumference, there was significant increase from average 85.37 ± 7.61 em to 89.16 ± 6.68 em. The increase in calorie, fat, and cholesterol intakes have caused an increase in subjects' LDL cholesterol level 7.21 % from average 15!.53 ± 24.81 mg/d1 to 160.45 ± 27.01 mg/dl. But this increase was not significant."

"ABSTRAKTujuan penelitian ini adalah untuk mengetahui efek pamberian bubuk susu kedelai2x30 gramlbari, selama 8 minggu terhadap kadarkolesterol LDL dan HDL serum pada wanitaparimenopauseBertempat di Klinik Seruni Departemen Ilmu Gizi Fakultas KedokteranUniversitas lndnesia, jalan Salemba Raya no.6, JakartaPenelitian dengan rancangan one group pre-post tes yangtelah disetujui Komite Etik FKUI. Subyek mendapatsuplementasi susu bubuk kedelai 2x30 g/hari selama 8minggu. Pada awal (minggu 0); pertengahan (minggu IV);dan akhir penelitian ( awal minggu IX) dilakukanpemeriksaan kadar kolesterol LDL dan HDL. Data isilpanzat gizi dilukukan sebelum dan selama penelitianberlangsung, dengan menggnnakan food recall l x24 jam.Uji statistik yang digunakan adalah uji t berpasangan jikadata berdistnbusi normal dan Wilcoxon, jika databerdistribusi tidak normal. Tingkat kemaknaan yangdigunakan p<0,05.Sebanyak 19 subyek penelitian yang dapat mengikutipenelitian sampai selesai. Setelah delapan mingguperlakuan, didapatkan adanya penurunan yang bermakna(p<0,05) pada kadar kole-ol LDL, yaitu sebesar8,59±17,31% di minggu IV dan 7,81±11,32% di minggu IX.Kadar kolesterol HDL menurun pada minggu IV dan IX,namun tidak bermakna (p>0,05). Rasio kolesterol LDLterhadap HDL, men= secilla bermakna (p<0,05) diminggu IV, yaitu sebesar 7,03±16,82%, sedangkan diminggu IX terjadi penurunan, namun tidak bermakna(p>0,05), sebesar 4,04±12,25%.Pemberian bubuk susu kedelai 2x30 g/hari selama delapanminggu, dapat menurunkan kadar kolesterol LDL sertarasio LDLIHDL secara bermakna.

---

AbstractThis research aim to investigate the effects of2x30 lifd soy milk flour, for eight. weeks on serumo cholesterol LDL andHDL levels inhypercholesterolemic perimenopausal womenLocated at Seruni Clinic, Depar1ment of Nutrition, Faculty of MedicineUniversity of IndonesiaThe study was a one group pre-post test design, which wasapproved by The Ethical Clearance Research Committee ofFaculty of Medicine University of Indonesia. The subjectsreceived 2x30 g/d soy milk powder for eight weeks. Serum LDLand HDL cholesterol levels were determined at the heghming(week 0), the middle (week4), and the end of the stndy(earlyweek 9). Dietery intakes were assessed using lx24 hours foodrecall. Statistical analysis was performed using dependent t tesfor normal distribution and Wilcoxon for not normal distributiondata. The level of significancy was 5% (p<0,05)There were 19 subjects who completed the study. After eightweeks intervention, there was 8.59±17.31% significant decreasedin LDL cholesterol levels at the 4th week of the study and7.81±1 1.32% at the s"' week of the study (p<0,05).HDLcholesterol levels decreased at the 4\h and 8" weeks, but notsignificant(p>0,05). The ratio ofLDL to HDL was 7,03±16,82o/o,which was significant decreased at the 4" week (p<0,05), while atthe 9th week the decrement was not significant (4.04±12.25%),p> 0.05.Consuming soy milk powder 2 x 30 g/dduring eight weeks, canreduce the LDL cholesterol level and LDLIIIDL ratiosignificantly."

"Hiperkolesterolemia merupakan salah satu prediktor kuat berbagai penyait jantung yang merupakan penyebab utama kematian di dunia. Penelitian ini bertujuan untuk mengetahui apakah ada perbedaan berbagai faktor yang berkaitan dengan kejadian hiperkolesterolemia pada penderita diabetes melitus di Puskesmas Pasar Minggu pada tahun 2018. Penelitian ini menggunakan metode cross-sectional dengan jumlah sampel sebesar 126 responden menggunakan consecutive sampling. Variabel penelitian yang diteliti adalah kejadian hiperkolesterolemia, jenis kelamin, lama menderita diabetes melitus, riwayat DM keluarga, kebiasaan merokok, aktivitas fisik, tingkat stress, persen lemak tubuh dan asupan lemak. Hasil dari penelitian ini menunjukkan bahwa prevalensi kejadian hiperkolesterolemia pada penderita DM adalah 56,3% dengan 37,1% pada pria dan 63,7% pada wanita. Dari seluruh variabel independent yang diteliti, perbedaan yang bermakna dengan hasil uji chi square terdapat pada variabel jenis kelamin (OR = 2,947; CI = 1,326-6,672), riwayat keluarga (OR = 0,443; CI = 0,209-0,895) dan kebiasaan merokok (OR = 1,233; CI = 0,990-11,898). Sementara itu, tidak terdapat perbedaan bermakna kejadian hiperkolesterolemia berdasarkan lama menderita DM, aktivitas fisik, tingkat stress, antropometri dan asupan lemak karena p > 0,05. Untuk menyimpukan, terdapat perbedaan yang signifikan pada jenis kelamin, riwayat DM keluarga dan kebiasaan merokok dengan kejadian hiperkolesterolemia, dengan peningkatan risiko hiperkolesterolemia sejalan dengan jenis kelamin perempuan, adanya riwayat DM keluarga dan kebiasaan aktif merokok

---

Hypercholesterolemia is the leading predictor of various cardiac disease (CVD) which is the leading cause of death in the world. This study aims to determine whether there are any differences the incidence of hypercholesterolemia based on factors related to it in people with diabetes mellitus at Pasar Minggu Primary Health Care in 2018. This study used a cross-sectional method with a sample size of 126 respondents using consecutive sampling. Research variables studied were incidence of hypercholesterolemia, sex, duration of diabetes mellitus, family history of diabetes mellitus, smoking habit, physical activity, stress level, body fat percentage and fat intake. The results of this study showed that the prevalence of hypercholesterolemia incidence in DM patients was 56.3% with 37.1% in men and 63.7% in women. Of all independent variables studied, significant differences with statistical analysis were in sex (OR = 2.947, p = 0.009), family history (OR = 0.443, p = 0.018) and smoking habits (OR = 1,233; p = 0.038). Meanwhile, there was no significant the incidence of hypercholesterolemia differences based on duration of diabetes mellitus, physical activity, stress level, anthropometry and fat intake due to p > 0.05. To conclude, there were significant differences in sex, family history of diabetes mellitus and smoking habits with hypercholesterolaemia incidence, with an increased risk of hypercholesterolemia in line with female sex, family history of DM and active smoking habits."

"Tujuan penelitian adalah diketahuinya kolerasi antara IMT dan kadar kolesterol LDL serum pada subyek dengan hiperkolesterolemia Penelitian ini menggunakan disain pre post test, pada penderita hiperkolesterolemia yang mernenuhi kriteria penerimaan dan tidak memenuhi kriteria penolakan, Serta telah mengikuti penelitian yang telah diselenggarakan di Departernen Ilmu Gizi Fakultas Kedokteran Universitas Indonesia satu tahun lalu yang beijudul ?Pengaruh Pemberian Fitosterol dan Serat terhadap Profil Lipid dan [3 Karoten pada usia 20 tahun atau lebih?. Data yang diambil meliputi, karaktcristik demografi, asupan makanan., aktivitas fisik, IMT, dan kadar kolesterol LDL serum. Jumlah subyek adalah 38 orang berusia rata-rata 43,26 ;l: 8,08 tahun dan 68,42% subyek adalah perempuan dan 44,'74% berpendidikan tinggi.Rerata pola asupan: pola asupan kalori 1388,ll i- 274,08 kkal; pola asupan 1-carbohidrat 166,13 =I= 41,39 g, pola asupan lcmak 61,76 i 17,76 g; pola asupan kolestcrol 169,31 i 71,83 mg dan pola asupan serat 7,5 i 2,22 g; Rerata asupan: asupan kalori l4l3,07 i 482,71 kkal atau 77,30 i 28,00% KKT; asupan karbohidrat 182,01 J; 67,87 g atau 34,93 4: l0,34% KKT; asupan lernak 51,58 i 26,36 g atau 17,15 3; 8,64% KKT; asupan kolesterol 145,86 i 120,44 mg dan asupan serat 16,82 t 11,38 g. Rerata Indeks aktivitas fisik 8,05 i 1,12 dan 100% subyek penelitian memiliki aktivitas tergolong scdang dan tinggi. Rerata IMT 26,84 i 4,84 kg/m2 dengan 89,5% tergolong obes sekarang. Rerata kadar kolesterol LDL 160,24 4; 27,06 mg/dL dengan 4'/,37% memiliki kadar kolesterol LDL tinggi dan sangat tinggi sekarang. Tidak terdapat korelasi antara IMT dan kadar kolesterol LDL serum.

---

To determine the correlation of BMI and LDL Cholesterol Serum in hypercholesterolemia subject Research with pre post rest design in hypercholesterolernia subject that fulfill the inclusion criteria and not in exclusion criteria, and has joined last year research executed by Department of Nutrition of Medical Faculty, University of Indonesia with title ? The Effect of Phytosterol and Fibre toward Lipid Profile and [3 Karoten at the age of 20 years old or upper ?. Data taken include demographic characteristic, nutrition intake, physical activity, BMI, and LDL cholesterol scrum level. Number of subject is 38 people within average of 43,26 i 8,08 years old, 68,42% are women and 44,74% are graduated.The average intake pattern : calory intake l388,ll i 274,08 kkal; carbohydrate intake 166,13 i 41,39 g, fat intake 61,76 i 17,76 g; cholesterol intake 169,31 i 71,83 mg and fibre intake 7,5 1 2,22 g. Intake average 1 calory intake 1413,ov e 422,71 mal or 77,30 1 28,00% KKT; carbohydrate intake 182,01 :te 67,87 g or 34,93 :iz l0,34% KKT; fat intake 51,58 i 26,36 g or 17,15 :t 8,64% KKT; cholesterol intake l45,86 i 120,44 mg and fibre intake 16,82 i 11,38 g. Average of the physical activity index 8,05 i 1,12 and l00%. Research subject have middle and high activities. Average BMI 26,84 i 4,84 kg/m2 with 89,5% in obese. The average of LDL cholesterol serum 160,24 i 27,06 mg/dL with 47,37% have high and highest LDL cholesterol level. There is no correlation between BMI and LDL cholesterol serum."

"Latar belakang : Hiperkolesterolemia antara lain menjadi faktor risiko penyakit jantung koroner dan komplikasinya dapat menyebabkan inkapasitasi pada pilot. Tujuan penelitian ini adalah mengidentifikasi hubungan kebiasaan makan lemak dan faktor lainnya terhadap risiko hiperkolesterolemia pada pilot sipil di Indonesia. Metode : Penelitian menggunakan metode potong lintang dengan sampel purposif pada pilot sipil di Balai Kesehatan Penerbangan Jakarta tanggal 18-29 Mei 2015. Karakteristik demografi, pekerjaan, kebiasaan diperoleh melalui wawancara. Data kolesterol total diperoleh dari laboratorium yang telah dikalibrasi. Kategori kolesterol total dibagi dua yaitu hiperkolesterolemia ( ≥ 240 mg/dl) dan normal (< 200 mg/dl). Analisis menggunakan risiko relatif yaitu regresi Cox dengan waktu konstan. Hasil : Di antara 690 pilot yang melakukan pemeriksaan medis, 428 subjek bersedia mengikuti penelitian. Subjek yang diikutsertakan dalam analisis sebanyak 327 pilot, 12,3% memiliki hiperkolesterolemia dan 87,7% memiliki kadar kolesterol normal. Subjek dengan kebiasaan makan lemak hampir setiap hari dibandingkan hampir tidak pernah berisiko 3,8 kali lipat lebih besar hiperkolesterolemia [risiko relatif suaian (RRa)=3,78; p=0,223]. Subjek dengan usia 50-65 tahun dibandingkan dengan 19-34 tahun berisiko 1,8 kali lipat lebih besar hiperkolesterolemia (RRa=1,82; p=0,103). Selanjutnya subjek dengan riwayat hiperkolesterolemia dibandingkan tanpa riwayat hiperkolesterolemia berisiko 2,1 kali lipat lebih besar hiperkolesterolemia (RRa=2,13; p=0,118). Simpulan : Kebiasaan makan lemak hampir tiap hari, usia 50 tahun atau lebih, riwayat keluarga hiperkolesterolemia dalam keluarga meninggikan risiko hiperkolesterolemia di antara pilot sipil di Indonesia.

---

Background : Hypercholesterolemia becoming one of a risk factor for coronary heart disease and complications may cause the pilots incapacitation. The purpose of this study was to identify eating fatty food habits and other factors and the risk of hypercholesterolemia in civilian pilots in Indonesia.

Methods : A cross sectional study with purposive sampling was conducted in civilian pilots at Indonesian Aviation Medical Center in Jakarta from 18-29 May, 2015. Demogrhapic characteristics, employment, habits was obtained through interviews. Total cholesterol data obtained from laboratory test had been calibrated. Category of cholesterol total was divided into hypercholesterolemia (≥ 240 mg/dl) and normal (<200 mg/dl). Analysis using risk relative by Cox regression with a constant time.

Result : Among the 690 pilots who conducted medical examination, 428 subjects agree to join the study. This analysis included 327 pilots, 12.3% had hypercholesterolemia, and 87.7% normal cholesterol levels. The subjects who had eating fatty food habits almost every day compared to almost never, had 3.8 fold higher risk to be hypercholesterolemia [adjusted relative risk (RRa)=3.78; p=0.223]. The subject aged of 50-65 years compared to 19-34 years, had 1.8 fold higher risk to be hypercholesterolemia (RRa=1.82; p=0.103). Furthermore, subjects with a family history of hypercholesterolemia compared with no family history, had 2.1 fold higher risk to be hypercholesterolemia (RRa=2.13; p=0.118).

Conclusions : Having eating fatty food habits almost every day, age 50 and over, history of hypercholesterolemia elevate the risk of hypercholesterolemia."

"ABSTRAK Hipertensi dan hiperkolesterol merupakan penyebab terjadinya penyakit jantung koroner (PJK) sehingga adanya hiperkolesterolemia pada penderita hipertensi akan meningkatkan risiko terjadinya PJK. Obesitas sentral menggambarkan penumpukan lemak di perut yang dapat mengakibatkan adanya keabnormalan jumlah lipid dalam darah, ketika terjadi pada penderita hipertensi dapat menimbulkan progresifitas terjadinya kolesterol darah tinggi dan berisiko menyebabkan aterosklerosis dan penyakit jantung. Tujuan penelitian ini untuk mengetahui hubungan lingkar pinggang dan faktor lainnya dengan kejadian hiperkolesterolemia pada penderita hipertensi. Penelitian ini adalah studi kuantitaf melalui data sekunder dengan desain Cross Sectional. Menurut hasil uji multivariat dengan regresi logistik ganda menunjukan terdapat hubungan antara lingkar pinggang, jenis kelamin dan umur setelah dikontrol oleh variabel aktifitas fisik. Jenis kelamin sebagai faktor risiko yang paling berhubungan dengan kejadianhiperkolesterolemia dengan risiko 8,5 kali lebih tinggi pada perempuan dibandingkan laki-laki. Uji stratifikasi lingkar pinggang menurut jenis kelamin pada penderita hipertensi dengan kasus obesitas sentral didapatkan hubungan yang signifikan bahwa penderita obesitas sentral perempuan memiliki risiko mengalami hiperkolesterolemia sebanyak 5,5 kali dibandingkan obesitas sentral pada laki-laki dengan nilai p <0,05. Terdapat hubungan yang signifikan antara lingkar pinggang dengan kejadian hiperkolesterolemia, pada perempuan yang obesitas sentral lebih berisiko mengalami hiperkolesterolemia dibandingkan laki-laki yang obesitas sentral.

---

ABSTRACT

Hypertension and hypercholesterolemia are the causes of coronary heart disease (CHD) so that the presence of hypercholesterolemia in patients with hypertension will increase the risk of CHD. Central obesity describes the accumulation of fat in the stomach which can lead to abnormalities in the amount of lipids in the blood, when it occurs in patients with hypertension can lead to progression of the occurrence of high blood cholesterol and the risk of causing atherosclerosis and heart disease. The purpose of this study was to determine the relationship of waist circumference and other factors with the incidence of hypercholesterolemia in patients with hypertension. This research is a quantitative study through secondary data with Cross Sectional design. According to the results of multivariate tests with multiple logistic regression, there was a relationship between waist circumference, gender and age after being controlled by physical activity variables. Gender as a risk factor most associated with the incidence of hypercholesterolemia with a risk 8.5 times higher in women than men, then carried out waist circumference stratification test by sex in hypertensive patients with cases of central obesity found a significant relationship that central obesity patients women have a risk of experiencing hypercholesterolemia as much as 5.5 times more than central obesity in men with a value of p <0.05. There is a significant relationship between waist circumference and the incidence of hypercholesterolemia in women who are obese obese at greater risk of hypercholesterolemia than men who are obese central."

"Mengetahui pcngaruh pemberian kombinasi suplementasi vitamin E dan C terhadap peroksidasi lipid pada usila dengan hiperkolesterolemia. Penelitian uji klinis paralel, tertutup timggai, alokasi acak, untuk membandingkan kadar malondialdehida usila 2,60 tahun dengan hiperkolesterolemia yang mendapatkan kombinasi supiementasi vitamin E 400 IU dan vitamin C 500 mg, masing~masing sebutir sehari selama 45 hari dengan kelompok yang mendapat vitamin E 400 IU dan plascbo.Terdapat 42 subyek penelitian yang berasal dari Yayasan Kebagusan, Yayasan Yasni, dan Yayasan Yakin, Pasar Minggu Jakarta Selatan yang dibagi menjadi dua kelompok masing-masing berjumlah 21 orang. Data yang diambil adalah : data dcmograti, antropometzi, data asupan makanan pada minggu pertama, ketiga dan ketujuh, kadar kolesterol LDL dan MDA plasma sebelum dan sesudah perlakuan. Uji statistik yang digunakan adalah uji t-tidak bezpasangan bila distribusi nonnal dan uji Manmwhimey bila distribusi tidak normal dengan tingkat kemaknaan p<0.05. Sebanyak 20 subyek penelitian dad masing-masing kelompok yang dapat mengikuti penelitian sampai sclesai. Sebelum perlakuan, nilai median kadar kolesterol LDL kelompolc vitamin E+plasebo dan vitamin E+C masing- masing adalah I46.50(l30-190) mg/dL dan 146.50(l3I-196) mg/dL. Setelah 45 hari perlakuan, rerata kadar kolesterol LDL kelompok vitamin E4-plasebo (151.9.+:2.2.l mg/dl.) meningkat sedangkan kelompok vitamin B+-C (l46.8i28.21 mg/dL) menurun. Sebelum p¢rIakuan, nilai median kadar MDA plasma kelornpok vitamin E+plasebo dan rerata kadar MDA plasma kelompok vitamin E4-C masing-masing adalah 2.63(l.92-4.42) nmol/ml., dan 3.03:l:0.62 nmol/mL. Setelah 45 haii pcrlakuan rerata kadar MDA plasma kedua keiompok menunm menjadi 2.30i0.67 nmol/mL (p<0.01) pada kelompok vitamin E+plasebo dan 28810.88 nmol/mL (p=0.36) untuk kelompok vitamin E+C. Penurunan kadar MDA plasma kelompok vitamin E+plasebo lcbih besar (-0.5:!:0.55 nmol/mL) daripada kelompok vitamin E+C (-0.28(l.31-1.63) nmol/mL), tetapi dcngan uji statislik terhadap kedua nilai tersebut, tidalc berbeda bcrma!ma(p=0.09). Pembenan kombinasi vitamin E dan vitamin C pada usila dengan hiperkolesternlemia tidak dapat rnenurunkan kadar MDA plasma lcbih besar dibandingl-can dengan hanya pemberian vitamin E.

---

This parallel, single blind, randomization clinical trial purpose was to compare plasma malondyaldehydc level in hypercholesterolemic elderly aged more than 60 years old. Forty two people from Yayasan Kebagusan, Yayasan Yasni and Yayasan Yakin, Pasar Minggu, South Jakarta which participated the study, were divided into two groups. Twenty one elderly were supplemented with 400 IU vitamin E and 500 mg vitamin C for 45 consecutive days, while the other group was supplemented with 400 IU vitamin E and placebo. The data of demographic, anthropometric, food intake in the first, third and seventh weeks, plasma LDL and MDA levels before and alter period were taken. Statistical analyzes was performed by SPSS 11.5.

Twenty people for each group had followed the study until the end of period. Before study, LDL cholesterol median for vitamin E + placebo group and vitamin E+C group were 146.50(l30-190) mg/dL and l46.50( 130-190) mg/dL respectively. Alter 45 of days treatment, there was an increase in mean LDL cholesterol in vitamin E + placebo group 15l.9i22.1 mg/dL while in vitamin E+C group was decreased to l46.8:l:28.2l mg/dl Before study, plasma MDA level in vitamin E + placebo group and vitamin E+C group were 2.63(l.92-4.42) and 3.031052 nmol/mL, respectively. After 45 days, mean MDA plasma in vitamin E + placebo group was 2.30i0.67 nmol/mL (p<0.01) and was 2.881088 nmol/ml.. (p=0.36) in vitamin E+C group. The decreased on plasma MDA levels in vitamin E+placebo group was higher (-0,510.55 nmol/mL) than vitamin E+C (-0.28(1.3l-1.63) nmol/mL), but statistical test showed not significant different between both group (p=0.09). Combined supplementation vitamin E and vitamin C in hypercholesterolemic elderly couldnot decrease plasma MDA higher than supplementation of vitamin E alone."

"Prevalensi penyakit akibat inflamasi di Indonesia dilaporkan cukup tinggi, dengan dampak jangka panjang seperti kanker, gangguan saraf, dan masalah peredaran darah. Salah satu faktor penyebab inflamasi adalah kolesterol tinggi dalam darah, yang meningkatkan risiko penyakit jantung dan stroke. Hiperkolesterolemia, kondisi di mana kadar kolesterol total, LDL, dan trigliserida dalam darah terlalu tinggi, merupakan masalah kesehatan yang signifikan. Bromelain, enzim dari buah nanas, telah terbukti memiliki sifat antiinflamasi dan antikolesterol. Meskipun bromelain dapat diserap dengan baik di usus halus, pemberian secara oral menghadapi tantangan asam lambung yang dapat mendenaturasi enzim ini, mengurangi efektivitasnya. Oleh karena itu, diperlukan enkapsulasi untuk melindungi bromelain dari asam lambung dan memastikan khasiatnya tetap terjaga. Penelitian ini telah mengkaji enkapsulasi bromelain dalam matriks kering beku kitosan-alginat-pektin, yang diharapkan dapat memungkinkan pelepasan lambat di lambung dan pelepasan kumulatif tinggi di usus halus. Kapsul HPMC dengan matriks kitosan-alginat-pektin menurunkan pelepasan bromelain sebesar 19% dalam SGF dan 17% dalam SIF, melindungi enzim dari degradasi asam dan memastikan lebih banyak bromelain aktif mencapai usus halus. Dalam pengujian aktivitas antiinflamasi, kapsul bromelain menunjukkan IC50 untuk inhibisi denaturasi protein pada 66,999 ppm, mendekati natrium diklofenak dan lebih efisien daripada ekstrak bromelain. Pada konsentrasi 100 µg/ml, efisiensi matriks bromelain mencapai 106%, lebih efektif daripada natrium diklorofenak. Pada konsentrasi tertinggi (1000 µg/ml), efisiensi adalah 84%, menunjukkan efektivitas pada konsentrasi menengah hingga tinggi. Dalam pengujian antikolesterol, matriks bromelain mencapai IC50 pada 33,18 ppm, lebih efektif dibandingkan ekstrak bromelain. Pada konsentrasi tertinggi (1000 µg/ml), efisiensi inhibisi mencapai 83%, menunjukkan bahwa pada konsentrasi tinggi, matriks bromelain hampir seefektif simvastatin. Pengujian in vivo menunjukkan matriks bromelain memiliki potensi signifikan dalam efek antiinflamasi dan antikolesterol, setara atau lebih tinggi dari ekstrak bromelain, didukung oleh hasil in vitro yang menunjukkan peningkatan stabilitas dan aktivitas enzimatik melalui enkapsulasi.

---

The prevalence of inflammation-related diseases in Indonesia is reported to be quite high, with long-term impacts such as cancer, nerve disorders, and circulatory problems. One contributing factor to inflammation is high blood cholesterol, which increases the risk of heart disease and stroke. Hypercholesterolemia, a condition where total cholesterol, LDL, and triglyceride levels in the blood are excessively high, is a significant health issue. Bromelain, an enzyme from pineapple, has been proven to have anti-inflammatory and anti-cholesterol properties. Although bromelain is well absorbed in the small intestine, oral administration faces the challenge of stomach acid that can denature this enzyme, reducing its effectiveness. Therefore, encapsulation is needed to protect bromelain from stomach acid and ensure its efficacy. This study has examined the encapsulation of bromelain in a freeze-dried chitosan-alginate-pectin matrix, which is expected to allow slow release in the stomach and high cumulative release in the small intestine. HPMC capsules with a chitosan-alginate-pectin matrix reduced bromelain release by 19% in SGF and 17% in SIF, protecting the enzyme from acid degradation and ensuring more active bromelain reaches the small intestine. In anti-inflammatory activity testing, bromelain capsules showed an IC50 for protein denaturation inhibition at 66.999 ppm, close to that of diclofenac sodium and more efficient than bromelain extract. At a concentration of 100 µg/ml, the efficiency of the bromelain matrix reached 106%, more effective than diclofenac sodium. At the highest concentration (1000 µg/ml), the efficiency was 84%, indicating effectiveness at medium to high concentrations. In anti-cholesterol testing, the bromelain matrix achieved an IC50 at 33.18 ppm, more effective than bromelain extract. At the highest concentration (1000 µg/ml), the inhibition efficiency reached 83%, indicating that at high concentrations, the bromelain matrix is almost as effective as simvastatin. In vivo testing shows that the bromelain matrix has significant potential in anti-inflammatory and anti-cholesterol effects, comparable to or higher than bromelain extract, supported by in vitro results showing increased stability and enzymatic activity through encapsulation."

"[ABSTRAKPenggunaan obat golongan statin (penghambat hidroksimetil glutaril-CoA reduktase) sebagai terapi lini pertama pada hiperkolesterolemia dapat menyebabkan terjadinya beberapa reaksi obat yang tidak dikehendaki (ROTD). Tujuan penelitian ini adalah menilai risiko penggunaan obat golongan statin terhadap kejadian ROTD pada pasien hiperkolesterolemia di Instalasi Rawat Jalan RSUD Pasar Rebo, Jakarta. Penelitian dilakukan dengan metode kohort prospektif pada pasien yang menggunakan atorvastatin dan simvastatin. Data primer diperoleh melalui wawancara dengan menggunakan kuesioner, data sekunder diperoleh melalui rekam medis dan resep yang diterima oleh pasien. Data yang diperoleh dianalisis menggunakan chi-square dan regresi logistik. Dari penelitian diketahui bahwa ROTD terjadi pada 38.20% pasien yang menggunakan obat golongan statin, kejadian ROTD terbesar adalah gangguan sistem pencernaan (35.45%) dan gangguan sistem saraf (23.64%). Sedangkan ROTD pada otot dan hati masing-masing sebesar 2.73%. Pasien yang menggunakan simvastatin memiliki risiko relatif mengalami ROTD lebih besar jika dibandingkan dengan pasien yang menggunakan atorvastatin (RR: 6.439; CI: 2.963-13.992). Variabel perancu yang secara signifikan mempengaruhi kejadian ROTD adalah aktivitas fisik. Pasien yang mengalami ROTD memiliki risiko relatif lebih besar mengalami putus obat daripada pasien yang tidak mengalami ROTD (RR: 2.554; CI: 1.724- 3.754).

---

ABSTRACTThe use derivate of statin (hydroxymethylglutaryl-CoA reductase inhibitors) for management of hypercholesterolemia can cause advers drug reactions (ADR). The purpose of this study was to assess the risk of the use of statins on the incidence of ADR in hypercholesterolemic patients in the Outpatient Installation in RSUD Pasar Rebo, Jakarta. This study was conducted using a prospective cohort to the patients using atorvastatin and simvastatin, the data obtained by interview with questionnaires, medical records, and patient prescriptions. The data collected analyzed using chi-square and logistic regression. ADR occurred in 38.20% patients who treated with statins, the most often ADR experienced by patient are gastrointestinal disorder (35.45%) and nerve system disorder (23.64%). Muscle and liver disorder experienced by 2.73% patients respectively. The patients using simvastatin have a greater risk of experiencing ADR compared to atorvastatin (RR: 6.439; CI: 2.963-13.992). Physical activity is the confounding variable significantly influence the incidence of ADR. Patients who experience ADR had a greater risk for experiencing drug withdrawal than patients who did not experience ADR (RR: 2.554; CI: 1.724- 3.754).;The use derivate of statin (hydroxymethylglutaryl-CoA reductase inhibitors) for management of hypercholesterolemia can cause advers drug reactions (ADR). The purpose of this study was to assess the risk of the use of statins on the incidence of ADR in hypercholesterolemic patients in the Outpatient Installation in RSUD Pasar Rebo, Jakarta. This study was conducted using a prospective cohort to the patients using atorvastatin and simvastatin, the data obtained by interview with questionnaires, medical records, and patient prescriptions. The data collected analyzed using chi-square and logistic regression. ADR occurred in 38.20% patients who treated with statins, the most often ADR experienced by patient are gastrointestinal disorder (35.45%) and nerve system disorder (23.64%). Muscle and liver disorder experienced by 2.73% patients respectively. The patients using simvastatin have a greater risk of experiencing ADR compared to atorvastatin (RR: 6.439; CI: 2.963-13.992). Physical activity is the confounding variable significantly influence the incidence of ADR. Patients who experience ADR had a greater risk for experiencing drug withdrawal than patients who did not experience ADR (RR: 2.554; CI: 1.724- 3.754)., The use derivate of statin (hydroxymethylglutaryl-CoA reductase inhibitors) for management of hypercholesterolemia can cause advers drug reactions (ADR). The purpose of this study was to assess the risk of the use of statins on the incidence of ADR in hypercholesterolemic patients in the Outpatient Installation in RSUD Pasar Rebo, Jakarta. This study was conducted using a prospective cohort to the patients using atorvastatin and simvastatin, the data obtained by interview with questionnaires, medical records, and patient prescriptions. The data collected analyzed using chi-square and logistic regression. ADR occurred in 38.20% patients who treated with statins, the most often ADR experienced by patient are gastrointestinal disorder (35.45%) and nerve system disorder (23.64%). Muscle and liver disorder experienced by 2.73% patients respectively. The patients using simvastatin have a greater risk of experiencing ADR compared to atorvastatin (RR: 6.439; CI: 2.963-13.992). Physical activity is the confounding variable significantly influence the incidence of ADR. Patients who experience ADR had a greater risk for experiencing drug withdrawal than patients who did not experience ADR (RR: 2.554; CI: 1.724- 3.754).]"

"ABSTRAK

Skripsi ini membahas mengenai hubungan merokok dengan hiperkolesterolemia LDL (Low Density Lipoprotein) pada kelompok pekerja di wilayah Jalan Raya Bogor tahun 2012 ? 2014. Rumusan masalah pada penelitian ini adalah pasien yang menderita hiperkolesterolemia mengalami kenaikan berdasarkan data administrasi laboratorium / rekap Caya Laboratorium dan Klinik Kota depok pada tahun 2012 ? 2014. Tujuan dari penelitian ini untuk mengetahui hubungan merokok dengan hiperkolesterolemia LDL pada kelompok pekerja di wilayah Jalan Raya Bogor. Penelitian ini merupakan survey analitik dengan pendekatan Cross Sectional. Penelitian ini menunjukkan adanya hubungan yang signifikan antara merokok dengan hiperkolesterolemia LDL dengan nilai P value 0.00. Kelompok pekerja dengan kriteria perokok ringan mempunyai peluang menderita hiperkolesterolemia LDL 2.91 kali lebih besar dibandingkan dengan pekerja yang tidak merokok dan perokok sedang berat mempunyai peluang menderita hiperkolesterolemia 5.07 kali lebih besar dari pada pekerja yang tidak merokok.

---

ABSTRACT

This research explained about the relationship of smoking with hypercholesterolemia LDL (Low Density Lipoprotein) in the group of workers in the area of Jalan Raya Bogor in 2012 - 2014. The problems in this research are patients suffering from hypercholesterolemia increased based on administrative data at Caya and Clinical Laboratory Depok in 2012 - 2014. The purpose of this research was to determine the relationship of smoking with LDL hypercholesterolemia in the group of workers in the area of Jalan Raya Bogor. This research is an analytic survey with cross sectional approach. This research showed a significant association between smoking and LDL hypercholesterolemia with P value 0.00. Worker groups with the criteria of light smokers had 2.91 times the chance of suffering from LDL hypercholesterolemia larger than the workers who did not smoke and were heavy smokers have a chance of suffering from LDL hypercholesterolemia 5.07 times greater than on workers who do not smoke

"