Ditemukan 2 dokumen yang sesuai dengan query
Sotriffer, Christoph., editor
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Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy. Alternatively, if active ligands are already available, molecular similarity searches can be used to find new molecules. This virtual screening can even ...
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Weinheim: Wiley-VCH, 2011
e20395196
eBooks Universitas Indonesia Library
Song, Seo Woo
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This thesis demonstrates a technology that enables pipetting-free high-throughput screening (HTS) on a miniaturized platform, eliminating the need for thousands of one-by-one pipetting and conventional liquid handling systems. This platform enhances accessibility to HTS and enables HTS to be used in small-to-medium scale laboratories. In addition, it allows large-scale combinatorial screening with a small number of valuable cells, such as patients primary cancer cells. This technique will have a high impact for widespread use of ...
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Singapore: Springer Nature, 2019
e20509327
eBooks Universitas Indonesia Library
