Hasil Pencarian  ::  Simpan CSV :: Kembali

"Latar Belakang: Endometriosis adalah terdapatnya jaringan (kelenjar dan stroma) abnormal mirip endometrium di luar uterus yang menyebabkan proses reaksi inflamasi kronis. Penderita endometriosis mengalami gangguan yang bersifat siklik dan terus menerus.Masalah lain adalah keterlambatan diagnosis. Laparoskopi adalah baku emas endometriosis, namun sulit untuk mengenali endometriosis pada stadium minimal dan ringan. Penanda atau biomarker sangat berguna untuk menghindari tindakan invasif yang tidak diperlukan, belum ada biomarker dapat memberikan gambaran secara jelas pada penggunaan klinis sehari-hari. Calprotectin adalah penanda dari inflamasi akut dan kronis yang diekspresikan pada granulosit terutama pada neutrofil, dan juga pada monosit, dan makrofag.25,26 belum ada penelitian yang meneliti hubungan calprotectin dengan penderita endometriosis. CRP merupakan marker inflamasi sistemik dan secara rutin digunakan sebagai penanda infeksi, inflamasi, atau kerusakan jaringan.30,31 Data mengenai kadar CRP perifer pada endometriosis jarang dan kontroversial.31Tujuan: Diketahui korelasi calprotectin dan hs-CRP serum sebagai penanda inflamasi kronis terhadap derajat endometriosis menurut klasifikasi rASRM, yaitu derajat minimal, ringan, sedang, dan beratMetode: Analisis observasional dengan desain potong lintang pada bulan Juli 2017-April 2018 di RSUPN Cipto Mangunkusumo Jakarta, RSUP Fatmawati dan RSUP Persahabatan, Jakarta. Empat puluh enam pasien endometriosis yang akan menjalani laparoskopi atau laparotomi yang memenuhi syarat penelitian direkrut consecutive sampling diperiksa kadar serum Calprotectin dan hs-CRP. Penelitian ini disetujui oleh Komite Etik dan Penelitian tahun 2017Hasil: Tidak adanya korelasi antara Calprotectin dengan derajat endometriosis (r=-0,16, p=0,278). Adanya korelasi positif lemah antara HsCRP dengan derajat endometriosis (r=0,29, p=0,050)Kesimpulan: Kadar Calprotectin serum tidak memiliki korelasi dengan derajat endometriosis. Kadar HsCRP serum memiliki korelasi positif lemah dengan derajat endometriosis, HsCRP dan Calprotectin serum tidak dapat membedakan derajat endometriosis

---

Background: Endometriosis is defined as the presence of endometrial-like tissue (gland and stroma) outside the uterus, which induces a chronic inflammatory reaction. Patients with endometriosis experience cyclic and continuous symptoms. Another problem is delays in diagnosis. Laparoscopy is gold standart in endometriosis, but it is difficult to recognize endometriosis at minimal and mild stage. Biomarkers are very useful to avoid invasive procedure that are not needed, none of these have been clearly shown to be of clinical use. Calprotectin is a marker of acute and chronic inflammation which is expressed on granulocytes, especially in neutrophils, and also in monocytes, and macrophages. There have been no studies examining the relationship between calprotectin and endometriosis. CRP is a systemic inflammatory marker and it routinely used as a marker of infection, inflammation, or tissue damage. Data regarding the CRP level in peripheral blood of endometriosis patients are relatively scarce and controversial. Purpose: The purpose of this research is to identify correlation between calprotectin and hs-CRP as a marker of chronic inflammation with the degree of endometriosis according to the rASRM classification, which is minimal, mild, moderate, and severe. Method: Analysis observational with cross sectional study design in July 2017-April 2018 at Cipto Mangunkusumo General Hospital Jakarta, Fatmawati General Hospital and Persahabatan Hospital, Jakarta. Forty-six endometriosis patients undergoing laparoscopy or laparotomy who met the study requirements were recruited by consecutive sampling to be examined for serum levels of Calprotectin and hs-CRP. This study was approved by Ethics and Research Committee in 2017 Results: No correlation between Calprotectin and the degree of endometriosis (r=-0.16, p=0.278). There was a weak positive correlation between HsCRP and the degree of endometriosis (r=0.29, p=0.050). Conclusion: Calprotectin levels uncorrelated with the degree of endometriosis. HsCRP levels have a weak positive correlation with the degree of endometriosis, HsCRP dan Calprotectin cannot distinguish the degree of endometriosis"

"Inflamasi derajat rendah diduga terlibat dalam patogenesis penyakit kronis yangterjadi secara global. Salah satu penanda inflamasi yang kerap digunakan adalahhigh sensitivity C-reactive protein (hsCRP). Asupan serat pangan yang lebih rendahdiduga berperan terhadap kadar hsCRP serum, akan tetapi hasil penelitiansebelumnya masih bervariasi. Studi ini bertujuan untuk mengetahui korelasi antaraasupan serat pangan dengan kadar hsCRP serum pada pekerja sedentari usia 19-49tahun di Jakarta Timur, Indonesia. Studi ini merupakan studi potong lintang pada58 pekerja sedentari yang dilaksanakan pada Bulan Agustus hingga Oktober 2020.Data dasar dikumpulkan memakai kuesioner. Asupan makanan dicatat dengan 3-day food record dan dilakukan pengukuran antropometri untuk mengetahui indeksmassa tubuh (IMT) dan ukuran lingkar pinggang. Pemeriksaan hsCRP serummemakai metode imunoturbidimetri. Analisis untuk menilai korelasi antara asupanserat pangan dan kadar hsCRP serum dilakukan menggunakan uji Spearman jikanilai p<0,05 dianggap bermakna. Mayoritas subjek adalah perempuan, tidakmerokok, dengan aktivitas fisik kurang dan memiliki status gizi normal serta tidakobesitas abdominal. Berdasarkan data asupan makanan didapatkan asupan energi,karbohidrat total, dan serat pangan total berada dibawah rekomendasi AKG. Hanyaasupan lemak total yang sesuai dengan rekomendasi AKG. Asupan serat pangantotal didapatkan sebesar 7,45 g/hari. Nilai hsCRP serum masih dalam batasannormal, yaitu sebesar 0,4 mg/L. Pada analisis bivariat tidak didapatkan korelasiantara asupan serat pangan dengan kadar hsCRP serum (r=0,003, p=0,981). Hasilpenelitian ini tidak mendapatkan adanya korelasi antara asupan serat pangandengan kadar hsCRP serum, namun diketahui asupan serat pangan masih sangatrendah sehingga perlu dilakukan promosi kesehatan untuk meningkatkan asupanserat pangan pada pekerja sedentari.

---

Low grade inflammation has previously been linked to the global development of

chronic disease. High sensitivity C-reactive protein (hsCRP) is commonly used to

detect inflammation. Low dietary fiber intake was hypothesized to have an effect

on serum hsCRP concentration. To this day, studies on the relationship between

dietary fiber and serum hsCRP have shown inconclusive result. In this study, we

aimed to find a correlation between dietary fiber intake and serum hsCRP on

sedentary worker age 19-49 years old at East Jakarta, Indonesia. This was a cross

sectional study on 58 sedentary workers. This study was conducted in August-

October 2020. Subject’s characteristics was obtained using a questionnaire. Dietary

assessment was conducted using 3-day food record. Anthropometic measurements

included body mass index (BMI) and waist circumference. Serum hsCRP

concentrations were measured using immune turbidimetry. Spearman test was used

to determine correlation between dietary fiber intake and serum hsCRP, with

p<0,05 being significant. Subjects were mostly female, non-smoker, with

inadequate physical activity. A majority of subjects had normal BMI and waist

circumference. Dietary assessment showed subject has inadequate intake of energy,

carbohydrate, and dietary fiber. Only fat intake was adequate in the present study.

Total dietary fiber intake was 7,45 g/day. Median value of serum hsCRP was 0,4

mg/L. There was no correlation between dietary fiber intake and serum hsCRP

(r=0,003, p=0,981). However, this study found that dietary fiber intake was very

low. Thus, education on increasing dietary fiber intake is necessary for sedentary

workers."

"Menentukan rerata kadar Protein C-Reaktif sensitivitas tinggi (hs-CRP) pada penyakit jantung koroner, hubungan antara kadar hs-CRP dengan luas lesi koroner dan fungsi sistolik jantung. Telah dilakukan penelitian observasional dengan disain potong lintang terhadap 106 pasien penyakit jantung koroner yang meliputi 90 angina pektoris stabil, 11 angina pektoris tidak stabil dan 5 infark miokard akut. Dilakukan pemeriksaan kadar kuantitatif hs-CRP, angiografi koroner untuk menentukan luas lesi koroner dan ejection fraction. Rerata kadar hs-CRP pada luas lesi koroner SVD 5,5 ± 7,6 mg/L, DVD 6,6 ± 21,7 mg/L dan TVD 5,5 ± 8,0 mg/L dengan p=0,056. Tidak didapatkan hubungan bermakna antara kadar hs-CRP dengan luas lesi koroner. Fungsi sistolik jantung mempunyai korelasi negatif dengan kadar hs-CRP (p=0,015, r = -0,235). Penelitian ini menunjukkan bahwa kadar hs-CRP tidak dapat menggambarkan luas lesi koroner, kadar hs-CRP mempunyai korelasi negatif dengan fungsi sistolik jantung. (Med J Indones 2003; 12: 201-6)

---

To determine the mean value of high sensitivity C-Reactive Protein (hs-CRP), association between plasma level of hs-CRP with extent of disease and systolic function. A cross sectional study had been conducted to 106 coronary artery disease patients (90 stable angina pectoris, 11 unstable angina pectoris and 5 acute myocardial infarction). Plasma quantitative level of hs-CRP with cor angiography to determine extent of disease and ejection fraction were measured. The mean of hs-CRP levels in patients with SVD were 5,5 ± 7,6 mg/L, DVD were 6,6 ± 21,7 mg/L and TVD were 5,5 ± 8,0 mg/L and p=0,056, respectively. There were no significant association between hs- CRP levels with extent of disease. Systolic function had negative correlation with levels of hs-CRP (p=0,015, r=-0,235). This study showed that plasma level of hs-CRP cannot reflect the extent of disease, and it had negative correlation with systolic function. (Med J Indones 2003; 12: 201-6)"

"Latar belakang : Inflamasi dan stres oksidatif merupakan faktor risiko terhadap penyakit kardiovaskuler pada pasien penyakit ginjal kronis yang menjalani hemodialisis. Pasien hemodialisis kronis akan mengalami peningkatan kadar hs-CRP.hs-CRP merupakan marker inflamasi yang telah terbukti pada beberapa penelitian bermanfaat dalam memprediksi cardiovascular event. Pemberian N-Acetylcysteine(NAC)oral dapat digunakan sebagai strategi untuk menurunkan proses inflamasi yaitu disfungsi endotel dan stress oksidatif yang berperan pada atherosclerosis pada pasien hemodialisis sehingga dapat menurunkan angka morbiditas dan mortalitas karena penyakit kardiovaskuler. Tujuan penelitian : Mengetahui pengaruh pemberian N-Acetylcysteine oral terhadap penurunan kadar hs-CRP pada pasien hemodialisis kronis. Metode : Penelitian eksperimen dengan Randomized Double Blind Controlled Trial yang dilakukan selama periode Agustus sampai Oktober 2013 di unit hemodialisis RS.Cipto Mangunkusumo Jakarta. Subjek penelitian ini adalah pasien dengan penyakit ginjal kronis yang menjalani hemodialisis. Sebanyak 87 subjek direkrut, hanya 65 subjek yang memenuhi kriteria inklusi sebagai sampel. Sampel dirandomisasi menjadi dua kelompok, 33 subjek kelompok intervensi yang mendapatkan NAC 2x600 mg per hari dan 32 subjek kelompok kontrol yang menerima placebo 2x1 per hari selama dua bulan (60 hari). Terdapat 5 subjek yang drop out, sehingga hanya 60 subjek yang dapat menyelesaikan penelitian 30 subjek dalam kelompok NAC dan 30 subjek placebo. hs-CRP diukur dalam tiga interval waktu, sebelum (baseline), setelah bulan pertama (post 1), dan setelah bulan kedua (post 2). Hasil : Perlakuan dengan NAC oral selama 60 hari tidak memberikan perbedaan dibanding dengan plasebo. Analisis statistik dengan Mann Whitney menunjukkan bahwa tidak ada penurunan kadar hs-CRP yang signifikan diantara kedua kelompok dengan p value Δ post1-baseline, Δ post2-baseline, and Δ post2-post1 kelompok NAC disbanding kelompok placebo secara berurutan (p=0.796, p=0.379, p=0.712). Kami juga mencoba membandingkan penurunan kadar hs-CRP secara statistik pada tiap kelompok untuk tiga interval pengukuran hs-CRP dengan menggunakan uji Wilcoxon Signed Ranks hasilnya menunjukkan p value dari perbandingan kadar hs-CRP untuk masing-masing kelompok Baseline:Post1,Baseline:Post2,Post1:Post 2 (kelompok NAC vs kelompok plasebo) secara berurutan (0.821vs0.651; 0.845vs0.358; 0.905vs0.789).

---

Background: Inflammation and oxidative stress are the risk factor for cardiovascular disease in patients with chronic kidney disease undergoing hemodialysis will have elevated levels of hs-CRP. hs-CRP is a marker of inflammation that has been provenin several studies use fulto predict cardiovascular events. The administration of oral N-Acetylcysteine (NAC) can be used as a strategy lowering the in flammatory process which end o the lialdys function and oxidative stress play a role in a the rosclerosis for hemodialysis patients there fore reduces morbidity and mortalitydue to cardiovascular disease. Objective: To determine the effect of oral N-Acetylcysteine in lowering the levels of hs-CRPin chronic hemodialysis patients. Methods: Randomized Double Blind Controlled Trialexperimental study conducted during the period August to November 2013 in the hemodialysis unit of Cipto Mangun kusumo Hospital. The subjects were patients with stage 5 chronic kidney disease undergoing hemodialysis. Eighty seven subjects were recruited, but only 65 subjects matched for inclusion criteria as samples. The samples were randomized into two groups : intervention group 33 subjects who received NAC2x600 mg per day and control group of 32 subjects who received placebo, both groups consumed the medicine for two months (60 days). There were 5 subjects dropped out, so there search completed by the end of 60 subjects with 30 subjects in NAC groupand 30 subjects in the placebo group. The hs-CRP levels were measuredin 3 interval of time, before (baseline), the first month (post1), and second month (post2). Result: Treatment with oral NAC for 60 days did not give any difference compare to PB. Statistically analysis with Mann Whitney test showed that there is no significant decrease of hs-CRP levels between two groups with the p value of Δ post1-baseline, Δ post2-baseline, and Δ post2-post1 NAC group compare to plasebo group respectively (p=0.796, p=0.379, p=0.712). We also try to compare the decrease of hs-CRP levels statistically in each group for 3 interval of hs-CRP check with Signed Ranks Wilcoxon test. The result showed p value of hs-CRP levels comparison within each group for Baseline : Post1, Baseline :Post2,Post1:Post2 (NAC group vs plasebo group)respectively (0.821vs0.651; 0.845vs0.358; 0.905vs 0.789). Conclusion: The administration of oral NAChas not been shown lowering the levels of hs-CRPin chronic hemodialysis patients."