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"When John Schilling, an unassuming mid-level accountant, went to work for the Columbia Hospital Corporation, he never expected to become the catalyst for the series of 'whistleblower' cases that ripped through the healthcare industry in the late 1990s. But when he unwittingly discovered that the company was siphoning billions of dollars away from Medicare and stealing from American taxpayers, he was faced with a choice: speak up for what he believed to be right, or remain silent. "Whistleblower" tells the story of Schilling's incredible, harrowing journey from ordinary citizen to federal informant, as he bravely stands up for the truth, treading a dangerous path against corrupt executives, and putting himself in serious personal jeopardy. The book recounts how Schilling, unable to confide in friends or family, allied himself with the FBI and the Justice Department and journeyed into an undercover world in which he learned to wear a wire, and mapped out offices for secret government raids. Suspenseful and provocative, "Whistleblower" chronicles the series of steps that eventually led to the resignation of high-level executives and forced Columbia to return 1.7 billion dollars to the federal government. A compelling account of one man's decision to risk everything for the greater good, this book reveals the personal side of a thankless role that resulted, ultimately, in justice."

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Aktivitas manusia dalam memenuhi kebutuhan hidupnya akan berdampak terhadap lingkungan, termasuk dampak negatif seperti turunnya kualitas lingkungan karena pencemaran timbal. Timbal (Pb) merupakan unsur yang tidak esensial bagi tanaman, namun dapat terserap dan meracuni tanaman. Telah dilakukan penelitian mengenai dampak timbal terhadap profil metabolomik tanaman jahe merah (Zingiber officinale var Rubrum.). Tujuan penelitian untuk mengetahui pengaruh timbal terhadap pertumbuhan dan profil metabolomik rimpang jahe merah. Perlakuan yang diberikan selama 1 bulan adalah PbCl2 50, 100, dan 150 ppm dengan Rancangan Acak Lengkap (RAL) 6 ulangan. Analisis profil metabolomik dilakukan dengan metode HPLC. Analisis statistik menggunakan Principle Component Analysis (PCA) dan Hierarchical Cluster Analysis (HCA). Hasil penelitian menunjukkan pemberian PbCl2 100 ppm dan 150 ppm pada tanaman jahe merah menghasilkan perbedaan yang signifikan terhadap pertumbuhan tinggi tanaman dan gejala toksisitas. Sedangkan perlakuan 50 ppm tidak memberikan pengaruh. Hal tersebut menunjukkan bahwa jahe merah memiliki toleransi terhadap PbCl2 hingga konsentrasi 50 ppm. Hasil PCA dan HCA berupa scatter plot dan dendrogram telah berhasil mengelompokkan tanaman kontrol dengan tanaman perlakuan 50 ppm ke dalam satu klaster, sementara perlakuan 100 ppm membentuk klaster dengan perlakuan 150 ppm. Pemberian PbCl2 lebih dari 100 ppm menghasilkan perbedaan terhadap profil metabolit jahe merah jika dibandingkan dengan kontrol.

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Human activities meeting their daily needs will impact the environment, including negative impacts such as the decline in the quality of the environment due to lead pollution. Lead is an element that is not essential for plants but can be absorbed and poison plants. Research has been conducted on the impact of lead on the metabolomics profile of red ginger (Zingiber officinale var Rubrum.). This study aimed to determine the effect of lead on the growth and metabolism of red ginger. The treatments were PbCl2 50, 100, and 150 ppm with a Completely Randomized Design with six replications. Metabolic profile analysis was performed using HPLC method. Statistic analysis using multivariate Principle Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA). The research showed that the treatment of 100 and 150 ppm PbCl2 in the sample resulted significant differences in plant height growth and toxicity symptoms. These results show that ginger has a tolerance of PbCl2 at a concentration of 50 ppm. PCA and HCA result have separated control with 50 ppm treatment into one cluster, while 100 ppm treatment forms another cluster with 150 ppm treatment. PbCl2 treatment higher than 100 ppm showed a different metabolite profile compared to the control.

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"Sebagai salah satu negara kepulauan terbesar di dunia dan memiliki kekayaan keanekaragaman hayati yang tinggi, membuat Indonesia memiliki banyak perbedaan pada kondisi lingkungan, tingkat keanekaragaman hayati, hingga pada tingkat komposisi kimia dan kuantitas suatu senyawa yang terdapat dalam suatu makhluk hidup, salah satunya adalah senyawa metabolit sekunder. Hal ini membuat perlu adanya analisis secara metabolomik terhadap suatu makhluk hidup dengan membandingkan lokasi yang berbeda. Phyllidiella nigra merupakan salah satu Nudibranchia yang banyak ditemui di Pulau Rambut dan Pulau Pramuka, Kepulauan Seribu, DKI Jakarta. Phyllidiella nigra mendapatkan metabolit sekunder dari mangsanya dengan cara mengakumulasi kemudian memanfaatkan senyawa metabolit sekunder untuk peran ekologisnya seperti sebagai antimicrobial, antifeedant, dan antifouling. Penelitian ini bertujuan untuk menganalisis dan mengetahui perbandingan metabolit sekunder pada Phyllidiella nigra di lokasi yang berbeda yaitu Pulau Rambut dan Pulau Pramuka. Sampel diambil dengan cara jelajah bebas sebanyak sepuluh sampel. Metabolit sekunder diekstraksi menggunakan metanol 96%, diuapkan, kemudian dideteksi menggunakan GC-MS. Data kemudian dianalisis dengan PCA dengan scatter plot dan HCA dengan dendrogram. Terdapat delapan senyawa yang dapat dianalisis, tiga senyawa diantaranya memiliki pengaruh yang tinggi dalam pembentukan kelompok yaitu 1-propene-1,2,3-tricarboxylic acid, tributyl ester; tributyl acetylcitrate; dan phenol, 2,4-bis (1,1- dimethylethyl)-. Senyawa metabolit sekunder di kedua pulau tidak ditemukan adanya perbedaan karena berdasarkan PCA dan HCA, sampel di kedua pulau saling campur dan tidak membentuk kelompok sesuai lokasinya yaitu Pulau Rambut dan Pulau Pramuka.

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As one of the largest archipelagic countries in the world that is rich in biodiversity, Indonesia has various environmental conditions and biodiversity, either at the chemical composition and quantity contained in a living thing such as secondary metabolites. Hence, there is a need to perform a metabolomic analysis of a living thing that lived at different locations. Phyllidiella nigra is one of the Nudibranchia that is commonly found on Rambut Island and Pramuka Island, Kepulauan Seribu, DKI Jakarta. Phyllidiella nigra accumulates secondary metabolites from its prey and then used the compounds for several ecological roles such as antimicrobial, antifeedant, and antifouling. This study analyses and compares the secondary metabolites of Phyllidiella nigra from two different locations, namely Rambut Island and Pramuka Island. Samples were taken by free-roaming as many as ten. The secondary metabolites were extracted using 96% methanol, evaporated, and then detected using GC-MS. Data was then analyzed by PCA with scatter plot and HCA with dendrogram. Eight compounds could be analyzed, three of which were dominant on group formation, namely 1-propene-1,2,3-tricarboxylic acid, tributyl ester; tributyl acetylcitrate; and phenol, 2,4-bis (1,1-dimethylethyl)-. There were no differences in the secondary metabolites between islands. Based on PCA and HCA, the samples on the two islands mixed and did not form groups according to their location, namely Rambut Island and Pramuka Island."