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"Teiah dilakukan penelitian tentang mikroenkapsulasifurasemida dengan metode koaservasi pemisahan fase Fenyalutyang diqunakan adaiah campuran gelatin dan gorn - akasia.Perbandingan antara furosemlda gelatin dan gom akasiaadalah 111 dengan berat masing-masing bahan 1q5 grarnFercobaan liii d.ilakukan pada empat kondisi yaltu pH 3..840; 4,2 dan 4. Formalin sejumlah 10 mililiter d.igunakansebaaai pengeras dinding mikrokapsul.Secara urnum mikrokapsui yang diperoich berbentLkmononukleus Mikrokapsul dengan kondisi pembuatan pH 40mempunyai ben tuk yang lebih baik dibanding mikrokapsuilainnyaq yutu berhentuk hulat dencjan permukaan dindingyang licin dan intl (nengumpul di teh qah cnikrokapsul.Fersentase furosemida yang tersalut antara 89% sampal95/.. Hasil ter-tinggi diperaleh rnikrokapsul pada pH 4q0,.

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Microencapsultion of furosemide with caaservation

separation phase method had been investigated. The coating

material were mixture of gelatin and gummi acaciae The

ratio of furosemide gelatin and gummi acaciae was 1:11

and each of the material weight was 15 gram. There were

four treatment 4 pH 38; 40 42; and 45. A hardening

agent was Used 10 mililiter of forrnalin.

Generally, microcapsules was founded formed spherical

mononucleus. Microca psules pH 4 1 0 has better performance

than the othersq because it has smooth surface wall, spherical

and mononucleus.

The persentations of coated furosemide between 89% -

The lithhest result was achived at microcapsules with

pH 40."

"Telah dilakukan penelitian pengaruh bahan pengisi terhadap pelepasan furosemida dalam sediaan tablet. Tablet dibuat menggunakan metode granulasi basah dengan bahan pengikat larutan karboksimetil kitosan 5% dan bahan pengisi yang berbeda yaitu laktosa (formula A), avicel 101 (formula B), amilum jagung (formula C) dan dikalsium fosfat (formula D). Pelepasan furosemida dari masing-masing tablet dievaluasi menggunakan alat disolusi tipe 2 dengan medium dapar fosfat pH 5,8. Sampel dianalisis menggunakan spektrofotometer pada גּ 274 nm. Hasil penelitian menunjukkan pelepasan furosemida terbesar yaitu 97,91% dihasilkan oleh formula A, kemudian diikuti oleh formula C 97,56%, formula B 78,56% dan formula D 35,82%.

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It is been done experiment toward the influence of filler toward the releasing of furosemida from the tablet dosage form. The tablet is made by using the wet granulation method with carboxymethyl chitosan solution as the binding agent and different filler lactose (formula A), avicel 101 (formula B), corn starch (formula C) and dicalsium fosfat (formula D). The releasing of furosemida from tablet is evaluated by using the disolution apparatus type 2 with buffer fosfat pH 5,8 as medium. The sample is analyzed by using the spektrofotometer on the גּ 274 nm. The results showed the releasing of furosemida of formula A (97,91%), formula C (97,17%), formula B (78,56%) and formula D (35,82%)."