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"Latar belakang: Studi epidemiologi menunjukkan bahwa jumlah akne vulgaris AV perempuan dewasa mengalami peningkatan. Hormon, produksi sebum, p. ance, proses inflamasi menjadi berbagai faktor yang terlibat dalam patogenesis terbentuknya AV dewasa. Tujuan: Mengetahui korelasi antara kadar Dehydroepiandrosterone sulfate DHEAS dan kadar sebum pada pasien AV perempuan dewasa. Metode: Studi potong lintang dilakukan pada Bulan Juni-Oktober 2017. Sebanyak 50 sampel perempuan dewasa usia 25-49 tahun didapatkan dengan consecutive sampling. Dilakukan anamnesis, pemeriksaan fisik, pengukuran kadar sebum wajah dan pengukuran kadar hormon DHEAS. Hasil: Terdapat hubungan bermakna antara kadar DHEAS dengan kadar sebum wajah pada pasien AV p:0.008; r:0.371 . Setiap kenaikan kadar DHEAS diikuti dengan peningkatan kadar sebum wajah. Diskusi: Androgen berikatan dengan reseptor androgen pada sebosit kulit sehingga androgen dapat mengontrol perkembangan kelenjar sebasea dan produksi sebum. Selain diproduksi secara sistemik, hormon androgen juga diproduksi secara lokal di kulit. Hal inilah yang dapat menjelaskan terjadinya AV dewasa tanpa disertai adanya hiperandrogenisme.

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Background: Epidemiologic studies have shown that number of adult female acne vulgaris AV increases. Hormone, sebum production, Propionibacterium acne and inflammatory process are factors involved in adult AV development.

Objective: The aims of this study is knowing the correlation between Dehydroepiandrosterone sulfate DHEAS and sebum level in adult female acne.

Method: This research used cross sectional study, and held from June to October 2017. Fifty samples aged 25 49 years were collected by consecutive sampling. Anamnesis, physical examination, sebum and DHEAS measurement were conducted.

Result: There was significantly difference between DHEAS and skin sebum level in AV patients p 0.008 r 0.371. Every increased DHEAS level was followed by increasing of sebum production in AV patient.

Discussion: Androgen binds to androgen reseptor in skin sebocyte, so that androgen could control sebaceous gland development and sebum production. Besides being produced by systemic, androgen is also produced locally in the skin. This could explain how adult AV develops without any hyperandrogenism."

"Aging is closely associated with physical disability that mostly causes by the onset of degenerative diseases. Due to the increasing mean age in most of the societies, the relationship between nutrition and aging is growing interest. The study aims to investigate the association of diet and biological age. A cross sectional study was conducted amongst male elderly (60 years and over) living in Jakarta. Eighty-four subjects were selected randomly. Biological age was determined by measuring skin wrinkling using skin microtopograph and serum dehydroepiandrosterone sulfate (DHEAS). Data collection was done using interviewer-administrated structured questionnaire and semi quantitatvive food frequency questionnaire (FFQ). After adjustment for age, elderly with high sosioeconomic status had higher energy, protein, meat, fish, and egg intakes. Low sosioeconomic class ad more extensive hand skin wrinkling and although not significant, arm sites. Serum DHEAS level was similar, respectively for high and low socioeconomic class. Serum DHEAS was positively correlated with the vitamin c intake and negatively correlated with cereal consumption. Skin wrinkling was positively collerated with cereal consumption. Since the design of this study was cross sectional, further studies are recommended to elaborate the protective effect of vitamin C and damaging effect of high cereal consumption on biological age as indicated by serum DHEAS levels and skin wrinkling."