Ditemukan 1 dokumen yang sesuai dengan query
Diah Rini Handjari
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Loss of adenomatous polyposis coli (APC) function is typically an early event in sporadic colorectal cancer (CRC) pathogenesis. The key tumor suppressor function of the APC protein lies in its ability to destabilize free cytoplasmic beta catenin. This lead to the accumulation of nuclear beta catenin, and together with the DNA binding protein Tcf-4, function as a transcriptional activator. Accumulation of stabilized free รข-catenin is considered as an early event and perhaps initiating the process ...
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2011
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