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"ABSTRAKMetode sederhana untuk mensintesis turunan lawson 2-Hidroksi-1,4-naftoquinon dari sinamaldehida telah berhasil dilakukan menggunakan nanokatalis CuFe2O4. Nanokatalis CuFe2O4 diperoleh dengan metode kopresipitasi dan dikarakterisasi menggunakan XRD, TEM, dan PSA. Hasil TEM menunjukkan nanokatalis CuFe2O4 yang memiliki ukuran 15-36 nm. Nanokatalis CuFe2O4 mampu mengkatalis pembentukan senyawa turunan lawson 2-Hidroksi-1,4-naftoquinon dan dapat digunakan sampai 5 kali pengulangan reaksi dengan recovery yang baik. Senyawa turunan lawson yang diperoleh dikarakterisasi melalui Spektrofotometer UV-Vis, Spektroskopi IR, dan GCMS. Produk yang dihasilkan memiliki yield sebesar 48,62 hingga 81,52 dan memiliki aktivitas antioksidan dengan nilai IC50 sebesar 8 ppm, 50 ppm dan 77 ppm.

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ABSTRACTA simple method for synthesis of derivates lawsone 2 hydroxy 1,4 nafttoquinone from cinnamaldehyde has been successfully synthesis used nanocatalyst CuFe2O4. Nanocatalyst CuFe2O4 were obtained from co precipitation methode and characterized by XRD, TEM and PSA. The result of TEM show that CuFe2O4 nanocatalyst that were 15 36 nm. Nanocatalyst CuFe2O4 was able catalyzed the formation of the lawsone derivatives 2 hydroxy 1,4 naftoquinone and can be used up to 5 times in the same reaction procedure with good recovery. The compounds obtained were characterized by Spectrofotometry UV Vis, Spectroscopy IR and GCMS. The product is obtained in fairly high yield from 48,62 to 81,52 and has antioxidant activity with IC50 value 8 ppm, 50 ppm and 77 ppm."

"Minyak atsiri kayu manis dapat diperoleh dari kulit batang kayu manis melalui teknik destilasi uap dan menghasilkan 0,06% rendemen. Proses selanjutnya minyak kayu manis dipisahkan melalui kromatografi kolom dan salah satu hasilnya yaitu fraksi A yang merupakan gabungan dari botol vial 1,2 dan 3 karena memiliki kemiripan spot pada KLT. Senyawa utama dari minyak kayu manis yakni sinamaldehid mengalami peningkatan luas area menjadi 20,95%. Reaksi prenilasi dari fraksi A yang menggunakan reagen prenil-bromida dan katalis heterogen K2CO3 diduga masuk pada senyawa trans-sinamaldehid, kalamenen, dan kumarin yang ditunjukkan pada perubahan spektrum IR, UV-Vis dan MS/MS. Hasil uji anti oksidan dari prenilasi fraksi A mengalami peningkatan kemampuan sebesar 51,61 % dibandingkan fraksi A itu sendiri.

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The essential cinnamon oil can be obtained with steam distillation technique from the cinnamon bark and the yield percentage is 0,06 %. Furthermore the cinnamon oil was being extracted to chromatography column and the result is fraction A which is the combination of vial 1,2, and 3 who has the similarity spot on TLC. The main compound of cinnamon oil which is cinnamaldehyde had increase in widen area to 20,95 %. The prenylation of reaction of fraction A were using prenyl bromide reagent and heterogen K2CO3 catalyst suspected infiltrate the trans-cinnamaldehyde, calamenene, and coumarine that showed by the change of IR, UV-Vis and MS/MS spectrum. The result of antioxidant test from fraction A prenylation had increase the ability of antioxidant as much as 51,61 % than fraction A it self."

"ABSTRAK"Reaksi basa Schiff banyak digunakan untuk pembuatan senyawa yang mempunyai" "aktivitas biologis yang tinggi. Sintesis basa Schiff dapat dilakukan dengan ataupun tanpa menggunakan katalis CES (Calcined Eggshells) dimana penggunaan katalis selain mempercepat waktu reaksi juga memperbesar yield yang dihasilkan. Katalis CES dibuat dari kulit telur yang telah dibersihkan dan dikalsinasi pada suhu 900 oC. Kandungan utama kulit telur setelah dikalsinasi merupakan CaO (Kalsium Oksida). Sintesis basa Schiff derivat minyak kulit kayu manis menggunakan katalis CES menghasilkan persen yield yang lebih besar yaitu sebesar 74,3% dibandingkan dengan sintesis yang tanpa menggunakan""katalis yang hanya 59,6 %. Derivat minyak kulit kayu manis kemudian diuji""aktivitas biologisnya yaitu berupa uji antirematik dan antioksidan."

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ABSTRACT"Schiff base reaction is widely used for the manufacture of compounds that have a" "high biological activity. Synthesis of Schiff bases can be done with or without the use of catalysts CES (Calcined Eggshells) where the use of catalysts in addition to speeding up the reaction time also increases the yield produced. CES catalyst made from egg shells that have been cleaned and calcined at 900 oC. The main content of egg shells after a calcined is CaO (Calcium Oxide). Synthesis of Schiff bases of cinnamon bark oil derivatives using a catalyst CES generate greater""percent yield is equal to 74.3% compared to the synthesis without the use of a catalyst which is only 59.6%. Cinnamon bark oil derivatives were then tested its" "biological activity in the form of antirheumatic and antioxidants test.""

"Senyawa turunan tiazolidin merupakan senyawa heterosiklik dengan atom nitrogen dan sulfur dalam struktur cincinnya yang dikenal memiliki aktivitas biologis, yaitu antioksidan, antitumor, anti-inflamasi, antimikorba, dan anti-hiperglikemia. Pada penelitian kali ini akan dilakukan sintesis senyawa turunan tiazolidin yang berasal dari 3- asetilpiridin dan memiliki subtituen aldehid aromatik dari senyawa sinamaldehid, benzaldehida, dan 4-hidroksi benzaldehida. Produk senyawa turunan tiazolidin ini diidentifikasi menggunakan KLT dan uji titik leleh, serta dikarakterisasi menggunakan spektrofotometer Ultraviolet-Visible (UV-Vis), Fourier Transform Infrared spectroscopy (FTIR), dan Liquid Chromatography Mass Spectrometry (LC-MS). Senyawa yang terbentuk dilakukan pengujian aktivitas antioksidan dengan menggunakan metode DPPH. Pada penelitian ini didapatkan produk 3-asetilpiridin tiosemikarbazon dengan persen rendemen sebesar 73,83%, 3-asetilpiridin tiazolidin-4-on sebesar 38,39%. turunan 3- asetilpiridin tiazolidin-4-on sinamaldehida sebesar 4,61%, turunan 3-asetilpiridin tiazolidin-4-on benzaldehida sebesar 15,82%, dan turunan 3-asetilpiridin tiazolidin-4-on 4-hidroksi benzaldehida sebesar 21,42%. Kemampuan antioksidan senyawa ditinjau dari nilai IC50 dimana senyawa 3-asetilpiridin tiazolidin-4-on sebesar 452,11 ppm, turunan 3-asetilpiridin tiazolidin-4-on sinamaldehida sebesar 1553,52 ppm, turunan 3- asetilpiridin tiazolidin-4-on benzaldehida sebesar 3484,42 ppm, dan turunan 3- asetilpiridin tiazolidin-4-on 4-hidroksi benzaldehida sebesar 1542,78 ppm.

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Thiazolidine derivative compounds are heterocyclic compounds with nitrogen and sulfur atom in their ring structure which are known to have biological activities, such as antioxidant, antitumor, anti-inflammatory, antimicrobial, and anti-hyperglycemic. In this study, the synthesis of thiazolidine derivatives derived from 3-acetylpyridine and aromatic aldehyde substituents from cinnamaldehyde, benzaldehyde, and 4-hydroxy benzaldehyde compounds will be carried out. Thiazolidine derivative product was identified using TLC and melting point test, and characterized using Ultraviolet-Visible (UV-Vis) spectrophotometer, Fourier Transform Infrared spectroscopy (FTIR), and Liquid Chromatography Mass Spectrometry (LC-MS). The compounds formed were tested for antioxidant activity using the DPPH method. In this study, 3-acetylpyridine thiosemicarbazone was obtained with a yield 73.83%, 3-acetylpyridine thiazolidine-4- one were 38.39%. the 3-acetylpyridine thiazolidine-4-one derivative of cinnamaldehyde were 4.61%, the 3-acetylpyridine thiazolidine-4-one benzaldehyde derivative were 15.82%, and the 3-acetylpyridine thiazolidine-4-one 4-hydroxy benzaldehyde derivative were 21.42 %. The antioxidant ability of the compound was assessed from the IC50 value where the 3-acetylpyridine thiazolidine-4-one compound was 452.11 ppm, 3- acetylpyridine thiazolidine-4-one derivative of cinnamaldehyde was 1553.52 ppm, 3- acetylpyridine thiazolidine-4-one derivative of benzaldehyde was 3484.42 ppm, and derivatives of 3-acetylpyridine thiazolidine-4-one 4-hydroxy benzaldehyde was 1542.78 ppm."

"Senyawa derivat kuinolin merupakan senyawa heterosiklik yang memiliki aktivitas biologis yang cukup baik seperti aktivitas antioksidan, antimikroba dan antivirus. Pada penelitian ini menggunakan alumunium klorida sebagai katalis yang dapat mempercepat laju reaksi serta hidrogen peroksida digunakan sebagai agen pengoksidasi yang dapat meningkatkan yield produk yang terbentuk. Hasil massa campuran sintesis derivat 1 menggunakan anilin diperoleh sebesar 48,2 mg dan sintesis derivat 2 dengan 4-nitroanlin sebesar 70,72 mg. Keberhasilan pembentukan senyawa derivat kuinolin dikarakterisasi dengan kromatografi lapis tipis, Uji titik leleh, Fourier Transform Infrared (FTIR) spectrophotometer, Ultraviolet- Visible (UV-Vis) spectrophotometer and Gas Chromatograph/Mass Spectrometer (GC-MS). Hasil sintesis senyawa derivat kuinolin kemudian diklorinasi menggunakan asam trikloroisosianurat dengan asetonitril (CH3CN). Hasil massa campuran derivat 1 terklorinasi diperoleh sebesar 70,1 mg dan derivat 2 terklorinasi sebesar 93,6 mg. Karakterisasi produk senyawa terklorinasi menggunakan gas chromatography mass spectrometry (GC-MS). Pengujian aktivitas antioksidan digunakan metode DPPH yang ditandai dengan perubahan warna ungu menjadi kuning. Hasil IC50 derivat 1 sebesar 311,5779 ppm, derivat 1 terklorinasi sebesar 276,785 ppm, derivat 2 sebesar 268,1427 ppm dan derivat 2 terklorinasi sebesar 192,8858 ppm.

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Quinoline derivate compounds are heterocyclic compounds that have a good biological activity such as antioxidant, antimicrobial, and antivirus activity. This study use aluminum chloride as a catalyst that can accelerate the reaction rate and hydrogen peroxide as an oxidizing agent that can increase the yield of the final product. The mass of a mixture of derivate 1 synthesis using aniline was 48,2 mg and the synthesis of derivate 2 with 4- nitroanline was 70,72 mg. The successful formation of quinoline derivate compounds was characterized by thin layer chromatography, melting point, Fourier Transform Infrared (FTIR) spectrophotometer, Ultraviolet-Visible (UV-Vis) spectrophotometer and Gas Chromatograph-Mass Spectrometer (GC-MS). The results of the synthesis of quinoline derivatives are then chlorinated using trichloroisocyanuric acid with acetonitrile (CH3CN). The mass of chlorinated derivate 1 mixture was obtained at 70,1 mg and chlorinated derivate 2 was obtained at 93,6 mg. Characterization of chlorinated compound products using Gas Chromatograph-Mass Spectrometer (GC-MS). The DPPH method was used to test for antioxidant activity which was marked by a change in color from purple to yellow. The result of IC50 for derivative 1 was 311.5779 ppm, chlorinated derivate 1 was 276.785 ppm, derivate 2 was 268.1427 ppm and chlorinated derivative 2 was 192.8858 ppm."