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"It is well known that almost all of dental treatment in dentistry especially in oral surgery associated with pain. It is make uncomfortable feeling and fear for the patient. It is responsibility for the dentist to know the patofisiology of pain and how to relief it. Recently, beyond knowledge and technology in dentistry and pharmacology, there are many drugs to relief of pain, especially from derived NSAID. For selecting analgesic drugs, accurately or effective and minimal side effect, perhaps we must to know the biotransformation of NSAID. Generally, NSAID drugs it choose who works specific in COX-2 inhibitor and work minimized in COX-1."

"Keratocyst is the mosy aggressive type of odontogenic cysts with high recurrence rate. The main factors that contribute to its recurrence rate are presumed to be thinness of the cyst wall, the high copability of the cyst epithelium to proliferate or multiplicate and the presence of the microcysts in the mother cyst capsule. The treatment of the lesion is still controversial and ranges from enucleation to resection. A relatively new approach to the therapy of keratocysts is to fix, that the cyst in a fixation agent for preventing spillage of vital epithelial cells during surgery."

"Oxford handbook of operative surgery "