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"Diminazen aseturat dilaporkan menghambat aktivitas balik enzim transkriptase melalui mekanisme aksi pengganjalan pada beberapa protozoa eukariyot parasitik seperti kerabat Tripanosoma. Telah dicari farmakokinetik plasma darah diminazen pada lima kambing terinfeksi yang diberi pengobatan 7 mg.kg-l berat badan dosis tunggal intra muskular. Konsentrasi obal ditetapkan melalui Kromatograji Cair Kinerja Tinggi fase lerbalik. Hasil menunjukan rerata <± galas baku) Absorbs}, Distribusi, Metabolisme, Ekskresi (ADME) berpola tri-eksponemial dengan Ka (menit'1) 5.1O2 ±26.1O\a (menif'), K!2 (menif1) dan K21 (menif1) 18.1O* ±J.10'2, 14.10'* ± 1.1O2 dan Lia3 ±LiaJ. Rerata harga fitments1) dan K13 (menit'') didapat 1.4.104 ±4. Iff* dan 3.10'* +2.W*. Rerata harga Tmtiks (menit) dan Kmaks (fig.mt1) didapat 53.71 ±30.61 and 13.40 ±8.13. Rerata harga Yds (L), Cl (ml.menif1), Tlfiffjam1) and Area di bawah kurva °-t~(fjg.L''.menit) didapat 4.91 ±3.12, 14.29 ±4.08, 94.91 ±33.23 dan 12.680 ±2.722. (MedJIndones 2006; 15:69-73).

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Diminazene aceturate has been reported to inhibit the reverse transcriptase activity by intercalating action mechanism of a number of protozoan eucaryol parasitic like Trypanosoma species. The phamacokinetics of diminazene in the blood plasma of five infected goaty treated with single intramuscular doses of 7 mg diminazen base kg body weight was investigated. The concentrations of the drug were determined by reverse phase high performance liquid chromatogmphy. Results show tlmt the mean (± SD) Absorption, Distribution, Metabolism and Excretion (ADME) of the drug plasma followed a tri-exponential process with Ka (minutes' ) were obtained at 5.10'' +26.10''. a (minutes' ), K12 (minutes') and K21 (minutes') were obtained at 18. /0"'f ± 1.10'2, 14. Iff* ± 1. !0'2 and 1./0~'! ± 1.Iff3. The mean values of fi (minutes' 1} and Kl3 (minutes') were obtained at 1.4.W4±4. JO* and 3.10~~f ±2.10''. The mean values of Tmax(minutes) and Cmax (fjg.m!'1) were obtained at 53.71 ±30.61 and 13.40 ±8.13. The mean values of Yds (L), Cl (ml .minutes''), Tl/2ff hours') and ALKf^fas.L''.minutes) were obtained at 4.91 ±3.12, 14.29 ±4.08,94.91 ±33.23 and 12.680 ±2.722. (MedJIndones 2006; 15:69-73)."

"Latar belakang: Diabetes Melitus hingga saat ini masih menjadi masalah global, termasuk di Indonesia. DM mampu menyebabkan komplikasi mikrovaskular dan makrovaskular, yang salah satunya adalah diabetik nefropati. Berbagai faktor dapat mempengaruhi perkembangan penyakit dari diabetes melitus menjadi diabetik nefropati, salah satunya adalah lingkungan tempat tinggal. Masyarakat yang tinggal di kampung kota memiliki keterbatasan untuk mengakses fasilitas kesehatan serta memiliki kesadaran yang rendah atas akibat dari penyakit kronis. Diduga, terdapat peningkatan risiko hiperglikemia yang berhubungan dengan diabetik nefropati. Oleh karena itu, kami melakukan studi yang bertujuan untuk mempelajari hubungan antara hiperglikemia dan penanda fungsi ginjal pada subjek dewasa yang tinggal di Kampung Kota Jakarta-Tangerang.Metode: Studi ini menggunakan data sekunder dengan desain cross-sectional pada subjek di atas umur 30 tahun di 4 wilayah Kampung Kota Jakarta-Tangerang tahun 2019-2020. Lalu, subjek disesuaikan dengan kriteria inklusi dan eksklusi untuk selanjutnya dinilai kadar gula darah menggunakan gula darah puasa (GDP) dan HbA1c, serta penanda fungsi ginjal dengan eGFR (estimated glomerular filtration rate).Hasil: Dari 220 subjek dewasa, 15 subjek (6,8%) berdasarkan gula darah puasa (GDP≥126 mg/dL) dan 26 subjek (11,8%) berdasarkan HbA1c (HbA1c ≥6,5%) digolongkan sebagai hiperglikemia. Sebanyak 12 subjek (5,5%) mengalami penurunan fungsi ginjal. Hasil uji statistik menjelaskan adanya hubungan bermakna antara GDP dan eGFR (p =0,005, OR= 8,955 , 95% CI=2,333 – 34,372). Namun, tidak terdapat hubungan bermakna antara HbA1c dan eGFR (p=0,156, OR=0, 156, 95% CI=0,677 – 10,621).Kesimpulan: Terdapat hubungan yang bermakna antara hiperglikemia yang ditentukan berdasarkan kadar glukosa darah puasa, tetapi tidak pada HbA1c, dengan penanda fungsi ginjal pada subjek dewasa yang tinggal di kawasan kampung kota.

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Introduction: Diabetes Mellitus is still a global problem, including in Indonesia. DM can cause microvascular and macrovascular complications, one of which is diabetic nephropathy. Various factors can affect the development of the disease from diabetes mellitus to diabetic nephropathy, one of which is the living environment. People living in urban kampung have limited access to health facilities and have low awareness of the consequences of chronic diseases. Presumably, there is an increased risk of hyperglycaemia associated with diabetic nephropathy. Therefore, we conducted a study aimed at studying the association between hyperglycaemia and markers of renal function in adult subjects living in Urban Kampung Jakarta-Tangerang.

Method: This study used secondary data with a cross-sectional design on subjects over the age of 30 years in the urban kampung area of Jakarta and Tangerang in 2019-2020. Then, subjects were selected using predetermined inclusion and exclusion criteria. Eligible subjects were further assessed for blood sugar levels using fasting blood sugar (FPG) and HbA1c, as well as kidney function markers eGFR (estimated glomerular filtration rate).

Result: : From 220 subjects whose data were obtained, 15 subjects (6.8%) based on fasting blood sugar (GDP≥126 mg/dL) and 26 subjects (11.8%) based on HbA1c (HbA1c ≥6.5%) were classified as hyperglycaemia. A total of 12 subjects (5.5%) had decreased kidney function. The results of the statistical test explained that there was a significant association between FPG and eGFR (p = 0.005, OR = 8.955, 95% CI = 2.333 – 34.372). However, there was no significant association between HbA1c and eGFR (p=0.156, OR=0.156, 95% CI=0.677 – 10.621)."