Ditemukan 7 dokumen yang sesuai dengan query
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Reviews of environmental contamination and toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications ...
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New York: Springer, 2012
e20405778
eBooks Universitas Indonesia Library
Iis Delly Apriyarni
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Peningkatan DNA adduct yaitu 8-OHdG dipengaruhi oleh adanya xenobiotik yang bersifat toksik dan karsinogenik. Xenobiotik yang digunakan pada penelitian ini adalah paraquat diklorida sebagaimana diketahui paraquat diklorida merupakan pestisida golongan II berdasarkan WHO yang memikili efek berbahaya karena dapat menyebabkan mutasi gen sehingga berdampak karsinogenik. Penambahan ion logam Cu(II) dan Ni(II) sebagai media yang dapat berekasi dengan hidrogen peroksida untuk mengahasilkan reaksi Fenton. Rekasi fenton akan menghasilkan hidroksil radikal yang dapat menyebabkan peningkatan ...
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Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2022
T-pdf
UI - Tesis Membership Universitas Indonesia Library
Connell, Des W.
Jakarta: UI-Press, 1995
661 CON bt
Buku Teks Universitas Indonesia Library
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Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind.
This book presents an overview of the underlying principles of PBPK model development. Then it provides a compendium of PBPK modeling information, including historical development, specific modeling challenges, and current practices for, ...
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Hoboken, New Jersey: John Wiley & Sons, 2005
e20410901
eBooks Universitas Indonesia Library
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Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically.
Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and ...
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Weinheim, Germany: Wiley-Vch, 2003
e20394191
eBooks Universitas Indonesia Library
Chang-Hwei, Chen
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The book discusses subjects associated with foreign compound metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, catalytic properties, reactive intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary related enzyme modulators, and structural characteristics of enzyme inducers. ...
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New York: Springer, 2012
e20401382
eBooks Universitas Indonesia Library
Singh, Shree Nath, editor
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This book covers breakthroughs in sequencing methodology which offer new insight into metabolic and regulatory networks, as well as clues to the evolution of degradation pathways and to molecular adaptation strategies to changing environmental conditions. ...
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Heidelberg : Springer, 2012
e20405462
eBooks Universitas Indonesia Library