Ditemukan 7 dokumen yang sesuai dengan query
"
A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration ...
"
Hoboken, New Jersey: John Wiley & Sons, 2009
e20385346
eBooks Universitas Indonesia Library
Boca Raton: CRC Press, Taylor & Francis Group, 2008
615.7 PRI
Buku Teks SO Universitas Indonesia Library
"
Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and ...
"
Weinheim, Germany: Wiley-VCH, 2003
e20385324
eBooks Universitas Indonesia Library
"
This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries, this handbook demonstrates the best and fastest way to estimate those properties most relevant for the efficiency and pharmacokinetic performance of a drug molecule: lipophilicity,solubility, ...
"
Weinheim, Germany: Wiley-VCH, 2008
e20395825
eBooks Universitas Indonesia Library
"
The essentials of drug metabolism vital to developing new therapeutic entities.
Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular ...
"
Hoboken, New Jersey: John Wiley & Sons, 2008
e20395867
eBooks Universitas Indonesia Library
"
Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug development. ...
"
Hoboken: John Wiley & Sons, 2010
e20393919
eBooks Universitas Indonesia Library
"
This book gives an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume ...
"
Hoboken, New Jersey: John Wiley & Sons, 2009
e20394374
eBooks Universitas Indonesia Library
