Ditemukan 7 dokumen yang sesuai dengan query
Trinovita Andraini
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ABSTRAK
Certaines r gions du cerveau adulte, comme l rsquo;hippocampe, produisent des nouveaux neurones qui participent certaines capacit s d rsquo;apprentissage et de m moire. Dans les maladies neurod g n ratives comme la maladie d rsquo;Alzheimer MA , ils sont alt r s. Dans des souris mod les de la MA, nous avons montr que ces nouveaux neurones souffraient de plus d rsquo;une r duction de leur contenu mitochondrial. Les mitochondries, lsquo;centrales lectriques rsquo; des ...
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2017
D-Pdf
UI - Disertasi Membership Universitas Indonesia Library
Amirah Yusnidar
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Penderita penyakit neurodegeneratif masih tinggi seiring pertambahan populasi manusia, diakibatkan oleh beberapa faktor seperti faktor lingkungan, neuroinflamasi, stress metabolik, neurovascular coupling dan genetik. Propolis telah banyak digunakan sebagai obat karena berbagai manfaatnya. Pada penelitian ini diteliti pengaruh propolis lebah yang tidak bersengat (Tetragonula sapiens) dari Sulawesi Selatan terhadap neurogenesis pada kultur primer embrio korteks serebri tikus Wistar dengan usia gestasi 17-18 hari. Penelitian ini merupakan penelitian eksperimental yang dibagi menjadi kelompok Kontrol, Vehicle dan kelompok ...
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Depok: Fakultas Kedokteran Univesitas Indonesia, 2022
T-pdf
UI - Tesis Membership Universitas Indonesia Library
Farid Rahimi, editor
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Amyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence suggests these lesions are the end state of aberrant protein folding whereas the actual disease-causing culprits likely are soluble, non-fibrillar assemblies preceding the aggregates. The non-fibrillar protein assemblies range from small, ...
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Dordrecht: [, Springer], 2012
e20417827
eBooks Universitas Indonesia Library
Wolfgang Linert, editor
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Metal ions in the brain are a necessity as well as a poison. The presence of metal ions in the active sites of biological catalysts or metalloproteins and in the biological functioning of nucleic acids is very well documented and they are required for brain activity. On the other hand, metals are very effective in generating oxidative stress. This effect does not only play a role in immunology but also is the root of practically ...
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Wien: [, Springer], 2012
e20418006
eBooks Universitas Indonesia Library
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The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current ...
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New York: Springer, 2012
e20417646
eBooks Universitas Indonesia Library
Vivi M. Heine
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This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM). ...
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Dordrecht: [, Springer], 2012
e20417567
eBooks Universitas Indonesia Library
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As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as parkinson’s disease, alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration. Mitochondrial dysfunction in neurodegenerative disorders brings together contributions from leaders in the field internationally on the ...
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London : Springer, 2012
e20426197
eBooks Universitas Indonesia Library
