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"Gizi adalah faktor penting yang berperan dalam pertumbuhan dan perkembangan balita. Gangguan gizi pada balita mengakibatkan penurunan kecerdasan, terhambatnya pertumbuhan, perkembangan motorik, perkembangan mental dan meningkatnya angka kesakitan, kematian balita. Masalah gizi balita salah satunya disebabkan kurangnya pengetahuan ibu sehingga pengetahuan gizi sangat penting agar asupan gizi balita diberikan sesuai kebutuhan. Diperlukan pendidikan kesehatan mengenai gizi balita. Tujuan penelitian ini untuk menjelaskan pengaruh pendidikan kesehatan terhadap peningkatan kemampuan ibu dalam memberikan asupan gizi balita di Indralaya Ogan Ilir. Penelitian ini, Quasi Experimental " Non-randomized Control Group Pretes-Postest Design" Populasinya adalah ibu-ibu balita di Kecamatan Indralaya, Desa Tebing Gerinting, Tanjung Seteko, dan Tanjung Agas. Jumlah sampel penelitian ini 120 orang, 40 orang kelompok intervensi 1 (buku panduan, penyuluhan), 41 orang kelompok intervensi 2 (buku panduan, penyuluhan dan kunjungan rumah) dan 39 orang kelompok kontrol (buku panduan). Pengambilan sampel dengan cara cluster sampling. Hasil uji homogenitas responden usia dan pendidikan (P<0,05) sedangkan pekerjaan dan pengeluaran RT (P ≥ 0,05). Analisis pengaruh pendidikan kesehatan terhadap peningkatan kemampuan ibu memberikan asupan gizi balita menggunakan uji beda lebih dan dua mean (Anova), menunjukkan perbedaan bermakna peningkatan kemampuan ibu antara kelompok intervensi 1, kelompok intervensi 2 dan kelompok kontrol dengan (P=0,0001) pada asupan gizi juga menunjukkan perbedaan peningkatan asupan gizi yang bermakna antara kelompok intervensi 1, intervensi 2 dan kelompok kontrol (P=0,0001) untuk status gizi balita belum dapat dievaluasi perubahannya karena keterbatasan waktu penelitian. Hubungan karakteristik ibu (usia, pendidikan, pekerjaan dan pengeluaran RT) intervensi 1, intervensi 2 dengan peningkatan pengetahuan dan perilaku menggunakan uji Regresi linear ganda menunjukkan tidak ada pengaruh karakteristik ibu terhadap peningkatan kemampuan ibu tetapi hanya dipengaruhi oleh intervensi 1 dan intervensi 2. Implikasi dari penelitian ini pendidikan kesehatan dengan menggunakan buku panduan, penyuluhan dan kunjungan rumah dapat diterapkan asuhan keperawatan keluarga dan masyarakat.

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Nutrition is an important factor which helps growth and development of child under five years old. Nutrition disturbance under five years old decreases intelligence, growth pursue, motoric development and increases illness and death among under five years old children. This problem nutrition under five years old is one of mother's less knowledge about nutrition under five years old, in order nutrition intake under five years old is gave according to health education of nutrition under five years old. This research purpose to explain the effect of health education for increasing mother's ability in giving nutrition intake under five years old at Indralaya district, Ogan Ilir regency. This research used Quation Experimental "Non-randomized Control Group Pretest-Postest Design". Population in this research is mothers who have under five years old children at Indralaya district, Desa Tebing Gerinting, Tanjung Seteko and Tanjung Agas. Amount of these samples in this research are 120 people, 40 people are intervention group 1 (guidance book, instruction), 4I people are intervention group 2 (guidance book, instruction, and home visit), and 39 people are control group (guidance book). Samples are taken by cluster sampling. Test result of respondent homogeneous according to age and education (P<0,05), according to job and home expenses (P>0,05). Analyzing the influence of health education for increasing mother's ability in giving nutrition intake under five years old used different test over two means (Anova), indicate meaning different of increasing mother's ability between intervention group 1, intervention group 2 and control group (P=0,0001), nutrition intakes also indicate meaning different of increasing nutrition intake between intervention group 1, intervention group 2 and control group (P-0,0001), nutrition status under five years old can not be evaluated its change yet because research time is short. Relation of mother's characteristic (according to age, education, job and home expenses), intervention 1, intervention 2 by increasing knowledge and behavior used Double Linear Regression test, indicate there are not effect for mother's characteristic in increasing mother's ability, but there are only effected by intervention I and intervention 2. This research Implication of health education by using guidance book, instruction and home visit can be applied nursing guidance for family and community."

"Wanita hamil sering (25%-45%) menjadi korban kekerasan yang dilakukan oleh suaminya, padahal dukungan sosial dari suami sangat dibutuhkan untuk meningkatkan kemampuan ibu beradaptasi pada masa post partum dan melakukan interaksi ibu-bayi secara adekuat. Tujuan penelitian ini adalah untuk menganalisa pengaruh kekerasan fisik, psikologis, ekonomi, dan seksual selama kehamilan terhadap interaksi ibu-bayi selama periode post partum awal. Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan desain kasus kontrol. Populasi penelitian ini adalah ibu post partum normal dengan persalinan spontan pervaginam tanpa komplikasi dan bayi sehat yang di rawat di RSUD Koja Jakarta, dan RSVP Fatmawati. Jumlah sampel dalam penelitian ini sebanyak 100 orang ibu post partum yang terdiri dari 50 orang kelompok kasus yang mengalami gangguan interaksi dan kelompok kontrol yang tidak mengalami gangguan interaksi. Teknik pengumpulan data dengan menggunakan lembar observasi untuk mengidentifikasi interaksi ibu-bayi selama tiga bari, dan pada hari ketiga post partum ibu diberi kuesioner untuk mengidentifikasi pengalaman kekerasan fisik, psikologis, ekonomi dan seksual yang dialami selama hamil. Pegujian pengaruh kekerasan dengan interaksi ibu-bayi dilakukan dengan menggunakan uji Chi Square. Hasil analisis pada a 5% diperoleh tidak ada pengaruh kekerasan fisik, psikologi, ekonomi dan seksual selama kehamilan terhadap interaksi ibu-bayi selama periode post partum. Variabel confounding lama perkawinan, paritas dan perencanaan kehamilan juga tidak mempengaruhi interaksi ibubayi. Disarankan kepada perawat untuk melakukan pengkajian tentang pengalaman kekerasan kepada ibu selama masa perinatal dan selalu mendorong interaksi ibu-bayi seawal mungkin.

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Pregnant women are vulnerable to violence victim by her husband (25%-45%), however, family support is highly needed for her in order to increase mother's ability in adapting in new inexperienced situation, which is the post partum period, therefore they can perform mother-baby relation adequately. The goals of this research are to analyze the influence of physical, psychological, economy, and sexual violence during pregnancy to the mother-baby interaction in the early post partum period. Sample used for this research are 100 post partum mothers, whom consist of two groups. The cases group is 50 mothers whose have adequacy interaction and the control group is 50 mothers whose have adequacy interaction. The data obtained using observation sheet that identified mother-baby interaction for three days, at the end of the observation day, mothers are given other questionnaire to identify physical, psychological, economical, and sexual violence experienced during pregnancy. The relation between violence during pregnancy and mother-baby interaction is using Chi Square Test. The results with a value 5% is there is no relation between physical, psychological, economical, and sexual violence experienced during pregnancy to the mother-baby interaction in the early post partum period. Confounding variables are length of marital status, parity status, and pregnancy management also doesn't have relation with the mother-baby interaction. It is suggested for the nurses always to assess prenatal mother violence experienced and always to promote mother-baby interaction as early as possible."

"Penelitian ini dilatarbelakangi oleh pentingnya pengetahuan, kepercayaan diri ibu dan perawatan bayi pada tahun pertama kehidupannya. Penelitian ini dirancang dengan desain kuasi eksperimen, dengan pendekatan pre dan post test dengan kelompok kontrol. Penelitian yang melibatkan 58 orang ibu primipara dengan persalinan normal ini bertujuan untuk menguji efektifitas pendidikan kesehatan dengan Metode Ceramah Plus Demonstrasi dan Latihan (CPDL) dalam meningkatkan pengetahuan dan perilaku ibu primipara merawat bayi. Pendidikan kesehatan dengan metode CPDL ini didasari oleh teori belajar dari Bandura, kerucut pembelajaran (cone of learning), teori behavioristik dan teori humanistic. Pendidikan kesehatan diberikan pada hari kedua dan ketiga post partum selama 45-60 menit dengan materi menyusui, memandikan bayi, dan memberikan stimulasi. Evaluasi terhadap pengetahuan dan perilaku ibu merawat bayi dilakukan satu bulan setelah intervensi dilakukan. Hasil penelitian ini menunjukkan. pendidikan kesehatan dengan metode CPDL cukup efektif dalam meningkatkan pengetahuan ibu dalam merawat bayi, meliputi: menyusui (p =0,00), memandikan bayi (p=0,05) dan memberikan stimulasi (p=0,00). Perilaku menyusui (p=0,03), memandikan (p=0,05), memberikan stimulasi (p=0,00). Hasil penelitian ini menyarankan untuk perawat yang bekerja dalam area keperawatan maternitas untuk dapat menyiapkan pendidikan kesehatan dengan metode CPDL ini dengan tetap memperhatikan kesiapan fisik dan psikologis ibu post partum. Sehubungan dengan waktu kepulangan yang semakin singkat (48 - 72 jam) post partum pada persalinan normal, penelitian ini menyarankan agar pendidikan perawatan bayi telah diperkenalkan sejak masa prenatal.

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This research was considering the important of improvement mother's knowledge and self confidence of primipara in caring their infant on the first year of his life. This research design was quation experiment, pre-test and post-test with control group. The study involves 58 primiparas was normal delivery which purpose to examine the effectiveness of health education with CPDL method in improving mother's knowledge and behavior of primipara in caring their infant. Health Education with CPDL method was based on learning theory from Bandura, Cone of learning, Behavioral and Humanistic theory. The intervention was done on the second and third day of post partum during 45 - 60 minutes about breastfeeding, bathing baby, and stimulating for growth and development. Before intervention was provided, pre test was done of mother's knowledge about breastfeeding, bathing baby and stimulating, while evaluation of mother's knowledge and behavior in caring their infant was done for 1 month after intervention was done. The finding of this study indicate that health education with CPDL method was effective in improving mother's knowledge in caring their infant, breastfeeding (p=0,00), bathing baby (p=0,05) and stimulating (p=0,00). Mother's behavior in caring their infant of breastfeeding (p=0,03), baby bathing (p=0,05), stimulating (p=0,00). This research result suggests for maternity nurse to prepare health education with CPDL method without neglecting readiness of mother's physical and psychological of post partum. This health education integrated in nursing care during 24 hours. Referring to go home time which shorten progressively (48 - 72 hours) of partum post, this research also suggest that information about infant care had been provided since prenatal."

"Terbinanya ikatan tali kasih sayang antara ibu dan bayi pada periode awal postpartum(fuse taking in) dipengaruhi oleh 5 prakondisi. Tujuan dari penelitian untuk mengetahuifactor apa saja yang mempengaruhi terbinnya ikatan tali kasih sayang pada awal postpartum. Penelitian ini dilakukan di Rumah Sakit Karya Bhakti Bogor dengan jumlahresponden 55 orang ibu postpartum dengan kurun waktu 24 jam pertama sampai dengan2 hari . Desain penelitian yang digunakan adalah deskriptif sederhana dengan alatmenggunakan kuisioner. Analisis data yang digunakan adalah distribusi frekuensi darimasing-masing kategorik yang ditentukan oleh peneliti untuk menganalisis faktor yangmemepengaruhi variabel. Hasil penelitian ini menyimpulkan bahwa 5 prakondisimendukung terbinanya ikatan tali kasih sayang antara ibu dan bayi pada periode awalpostpartum. Penelitian ini merekomendasikan perlunya penelitian yang lebih lanjutdengan jumlah responden yang lebih banyak tetapi tidak pada periode awal sajamelainkan sampai dengan fase berikutnya."

"Ibu yang melahirkan bayi Berat Badan Lahir Rendah (BBLR) cenderung memiliki kepercayaan diri yang rendah. Salah satu intervensi BBLR adalah Perawatan Metode Kanguru (PMK). Penelitian ini bertujuan untuk mengidentifikasi hubungan antara pengetahuan dengan self-efficacy ibu dalam menerapkan PMK di Jakarta. Jenis penelitian analitik yang digunakan adalah studi observasi cross-sectional dengan metode pengambilan sampel convenience sampling terhadap 49 responden ibu yang memiliki bayi BBLR. Instrumen yang digunakan adalah instrumen pengetahuan ibu mengenai PMK dan instrumen self-efficacy ibu dalam menerapkan PMK. Analisis uji statistik yang digunakan yakni uji korelasi Gamma. Hasil penelitian menunjukkan adanya hubungan antara pengetahuan dengan self-efficacy ibu (p value = 0,011 r = 0,732). Peneliti merekomendasikan kepada tenaga kesehatan untuk memberikan pendidikan kesehatan yang lebih pada ibu yang memiliki BBLR mengenai PMK, terutama waktu yang disarankan untuk melakukan PMK, anggota keluarga lain yang bisa menggantikan ibu melakukan PMK, dan tanda bahaya pada bayi yang mungkin ditemukan saat melakukan PMK.

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Mothers who give birth to babies with low birth weight (LBW) tend to have low self-esteem. One of the LBW interventions is the Kangaroo Mother Care (KMC). This study aims to identify the relationship between knowledge and mother's self-efficacy in implementing KMC in Jakarta. The type of analytic research used was a cross-sectional observational study with a convenience sampling method of 49 respondents who have LBW babies. The instruments used were the mother's knowledge instrument regarding KMC and the mother's self-efficacy instrument in implementing KMC. The statistical test analysis used is the Gamma correlation test. The results showed that there was a relationship between knowledge and mother's self-efficacy (p value = 0.011 r = 0.732). Researchers recommend that health workers provide more health education to mothers who have LBW regarding KMC, especially when it is recommended to do KMC, other family members who can replace mothers doing KMC, and danger signs in babies that may be found when doing KMC."

"[Upaya peningkatan pemberian ASI Eksklusif masih terus dilakukan. Kondisi ini yang mendasari dilakukannya penelitian ini dengan tujuan untuk mengetahui gambaran pengalaman menyusui ibu multipara. Penelitian ini menggunakan disain deskriptif melalui pendekatan cross-sectional. Pengambilan data dilakukan pada 107 responden menggunakan Breastfeeding Study Questionnaire yang sudah diterjemahkan ke dalam Bahasa Indonesia. Hasil uji coba pada uji validitas didapatkan 35 pertanyaan bernilai valid sedangkan uji reliabilitas didapatkan 13 pertanyaan bernilai reliabel. Hasil penelitian pengalaman menyusui menunjukkan bahwa 88,8% ibu multipara memiliki pengalaman menyusui yang baik. Ibu multipara dengan riwayat menyusui sebelumnya memiliki pengalaman menyusui yang baik. Instrumen penelitian ini dapat digunakan sebagai instrumen untuk survei tentang pengalaman menyusui dan memberikan data yang lebih detil, hanya perlu ditambahkan pertanyaan mengenai menyusui eksklusif.

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Effort increase exclusive breastfeeding are still underway. This condition underlying this study to describe breastfeeding experiences in multiparas mother. This study using descriptive design trough cross-sectional. Data were collected on 107 respondents using breastfeeding study questionnaire that has been translated into Bahasa. The result on validity test shows that 35 questions are valid while reliability test shows that 13 questions are reliable. Result from breastfeeding experiences study shows that 88,8% multiparas mother has good experience. Mother with breastfeeding history has good breastfeeding experience. The instrument in this study can be use for survey study about breastfeeding experience and give more detailed information, additional questions about exclusive breastfeeding are needed;Effort increase exclusive breastfeeding are still underway. This condition underlying this study to describe breastfeeding experiences in multiparas mother. This study using descriptive design trough cross-sectional. Data were collected on 107 respondents using breastfeeding study questionnaire that has been translated into Bahasa. The result on validity test shows that 35 questions are valid while reliability test shows that 13 questions are reliable. Result from breastfeeding experiences study shows that 88,8% multiparas mother has good experience. Mother with breastfeeding history has good breastfeeding experience. The instrument in this study can be use for survey study about breastfeeding experience and give more detailed information, additional questions about exclusive breastfeeding are needed;Effort increase exclusive breastfeeding are still underway. This condition underlying this study to describe breastfeeding experiences in multiparas mother. This study using descriptive design trough cross-sectional. Data were collected on 107 respondents using breastfeeding study questionnaire that has been translated into Bahasa. The result on validity test shows that 35 questions are valid while reliability test shows that 13 questions are reliable. Result from breastfeeding experiences study shows that 88,8% multiparas mother has good experience. Mother with breastfeeding history has good breastfeeding experience. The instrument in this study can be use for survey study about breastfeeding experience and give more detailed information, additional questions about exclusive breastfeeding are needed;Effort increase exclusive breastfeeding are still underway. This condition underlying this study to describe breastfeeding experiences in multiparas mother. This study using descriptive design trough cross-sectional. Data were collected on 107 respondents using breastfeeding study questionnaire that has been translated into Bahasa. The result on validity test shows that 35 questions are valid while reliability test shows that 13 questions are reliable. Result from breastfeeding experiences study shows that 88,8% multiparas mother has good experience. Mother with breastfeeding history has good breastfeeding experience. The instrument in this study can be use for survey study about breastfeeding experience and give more detailed information, additional questions about exclusive breastfeeding are needed;Effort increase exclusive breastfeeding are still underway. This condition underlying this study to describe breastfeeding experiences in multiparas mother. This study using descriptive design trough cross-sectional. Data were collected on 107 respondents using breastfeeding study questionnaire that has been translated into Bahasa. The result on validity test shows that 35 questions are valid while reliability test shows that 13 questions are reliable. Result from breastfeeding experiences study shows that 88,8% multiparas mother has good experience. Mother with breastfeeding history has good breastfeeding experience. The instrument in this study can be use for survey study about breastfeeding experience and give more detailed information, additional questions about exclusive breastfeeding are needed, Effort increase exclusive breastfeeding are still underway. This condition underlying this study to describe breastfeeding experiences in multiparas mother. This study using descriptive design trough cross-sectional. Data were collected on 107 respondents using breastfeeding study questionnaire that has been translated into Bahasa. The result on validity test shows that 35 questions are valid while reliability test shows that 13 questions are reliable. Result from breastfeeding experiences study shows that 88,8% multiparas mother has good experience. Mother with breastfeeding history has good breastfeeding experience. The instrument in this study can be use for survey study about breastfeeding experience and give more detailed information, additional questions about exclusive breastfeeding are needed]"

"Upaya peningkatan pemberian ASI Eksklusif masih terus dilakukan. Kondisi ini yang mendasari dilakukannya penelitian ini dengan tujuan untuk mengetahui gambaran pengalaman menyusui ibu multipara. Penelitian ini menggunakan disain deskriptif melalui pendekatan cross-sectional. Pengambilan data dilakukan pada 107 responden menggunakan Breastfeeding Study Questionnaire yang sudah diterjemahkan ke dalam Bahasa Indonesia. Hasil uji coba pada uji validitas didapatkan 35 pertanyaan bernilai valid sedangkan uji reliabilitas didapatkan 13 pertanyaan bernilai reliabel. Hasil penelitian pengalaman menyusui menunjukkan bahwa 88,8% ibu multipara memiliki pengalaman menyusui yang baik. Ibu multipara dengan riwayat menyusui sebelumnya memiliki pengalaman menyusui yang baik. Instrumen penelitian ini dapat digunakan sebagai instrumen untuk survei tentang pengalaman menyusui dan memberikan data yang lebih detil, hanya perlu ditambahkan pertanyaan mengenai menyusui eksklusif.

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Effort increase exclusive breastfeeding are still underway. This condition underlying this study to describe breastfeeding experiences in multiparas mother. This study using descriptive design trough cross-sectional. Data were collected on 107 respondents using breastfeeding study questionnaire that has been translated into Bahasa. The result on validity test shows that 35 questions are valid while reliability test shows that 13 questions are reliable. Result from breastfeeding experiences study shows that 88,8% multiparas mother has good experience. Mother with breastfeeding history has good breastfeeding experience. The instrument in this study can be use for survey study about breastfeeding experience and give more detailed information, additional questions about exclusive breastfeeding are needed."

"Malformasi fasial sebagai kondisi cacat bawaan terdiri dari labioskizis, palatoskizis dan labiopalatoskizis. Tujuan penelitian untuk mendeskripsikan pengalaman ibu dalam memberi nutrisi pada anak dengan malformasi fasial. Penelitian ini adalah penelitian kualitatif dengan pendekatan fenomenologi. Pemilihan partisipan secara purposive sampling, diikuti oleh 5 partisipan. Teknik pengumpulan data dengan cara wawancara mendalam dan catatan lapangan. Analisis data dengan menggunakan langkah-langkah dari Colaizzi. Terdapat 4 tema utama yang teridentifikasi yaitu: kendala dalam pemberian nutrisi, upaya orang tua, pemberian nutrisi, tantangan yang terjadi selama 2 minggu pascaoperasi. Saran yang diajukan untuk meningkatkan penyuluhan mengenai metode dan cara yang tepat dalam pemberian nutrisi pada ibu yang memiliki anak dengan malformasi fasial serta dibentuk sistem pendukung.

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Facial malformations as a condition of congenital malformations consisting of labioskizis, palatoskizis and labiopalatoskizis. The goal of research to describe the experience of the mother in giving nutrition in children with facial malformations. This study is a qualitative research with phenomenology approach. Selection of participants by purposive sampling, followed by 5 participants. Data collection techniques by in-depth interviews and field notes. Analysis of data by using the steps of Colaizzi. There are four main themes identified are: the constraints in the provision of nutrition, the efforts of parents, nutrition, challenges that occurred during the 2 weeks postoperatively. Suggestions put forward to improve the extension of the method and the proper way in the provision of nutrition in mothers of children with facial malformations and established support system."

"Human milk oligosaccharides (HMO) adalah karbohidrat yang terdiri dari 3–10 monosakarida dan tidak dapat dicerna oleh manusia. Fungsi HMO adalah prebiotik untuk mikrobiota usus. Metabolit yang dihasilkan mikrobiota adalah asam lemak rantai pendek (short chain fatty acid/SCFA). Sintesis HMO ditentukan oleh enzim fukosiltransferase 2 (FUT2) dan fukosiltransferase 3 (FUT3), yang disandi gen FUT2 dan FUT3. Polimorfisme gen FUT2 menyebabkan perbedaan HMO pada ASI. Ibu dengan kadar 2’fukosillaktosa (2’FL) ≥ 50 mg/L disebut ibu sekretor. Proporsi ibu sekretor bervariasi, karena polimorfisme gen FUT2 berbeda antar ras. Proporsi sekretor di Eropa > 80%, namun belum ada data di Indonesia. Penelitian ini bertujuan menganalisis proporsi sekretor dan polimorfisme gen FUT2, serta profil SCFA berdasarkan pasangan genotipe ibu-bayi. Penelitian menggunakan desain potong lintang, dilakukan di RSIA Bunda selama bulan Desember 2021–Juli 2022. Subjek penelitian adalah ibu berusia minimal 18 tahun, menyusui eksklusif, dan sehat. Ibu dengan ras Kaukasia di atas 2 generasi dieksklusi. Bayi dari ibu yang memenuhi kriteria inklusi automatis menjadi subjek penelitian dan dieksklusi bila bayi pernah mendapat antibiotik. Pemeriksaan HMO dilakukan saat bayi berusia 2–5 minggu, sedangkan SCFA feses bayi saat usia 4 minggu. Sekuensing coding region FUT2 dilakukan pada ibu dan bayi. Sebanyak 120 pasangan ibu-bayi memenuhi kriteria inklusi dengan proporsi ibu fenotipe sekretor 65,8% dan genotipe sekretor 65,8%. Hubungan antara genotipe FUT2 dan kadar 2’FL bermakna. Penelitian ini menemukan varian baru c.851C>G yang bersifat merusak berdasarkan prediksi in silico. Berdasarkan genotipe FUT2, diusulkan nilai ambang baru 2’FL 425,9 mg/L dengan nilai sensitivitas 98,7% dan spesifisitas 100%. Tidak terdapat hubungan antara proporsi relatif asetat, propionat, butirat dan genotipe ibu, genotipe bayi, maupun pasangan genotipe ibu-bayi.

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Human milk oligosaccharides (HMO) are complex carbohydrates consisting of 3–10 monosaccharides which is undigestible to human. HMO acts as a prebiotic for gut microbiota, which produce short chain fatty acid (SCFA). The synthesis of HMO is determined by the activity of fucosyltransferase 2 (FUT2) and fucosyltransferase 3 (FUT3) enzymes, which are encoded by the FUT2 and FUT3 genes. Polymorphisms of the FUT2 gene result in different secretor status. Mothers with 2'-fucosyllactose (2'FL) level of ≥ 50 mg/L are referred to as secretor. The proportion of secretor varies worldwide due to FUT2 polymorphisms among races. The proportion of secretor in Europe is generally > 80%, but there is no data on secretor status in Indonesia. Thus, baseline data about secretor phenotype and genotype status in Indonesia is needed. This study aimed to analyze the proportion of secretor and FUT2 gene polymorphism in Indonesia, as well as the stool SCFA profile based on the mother-infant dyad genotype.

This was a cross-sectional study conducted at Bunda Mother and Child Hospital from December 2021 to July 2022. The study subjects were healthy mothers aged at least 18 years, exclusively breastfeeding. Mothers with Caucasion ancestor from two generations above were excluded. Infants from eligible mothers were automatically included as study subjects but excluded if they had history of antibiotic administration. Breastmilk samples were obtained at infant’s age 2–5 weeks old, while infant’s stool at 4 weeks old. Sequencing of the entire coding region of FUT2 was performed for mothers and infants.

A total of 120 mother-infant dyads met the eligibility criteria. The proportion of secretor mother was 65.8%. Secretor genotypes were found in 65.8% of mothers. There was a significant association between secretor genotype and 2’FL level. A novel variant was identified, c.851C>G, which showed deleterious effect based on in silico analysis. A new threshold value of 425.9 mg/L for 2'FL is proposed, with 98.7% sensitivity and 100% specificity. There was no significant relationship between the relative proportion of acetate, propionate, butyrate, and valerate among the mother-infant’s genotype dyads."

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Bayi prematur memiliki masalah imaturitas dalam mengatur suhu tubuhnya sehingga membutuhkan energi untuk menjaga suhu tubuhnya tetap stabil. Kondisi ini menyebabkan kalori yang diperoleh bayi tidak terfokus pada pertumbuhannya. Penelitian ini bertujuan untuk mengetahui pengaruh Perawatan Metode Kanguru (PMK) durasi enam jam terhadap kenaikan berat badan bayi prematur dan ikatan emosional ibu dan bayi. Desain penelitian ini adalah pilot study randomized control trial dengan pendekatan crossover yang melibatkan 10 bayi prematur dan ibu. Randomisasi dilakukan dengan computer generated block randomization. Penelitian dilakukan sejak April sampai Juni 2024 di Rumah Sakit Universitas Indonesia dan Alia Hospital. Responden menerima intervensi PMK selama enam jam (kelompok intervensi) dan intervensi PMK selama satu jam (kelompok kontrol). Analisis hasil menggunakan uji Wilcoxon didapatkan rerata pertambahan berat badan bayi (gr/kg/hari) pada kelompok intervensi (H1 16,4, H2 13,3, p>0.05) dan pada kelompok kontrol (H1 9,1, H2 6,6, p>0.05), dengan pertambahan berat badan lebih banyak pada kelompok intervensi namun tidak signifikan. Sedangkan untuk rerata nilai ikatan emosional ibu dan bayi yang diukur sebelum dan sesudah PMK menggunakan Postpartum Bonding Questionnaire (PBQ), analisis hasil menggunakan uji t berpasangan didapat penurunan nilai pada kelompok intervensi (14,4-9,2, p>0.05) dan pada kelompok kontrol (11,3-11,4, p>0.05). Penurunan nilai PBQ lebih banyak pada kelompok intervensi yang artinya ikatan emosional ibu dan bayi makin erat namun tidak signifikan. Intervensi PMK selama enam jam tidak memberikan pengaruh yang signifikan terhadap peningkatan berat badan bayi prematur dan penguatan ikatan emosional antara ibu dan bayi.

Kata Kunci: crossover, kenaikan berat badan per hari, perawatan metode kanguru, uji pilot.

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Premature infants have immaturity problems in regulating body temperature, requiring energy to keep their body temperature stable. This condition causes the calories obtained by the baby not to focus on growth. This study aims to determine the effect of six-hour Kangaroo Mother Care (KMC) on weight gain in premature infants and mother-infant bonding. The design of this study is a pilot study randomized control trial with a crossover design involving 10 premature infants. The respondents received a six-hour KMC intervention (intervention group) and a one-hour KCM intervention (control group). The results of the study identified the average weight gain of infants in the intervention group (16.4, 13.3, p>0.05) and in the control group (9.1, 6.6, p>0.05), with more weight gain in the intervention group but not significantly. Meanwhile, for the average mother-infant bonding scores measured before and after KMC, in the intervention group (14.4, 9.2, p>0.05) and in the control group (11.3, 11.4, p>0.05). The six-hour PMK intervention does not have a significant effect on increasing weight gain in premature babies and on strengthening the emotional bond between mother and baby.

Keywords: crossover, kangaroo care method, kangaroo mother care, mother-infant bonding, premature infants"