Ditemukan 5 dokumen yang sesuai dengan query
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Developments in molecular modeling from experimental and computational techniques have enabled a wide range of biological applications. This timely summary reflects the recent advances in bridging novel algorithms and high performance computing with characterization of important biological processes, such as folding dynamics of key proteins. It encompasses the perspectives of leading experts on this transformation in molecular biology, illustrating with state of the art examples how molecular modeling approaches are being applied to critical questions ...
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Boca Raton: CRC press, 2015
570.285 MOL
Buku Teks Universitas Indonesia Library
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Over the past 40 years the field of molecular simulations has evolved from picosecond studies of isolated macromolecules in vacuum to studies of complex, chemically heterogeneous biological systems consisting of millions of atoms, with the simulation time scales spanning up to milliseconds. In Biomolecular Simulations: Methods and Protocols, expert researchers illustrate many of the methods commonly used in molecular modelling of biological systems, including methods for electronic structure calculations, classical molecular dynamics simulations and coarse-grained ...
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New York, NY: Humana Press : Springer, 2013
572.801 13 BIO
Buku Teks Universitas Indonesia Library
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The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can ...
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Weinheim, Germany: Wiley-VCH, 2003
e20394591
eBooks Universitas Indonesia Library
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This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries, this handbook demonstrates the best and fastest way to estimate those properties most relevant for the efficiency and pharmacokinetic performance of a drug molecule: lipophilicity,solubility, ...
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Weinheim, Germany: Wiley-VCH, 2008
e20395825
eBooks Universitas Indonesia Library
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This volume provides a comprehensive overview of current progress in the field by leading practitioners employing a variety of methods to model RNA 3D structures by homology, by fragment assembly, and by de novo energy and knowledge-based approaches ...
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Berlin: Springer-Verlag, 2012
e20417822
eBooks Universitas Indonesia Library
