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As a member of 18 glycosyl hydrolase(GH), chitotriosidase (Chitinase 1, CHIT1) is a true chitinase mainly expressed in the differentiated family polarized macrophages. CHIT1 is an immune mediator that digest the cell walls of chitin-containing eukaryotic pathogens, such as fungi. These However CHIT1 is dysregulated in granulomatous and fibrotic interstitial lung diseases characterized by inflammation and tissue remodeling. These include tuberclosis, sarcoidosis, idiopathic pulmonary fibrosis interstitial lung diseases(SSc-ILD) and chronic obstructive of lung diseases(COPD). CHIT1 ...
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AAIR 7:1 (2015)
Artikel Jurnal Universitas Indonesia Library