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Andika Dwiputra Djaja
Pengaruh pajanan extreme low frequency pulsed electromagnetic field dalam proses penyembuhan fraktur delayed union femur tikus sprague dawley kajian terhadap skor radiologi rust dan failure load dari pemberian gaya radiologi rust dan failure load dari pemberian gaya aksial = The effect of extreme low frequency pulsed electromagnetic field exposure in the healing process of sprague dawley mouse delayed union femur fracture study of rust radiology score and failure load of axial force
"Pendahuluan: Fraktur adalah salah satu penyakit yang menjadi permasalahan yang cukup besar dalam bidang kesehatan di dunia, terutama di negara berkembang. Secara umum fraktur dapat sembuh dengan normal. Pada beberapa kondisi, penyembuhan fraktur mengalami komplikasi seperti delayed union atau non union. Penyembuhan fraktur yang sukses merupakan suatu interaksi yang kompleks antara proses angiogenesis dan osteogenesis. Stimulus fisika berupa pajanan PEMF (pulsed electromagnetic fields) menunjukkan pengaruh proses osteogenesis baik dalam tahap perkembangan penulangan embrio dan tahap penyembuhan fraktur.
Tujuan: Penelitian ini bertujuan untuk mengetahui penyembuhan fraktur tulang delayed union pada hewan coba pada pemberian ELF-PEMF dengan melihat skor radiologi RUST dan Failure Load dari Pemberian Gaya Aksial.
Metode: Dilakukan uji eksperimental pada 56 hewan coba di Laboratorium Hewan Departemen Gizi, Fakultas Kedokteran Universitas Indonesia, dengan membandingkan nilai RUST Score dan Load Score pada kedua kelompok hewan coba.
Hasil: Penelitian dilakukan selama Agustus-September 2018. Tidak ada perbedaan karakteristik hewan coba pada penelitian. Didapati bahwa terdapat perbedaan bermakna Rust Score pada kelompok perlakuan dan kelompok kontrol pada setiap minggu pemeriksaan dan terdapat perbedaan bermakna Load Score pada minggu keempat dan kelima.
Kesimpulan: Penelitian ini menyimpulkan terdapat perbaikan penyembuhan fraktur delayed union pasca pemberian ELF-PEMF dilihat dari perbedaan nilai Rust score dan load score.
Background: Fracture is a major health problem in the world, especially in developing countries. Usually, fractures can heal normally. In some conditions, the healing process becomes delayed union or non union. Successful healing of fractures is a complex interaction between angiogenesis and osteogenesis. Physical stimuli such as exposure of PEMF (pulsed electromagnetic fields) influences the osteogenesis process both in the development stage of embryo reinforcement and the fracture healing stage.
Objective: The aim is to determine the healing of delayed union fractures in experimental animals after exposure to ELF-PEMF.
Methods: The experimental study was conducted at Department of Nutrition Animal Laboratory, Faculty of Medicine, Universitas Indonesia with 56 experimental rats. The study was conducted by comparing the RUST Score and Load Score values ​​in the two experimental animal groups
Result: The study was conducted during August-September 2018 There was no difference in animal characteristics in the study. There was significant difference in Rust Score in both groups in each examination week and there were significant differences in Load Score in the fourth and fifth weeks.
Conclusion: There was improvement in delayed union fracture healing after the administration of ELF-PEMF as seen from the difference in Rust score and load score."
Depok: Fakultas Kedokteran Universitas Indonesia, 2018
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Persepsi klien fraktur yang mengalami nyeri pada teknik relaksasi napas dalam yang diberikan untuk menurunkan nyeri
"Penelitian ini bertujuan untuk mengetahui persepsi klien fraktur yang mengalami nyeri pada teknik relaksasi napas dalam. Desain peneiitian yang digunakan adalah deskriptif sederhana. Responden di ambil di RSUPN Cipto Mangunkusumo IRNA A lantai H1 kiri dan lantai IV kanan dengan kriteria klien fraktur yang pemah melakukan napas dalam. Instrumen pengumpulan data berupa kuisioner dengan 4 data tentang demografi dan 17 pertanyaan tentang persepsi. Hasil penelitian menunjukkan 75% klien persepsinya positif dan 25% yang lain persepsinya negatif terhadap napas dalam. Keberhasilan napas dalam yang dilakukan oleh klien salah satunya dipengaruhi oleh keterlibatan perawat dalam memberikan penjelasan tentang cara melakukan napas dalam dengan tepat. Kondisi dilapangan menunjukkan. 42% perawat memberikan penjelasan kepada klien sedangkan 58% lainnya tidak. Penelitian ini akhirnya menyimpulkan bahwa persepsi klien fraktur pada napas dalam cukup positif."
Fakultas Ilmu Keperawatan Universitas Indonesia, 2001
TA5067
UI - Tugas Akhir  Universitas Indonesia Library
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Panjaitan, Troydimas
Efek inhibisi enzim konversi angiotensin pada proses penyembuhan fraktur model delayed union uji eksperimental pada tikus sprague dawley = Inhibition effect of angiotensin converting enzyme to fracture healing in delayed union model experimental study in sprague dawley rats
"Latar Belakang Hipertensi dan fraktur merupakan masalah kesehatan yang sering terjadi ACE inhibitor telah dilaporkan dapat mempromosikan diferensiasi osteoblas meningkatkan mineralisasi dan sekresi matriks tulang sehinga konsumsinya diharapkan mampu mempercepat penyembuhan Tujuan Penelitian bertujuan mengetahui efek pemberian ACE inhibitor terhadap proses penyembuhan fraktur model delayed union Metode Enam belas femur tikus yang dibuat sesuai model delayed union dibagi secara acak menjadi kelompok kontrol kelompok perlakuan Captopril dosis 4 mg kgBB kelompok perlakuan Captopril dosis 8 mg kgBB dan kelompok Captopril dosis 16 mg kgBB Evaluasi dilakukan pada minggu ke 4 secara radiologis foto polos dan histomorfometri Hasil Pada histomorfometri minggu ke 4 didapatkan peningkatan area penulangan yang bermakna terhadap kontrol p 0 033 terutama pada pemberian Captopril dosis 8 mg kgBB p 0 008 dan dosis 16 mg kgBB p 0 015 Penurunan area fibrosa yang bermakna terhadap kontrol p 0 042 terjadi pada Captopril dosis 4 mg kgBB p 0 020 dan dosis 8 mg kgBB p 0 012 Secara radiologis didapatkan peningkatan skor RUST semua kelompok perlakuan yang bermakna terhadap kontrol p 0 021 Kesimpulan Pemberian Captopril dapat menstimulasi proses penyembuhan fraktur pada model delayed union secara radiologis dan histomorfometri Captopril dosis 8 mg kgBB menunjukkan efek yang paling signifikan dalam proses penyembuhan fraktur."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Grace Boaz
Hasil Fungsional Operasi ORIF pada Pasien Fraktur Midface di Divisi Bedah Plastik Rumah Sakit Cipto Mangunkusumo Tahun 2009-2014 = Functional Outcome of ORIF Surgery on Midface Fracture Patients in Plastic Surgery Division Cipto Mangunkusumo Hospital from 2009-2014
"[Pendahuluan:
Fraktur yang mengenai midface akan menyebabkan gangguan fungsi baik fungsi mata maupun oklusi. Walaupun angka kejadian fraktur midface cukup tinggi, terdapat gangguan fungsional, dan membutuhkan biaya yang besar untuk tatalaksana menggunakan mini plate dan screw, tidak ada informasi mengenai hasil fungsional setelah tatalaksana fraktur midface.
Metode:
Data mengenai status fungsional pasien dengan fraktur midface sebelum operasi ORIF didapatkan dari data rekam medis dan data setelah operasi ORIF didapatkan dari pemeriksaan objektif dan subjektif. Status fungsional meliputi diplopia, gerakan bola mata, maloklusi, dan gangguan nervus fasialis dan nervus infraorbita.
Hasil:
Semua pasien yang dievaluasi menunjukkan perbaikan status fungsional setelah operasi ORIF.
Kesimpulan:
Pasien dengan fraktur midface yang telah menjalani operasi ORIF di Divisi Bedah Plastik Rumah Sakit Cipto Mangunkusumo menunjukkan adanya perbaikan pada diplopia, gerakan bola mata, oklusi, dan fungsi nervus fasialis dan infraorbita pada evaluasi jangka panjang.;Background:
Fractures involving the midface present more challenges due to the impairment on function both occlusion and visual function. In spite of the high number of occurrence, high impact to the impairment on function, and high cost in the treatment due to relatively expensive hardware required (mini plate and screw), there is inadequate information about the outcome after treating midface fracture.
Methods:
Data on functional status of patients with midface fracture before ORIF surgery collected from medical records and data after ORIF surgery gathered objectively and subjectively. Functional status including diplopia, eye motility, cranial facial nerve impairment, infraorbita nerve impairment and malocclusion.
Results:
All of the patients that have been evaluated was showing improvement in total functional status after treatment with ORIF surgery.
Conclusion:
Midface fracture patients underwent ORIF surgery in Plastic Surgery Division, Cipto Mangunkusumo hospital, resulted in the recovery of eye motility function, diplopia, malocclusion and facial and infraorbital nerve impairment at longterm evaluation., Background:
Fractures involving the midface present more challenges due to the impairment on function both occlusion and visual function. In spite of the high number of occurrence, high impact to the impairment on function, and high cost in the treatment due to relatively expensive hardware required (mini plate and screw), there is inadequate information about the outcome after treating midface fracture.
Methods:
Data on functional status of patients with midface fracture before ORIF surgery collected from medical records and data after ORIF surgery gathered objectively and subjectively. Functional status including diplopia, eye motility, cranial facial nerve impairment, infraorbita nerve impairment and malocclusion.
Results:
All of the patients that have been evaluated was showing improvement in total functional status after treatment with ORIF surgery.
Conclusion:
Midface fracture patients underwent ORIF surgery in Plastic Surgery Division, Cipto Mangunkusumo hospital, resulted in the recovery of eye motility function, diplopia, malocclusion and facial and infraorbital nerve impairment at longterm evaluation.]"
Fakultas Kedokteran Universitas Indonesia, 2014
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Marpaung, Yanthi
Analisis praktik klinik Keperawatan Kesehatan Masyarakat Perkotaan (KKMP) pada pasien fraktur radius ulna di Rumah Sakit Cipto Mangunkusumo = The analysis of clinical practice of Urban Nursing on patient with radius ulna fracture at Cipto Mangunkusumo Hospital
"[ABSTRAK
Keperawatan kesehatan masyarakat perkotaan merupakan bagian keperawatan
komunitas yang memfokuskan pelayanan pada penyelesaian masalah kesehatan.
Masyarakat perkotaan memiliki karakteristik yaitu padat penduduk, tingginya angka
pertumbuhan kendaraan bermotor, dan mobilitas yang tinggi. Karakteristik ini
mempengaruhi pola aktivitas masyarakat, salah satunya penggunaan alat transportasi
untuk efektivitas waktu. Faktor mobilitas yang tinggi, tingginya angka pertumbuhan
kendaraan, dan ketidakdisiplinan pengemudi kendaraan menimbulkan risiko
kecelakaan yang berdampak pada masalah kesehatan salah satunya fraktur. Selama
praktik di ruang bedah RSUP Cipto Mangunkusumo penulis mengambil kasus klien
fraktur radius ulna dengan ansietas tinggi selama hospitalisasi. Penulis menganalisis
salah satu tindakan keperawatan untuk mengurangi ansietas klien.ABSTRACT Urban health nursing is part of the community nursing service that focuses on
addressing health problems in urban areas. Urban community is characterized by
dense population, a high rates in the growth of motor vehicles, and high mobility of
the society. These characteristics affect the pattern of community activities, one of
which is in the use of motor vehicle for transportation. High mobility factor, a high
rates of growth in motor vehicle and inappropriate behavior may increase the risk of
accidents that may impact on health, one of which is a fracture. During the practice in
the surgery department of Cipto Mangunkusumo Hospital, the author cared for the
patient with fracture of the radius ulna with high anxiety during hospitalization. The
authors analyze done of the nursing intervention provided to reduce client anxiety;Urban health nursing is part of the community nursing service that focuses on
addressing health problems in urban areas. Urban community is characterized by
dense population, a high rates in the growth of motor vehicles, and high mobility of
the society. These characteristics affect the pattern of community activities, one of
which is in the use of motor vehicle for transportation. High mobility factor, a high
rates of growth in motor vehicle and inappropriate behavior may increase the risk of
accidents that may impact on health, one of which is a fracture. During the practice in
the surgery department of Cipto Mangunkusumo Hospital, the author cared for the
patient with fracture of the radius ulna with high anxiety during hospitalization. The
authors analyze done of the nursing intervention provided to reduce client anxiety;Urban health nursing is part of the community nursing service that focuses on
addressing health problems in urban areas. Urban community is characterized by
dense population, a high rates in the growth of motor vehicles, and high mobility of
the society. These characteristics affect the pattern of community activities, one of
which is in the use of motor vehicle for transportation. High mobility factor, a high
rates of growth in motor vehicle and inappropriate behavior may increase the risk of
accidents that may impact on health, one of which is a fracture. During the practice in
the surgery department of Cipto Mangunkusumo Hospital, the author cared for the
patient with fracture of the radius ulna with high anxiety during hospitalization. The
authors analyze done of the nursing intervention provided to reduce client anxiety, Urban health nursing is part of the community nursing service that focuses on
addressing health problems in urban areas. Urban community is characterized by
dense population, a high rates in the growth of motor vehicles, and high mobility of
the society. These characteristics affect the pattern of community activities, one of
which is in the use of motor vehicle for transportation. High mobility factor, a high
rates of growth in motor vehicle and inappropriate behavior may increase the risk of
accidents that may impact on health, one of which is a fracture. During the practice in
the surgery department of Cipto Mangunkusumo Hospital, the author cared for the
patient with fracture of the radius ulna with high anxiety during hospitalization. The
authors analyze done of the nursing intervention provided to reduce client anxiety]"
Fakultas Ilmu Keperawatan Universitas Indonesia, 2015
PR-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Sahrudin
Analisis praktik keperawatan kesehatan masyarakat perkotaan pada pasien post Open Reduction Internal Fixation (ORIF) fraktur tibia fibula tertutup dengan intervensi ambulasi di Ruang Angrek tengah kanan RSUP Persahabatan. = Analysis of professional practice of urban health nursing in patients post Open Reduction Internal Fixation (ORIF) tibia fibula closed fracture with ambulation intervention in Anggrek tengah kanan ward At Persahabatan Hospital.
"[ABSTRAK
Mayoritas populasi masyarakat dunia menepati daerah perkotaan. Akibat dari
kepadatan penduduk di daerah perkotaan timbul masalah yang berkaitan dengan lalulintas
salah satunya adalah tingginya jumlah kecelakaan lalu-lintas. Fraktur
merupakan salah satu akibat dari kecelakaan lalu-lintas yang memerlukan
penanganan segera untuk mempertahankan anatomi dan fungsi tubuh seperti semula.
Pasien post ORIF tibia dan fibula memerlukan tindakan ambulasi untuk
memperlancar sistem peredaran darah pasien. Karya ilmiah ini bertujuan untuk
menganalisis intervensi keperawatan ambulasi yang diberikan pada pasien post ORIF
fraktur tibia dan fibula di Ruang Angrek tengah kanan RSUP Persahabatan. Pasien
yang dilakukan tindakan ambulasi secara bertahap adalah pasien dapat terhindar dari
komplikasi akibat vaskularisasi yang buruk, dapat mempercepat proses penyembuhan
serta memperpendek masa perawatan pasien di rumah sakit.ABSTRACT The majority of world's population lived in urban areas. As a result of population
density in urban areas, problem relating to traffic is the high number of traffic
accident. Fracture is one result of a traffic accident that requires immediate action to
preserve the anatomy and function of the body as before. The tibia and fibula
fractures post ORIF patient requires ambulation intervention to expedite the
circulatory system of the patient. This scientific work aimed to analyze ambulation of
the nursing intervention which given to tibia and fibula fractures post ORIF patient
at Angrek tengah kanan ward RSUP Persahabatan. The patient who performed the
gradually ambulation intervention can avoid the complications due to poor
vascularization, accelerate the healing process, and shorten patient care in hospital.;The majority of world's population lived in urban areas. As a result of population
density in urban areas, problem relating to traffic is the high number of traffic
accident. Fracture is one result of a traffic accident that requires immediate action to
preserve the anatomy and function of the body as before. The tibia and fibula
fractures post ORIF patient requires ambulation intervention to expedite the
circulatory system of the patient. This scientific work aimed to analyze ambulation of
the nursing intervention which given to tibia and fibula fractures post ORIF patient
at Angrek tengah kanan ward RSUP Persahabatan. The patient who performed the
gradually ambulation intervention can avoid the complications due to poor
vascularization, accelerate the healing process, and shorten patient care in hospital.;The majority of world's population lived in urban areas. As a result of population
density in urban areas, problem relating to traffic is the high number of traffic
accident. Fracture is one result of a traffic accident that requires immediate action to
preserve the anatomy and function of the body as before. The tibia and fibula
fractures post ORIF patient requires ambulation intervention to expedite the
circulatory system of the patient. This scientific work aimed to analyze ambulation of
the nursing intervention which given to tibia and fibula fractures post ORIF patient
at Angrek tengah kanan ward RSUP Persahabatan. The patient who performed the
gradually ambulation intervention can avoid the complications due to poor
vascularization, accelerate the healing process, and shorten patient care in hospital., The majority of world's population lived in urban areas. As a result of population
density in urban areas, problem relating to traffic is the high number of traffic
accident. Fracture is one result of a traffic accident that requires immediate action to
preserve the anatomy and function of the body as before. The tibia and fibula
fractures post ORIF patient requires ambulation intervention to expedite the
circulatory system of the patient. This scientific work aimed to analyze ambulation of
the nursing intervention which given to tibia and fibula fractures post ORIF patient
at Angrek tengah kanan ward RSUP Persahabatan. The patient who performed the
gradually ambulation intervention can avoid the complications due to poor
vascularization, accelerate the healing process, and shorten patient care in hospital.]"
Fakultas Ilmu Keperawatan Universitas Indonesia, 2015
PR-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Annas Sumeru
Analisis praktik residensi keperawatan medikal bedah pada pasien dengan multiple fraktur dan sindroma kompartemen dengan penerapan model teori adaptasi roy di Rumah Sakit Umum Pusat Fatmawati Jakarta dan Rumah Sakit Orthopedi Prof Soeharso Surakarta = Analysis of medical surgical nursing clinical practise of residency on patient with multiple fracture and compartment syndrome using roy adaptation model approach in RSUP Fatmawati Jakarta and RSOP Prof Soeharso Surakarta
"Sistem muskuloskeletal memberikan perlindungan terhadap organ vital tubuh gangguan pada sistem tersebut memberikan dampak serius bagi kondisi kesehatan seseorang kualitas hidup keuangan kenyamanan fisik dan kesehatan psikologis Penyakit dan cidera di Indonesia paling banyak merupakan kejadian patah tulang Pada kondisi patah tulang dapat mengakibatkan insufisiensi vaskuler dan kompresi saraf serta sindroma kompartemen Perawat spesialis medikal bedah berperan penting dalam penatalaksanaan asuhan keperawatan melalui pendekatan Model Adaptasi Roy pada kasus multipel fraktur dan sindroma kompartemen penerapan pemberian edukasi singkat dan latihan relaksasi nafas dalam sebagai upaya menurunkan nyeri pada klien post operasi ORIF Open Reduction Intra Fixation serta peran sebagai inovator melalui pengembangan program SBAR Situation Background Assessment Recommendation dalam handover perawat ruangan Hasil analisis praktik menunjukkan bahwa Model Adaptasi Roy sesuai dalam pengelolaan asuhan keperawatan pada multipel fraktur dan sindroma kompartemen Pemberian edukasi singkat dan latihan relaksasi nafas dalam mampu menurunkan tingkat nyeri secara efektif hingga hari ke 7 setelah operasi pemasangan ORIF Pengembangan program SBAR dilakukan melalui pembuatan panduan berdasarkan kasus yang sering terjadi di ruangan bedah orthopedi RSUP Fatmawati sehingga melalui panduan tersebut perawat dapat melakukan timbang terima menggunakan SBAR khususnya pada pasien dengan gangguan muskuloskeletal Kata kunci Model Adaptasi Roy fraktur multipel Edukasi singkat dan nafas dalam SBAR Depok 21 Agustus 2015 Mengetahui Suvervisor Utama Mahasiswa Dr Debie Dahlia S Kp MHSM Annas Sumeru.
The musculoskeletal system provides protection against the body 39 s vital organs disturbances in the system create serious implications for a person 39 s health condition quality of life financial physical comfort and psychological health Disease and injury in Indonesia mostly caused by incidence of fractures Fractures could possibly lead to vascular insufficiency and nerve compression as well as compartment syndrome Medical surgical nurse specialist plays an important role in the management of nursing care by Roy Adaptation Model approach in the case of multiple fractures and compartment syndrome the application of brief educational and breathing relaxation exercises to reduce pain level of patient attempt ORIF Open Reduction Intra Fixation as well as a role as innovator through the development of SBAR Situation Background Assessment Recommendation programs for nurse handover The results of the analysis of practices shows that Roy Adaptation Model fit in the management of nursing care in multiple fractures and compartment syndrome Giving a brief educational and breathing relaxation exercises able to effectively reduce pain until the 7th day after ORIF surgery SBAR program development is done through the creation of guidelines based on the case that often occur in orthopedic ward of RSUP Fatmawati so that through the guidance of nurses can using SBAR particularly in patients with musculoskeletal disorders Keywords Roy Adaptation Model multiple fracture brief educational and breathing relaxation exercise SBAR Depok 21 Agustus 2015 Mengetahui Suvervisor Utama Mahasiswa Dr Debie Dahlia S Kp MHSM Annas Sumeru."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2015
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Solomon, Louis
Apley and Solomon's concise system of orthopaedics and trauma
"Summary:
Apley and Solomon's Concise System of Orthopaedics and Trauma is firmly established as the leading introductory textbook of orthopaedic practice and the principles of fracture management. Praised in previous editions for its systematic approach, balanced content and easy-to-read style, the fourth edition has been brought fully up to date with more than 800 illustrations, many new to this edition, providing an invaluable pictorial account of this highly visual subject. Key features of the Fourth Edition: Reflects the changing pattern of musculoskeletal disease around the world Focuses on actua"
Hoboken: CRC Press, 2014
617.5 SOL a
Buku Teks SO  Universitas Indonesia Library
cover
Rr. Prasetyanugraheni Kreshanti
Pengembangan Desain Dan Pengujian Plat Tiga Dimensi Interlocking Sistem 2.0 Untuk Tata Laksana Fraktur Mandibula = Development and Evaluation of Novel Interlocking Three-Dimensional Plate 2.0 System for Managing Mandibular Fractures
"Fraktur mandibula merupakan fraktur kraniomaksilofasial yang paling umum dan seringkali menyebabkan gangguan mengunyah. Tata laksana definitif fraktur mandibula adalah reduksi terbuka dan fiksasi interna menggunakan plat dan sekrup sistem 2.0, seperti plat tiga dimensi (3D). Namun, desain plat 3D konvensional memiliki keterbatasan karena bentuknya yang tidak dapat diubah, sehingga sulit menghindari garis fraktur atau struktur anatomi penting seperti akar gigi dan saraf saat melakukan pemasangan sekrup. Untuk mengatasi masalah ini, diperlukan desain plat 3D yang dapat diubah konfigurasinya. Oleh karena itu, dikembangkanlah desain plat 3D interlocking. Berbeda dengan plat 3D yang sudah ada selama ini, plat 3D interlocking memiliki kebaruan yaitu plat ini dapat dirangkai dari beberapa jenis plat dengan menumpuk 2 buah plat menjadi 1 kesatuan plat. Sambungan kedua buah plat ini tidak menambah ketebalan plat dan dapat diubah konfigurasinya dengan menyesuaikan sudut antara plat horizontal dan plat vertikal. Finite Element Analysis (FEA) dilakukan untuk menentukan kelayakan desain plat 3D interlocking. Setelah FEA memastikan kelayakan desain, purwarupa yang diproduksi dilakukan pengujian biomekanik menggunakan sepuluh mandibula kambing untuk menilai kekuatan mekanik dan stabilitas plat 3D interlocking. Biokompatibilitas dan penyembuhan tulang dievaluasi dalam uji hewan coba yang melibatkan 28 kambing. Biokompatibilitas dinilai dengan mengevaluasi respons inflamasi dari uji radiologik dan histopatologik (pewarnaan Hematoxylin-Eosin). Penyembuhan tulang dinilai melalui berbagai metode, termasuk uji radiologik yang mengukur kepadatan tulang, uji histopatologik menggunakan pewarnaan Mason Trichome, dan analisis penanda tulang melalui imunohistokimia dan ELISA. Selain itu, uji kemudahan penggunaan dilakukan dengan sembilan Spesialis Bedah Plastik Rekonstruksi dan Estetik untuk menilai tingkat kenyamanan dan durasi yang diperlukan untuk mengaplikasikan plat pada model mandibula sintetik. Uji biomekanik juga dilakukan pada uji kemudahan penggunaan sebagai komponen evaluasi objektif. Dalam uji biomekanik, plat 3D interlocking menunjukkan kemampuan yang lebih baik dalam mempertahankan stabilitas fraktur yang memungkinkan gerakan mikro yang terkendali. Selanjutnya, uji biokompatibilitas menunjukkan bahwa kelompok plat 3D interlocking menghasilkan reaksi jaringan dan respons inflamasi yang lebih rendah dibandingkan plat tolok ukur pada uji hewan coba. Selain itu, plat 3D interlocking juga mempercepat proses penyembuhan tulang, terbukti dari peningkatan bermakna dalam pembentukan dan kepadatan tulang pada uji hewan coba. Hasil uji kemudahan penggunaan menunjukkan bahwa plat 3D interlocking dapat digunakan dengan mudah seperti halnya plat tolok ukur. Secara keseluruhan, plat 3D interlocking menunjukkan potensi sebagai alternatif yang layak untuk tata laksana fraktur mandibula.
Mandibular fractures are the most common craniomaxillofacial fractures, often resulting in mastication disturbances. Mandibular fracture management typically involves the use of 2.0 system plates and screws, such as three-dimensional (3D) plates. However, the conventional 3D plate designs for mandibular fracture management have limitations. Their fixed shape makes it challenging to avoid fracture lines or vital anatomical structures, such as dental roots and nerves when placing screws. A 3D plate design that allows for configuration changes is needed to address this issue. Therefore the interlocking 3D plate was developed. This novel design features components that can be adjusted to avoid critical anatomical structures and fracture lines while still offering the stability of a 3D plate, enhancing its utility in mandibular fracture management. Finite element analysis was performed to establish the feasibility of the interlocking 3D plate design. Once that was established, biomechanical evaluation was conducted using ten goat mandibles to assess the mechanical strength and stability of the interlocking 3D plate. Biocompatibility and bone healing properties were evaluated in an animal study involving 28 goats. Biocompatibility was assessed by evaluating inflammatory responses from radiological and histopathological (Hematoxylin-Eosin staining) study. Bone healing properties were assessed through various methods, including radiological study measuring bone density, histopathological study using Mason Trichome staining, and analyzing bone markers through immunohistochemistry and ELISA. Additionally, usability study were conducted with nine plastic surgeons to assess the level of comfort and the duration required to apply the plate on a synthetic mandibular model. These findings were correlated with biomechanical test results. The biomechanical evaluation revealed that the interlocking 3D plate design better-maintained fracture stability while allowing controlled micro-movement. Regarding biocompatibility, the interlocking 3D plate exhibited better results than the standard plate, as indicated by lower tissue reaction and inflammatory response in animal study. The interlocking 3D plate also facilitated faster bone healing, with significant bone formation and bone density improvements in animal study. Usability study demonstrated that the interlocking 3D plate was as easy to use as the standard plate, with no significant differences in application time. Overall, the interlocking 3D plate demonstrates significant potential as a viable alternative for managing mandibular fractures."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
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UI - Disertasi Membership  Universitas Indonesia Library