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"Latar Belakang: Dislipidemia merupakan masalah penting dalam kesehatan masyarakat yang jarang disadari dan dapat menyebabkan beberapa komplikasi fatal. Di Indonesia, belum banyak dilakukan penelitian tentang hubungan dislipidemia dengan faktor-faktor yang bepengaruh. Tujuan: Mengetahui prevalensi dislipidemia pada masyarakat kota Ternate dan hubungan antara perilaku masyarakat dengan prevalensi dislipidemia. Metode: Sebuah studi potong lintang dilakukan pada penduduk berumur lebih dari 20 tahun di 3 kecamatan kota Ternate. Wawancara responden dilakukan pada tanggal 25-31 Mei 2008 sementara pemeriksaan fisik dan laboratoris dilakukan pada tanggal 26 Mei-3 Juni 2008. Pengambilan sampel dilakukan dengan metoda multi-stage-random-sampling. Hasil: Sebanyak 502 responden berhasil diwawancarai. Prevalensi dislipidemia didapatkan sebesar 59,2%. Terdapat hubungan bermakna antara kebiasaan mengudap jajanan pasar (p=0,013) dengan prevalensi dislipidemia. Tidak ditemukan hubungan bermakna antara pernikahan dengan kerabat dekat, aktivitas fisik, kebiasaan merokok dan konsumsi alkohol dengan prevalensi dislipidemia. Kesimpulan: Prevalensi dislipidemia pada masyarakat kota Ternate cukup tinggi. Hal itu memiliki hubungan dengan pola makan.

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Background: Dyslipidemia are critical issues in public health that were rarely realized and may cause some fatal complications. In Indonesia, there has not been done much research on the relationship of dyslipidemia with confounding factors. Objective: To investigate the prevalence of dyslipidemia in Ternate city community and the relationship between the behavior and prevalence of dyslipidemia. Method: A cross-sectional study was done at population aged over 20 years in 3 districts of Ternate city. Interview on respondents conducted on May 25st-31st 2008 while laboratory and physical examination conducted on 26 May-3 June 2008. Sampling is done with a multi-stage-random-sampling method. Results: There were 502 respondents successfully interviewed. Prevalence of dyslipidemia was 59.2%. There are significant relationships between the snacking habit (p=0.013) with prevalence of dyslipidemia. No significant relationships found between marriage to close relatives, physical activity, smoking habits and alcohol consumption with the prevalence of dyslipidemia. Conclusion: Prevalence of dyslipidemia in the community of Ternate city is quite high. Indeed, it has a relationship with the pattern of eating."

"Latar Belakang. Aktivitas fisik yang kurang aktif merupakan salah satu faktor risiko terjadinya dislipidemia. Pegawai perkantoran merupakan pekerjaan dengan aktivitas fisik rendah. Program wellness diketahui dapat meningkatkan aktivitas fisik dan kebugaran kardiorespirasi di tempat kerja. Tujuan penelitian ini adalah untuk mengetahui penerapan program wellness terhadap kepatuhan menjalankan latihan fisik aerobik dan perubahan profil lipid darah pada pegawai pemerintah. Metode. Desain penelitian ini adalah randomized controlled trial RCT yang dilakukan selama 6 minggu. Sebanyak 30 orang subjek penelitian yang merupakan pegawai pemerintah dibagi menjadi 2 kelompok. Kelompok perlakuan n=15 mendapat program wellness secara intensif sedangkan kelompok kontrol n=15 hanya mendapat edukasi. Dinilai tingkat kepatuhan menjalankan latihan fisik aerobik serta kadar profil lipid antara dua kelompok. Hasil. Kelompok perlakuan lebih patuh menjalankan latihan fisik aerobik dibandingkan kelompok kontrol OR=42,2, IK95 5,1-346,9 . Terdapat perbedaan rerata kadar kolesterol total sesudah perlakuan yang bermakna antara kelompok perlakuan 181,4 23,1 dan kontrol 183,5 25,3 dengan nilai p=0,011. Tidak ada perbedaan rerata bermakna pada kadar High Density Lipoprotein, Low Density Lipoprotein dan trigliserida sesudah perlakuan antara kedua kelompok. Simpulan. Program wellness dapat meningkatkan kepatuhan menjalankan latihan fisik aerobik dan menurunkan kadar kolesterol total dalam darah.

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Background. Lack of physical activity is a risk factor for dyslipidemia. Office workers are jobs with low physical activity. Wellness programs are known to increase physical activity and cardiorespiratory in the workplace. This study aims to know the effect of a wellness program implementation on the aerobic physical exercise adherence and blood lipid profile change of the government employee.

Methods. This study is randomized controlled trial RCT design that was conducted for 6 weeks. A total of 30 subjects who are government employees is allocated into 2 groups. Intervention group n 15 received intensive wellness program while control group n 15 only get education. Adherence to exercise and lipid profile levels between two groups were compared.

Result. Intervention group was more adherent to do aerobic exercise than control group OR 42,2, CI95 5,1 346,9 . There was a significant mean difference of total cholesterol level after intervention between intervention group 181,4 23,1 and control group 183,5 25,3 with p value 0,011. There were no significant mean difference p 0.05 in High Density Lipoprotein, Low Density Lipoprotein and triglycerides levels after intervention in both group.

Conclusion. Wellness programs can enhance aerobic exercise adherence and decrease blood total cholesterol level. "

"Penelitian ini bertujuan untuk mengetahui prevalensi dislipidemia pada ibu menyusui dan hubungannya dengan status seng. Dislipidemia, yaitu abnormalitas pada kadar profil lipid, merupakan salah satu faktor risiko dari penyakit tidak menular, khususnya penyakit jantung koroner. Keadaan dislipidemia pada perempuan dapat diakibatkan oleh perubahan metabolisme lipid saat kehamilan yang dapat terus menetap hingga masa menyusui. Seng merupakan salah satu mikronutrien yang dapat mempengaruhi kadar profil lipid dan kadarnya ditemukan rendah pada ibu menyusui. Penelitian ini merupakan penelitian potong lintang yang dilakukan di Puskesmas Cilincing dan Grogol Petamburan, Jakarta pada bulan Februari-April 2019. Sebanyak 75 subjek ibu menyusui 3-6 bulan postpartum berusi 20-35 tahun direkrut menggunakan metode sampel konsekutif. Data karakteristik dasar dan asupan nutrien diambil melalui wawancara. Pemeriksaan laboratorium dilakukan untuk mengetahui kadar profil lipid dan seng serum. Kriteria dislipidemia menggunakan acuan NCEP ATP III. Hasil penelitian didapatkan prevalensi dislipidemia 69,3% (n=52) dengan 36,5% (n=19) nya akibat kadar HDL yang rendah. Sebanyak 77,3% (n=58) subjek tidak mendapatkan asupan seng yang cukup dan berdasarkan kadar seng serum ditemukan 78,7% (n=59) subjek mengalami defisiensi seng. Tidak didapatkan hubungan bermakna antara status seng dengan dislipidemia, baik berdasarkan status asupan seng maupun status seng serum.This study was conducted to determine the prevalence of dyslipidemia in lactating mother and its relationship with zinc status. Dyslipidemia, an abnormality in lipid profile, is one of major risk factor for non communicable disease, such as coronary heart disease. Physiologic condition, such as pregnancy, may caused physiologic changes, including alterations in lipid profile on healthy, pregnant women which may persist after delivery. Zinc may influence serum lipid profil and its level was found to be low in lactating mothers. This was a cross sectional study conducted in Puskesmas Kecamatan Cilincing, North Jakarta and Puskesmas Kecamatan Grogol Petamburan, West Jakarta between February and April 2019. Seventy five lactating mothers at 3-6 months postpartum aged 20-35 years old were recruited using consecutive sampling method. Interview were performed to collect basic characteristic and evaluate nutrient intake. Weight and height were measured to calculate body mass index (BMI). Blood sample was obtained after 10-12 hour overnight fast to analyze serum lipid profile and zinc serum. Dyslipidemia was diagnosed using NCEP ATP III criteria. The prevalence of dyslipidemia was 69.3% (n=52) with 38.5% (n=19) of them due to low HDL level. Approximately 77.3% (n=58) subjects had low zinc intake and zinc deficiency was found 78.7% (n=59) subjects. Zinc status, both based on intake and serum, showed no significant relationship with dyslipidemia."

"Chitosan, a cationic polysaccharide derived from the cuticle of crustacean, ispromoted as a remedy to reduce fat absorption, might help reducing body weight andnormalizing lipid profile without any harmful effect. However, its clinical effectivenessfor this condition remains disputed. Therefore, study on that matters are required toinvestigate the effect of chitosan on human body weight and lipid profile. This research report is divided in three sequential parts. Part 1 contentscomprehensive reviews on the background and rationale of the study, problemstatements, literature review, causal model, objectives of the study and the hypotheses. Part 2 covers manuscript for publication entitled ?The effects of chitosan onbody weight, body fat and lipid profiles among Vietnamese overweight obesitydyslipdaemia female teachers? that presents the main findings of the study. Themanuscript is written in accordance with the ?Instructions for Authors? of PeerReviewed Journal ?Asia Pacific Journal of Clinical Nutrition?. Part 3 consists of detailed questionnaire, methodology, and other importantresults that are not included in manuscript. Form used for inform consent as well asreferences are also attached. Hopefully, this research report will give more information for better understandof the emerging issues and give benefit for future studies."

"Latar belakang: Lingkungan kerja pilot dengan paparan radiasi kosmik dan hipoksia dapat menyebabkan gangguan metabolisme lemak yang terlihat pada pemeriksaan profil lipid darah. Dislipidemia merupakan faktor risiko utama aterosklerosis yang menyebabkan serangan jantung sehingga dapat mengancam keselamatan penerbangan. Tujuan dari penelitian ini adalah untuk mengetahui faktor - faktor risiko dislipidemia pada pilot sipil di Indonesia. Metode: Penelitian ini menggunakan desain potong lintang dengan consecutive sampling pada pilot sipil yang memeriksakan kesehatan berkala di Balai Kesehatan Penerbangan. Data profil lipid didapatkan dari pengisian kuesioner. Variabel yang dianalisis adalah jam terbang total, asupan makanan, Indeks Massa Tubuh IMT, kebiasaan merokok, dan latihan fisik. Hasil: Terdapat 128 responden yang memenuhi kriteria inklusi dan bersedia mengikuti penelitian. Didapatkan prevalensi dislipidemia 61,7 dengan mayoritas kadar HDL rendah sebesar 57. Faktor - faktor dominan yang berhubungan dengan dislipidemia adalah obesitas dan asupan makanan tidak sesuai. Pilot sipil dengan asupan makanan tidak sesuai meningkatkan risiko dislipidemia sebesar 2x lipat dibandingkan pilot sipil dengan asupan makanan sesuai OR= 2,44; IK 95 = 1,15 - 5,18; p= 0,02. Jika dibandingkan dengan pilot sipil dengan IMT normal, pilot obese berisiko 4x lipat terjadi dislipidemia OR= 4,21; IK 95 = 1,48 - 11,99; p= 0,007. Simpulan: Asupan makanan tidak sesuai dan obesitas berhubungan dengan terjadinya dislipidemia pada pilot sipil di Indonesia.

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Background: Pilot's occupational environment with cosmic radiation and hypoxia exposure can influence lipid metabolism which reflected in blood lipid profile. Dyslipidemia is the main risk for atherosclerosis that lead to heart attack which can threats flight safety. The purpose of this study was to identify associated risk factors for dyslipidemia among civilian pilot in Indonesia.

Methods: This was cross - sectional study using consecutive sampling among civilian pilots who went to periodic medical check - up in Balai Kesehatan Penerbangan. Blood lipid profiles data was obtained from questionnaire. Variables that went into analyze are total flight hours, food intake, Body Mass Index BMI, smoking habit, and physical activity.

Results: There were 128 respondents who met the inclusion criteria and willing to participate. The dyslipidemia prevalence was 61,7 with low - HDL index was the highest up to 57. Obesity and inapproriate food intake were dominant risk factors that associated with dyslipidemia. Civilian pilots with inapproriate food intake compared with those who had appropriate food intake had 2 - fold risk to have dyslipidemia OR 2,44 95 CI 1,15 - 5,18 p 0,02. Obese pilots had 4 - fold risk to have dyslipidemia compared with those pilots with normal BMI OR 4,21 IK 95 1,48 - 11,99 p 0,007.

Conclusion: Inapropriate food intake and obesity associated with dyslipidemia among civilian pilots in Indonesia. "

"Retinopati diabetik (DR) merupakan komplikasi mikrovaskular diabetes melitus (DM). Fenofibrat oral dapat mencegah progresivitas DR dengan mekanisme pengaturan kadar lipid lipid-related dan mekanisme lain nonlipid-related, antara lain dengan mencegah disfungsi endotel, mengurangi inflamasi, dan angiogenesis. Penelitian ini bertujuan mengetahui efek fenofibrat oral terhadap ketebalan makula sentral (CMT) dan volume makula, serta pengaruhnya pada kadar penanda biologis serum disfungsi endotel eNOS, inflamasi (VCAM-1), dan angiogenesis (VEGF) pada penyandang DR dengan dislipidemia.Penelitian prospektif ini menggunakan disain uji klinis acak tersamar ganda dengan membagi subjek menjadi kelompok intervensi simvastatin dan fenofibrat dan kontrol simvastatin dan plasebo. Penelitian berlangsung sejak Nopember 2016 hingga Oktober 2017, di Klinik Vitreo-retina, Departemen Medik Mata ndash;RSCM Kirana, melibatkan 60 mata dari 30 pasien penyandang DR non-proliferatif NPDR dengan dislipidemia. Penelitian pada tiap subjek dilakukan selama tiga bulan dengan evaluasi klinis, foto fundus, dan spectral domain optical coherence tomography (SD-OCT) makula tiap bulan. Pengukuran kadar eNOS, VCAM-1, dan VEGF, serta HbA1c dan profil lipid dilakukan sebelum dan setelah tiga bulan pengobatan.Sebelum intervensi, pada kedua kelompok tidak didapatkan perbedaan karakteristik demografik, klinik, dan penanda biologis serum. Tidak didapatkan perbedaan bermakna pada CMT kelompok simvastatin fenofibrat 248,0 40,4 m dibandingkan kelompok simvastatin plasebo 265,8 40,8 m, namun CMT lebih rendah secara bermakna pada bulan ke-1 pada kelompok simvastatin fenofibrat. Pada subjek dengan edema makula diabetik DME pemberian simvastatin fenofibrat setelah tiga bulan menunjukkan CMT lebih rendah secara bermakna. Volume makula setelah tiga bulan pemberian obat 10086 886,4 m3 pada kelompok simvastatin fenofibrat dan 10307 1058,6 m3 pada simvastatin plasebo. Perbedaan tersebut tidak bermakna, namun pada subjek dengan regulasi glukosa darah yang baik HbA1c 7 didapatkan volume makula lebih rendah pada bulan ke-2. Kadar penanda biologis serum setelah tiga bulan pemberian obat menunjukkan rerata kadar eNOS dan median VEGF sebesar 3878,8 873,33 pg/mL dan 242,8 86 - 1123,3 pg/mL pada kelompok simvastatin fenofibrat, dibandingkan 4031,2 742,56 pg/mL dan 370 134,8 - 810,6 pg/mL pada kelompok simvastatin plasebo, yang tidak berbeda bermakna, namun penurunan kadar VCAM-1 serum lebih besar secara bermakna pada kelompok simvastatin fenofibrat 50,7 pg/mL, 32,5 - 223,4 pg/mL vs. 40,4 pg/mL, 27,9 - 94,2 pg/mL . Pada subjek dengan kontrol glukosa darah ketat HbA1c 6,5 kadar VEGF 128,7 114,5 - 145,2 pg/mL, lebih rendah secara bermakna dibandingkan 423 86 - 1233,3 pg/mL pada subjek dengan HbA1c > 6,5 .Disimpulkan pemberian simvastatin fenofibrat selama tiga bulan pada subjek DR dengan dislipidemia secara umum tidak menurunkan CMT dan volume makula, namun menurunkan CMT khusus pada subjek DR dengan DME. Pemberian simvastatin fenofibrat pada subjek DR tidak mencegah penurunan kadar eNOS, peningkatan kadar VCAM-1 dan VEGF, namun pengendalian gula darah yang baik dapat mencegah peningkatan kadar VEGF. Simvastatin fenofibrat dapat dipertimbangkan sebagai terapi ajuvan pada penyandang DR dengan DME yang disertai dislipidemia. Pengontrolan glukosa yang baik merupakan manajemen utama pada DR.

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Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM) due to structural and biochemical changes. Previous studies showed that oral fenofibrate prevents DR progression through lipid-regulating and nonlipid-related mechanisms, including preventing endothelial dysfunction, reducing inflammation and angiogenesis. This study aims to investigate the effects of oral fenofibrate on central macular thickness CMT and macular volume, and on specific biomarkers of endothelial dysfunction eNOS, inflammation VCAM-1 , and angiogenesis VEGF in DR individuals with dyslipidemia.This is a prospective, double-blind randomized clinical trial, with subjects divided into intervention group simvastatin fenofibrate and control group simvastatin placebo. This study was conducted from November 2016 to October 2017 at the Vitreo-retina Clinic, Department of Ophthalmology ndash; RSCM Kirana, involving 60 eyes from 30 non-proliferative DR patients NPDR with dyslipidemia that met inclusion criteria. Each subject was observed for three months, with monthly clinical evaluation, fundus photo, and macular spectral domain optical coherence tomography SD-OCT . Serum eNOS, VCAM-1, and VEGF biomarkers, as well as HbA1c and lipid profile, were examined before and after intervention.Before intervention, there were no differences in demographic and clinical characteristics, and serum biomarker levels between two groups. After three months of treatment, there was no significant difference between CMT in the intervention group and the control group 248 40.4 ? m vs. 265.8 40.8 ? m , but a significantly lower CMT was observed in the intervention group at the first month. There was also a significantly lower CMT compared to the control group 294 39,2 vs 263 24,4, p=0,045 in eyes with diabetic macular edema DME . Macular volume after three-month treatment was 10086 886.4 ? m3 in the intervention group and 10307 1058.6 ? m3 in the control group, this difference was not significant. However, in all subjects with good blood glucose regulation HbA1c 7 , macular volume in the second month was significantly lower compared to subjects with HbA1c > 7 . Serum biologic marker levels after three-month treatment showed no significant difference between control and intervention group, respectively, in mean eNOS 3878.8 873.33 pg/mL vs 4031.2 742.56 pg/mL and median VEGF levels 242.8 86 - 1123.3 pg/mL vs 370 134.8 - 810.6 pg/mL . Nonetheless, the decrease in VCAM-1 level was significantly higher in the intervention group 50.7 pg/mL, 32.5 - 223.4 pg/mL vs. 40.4 pg/mL, 27.9 - 94.2 pg/mL . In subjects with tighter blood glucose control HbA1c 6.5 , serum VEGF level was 128.7 114.5 - 145.2 pg/mL, which was significantly lower compared to 423 86 - 1233.3 pg/mL in subjects with HbA1c > 6.5 .In conclusion, three-month treatment with simvastatin fenofibrate does not reduce CMT and macular volume in overall DR subjects with dyslipidemia, but it reduces CMT in subjects with DME. Simvastatin fenofibrate treatment in DR subjects does not prevent lowering of serum eNOS levels, elevation of VCAM-1 levels, and elevation of VEGF levels, but tight blood sugar control prevents elevation of serum VEGF. Although good glucose control remains the most essential in the management of DR, simvastatin fenofibrate may be considered as adjuvant therapy for DR with dyslipidemia and DME."

"Dislipidemia adalah suatu kelainan metabolisme lipid yang ditandai dengan peningkatan kadar kolesterol total, LDL atau trigliserida di atas nilai normal serta penurunan konsentrasi kolesterol HDL dalam darah atau kombinasi. Dislipidemia merupakan silent risk kesehatan populasi secara umum. Kondisi berat badan lebih berasosiasi terhadap kondisi dislipidemia sehingga meningkatkan risiko berbagai penyakit kronis. Penelitian ini bertujuan untuk mengetahui hubungan antara status gizi berisiko terhadap kejadian dislipidemia. Desain studi pada penelitian ini adalah cross sectional menggunakan data rekam medis pasien di Instalasi Rawat Jalan RSUD Cibabat tahun 2022. Analisis dilakukan secara deskriptif dan estimasi dengan analisis modifikasi cox regresi. Status gizi dibagi menjadi dua, yaitu berisiko jika berat badan lebih dan obesitas, tidak berisiko jika berat badan kurang dan normal. Total responden pada penelitian ini adalah 344. Hasil penelitian menunjukan bahwa proporsi insiden dislipidemia adalah 45,9%, dan 64,38% terjadi pada status gizi berisiko. Status gizi berisiko memiliki risiko dua kali lebih tinggi untuk mengalami dislipidemia dibandingkan status gizi tidak berisiko (PR= 2,154; 1,552-2,988). Status gizi berisiko meningkatkan risiko terhadap kejadian dislipidemia.

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Dyslipidemia is a disorder of lipid metabolism characterized by an increase in total cholesterol, LDL or triglyceride levels above normal values and a decrease in HDL cholesterol concentration in the blood or a combination. Dyslipidemia is a silent risk to the health of the population in general. Weight conditions are more associated with dyslipidemia conditions, thereby increasing the risk of various chronic diseases. This study aims to determine the relationship between risky nutritional status and the incidence of dyslipidemia. The study design in this study was cross sectional using patient medical record data at the Outpatient Installation of Cibabat Hospital in 2022. The analysis was carried out descriptively and estimated using a modified cox regression analysis. Nutritional status is divided into two, namely at risk if you are overweight and obese, not at risk if you are underweight and normal. The total number of respondents in this study was 344. The results showed that the proportion of incidents of dyslipidemia was 45.9%, and 64.38% occurred in at-risk nutritional status. At-risk nutritional status has a two times higher risk of experiencing dyslipidemia than nutritional status without risk (PR = 2.154; 1.552-2.988). Nutritional status is at risk of increasing the risk of dyslipidemia."

"Simvastatin merupakan obat lini pertama dalam pengobatan dislipidemia. Simvastatin praktis tidak larut dalam air, sehingga kelarutan simvastatin dalam larutan saluran cerna terbatas dan mengakibatkan bioavailabilitas yang rendah. Simvastatin juga bersifat tidak stabil dalam larutan. Penelitian ini bertujuan untuk meningkatkan kelarutan simvastatin dalam air dan memformulasikan sediaan cair yang stabil secara fisik. Peningkatan kelarutan simvastatin dilakukan dengan cara pembuatan dispersi padat menggunakan pembawa manitol dan PVP K-30. Evaluasi dispersi padat menunjukkan bahwa kelarutan simvastatin dalam dispersi padat F1 (simvastatin-manitol-PVP 1:1:0.02) memberikan kelarutan yang lebih besar daripada F2 (simvastatin-manitol-PVP 1:2:0.01), dengan kelarutan sebesar 25,514 mg/100 mL. Dispersi padat F1 diformulasikan dalam sirup kering dengan bahan tambahan natrium benzoat, asam sitrat, natrium sitrat, dan perisa jeruk menghasilkan serbuk kering dengan laju alir 60,44 gram/detik, sudut istirahat 28,997o dan kandungan lembab 1,927 ± 0,032%. Evaluasi stabilitas fisik menunjukkan bahwa sirup yang terekonstitusi stabil dari segi organoleptis, pH 5,165, dan viskositas sebesar 58,521 cps. Pembuatan dispersi padat simvastatin menggunakan manitol dan PVP K-30 terbukti meningkatkan kelarutan simvastatin dan evaluasi stabilitas fisik sirup kering menunjukkan bahwa sirup kering stabil secara fisik setelah diamati selama 12 hari, sesuai dengan ketentuan BUD (beyond-use date) menurut USP 41.

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Simvastatin is a first-line drug in the treatment of dyslipidemia. Simvastatin is practically insoluble in water, so the solubility of simvastatin in gastrointestinal solutions is limited and results in low bioavailability. Simvastatin is also unstable in solution. This study aims to increase the solubility of simvastatin in water and formulate a physically stable liquid dosage form. The preparation for increasing the solubility of simvastatin was carried out by making a solid dispersion with mannitol and PVP K-30 as a carrier. Evaluation of solid dispersion showed that the solubility of simvastatin in solid dispersion F1 (simvastatin-mannitol-PVP 1:1:0.02) showed greater solubility than F2 (simvastatin-mannitol-PVP 1:2:0.01) with solubility in water of 25.514 mg/100 ml. F1 solid dispersion was formulated in dry syrup with sodium benzoate, citric acid, sodium citrate, and orange flavoring agent as excipients. Simvastatin dry powder with flowrate of 60.44 gram/second, angle of repose 28.997o and moisture content of 1.927 ± 0.032% was obtained. Physical stability evaluation showed that the reconstituted syrup was stable in terms of organoleptic, pH of 5.165, and viscosity of 58.521 cps. Preparation of simvastatin solid dispersion using mannitol and PVP K-30 was shown to increase the solubility of simvastatin and evaluation of the physical stability of dry syrup showed that dry syrup was physically stable after being observed for 12 days, in accordance with the provisions of the BUD (beyond-use date) according to USP 41. "

"Dislipidemia merupakan kelainan metabolisme lipid yang ditandai dengan peningkatan maupun penurunan kadar lipid dalam plasma. Dislipidemia merupakan salah satu penyakit kronis yang memiliki prevalensi yang tinggi hampir di seluruh negara di dunia. Dislipidemia merupakan salah satu faktor utama terjadinya penyakit jantung koroner (PJK) dan stroke yang merupakan penyebab kematian utama di dunia. Pengobatan dislipidemia dapat dilakukan dengan memberikan terapi farmakologis sesuai dengan tatalaksana untuk pasien dan terapi non farmakologis dengan mengubah asupan gizi serta gaya hidup pasien. Pengobatan dislipidemia berlangsung pada jangka waktu tertentu yang cukup lama, sehingga dibutuhkan kepatuhan pasien dalam melaksanakan pengobatan demi tercapainya target terapi. Ketidakpatuhan pasien dalam menjalani terapi dapat disebabkan oleh kurangnya pengetahuan pasien terkait penyakit dislipidemia. Pemberian edukasi terkait penyakit dislipidemia diharapkan dapat meningkatkan tingkat kepatuhan pasien. Tugas khusus praktik kerja di Puskesmas Kecamatan Pulogadung ini bertujuan untuk menyusun media edukasi digital untuk pasien dislipidemia. Penyusunan media edukasi digital dilakukan dengan melakukan penelusuran pustaka dengan menggunakan kata kunci dislipidemia di laman Google Cendekia. Informasi yang telah didapatkan kemudian dikumpulkan dan disunting menjadi dalam bentuk booklet yang dibuat menggunakan aplikasi canva dan flipbook. Pemberian edukasi kepada pasien dislipidemia dilakukan dengan menggunakan booklet digital yang dianggap menarik karena didesain dengan baik dan mudah untuk diakses dan dibaca. Pemberian edukasi kepada pasien dislipidemia menggunakan media edukasi digital berupa booklet yang berisi tentang pengertian, gejala, penyebab, pencegahan, terapi farmakologis, dan terapi non farmakologis dislipidemia yang dikemas dengan menarik untuk dibaca sehingga diharapkan dapat meningkatkan pengetahuan pasien sehingga kepatuhan pasien dalam melaksanakan pengobatan akan meningkat dan keberhasilan terapi akan tercapai.

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Dyslipidemia is a lipid metabolism disorder characterized by an increase or decrease in plasma lipid levels. Dyslipidemia is a chronic disease that has a high prevalence in almost all countries in the world. Dyslipidemia is one of the main factors in the occurrence of coronary heart disease (CHD) and stroke, which are the main causes of death in the world. Treatment of dyslipidemia can be done by providing pharmacological therapy according to the guidelines and non-pharmacological therapy by adjusting patient's nutritional intake and lifestyle. Dyslipidemia treatment usually going on for long period of time, so patient compliance is required in carrying out treatment in order to achieve therapy targets. Patient non-compliance with therapy can be caused by the patient's lack of knowledge regarding dyslipidemia. Providing education related to dyslipidemia is expected to improve patient’s compliance. This internship assignment at Pulogadung District Health Center aims to develop digital educational media for dyslipidemia patients. Preparation of digital educational media was carried out by conducting a literature search using the keyword dyslipidemia on the Google Scholar page. The information that have been obtained are then collected and edited into booklet form which is created using the Canva and Flipbook. Providing education to dyslipidemia patients is carried out using digital booklets which are considered interesting because they are well designed and easy to read. Providing education to dyslipidemia patients using digital educational media in the form of a booklet containing the meaning, symptoms, causes, prevention, pharmacological therapy and non-pharmacological therapy of dyslipidemia which are packaged in an interesting way to read is hoped to enhance patient’s knowledge so that patient compliance in carrying out treatment will increase and therapeutic success will be achieved."

"Latar belakang. Dislipidemia merupakan salah satu faktor resiko berkembangnya gagal jantung dan telah menjadi masalah kesehatan diseluruh dunia. Penelitian mengenai hubungan dislipidemia dan penyakit jantung belum banyak dilakukan di Indonesia.Tujuan. Mengetahui karakteristik pasien gagal jantung akut dan mengidentifikasi hubungan antara riwayat dislipidemia dengan mortalitas pasien gagal jantung akut selama perawatan.Metode. Penelitian dilakukan dengan desain potong lintang serta menggunakan 268 data sekunder dari studi Acute Decompensated Heart Failure Registry (ADHERE) di lima rumah sakit di Indonesia pada bulan Desember 2005 - 2006.Hasil. Pasien gagal jantung akut dalam penelitian ini dibagi kedalam dua kelompok. Kelompok pertama merupakan pasien dengan dislipidemia (88,8% dan kelompok kedua meupakan pasien tanpa dislipidemia (12,2%). Angka mortalitas pada kelompok pertama mencapai 3,0% dan pada kelompok kedua 0%. Melalui analisis bivariat tidak didapatkan hubungan bermakna antada riwayat dislipidemia dengan mortaitas pasien gagal jantung akut (p=0,603; OR: 0,828; CI: 0,101-6,759).Kesimpulan. Tidak terdapat hubungan bermakna antara riwayat dislipidemia dengan angka mortalitas gagal jantung akut selama perawatan di lima rumah sakit di Indonesia pada bulan Desember 2005 - 2006.

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Background. Dyslipidemia can promote the development of heart failure and has become one of global health problem. The study about associatin between dyslipidemia and in-hospital mortality of acute heart failure has never been done before in Indonesia.Objective. To define the characteristic of patient and to identify the association between dyslipidemia and in-hospital mortality of acute heart failure.Method. The design of this study was cross sectional with onsecutive sampling. This study used 976 acute heart failure patients from Acute Decompensated Heart Failure Registry (ADHERE) of 5 hospital in Indonesia from December 2005-2006.Result. Patiens with acute heart failure in this study were categorized in two groups. The first group was patients with dyslipidemia (88,8%) and the second was group wihout dyslipidemia (12,2%). The mortality rate of the first group was 3,0% and from the second was 0%. The bivariat analysis showed that there is no association between dyslipidemia and in-mortality of AHF patients (p=0,603; OR: 0,828; CI: 0,101-6,759).Conclusion. There is no significant association between Dyslipidemia and Inhospital Mortality of Acute Heart Failure in Five Hospital in Indonesia on December 2005 -2006."