Ditemukan 6 dokumen yang sesuai dengan query
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"First book to deal with this important area of adverse drug reactions -- cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals. Covers four important therapeutic classes: psychoactive drugs; anticancer drugs; non-steroidal anti-inflammatory drugs; and anti-retroviral drugs. - Emphasis on the preclinical screening of drug cardiotoxicity, to enable drug developers to test for this toxicity before starting expensive clinical ...
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Hoboken, NJ: John Wiley & Sons, 2010
616.1 CAR
Buku Teks Universitas Indonesia Library
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First book to deal with this important area of adverse drug reactions, cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals. Covers four important therapeutic classes: psychoactive drugs; anticancer drugs; non-steroidal anti-inflammatory drugs; and anti-retroviral drugs. Emphasis on the preclinical screening of drug cardiotoxicity, to enable drug developers to test for this toxicity before starting expensive clinical trials ...
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Chichester, West Sussex, U.K.: John Wiley & Sons, 2010
e20375778
eBooks Universitas Indonesia Library
Tsaioun, Katya
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This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In ...
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New Jersey: John Wiley & Sons, 2011
e20375655
eBooks Universitas Indonesia Library
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This book examines genotoxic impurities and their impact on the pharmaceutical industry.Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed byasection on safety aspects, including safety tests in vivo and ...
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Hoboken: John Wiley & Sons, 2010
e20393941
eBooks Universitas Indonesia Library
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The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. ...
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Hoboken, New Jersey: Wiley-VCH, 2008
e20394504
eBooks Universitas Indonesia Library
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Immunotoxicology is a highly specialized discipline that addresses potential adverse effects on the immune system, including immunosuppression, immunogenicity, hypersensitivity and other immune system functional disorders. A broad spectrum of xenobiotics, including agents present in our environment as well as pharmaceutical molecules may adversely affect the immune system ...
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Hoboken: John Wiley & Sons, 2008
e20394193
eBooks Universitas Indonesia Library
