Ditemukan 7 dokumen yang sesuai dengan query
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This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals.
Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus ...
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Chichester, West Sussex, England: John Wiley & Sons, 2007
e20395854
eBooks Universitas Indonesia Library
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This book the only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development from initial conceptualization to commercialization to clinicians and medical practitioners.
Volume 2 : drug development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing-including drug coloring and delivery methods.
Featuring contributions from a world-class team of experts, Drug discovery and development :
- Features ...
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Hoboken, New Jersey: John Wiley & Sons, 2007
e20395858
eBooks Universitas Indonesia Library
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Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. The authors discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results ...
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Weinheim: Wiley-VCH, 2006
e20395921
eBooks Universitas Indonesia Library
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This book contains case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil). Discusses the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer. Contains chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics.
The first volume of this set thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in ...
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Hoboken, New Jersey: Wiley-Interscience, 2006
e20395928
eBooks Universitas Indonesia Library
New Jersey: John Wiley & Sons, 2012
615.9 PRE
Buku Teks SO Universitas Indonesia Library
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Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug development. ...
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Hoboken: John Wiley & Sons, 2010
e20393919
eBooks Universitas Indonesia Library
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The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. ...
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Hoboken, New Jersey: Wiley-VCH, 2008
e20394504
eBooks Universitas Indonesia Library
