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"Latar belakang: Krioterapi adalah salah modalitas terapi yang sering dilakukan pada lesi IVA positif di Indonesia. Selain memiliki angka kesembuhan yang cukup tinggi, krioterapi tergolong murah dan mudah dilakukan dengan sumber daya yang terbatas. Namun, efek samping pasca krioterapi seperti keputihan, perdarahan bercak, dan nyeri adalah hal yang tidak bisa dihindari. Beberapa penelitian mengaitkan adanya hubungan derajat dan luas lesi prakanker dengan angka kesembuhan pasca krioterapi. Jenis krioterapi (single-freeze atau double-freeze) juga dihubungkan dengan luas area nekrosis pasca krioterapi.Tujuan: Tujuan penelitian ini adalah untuk mengetahui hubungan luas lesi IVA positif dan jenis krioterapi terhadap efek samping pasca krioterapiMetode: Penelitian ini merupakan studi kohort prosepektif. Populasi terjangkauadalah pasien dengan IVA positif yang menjalani krioterapi oleh Female Cancer Program dari Juli sampai dengan Oktober 2019 di Jakarta. Evaluasi dilakukan dengan pengisian lembar keluhan efek samping krioterapi selama satu bulan. Analisis data dalam bentuk deskriptif dan analitik.Hasil: Didapatkan 43 subjek IVA positif, 27 (62,8%) subjek lesi luas, dan 16 (37,2%) subjek lesi sempit, jenis krioterapi dibagi menjadi 33 (76,7%) subjek double-freeze, 10 (23,3%) subjek single-freeze, setelah sebulan didapatkan keluhan keputihan sebanyak 88,4%; perdarahan bercak 51,2%, nyeri 58,1%; tidak didapatkan hubungan bermakna antara luas lesi IVA positif dengan keputihan (nilai-p 0,63), perdarahan bercak (nilai-p 0,61), dan nyeri (nilai-p 0,54), krioterapi double-freeze berhubungan bermakna dengan efek samping perdarahan bercak (RR 0,5; nilai-p 0,0032; CI 0,3-0,9).Kesimpulan: krioterapi double-freeze berhubungan bermakna dengan efek samping perdarahan bercak pasca krioterap.

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Background: Cryotherapy is a procedure often performed in positive VIA lesions in Indonesia. Not only having a high cure rate, but cryotherapy is also relatively cheap and easy to perform with limited resources. However, side effects such as vaginal discharge, spotting, and pain are unavoidable. Several studies have linked the degree and width of precancerous lesions with cure rate after cryotherapy. Type of cryotherapy (single-freeze or double-freeze) is also related with amount of necrosis area produced after cryotherapy.

Objective: To determine the association of positive VIA area and the type of cryotherapy with post-cryotherapy side effects.

Method: This is a prospective cohort study. The population are women with positive VIA result who underwent cryotherapy by the Female Cancer Program from July to October 2019 in Jakarta. Evaluation was performed by filling out the patients complaint sheet for one month. Data was analysed descriptively and analytically.

Results: There were 43 women with positive VIA results, grouped into 27 (62.8%) large lesion, and 16 (37.2%) small lesion, types of cryotherapy was grouped into 33 (76.7%) double-freeze, 10 (23,3%) single-freeze, after one month follow-up there were complaints of vaginal discharge 88.4%; spotting 51.2%, pain 58.1%; found unsignificantly association between width of positive VIA area with vaginal discharge (p-value 0.63), spotting (p-value 0.61), and pain (p-value 0.54), double-freeze cryotherapy was significantly associated with side effect of spotting (RR 0.5; p-value 0.0032; CI 0.3-0.9).

Conclusion: double-freeze cryotherapy is significantly related with side effect of spotting.

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"Krioterapi adalah terapi yang rutin dilakukan pada lesi IVA positif di Indonesia. Selain terbukti efektif, krioterapi tergolong murah dan mudah dilakukan. Namun, efek samping pasca krioterapi seperti keputihan, perdarahan bercak, dan nyeri tidak bisa dihindari. Beberapa penelitian mengaitkan adanya hubungan luas lesi prakanker dengan angka kesembuhan. Jenis krioterapi (single-freeze atau double-freeze) juga dihubungkan dengan luas area nekrosis yang terbentuk. Tujuan penelitian ini untuk mengetahui hubungan luas lesi IVA positif dan jenis krioterapi terhadap efek samping krioterapi. Penelitian ini menggunakan studi kohort prosepektif observasional. Populasi terjangkau adalah pasien dengan IVA positif yang menjalani krioterapi oleh Female Cancer Program dari Juli hingga Oktober 2019 di Jakarta. Evaluasi dilakukan dengan pengisian lembar keluhan efek samping krioterapi. Didapatkan 43 subjek IVA positif, 27 (62,8%) subjek lesi luas, dan 16 (37,2%) subjek lesi sempit, jenis krioterapi dibagi menjadi 33 (76,7%) subjek double-freeze, 10 (23,3%) subjek single-freeze, setelah sebulan didapatkan keluhan keputihan sebanyak 88,4%; perdarahan bercak 51,2%, nyeri 58,1%; tidak didapatkan hubungan bermakna antara luas lesi IVA positif dengan keputihan (nilai-p 0,63), perdarahan bercak (nilai-p 0,61), dan nyeri (nilai-p 0,54), krioterapi double-freeze berhubungan bermakna dengan perdarahan bercak (RR 0,5; nilai-p 0,0032; CI 0,3-0,9).

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Cryotherapy is often performed to positive VIA lesions in Indonesia. Not only effective, it is also cheap and easy to perform. However, side effects such as vaginal discharge, spotting, and pain are unavoidable. Several studies have linked the width of lesions with cure rate. Type of cryotherapy (single-freeze or double-freeze) is also related with amount of necrosis area produced. This study was performed to determine the association of positive VIA area and type of cryotherapy with the side effects. This is a observational prospective cohort study. The population are women with positive VIA who underwent cryotherapy by the Female Cancer Program from July to October 2019 in Jakarta. Evaluation was performed by filling out the patients complaint sheet for one month. There were 43 women with positive VIA results, grouped into 27 (62.8%) large lesion, and 16 (37.2%) small lesion, cryotherapy was performed 33 (76.7%) double-freeze, 10 (23,3%) single-freeze, after one month follow-up there were complaints of vaginal discharge 88.4%; spotting 51.2%, pain 58.1%; found no association between width of positive VIA with vaginal discharge (p-value 0.63), spotting (p-value 0.61), and pain (p-value 0.54), double-freeze cryotherapy was significantly associated with side effect of spotting (RR 0.5; p-value 0.0032; CI 0.3-0.9)."

"Program ?see and treat? adalah program dengan metode IVA dan krioterapi untuk mengatasi lesi prakanker serviks di lokasi dengan keterbatasan sarana. Efektivitas dan keamanan krioterapi pada program ini belum dievaluasi dalam 5 tahun terakhir. Data dari rekam medis diambil dengan metode total sampling. Variabel yang dicatat adalah hasil IVA, tindakan krioterapi, usia pertama kawin, jumlah pernikahan, paritas, merokok, dan penggunaan kontrasepsi. Data dianalisis secara univariat. Dari 86 data yang dianalisis, persentase keberhasilan krioterapi dalam konversi hasil IVA mencapai 90,70%. Angka keluhan pasca krioterapi sebesar 1,3% yaitu perdarahan minimal. Krioterapi efektif dan aman pada program ?see and treat?. ?See and treat? was a program using VIA and cryotherapy to eliminate cervical precancerous lesion in a facility-limited location. Efficacy and safety of cryotherapy in this program had not been evaluated in the last 5 years. Data from medical record were taken with total sampling method. VIA result, cryotherapy procedure, first-marriage age, number of marriage, parity, smoking habit, and the use of contraception were assessed. Data were analyzed univariately. From 86 analyzed data, cryotherapy convert the VIA result in 90,70% patients. 1,3% patient complaint minimal bleeding. Cryotherapy was effective and safe in ?see and treat? program. "

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Karsinoma Nasofaring (KNF) merupakan salah satu tipe dari kanker leher dan kepala yang berasal dari sel skuamosa permukaan dinding nasofaring lateral. Penggunaan obat kemoterapi yang lazim digunakan dalam pengobatan KNF adalah Cisplatin, docetaxel, dan Fluorouracil (5-FU). Stomatitis seringkali terjadi pada pasien yang menjalani kemoterapi dengan regimen dasar obat kemoterapi Fluorouracil atau 5FU. Karya Ilmiah Akhir Ners (KIAN) ini bertujuan untuk menjabarkan hasil analisis asuhan keperawatan pencegahan stomatitis dengan metode pemberian Cryotherapy menggunakan ice chips NaCl 0,9% yang dikulum di mulut pasien 2-3 kali perhari selama pemberian obat kemoterapi 5FU. Sebagai kesimpulan, selama pemberian kemoterapi sampai dengan akhir hari rawat, klien tidak menunjukkan tanda-tanda stomatitis. Pemantauan stomatitis diharapkan dapat terus dilakukan selama perawatan dirumah, dikarenakan risiko terjadinya stomatitis masih mungkin terjadi selama perawatan dirumah

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Nasopharyngeal carcinoma (NPC) is a type of cancer of the neck and head originating from squamous cell surfaces of the lateral nasopharyngeal wall. The use of chemotherapy drugs commonly used in the treatment of NPC are Cisplatin, Docetaxel, and Fluorouracil (5-FU). Stomatitis often occurs in patients undergoing chemotherapy with a basic regimen of the drug Fluorouracil or 5FU chemotherapy. This final papers aims to describe the results of the analysis of Cryotherapy Interventions to Prevent Stomatitis using NaCl 0.9% ice chips which are chopped in the patients mouth 2-3 times per day during the administration of the 5FU chemotherapy drug. In conclusion, during the administration of chemotherapy until the end of the day of admission, the client shows no signs of stomatitis. Stomatitis monitoring is expected to continue during home treatment, because the risk of stomatitis is still possible during home treatment

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