Ditemukan 2 dokumen yang sesuai dengan query
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In this ground–breaking practical reference, the family of aspartic acid proteases is described from a drug developer′s perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV–1 protease, ...
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Weinheim: Wiley-VCH Verlag, 2010
e20375719
eBooks Universitas Indonesia Library
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BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE : lead target for orchestrated therapy of alzheimer's disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery ...
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Hoboken, New Jersey: John Wiley & Sons, 2010
e20410879
eBooks Universitas Indonesia Library
