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"Faktor Risiko Hipertensi pada Wanita Menopause di Rejomulyo, Madiun. Hipertensi merupakan keadaan dimana tekanan darah ≥140 mmHg (sistolik) atau ≥90 mmHg (diastolik). Kejadian hipertensi pada wanita di Rejomulyo pada bulan Januari-November 2013 mencapai 28,4%, dimana 87% dari jumlah tersebut merupakan wanita menopause. Faktor risiko meningkat sejak periode awal menopause. Tujuan dari penelitian ini adalah untuk menganalisis faktor- faktor risiko hipertensi pada wanita menopause di Rejomulyo, Madiun. Analisis pengamatan dilakukan dengan desain studi cross-sectional. Sampel studi adalah 90 wanita menopause berusia 50-80 tahun yang dipilih dengan stratified random sampling. Analisis bivariat menunjukkan adanya hubungan antara obesitas (p=0,023;CI: 1,4-116,8), obesitas abdominal (p=0,002;CI: 1,8-24,9), riwayat keluarga dengan hipertensi (p=0,018;CI: 1,2-7,1), usia lanjut (p=0,028;CI: 1,2-12,9), tingkat stres yang tinggi (p = 0,001;CI: 2,9-19,4), dan konsumsi natrium yang tinggi (p=0,001 CI: 2,4-15,2). Analisis multivariat menunjukkan bahwa faktor risiko hipertensi adalah obesitas abdominal (POR adj=9,2;CI: 1,7-50,9), usia tua atau >65 tahun (POR adj=8,6;CI: 1,6-45,1), tingkat stres tinggi (POR adj=8,6;CI: 2,6-28,3) dan konsumsi natrium yang tinggi (POR adj=6,4;CI: 1,9-20,5). Studi ini menemukan bahwa faktor risiko hipertensi adalah obesitas abdominal, usia tua (>65 tahun), tingkat stres yang tinggi, dan konsumsi natrium yang tinggi. Pusat Kesehatan Tawangrejo harus bekerja sama dengan berbagai sektor relevan seperti PKK dan kader kesehatan.;Hypertension is a state of blood pressure ≥140 mmHg (systolic) or ≥90 mmHg (diastolic). Incidence of women hypertension in Rejomulyo from January to November 2013 reached 28.4%, in which 87% were menopausal. Risk factors increased since early menopausal period. The aim of the study was to analyze risk factors of hypertension in menopausal women in Rejomulyo, Madiun. An observational analysis was conducted with cross-sectional study design. Samples were 90 menopausal women aged 50-80 years using stratified random sampling. Bivariate analysis showed association between obesity (p=0.023;CI: 1.4-116.8), abdominal obesity (p=0.002;CI: 1.8-24.9), family history suffering of hypertension (p=0.018;CI: 1.2-7.1), elderly age (p =0.028;CI: 1.2-12.9), high stress level (p=0.001;CI: 2.9- 19.4) and often natrium consumption (p=0.001;CI: 2.4-15.2). Multivariate analysis showed that risk factors of hypertension were abdominal obesity (POR adj=9.2 CI: 1.7-50.9), elderly age or >65 years old (POR adj=8.6;CI: 1.6- 45.1), high stress level (POR adj=8.6;CI: 2.6-28.3) and often natrium consumption (POR adj=6.4;CI: 1.9-20.5). This study found that risk factors of hypertension were abdominal obesity, elderly age (>65 years old), high stress level, and high natrium consumption. Tawangrejo Health Center should be in collaboration with relevant sectors such as the PKK and health cadres.

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Hypertension is a state of blood pressure ≥140 mmHg (systolic) or ≥90 mmHg (diastolic). Incidence of women hypertension in Rejomulyo from January to November 2013 reached 28.4%, in which 87% were menopausal. Risk factors increased since early menopausal period. The aim of the study was to analyze risk factors of hypertension in menopausal women in Rejomulyo, Madiun. An observational analysis was conducted with cross-sectional study design. Samples were 90 menopausal women aged 50-80 years using stratified random sampling. Bivariate analysis showed association between obesity (p=0.023;CI: 1.4-116.8), abdominal obesity (p=0.002;CI: 1.8-24.9), family history suffering of hypertension (p=0.018;CI: 1.2-7.1), elderly age (p =0.028;CI: 1.2-12.9), high stress level (p=0.001;CI: 2.9- 19.4) and often natrium consumption (p=0.001;CI: 2.4-15.2). Multivariate analysis showed that risk factors of hypertension were abdominal obesity (POR adj=9.2 CI: 1.7-50.9), elderly age or >65 years old (POR adj=8.6;CI: 1.6- 45.1), high stress level (POR adj=8.6;CI: 2.6-28.3) and often natrium consumption (POR adj=6.4;CI: 1.9-20.5). This study found that risk factors of hypertension were abdominal obesity, elderly age (>65 years old), high stress level, and high natrium consumption. Tawangrejo Health Center should be in collaboration with relevant sectors such as the PKK and health cadres."

"Hypertension is a state of blood pressure ≥140 mmHg (systolic) or ≥90 mmHg (diastolic). Incidence of womenhypertension in Rejomulyo from January to November 2013 reached 28.4%, in which 87% were menopausal. Riskfactors increased since early menopausal period. The aim of the study was to analyze risk factors of hypertension inmenopausal women in Rejomulyo, Madiun. An observational analysis was conducted with cross-sectional study design.Samples were 90 menopausal women aged 50-80 years using stratified random sampling. Bivariate analysis showedassociation between obesity (p=0.023;CI: 1.4-116.8), abdominal obesity (p=0.002;CI: 1.8-24.9), family historysuffering of hypertension (p=0.018;CI: 1.2-7.1), elderly age (p =0.028;CI: 1.2-12.9), high stress level (p=0.001;CI: 2.9-19.4) and often natrium consumption (p=0.001;CI: 2.4-15.2). Multivariate analysis showed that risk factors ofhypertension were abdominal obesity (POR adj=9.2 CI: 1.7-50.9), elderly age or >65 years old (POR adj=8.6;CI: 1.6-45.1), high stress level (POR adj=8.6;CI: 2.6-28.3) and often natrium consumption (POR adj=6.4;CI: 1.9-20.5). Thisstudy found that risk factors of hypertension were abdominal obesity, elderly age (>65 years old), high stress level, andhigh natrium consumption. Tawangrejo Health Center should be in collaboration with relevant sectors such as the PKKand health cadres.Faktor Risiko Hipertensi pada Wanita Menopause di Rejomulyo, Madiun. Hipertensi merupakan keadaan dimanatekanan darah ≥140 mmHg (sistolik) atau ≥90 mmHg (diastolik). Kejadian hipertensi pada wanita di Rejomulyo padabulan Januari-November 2013 mencapai 28,4%, dimana 87% dari jumlah tersebut merupakan wanita menopause.Faktor risiko meningkat sejak periode awal menopause. Tujuan dari penelitian ini adalah untuk menganalisis faktorfaktorrisiko hipertensi pada wanita menopause di Rejomulyo, Madiun. Analisis pengamatan dilakukan dengan desainstudi cross-sectional. Sampel studi adalah 90 wanita menopause berusia 50-80 tahun yang dipilih dengan stratifiedrandom sampling. Analisis bivariat menunjukkan adanya hubungan antara obesitas (p=0,023;CI: 1,4-116,8), obesitasabdominal (p=0,002;CI: 1,8-24,9), riwayat keluarga dengan hipertensi (p=0,018;CI: 1,2-7,1), usia lanjut (p=0,028;CI:1,2-12,9), tingkat stres yang tinggi (p = 0,001;CI: 2,9-19,4), dan konsumsi natrium yang tinggi (p=0,001 CI: 2,4-15,2).Analisis multivariat menunjukkan bahwa faktor risiko hipertensi adalah obesitas abdominal (POR adj=9,2;CI: 1,7-50,9),usia tua atau >65 tahun (POR adj=8,6;CI: 1,6-45,1), tingkat stres tinggi (POR adj=8,6;CI: 2,6-28,3) dan konsumsinatrium yang tinggi (POR adj=6,4;CI: 1,9-20,5). Studi ini menemukan bahwa faktor risiko hipertensi adalah obesitasabdominal, usia tua (>65 tahun), tingkat stres yang tinggi, dan konsumsi natrium yang tinggi. Pusat KesehatanTawangrejo harus bekerja sama dengan berbagai sektor relevan seperti PKK dan kader kesehatan."

"Hyperglycemia in diabetes mellitus results in oxidative stress and increases complication development. Experimentalstudies have shown that chlorophyll has antioxidant activity and papaya leaves contained chlorophyll more than theother green vegetables. This study aimed to evaluate the antioxidant and hypoglycemic role in chlorophyll rich inpapaya leaves on diabetic rats. Thirty six rats were randomly divided into 4 groups: without treatment (techniquecontrol/TC), diabetic (negative control/NC), diabetic with treatment A (100.3 mg/200 g BW of extract) and diabeticwith treatment B (200.6 mg/200 g BW of extract). Diabetic induction was conducted by injecting streptozotocin 40mg/kg BW intraperitoneally. Extract was given by nasogastric tube. Blood glucose level was measured using enzymaticcolorimetric GOD-PAP test at before, after 20 and 40 days of treatment. Hepatic superoxide dismutation (SOD) levelwas measured after 40 days of treatment. Blood glucose levels in 3 diabetic groups were significantly raised after sevendays of induction. In Anova and post hoc LSD analysis, both treatments had lower hepatic SOD level than TC (p =0.01), and blood glucose level also decreased after given the treatment (p = 0.01). Treatment B had a better antioxidantand hypoglycemic role than treatment A.Efek dari Klorofil di Daun Pepaya pada Dismutasi Superoksida dan Kadar Glukosa Darah Tikus Diabetes.Hiperglikemia pada pasien diabetes melitus menyebabkan stres oksidatif dan meningkatkan pengembangan komplikasi.Berbagai penelitian eksperimental telah memperlihatkan bahwa klorofil memiliki aktivitas antioksidan dan daun pepayamengandung klorofil lebih banyak dari sayuran hijau lainnya. Penelitian ini bertujuan untuk mengevaluasi peranantioksidan dan hipoglikemik pada kandungan klorofil di daun pepaya pada tikus diabetes. Tiga puluh enam tikussecara acak dibagi menjadi 4 kelompok: tanpa pengobatan (kontrol teknik/TC), diabetes (kontrol negatif/NC), diabetesdengan pengobatan A (100,3 mg /200 g BB ekstrak), dan diabetes dengan pengobatan B (200,6 mg/200 g BW ekstrak).Induksi diabetes dilakukan dengan menyuntikkan streptozotocin 40 mg/kg BW secara intraperitoneal. Ekstrak diberikanmelalui tabung nasogastrik. Kadar glukosa darah diukur dengan menggunakan uji enzim kolorimetri GOD-PAP disebelum, setelah 20 dan 40 hari pengobatan. Tingkat dismutasi superoksida (SOD) hati diukur setelah 40 haripengobatan. Kadar glukosa darah pada 3 kelompok diabetes meningkat secara signifikan setelah tujuh hari induksi.Dalam analisa Anova dan uji lanjut LSD, kedua kelompok dengan pengobatan memiliki tingkat SOD hati lebih rendahdari TC (p = 0,01) dan kadar glukosa darah juga menurun setelah diberi pengobatan (p = 0,01). Pengobatan B memilikiperan antioksidan dan hipoglikemik lebih baik daripada pengobatan A."