Ditemukan 3 dokumen yang sesuai dengan query
Sutriyo
"
The research to accelerate furosemide, dissolution rate has been done through physical property modification by solid dispersion forming polyvinylpyrolidone (PVP) carrier with solvent method.Pure furosemide prosses property of being practically insoluble in water and has low biovailability .In current research,six weight ratio of furosemide to PVP being used are 1:1;1:3;1:5;1:9 and 1:15.Physical mixtures are made in equivalent weight ratio. The dissolution rate was examined by paddle method in phosphat buffer pH5,8.Solid dispersion caracterised with ...
"
2005
MIKE-II-1-Apr2005-30
Artikel Jurnal Universitas Indonesia Library
Sutriyo
"
Chitosan is a polycatonis biopolymer that can form gel in acidic environment so that can be used as a hydrophilic matrix in controlled release drug delivery system. In this research, propranolol hydrochloride controlled release granule was made in chitosan matrix. Granules were made by wet granulation method with variety of matrices, i.e. chitosan, hydroxypropyl mthylcellulose (HPMC) and ethyl cellulose (EC). HPMC and EC were used as a comparing matrix. The release rates of propranolol HCl ...
"
2005
MIKE-II-3-Des2005-145
Artikel Jurnal Universitas Indonesia Library
Sutriyo
"
Propranolol hydrochloride is antihypertension agent that has a short biological half life of 2-6 hours. Microcapsules of propranolol hydrochloride are prepared by solvent evaporation method using ethylcellulose as a wall material with the drugpolymer ratio 1:1, 1:2, and 1:3 for sustained release oral delivery. The microcapsules were then evaluated by particle size distribution analysis, shape and morphology (SEM), drug content, and dissolution studies. In vitro dissolution was studied using the dissolution apparatus II (paddle) with ...
"
Depok: Fakultas Farmasi Universitas Indonesia, 2004
AJ-Pdf
Artikel Jurnal Universitas Indonesia Library
