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"Penyakit ginjal kronik (PGK) merupakan salah satu komplikasi serius yang sering terjadi pada pasien diabetes melitus tipe 2. Dibutuhkan sebuah penanda yang dapat mendeteksi PGK sejak awal untuk mencegah progresifitasnya. Penelitian ini bertujuan untuk menganalisis hubungan antara kadar malondialdehida (MDA) serum dengan estimasi laju filtrasi glomerulus (eLFG). MDA merupakan penanda stres oksidatif yang diprediksi berperan dalam tahap awal kerusakan ginjal. Desain penelitian ini adalah potong lintang. Populasi yang digunakan adalah pasien DM tipe 2 rawat jalan di Puskesmas Pasar Minggu. Sampel yang dianalisis sejumlah 50 orang (14 laki-laki, dan 36 perempuan, rentang usia 39-74 tahun), diambil dengan tenik total sampling. Kadar MDA diukur secara spektrofotometri berdasarkan reaksi antara MDA dengan asam tiobarbiturat, dengan nilai koefisien korelasi (r) dari metode tersebut 0,9996 dan koefisien variasi (%KV) intra dan antar pengukuran berkisar 2,75-13,33%. Nilai eLFG diukur berdasarkan metode kinetik Jaffe, dengan koefisien korelasi (r) 0,9994 dan %KV intra dan antar pengukuran berkisar 2,91 – 9,52%. Kadar MDA pasien DM tipe 2 diperoleh 0,82 ± 0,26 nmol/ml, dan nilai eLFG diperoleh 78,30 ± 26,77 (Cockroft-Gault); 76,08 ± 24,17 (MDRD study); dan 79,25 ± 21,04 (CKD-EPI). Terdapat hubungan yang bermakna antara kadar MDA dengan nilai eLFG berdasarkan persamaan Cockroft-Gault (p =0,039, r = -0,293), tetapi tidak terlihat hubungan yang bermakna dengan nilai eLFG berdasarkan persamaan MDRD study dan CKD-EPI (p = 0,051 dan p = 0,053; r = -0,277 dan r = -0,275).

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Chronic kidney disease (CKD) is one of serious complication that most common in type 2 diabetes mellitus patients. It is important to find a marker that can detect it earlier to prevent its progression. The aim of this study was to analyze the correlation between malondialdehyde (MDA) concentration and estimated glomerular filtration rate (eGFR). MDA is an oxidative stress marker which was predicted allies in early stage of kidney damage.

The design of this study is cross sectional. The population was type 2 DM outpatients at Pasar Minggu Local Government Clinic. Total sampling method was used in sample selection. Samples being analyzed were as much as 50 patients (14 males, 36 females, age ranges : 39-74 years). MDA was measured by spectrophotometric based on its reaction with thiobarbituric acid. The coefficient correlation (r) of this method was 0.9996 and the coefficient of variation (%CV) within and between run were 2.75 - 13.33%.

eGFR was measured based on kinetic Jaffe method. Its coefficient correlation (r) was 0.9994 and %CV within and between run were 2.91-9.52%. MDA concentration in type 2 DM patients in this research was 0.82 ± 0.26 nmol/mL and the eGFR values were 78.30 ± 26.77 (Cockroft-Gault); 76.08 ± 24.17 (MDRD study); and 79.25 ± 21.04 (CKD-EPI). There was a significant correlation between MDA concentration and eGFR based on Cockroft-Gault formula (p =0.039, r = -0.293), but there were no significant correlation between MDA concentration and eGFR based on MDRD study and CKD-EPI (p = 0.051 and p = 0.053; r = -0.277 and r = -0.275)."

"Praktik Kerja Profesi Apoteker dilaksanakan di PT. Boehringer Ingelheim Indonesia, Jalan Lawang Gintung No. 89, Bogor. Kegiatan PKPA ini bertujuan agar mahasiswa profesi apoteker dapat melihat langsung aktifitas yang berlangsung pada insudtri farmasi, serta memahami penerapan CPOB dan peran apoteker pada industri farmasi, khususnya PT. Boehringer Ingelheim Indonesia. Tugas khusus yang diberikan berjudul Proses Kualifikasi Alat Microwave Muffle Furnace di Laboratorium Quality Control PT. Boehringer Ingelheim Indonesia. Tujuan tugas khusus ini adalah untuk memahami tahapan proses kualifikasi alat baru serta pihak yang terlibat dalam proses tersebut, serta memahami dokumen yang harus dibuat dalam proses kualifikasi alat baru.

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Pharmacist Professional Practice was implemented in PT. Boehringer Ingelheim Indonesia, Lawang Gintung Street Number 89, Bogor. PKPA activity was intended that students can see the activities at pharmaceutical industry directly, and understand GMP practices and the roles of pharmacist in pharmaceutical idustry, especially at PT. Boehringer Ingelheim Indonesia. The title of special assignment was Qualification process of Microwave Muffle Furnace at Quality Control Laboratory of PT. Boehringer Ingelheim Indonesia. The aim of this assignment were to understand the steps of new equipment qualification, the departments involved, and the document that should be made in the qualification process."

"Praktik Kerja Profesi Apoteker dilaksanakan di Direktorat Bina Obat Publik dan Perbekalan Kesehatan Direktorat Jenderal Bina Kefarmasian dan Alat Kesehatan Kementerian Kesehatan Republik Indonesia. Kegiatan PKPA ini bertujuan agar mahasiswa profesi apoteker dapat memahami tugas pokok dan fungsi Direktorat Jenderal Bina Kefarmasian dan Alat Kesehatan, khususnya Direktorat Bina Obat Publik dan Perbekalan Kesehatan, serta memahami peran apoteker di direktorat tersebut. Tugas khusus yang diberikan berjudul biaya operasional dalam pengelolaan obat publik dan perbekalan kesehatan di instalasi farmasi kabupaten/kota. Tujuan tugas khusus ini adalah untuk mengetahui komponen biaya operasional yang dibutuhkan dalam menjalankan kegiatan di instalasi farmasi kabupaten/kota dan memahami dampak jika komponen biaya tersebut tidak diperhitungkan dengan tepat.

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Pharmacist Professional Practice was implemented in Development Directorate of Public Medicine and Health Provisions, Directorate of Pharmaceutical Care and Medical Devices of Ministry of Health , Republic of Indonesia. PKPA activity was intended that students can understand basic tasks and functions of Directorate of Pharmaceutical Care and Medical Devices of Ministry of Health, especially Development Directorate of Public Medicine and Health Provisions of Ministry of Health Republic of Indonesia, and understand the roles of pharmacist in the directorate.

The title of special assignment was operating costs in the management of public medicine and medical provisions in the pharmacy district/city. The aims of this task were to determine the component of operating cost in the public medicine and medical provisions management at pharmacy district/city and to understand the impact if these fees are not calculated correctly."

"Praktik Kerja Profesi Apoteker dilaksanakan di Apotek SamMari Basra Jalan Basuki Rachmat No. 31, Jakarta Timur. Kegiatan PKPA ini bertujuan agar mahasiswa profesi apoteker dapat memahami tugas pokok, peran dan fungsi apoteker di apotek serta memberikan kesempatan bagi mahasiswa calon apoteker untuk beradaptasi langsung pada lingkungan kerja kefarmasian yang sebenarnya di apotek. Tugas khusus yang diberikan berjudul pembuatan daftar dan pengkajian terhadap penyimpanan obat Look Alike Sound Alike (LASA) dan high alert di apotek Sammarie Basra. Tugas khusus ini bertujuan untuk mengetahui jenis obatobatan yang dapat dikategorikan sebagai LASA dan high alert di apotek SamMarie Basra serta mengetahui apakah penyimpanan obat-obatan sudah sesuai dengan ketentuan yang disarankan oleh Institute for Safe Medication Practices (ISMP).

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Pharmacist Professional Practice was implemented in Apotek SamMarie Basra, Basuki Rachmat Street Number 31, East Jakarta. PKPA activity was intended that students can understand the basic tasks, roles, and functions of pharmacist in pharmacy. Besides that, the aim of this activity was also to give chance for the students to adapt in the reality of pharmacist work environment at pharmacy. A special task was given as making list of and reviewing the storage of Look Alike Sound Alike (LASA) and High Alert drugs in Apotek SamMarie Basra. It was aimed to know LASA and high alert drugs that exist in this pharmacy. Also, to determine whether the storage of medicines is in conformity with the provisions suggested by the Institute for Safe Medication Practices (ISMP)."