Ditemukan 1 dokumen yang sesuai dengan query
Kamada, Rui
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This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of the mutant peptides varied widely. Formation of a tetrameric structure is to be critical for protein–protein interactions, DNA ...
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Tokyo : Springer, 2012
e20406084
eBooks Universitas Indonesia Library
