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"[ABSTRAKPenelitian ini bertujuan untuk mengevaluasi Program kerjasama yang telah dilakukan antara BNN dan PT. Indomarco prismatama, Penerapan program pelatihan pada terapi vokasional pada Balai Besar Rehabilitasi BNN serta mengidentifikasi faktor-faktor peghambat dan pendukung yang mempengaruhi keberhasilan program community service terhadap residen.Penelitian ini menggunakan pendekatan kualitatif dengan wawancara secara mendalam kepada para responden yang merupakan Residen dan konselor dari Balai Besar Rehabilitasi BNN serta pihak dari PT. Indomarco Prismatama selaku mitra kerjasama.Hasil Evaluasi menunjukkan bahwa Program pelatihan Laundry dan magang sudah berjalan dengan baik dan memiliki dampak yang positif terhadap perkembangan Residen pada setiap tahapannya. Meski dalam pelaksanaan program kerjasma ini belum ada bagian khusus yang mengevaluasi program kerjasama yang sedang beerlangsung.

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ABSTRACTThis research aims to evaluate cooperation programs that has been carried out between National Narcotics Board and PT .Indomarco Prismatama, the application of a training program on therapy vocational on the Center rehabilitation National Narcotics Board (BNN) and identify the factors a barrier and supporters that affects the success of the program community service to residentThis research using qualitative approach with deeply interview with the respondents who is resident and counselors of the agency as well as the Center rehabilitation National Narcotics Board from PT.Indomarco prismatama as a joint venture partner.The evaluation results show that the community service programs already run well and have a positive impact on development of the prefect at all levels. Although the implementation of the program is still a special partnership program is underway to evaluate, This research aims to evaluate cooperation programs that has been carried out between National Narcotics Board and PT .Indomarco Prismatama, the application of a training program on therapy vocational on the Center rehabilitation National Narcotics Board (BNN) and identify the factors a barrier and supporters that affects the success of the program community service to residentThis research using qualitative approach with deeply interview with the respondents who is resident and counselors of the agency as well as the Center rehabilitation National Narcotics Board from PT.Indomarco prismatama as a joint venture partner.The evaluation results show that the community service programs already run well and have a positive impact on development of the prefect at all levels. Although the implementation of the program is still a special partnership program is underway to evaluate]"

"Latar belakang: Rabdomiosarkoma (RMS) merupakan sarkoma yang banyak ditemukan pada anak dan dewasa muda. Secara histopatologik ada 4 tipe, yaitu embrional, alveolar, spindel, dan pleomorfik. Tipe histologi dan lokasi (favorable dan unfavorable) termasuk faktor yang menentukan prognosis RMS. Terapi kombinasi pada RMS dengan reseksi komplet, kemoterapi, dan radiasi belum meningkatkan kesintasan pasien RMS terutama pada stadium lanjut. Anti terhadap Epidermal growth factor receptor (EGFR) telah dipakai dalam terapi untuk tumor epitelial ganas, sedangkan penggunaannya pada sarkoma masih dalam penelitian. Dalam penelitian ini dibandingkan ekspresi EGFR pada rabdomiosarkoma anak tipe embrional (RMSE) dan alveolar (RMSA) yang memiliki perbedaan prognosis, serta dilihat ekspresi EGFR pada lokasi favorable dan unfavorable. Metode: Penelitian ini menggunakan metode potong lintang dengan pemilihan sampel secara konsekutif. Sampel terdiri atas 17 kasus RMSE dan 13 kasus RMSA di Departemen Patologi Anatomik FKUI/RSCM tahun 2008-2015. Diagnosis RMSE dan RMSA ditegakkan secara histopatologi dan imunohistokimia MyoD1 dan atau desmin positif. Dilakukan pulasan imunohistokimia EGFR pada RMSE dan RMSA dengan penilaian semikuantitatif, membandingkan kedua tipe histologik dan lokasi tumor. Hasil: Ekspresi EGFR pada RMSE lebih tinggi secara bermakna dibandingkan dengan RMSA (53% vs 23%, p=0,029). Bila dihubungkan dengan lokasi, maka ekspresi EGFR pada RMSE lebih tinggi pada lokasi unfavorabe dibanding lokasi favorable (p=0,412). Ekspresi EGFR pada RMSA lebih tinggi pada lokasi favorable dibanding lokasi unfavorable (p=0,592). Kesimpulan: Ekspresi EGFR pada RMSE lebih tinggi dibandingkan pada RMSA, dengan ekspresi EGFR pada RMSE di lokasi unfavorable lebih tinggi dibanding pada lokasi favorable walaupun tidak bermakna secara statistik.

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Background: Rhabdomyosarcoma (RMS) is the most common sarcoma in children and young adults. Histologically, RMS is divided into 4 types: embryonal, alveolar, spindle, and pleomorphic. Histologic type and location (favorable and unfavorable) are amongst factors that determine prognosis of rabdomyosarcoma. Combined therapies on RMS which consist of complete resection, chemotherapy, and radiation do not increase the survival, especially in advanced stage. Anti-EGFR therapy has been used in epithelial tumor, while its use in sarcoma is still in research. The aim of this study was to compare the expression of EGFR in rhabdomyosarcoma embryonal type (ERMS) and alveolar type (ARMS) which have different prognosis; and comparing EGFR expression in favorable and unfavorable locations.

Method: This was a restropective cross sectional study, using consecutive sampling. The cases consist of 17 ERMS and 13 ARMS in Departement of Anatomical Pathology FMUI/RSCM 2008-2015. ERMS and ARMS was diagnosed by histopathology and confirmed by immunostaining, MyoD1 and or desmin positive. EGFR immunostaining was performed and scored semiquantitatively, and compared the 2 histologic types and location.

Results: There was differences between EGFR expression on ERMS and ARMS (p=0.029). EGFR expression on ERMS was more frequent in unfavorable location than favorable location (p=0.412). EGFR expression on ARMS was more frequent in favorable location than unfavorable location (p=0.592).

Conclusions: Expression EGFR on ERMS was more frequent than ARMSA. RMSE on unfavorable location tented to express EGFR more frequent even did not reach statistical significance."