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"Siklovalon atau (2E,6E) - 2,6 - bis {(4-hidroksi-3-metoksifenil) metiliden} sikloheksan-1-on adalah salah satu analog kurkumin yang memiliki aktivitas antioksidan yang tinggi. Siklovalon memiliki kestabilan yang lebih tinggi dan profil faramakokinetik yang lebih baik dibandingkan kurkumin. Akan tetapi kemampuan siklovalon sebagai senyawa terapeutik masih belum optimal sehingga diperlukan suatu modifikasi struktur. Pada penelitian ini dilakukan modifikasi struktur siklovalon dengan metode reaksi Mannich atau aminometilasi yang diharapkan dapat meningkatkan efek terapeutiknya. Sintesis dilakukan dalam 2 tahap. Tahap pertama ialah sintesis siklovalon dengan mereaksikan vanillin dan sikloheksanon yang menghasilkan nilai rendemen sebesar 58,0%. Sedangkan tahap kedua ialah sintesis derivat di-Mannich siklovalon dengan substitusi gugus basa Mannich dari larutan paraformaldehid dan dietilamin dalam asetonitril menggunakan refluks selama 6 jam yang menghasilkan nilai rendemen sebesar 84,3%. Kemurnian senyawa sintesis tahap 1 dan 2 diuji menggunakan Kromatografi Lapis Tipis dan penetapan jarak lebur. Struktur senyawa hasil sintesis dianalisis menggunakan spektrofotometer FTIR, spektrometri 1H-NMR dan 13C-NMR. Senyawa derivat di-Mannich siklovalon ini terbukti memiliki aktivitas antioksidan (IC50=39,0 μM) dengan kemampuan 1,8 kali lebih tinggi daripada senyawa pemulanya, yaitu siklovalon (IC50= 72,0μM).

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Cyclovalone or (2E,6E)-2,6-bis {(4-hydroxy-3-methoxyphenyl) methylidene} cyclohexan-1-one is one of curcumin analog having high antioxidant activity. Cyclovalone have higher stability and better pharmacokinetic profile than curcumin. However, cyclovalone is still not optimal as a therapeutic compounds so its structure modification is needed. This study present structural modification of cyclovalone by Mannich reaction or aminomethylation that expected to enhance their therapeutic effects. This study was conducted in two steps. The first step was the synthesis of cyclovalone by reacting vanillin and cyclohexanone with 58.0% yield value. While the second step was the synthesis of di-Mannich cyclovalone derivatives by Mannich bases substitution with a solution of paraformaldehyde and diethylamine in acetonitrile with reflux for 6 hours that produce 84.3% yield value. The purity of the synthesized compounds were tested using Thin Layer Chromatography and determination of the melting range. The structure of the compounds was analyzed using FTIR spectrophotometer, spectrometry 1H-NMR and 13C-NMR. Di-Mannich cyclovalone derivatives in this study shown to have 1.8 times higher antioxidant activity (IC50 = 39 μM) than the actual compounds cyclovalone (IC50 = 72,0 μM)."

" ABSTRAKNama : Elizabeth Greffiana ChandraNPM : 1206260330Program Studi : Profesi ApotekerJudul : Praktik Kerja Profesi di PT Mahakam Beta Farma Periode Bulan Januari ndash; Februari Tahun 2017 Praktik Kerja Profesi di PT Mahakam Beta Farma bertujuan agar calon apoteker mampu memahami peranan, tugas dan tanggung jawab apoteker di Industri Farmasi; memperoleh wawasan, pengetahuan, keterampilan, dan pengalaman praktis dalam menjalankan pekerjaan kefarmasian di Industri Farmasi; memahami penerapan GMP dan Cara Pembuatan Obat yang Baik CPOB di Industri Farmasi; serta memperoleh gambaran nyata tentang permasalahan pekerjaan kefarmasian di Industri Farmasi. Adapun Tugas Khusus yang diberikan berjudul lsquo;Penanganan CAPA di PT Mahakam Beta Farma rsquo; bertujuan agar calon apoteker mampu mengetahui dan memahami Prosedur Tetap CAPA yang berlaku di PT Mahakam Beta Farma; mengetahui kesesuaian antara implementasi proses penanganan CAPA di PT Mahakam Beta Farma dengan Protap yang berlaku; mengetahui dan memahami pelaksanaan kegiatan monitoring CAPA di PT Mahakam Beta Farma; serta mengetahui dan memahami pelaksanaan kegiatan penilaian efektivitas CAPA di PT Mahakam Beta Farma. Kata Kunci : Apoteker, Industri Farmasi, CPOB, CAPATugas Umum : xii 46 halaman 1 gambar, 1 tabel, 7 lampiran Tugas Khusus : iii 19 halaman 4 lampiran Daftar Acuan Tugas Umum : 9 2008 ndash; 2013 Daftar Acuan Tugas Khusus : 6 2008 ndash; 2016

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ABSTRACTName Elizabeth Greffiana ChandraNPM 1206260330Study Program Apothecary ProfessionTitle Internship at PT Mahakam Beta Farma Month Period January ndash February 2017 Profession Internship at PT Mahakam Beta Farma aims for pharmacy student to understand the role, duties and responsibilities of pharmacists in the Pharmaceutical Industry gain insight, knowledge, skills and practical experience in performing pharmaceutical work in the Pharmaceutical Industry understand the application of GMP and Cara Pembuatan Obat yang Baik CPOB in the Pharmaceutical Industry as well as obtaining a clear picture of the pharmaceutical work problems in the Pharmaceutical Industry. The Special Task entitled 39 Penanganan CAPA di PT Mahakam Beta Farma 39 aims for pharmacy student to know and understand the CAPA Procedures applicable in PT Mahakam Beta Farma to know the suitability between the implementation of CAPA handling process in PT Mahakam Beta Farma with the prevailing procedures to know and understand the implementation of CAPA monitoring activities at PT Mahakam Beta Farma and also to know and understand the implementation of CAPA effectiveness assessment in PT Mahakam Beta Farma. Keywords Pharmacist, Pharmaceutical Industry, CPOB, CAPAGeneral Assignment xii 46 pages 1 pictures, 1 tables, 7 appendices Specific Assignment iii 19 pages 4 appendices Bibliography of General Assignment 9 2008 ndash 2013 Bibliography of Specific Assignment 6 2008 ndash 2016 "

"ABSTRAKNama : Elizabeth Greffiana ChandraNPM : 1206260330Program Studi : Profesi ApotekerJudul : Praktik Kerja Profesi di Apotek Kimia Farma No. 389 Depok Periode Bulan Maret Tahun 2017 Praktik Kerja Profesi di Apotek Kimia Farma No. 389 Depok bertujuan agar calon apoteker mampu memahami tugas dan tanggung jawab apoteker dalam pengelolaan apotek, mampu melakukan praktik pelayanan kefarmasian sesuai dengan ketentuan peraturan perundang-undangan dan etika yang berlaku; memiliki wawasan, pengetahuan, keterampilan, dan pengalaman praktis untuk melakukan praktik kefarmasian di apotek; serta memiliki gambaran nyata tentang permasalahan praktik kefarmasian serta mempelajari strategi dan kegiatan-kegiatan yang dapat dilakukan dalam rangka pengembangan praktik kefarmasian. Adapun Tugas Khusus yang diberikan berjudul lsquo;Home Pharmacy Care di Apotek Kimia Farma No. 389 Depok rsquo; bertujuan agar calon apoteker mampu mengetahui dan memahami apa yang dimaksud dengan home pharmacy care, prinsip serta manfaatnya; mengetahui penerapan home pharmacy care di Apotek Kimia Farma No. 389; serta mengetahui dan memahami peran apoteker dalam pelaksanaan home pharmacy care. Kata Kunci : Apoteker, Kimia Farma, Apotek, Pelayanan Kefarmasian di Rumah, Praktik KerjaTugas Umum : xii 43 halaman 8 gambar, 1 tabel, 3 lampiran Tugas Khusus : v 23 halaman 1 gambar, 4 lampiran Daftar Acuan Tugas Umum : 11 1980 ndash; 2016 Daftar Acuan Tugas Khusus : 5 2006 ndash; 2016

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ABSTRACTName Elizabeth Greffiana ChandraNPM 1206260330Study Program Apothecary ProfessionTitle Internship at Kimia Farma Pharmacy No. 389 Depok Month Period March 2017 Profession Internship Kimia Farma Pharmacy No. 389 Depok aims for pharmacy student to understand the duties and responsibilities of pharmacists in the pharmacy management, be able to perform pharmaceutical practices accordance with the applicable laws and ethics have the insight, knowledge, skills and practical experience to perform pharmaceutical practices at the pharmacy having a clear picture of pharmaceutical practice issues as well as studying strategies and activities that can be undertaken in order to develop the pharmaceutical practices. The Special Task entitled 39 Home Pharmacy Care di Apotek Kimia Farma No. 389 Depok rsquo aims for pharmacy student to know and understand what is home pharmacy care as well as its principles and benefits to know the application of home pharmacy care at Kimia Farma Farmacy No. 389 and also to know and understand the role of pharmacists in the home pharmacy care implementation. Keywords Pharmacist, Kimia Farma, Pharmacy, Home Pharmacy Care, InternshipGeneral Assignment xii 43 pages 8 pictures, 1 tables, 3 appendices Specific Assignment v 23 pages 1 pictures, 2 appendices Bibliography of General Assignment 11 1980 ndash 2016 Bibliography of Specific Assignment 5 2006 ndash 2016 "

"ABSTRAKNama : Elizabeth Greffiana ChandraNPM : 1206260330Program Studi : Profesi ApotekerJudul : Praktik Kerja Profesi di Direktorat Jenderal Kefarmasian dan Alat Kesehatan Kementerian Kesehatan Republik Indonesia Periode Bulan Mei Tahun 2017 Praktik Kerja Profesi di Direktorat Jenderal Kefarmasian dan Alat Kesehatan Kementerian Kesehatan Republik Indonesia bertujuan agar calon apoteker mampu memahami peranan, tugas dan tanggung jawab apoteker di instansi pemerintahan yaitu Direktorat Jenderal Kefarmasian dan Alat Kesehatan; memiliki pengetahuan tentang tupoksi instansi-instansi pemerintahan di bidang farmasi; memiliki wawasan, pengetahuan, keterampilan, dan pengalaman praktis melakukan pekerjaan di pemerintahan; serta memiliki gambaran nyata tentang permasalahan kefarmasian di pemerintahan. Adapun Tugas Khusus yang diberikan berjudul lsquo;Pengkajian Program Kerja Subdirektorat Analisis Farmakoekonomi Terkait Penyusunan Pedoman Teknis Analisis Farmakoekonomi di Fasilitas Kesehatan rsquo; yang bertujuan agar calon apoteker mampu mengetahui dan memahami tujuan pembuatan Pedoman Teknis Analisis Farmakoekonomi di Fasilitas Kesehatan serta menganalisis kesesuaian antara program kerja Pembuatan Pedoman Teknis Analisis Farmakoekonomi di Fasilitas Kesehatan ini dengan tugas pokok dan fungsi Subdirektorat Analisis Farmakoekonomi. Kata Kunci : Apoteker, Direktorat Jenderal Kefarmasian dan Alat Kesehatan, Kemenkes RI, Analisis Farmakoekonomi, Praktik KerjaTugas Umum : x 39 halaman 8 lampiran Tugas Khusus : iv 13 halaman 1 gambar, 1 tabel Daftar Acuan Tugas Umum : 2 2015 ndash; 2017 Daftar Acuan Tugas Khusus : 4 2015 ndash; 2017

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ABSTRACTName Elizabeth Greffiana ChandraNPM 1206260330Study Program Apothecary ProfessionTitle Internship at Directorate General of Pharmaceutical and Medical Devices The Ministry of Health Republic of Indonesia Month Period May 2017 Profession Internship at Directorate General of Pharmaceutical and Medical Devices The Ministry of Health Republic of Indonesia aims for pharmacy student to understand the role, duties and responsibilities of pharmacists in government institution, especially Directorate General of Pharmaceutical and Medical Devices have knowledge about government task and function in pharmacy field have the insight, knowledge, skills, and practical experience of working in government institutions and has a real picture of pharmaceutical problems in the government institutions. The Special Task entitled lsquo Pengkajian Program Kerja Subdirektorat Analisis Farmakoekonomi Terkait Penyusunan Pedoman Teknis Analisis Farmakoekonomi di Fasilitas Kesehatan rsquo aims for pharmacy student to know and understand the purpose of making Technical Guidance of Pharmacoeconomics Analysis in Health Facility as well as to analyze suitability between this work program of making Technical Guideline of Pharmacoeconomics Analysis at Health Facility with the main task and function of Sub Directorate of Pharmacoeconomics Analysis. Keywords Pharmacist, Directorate General of Pharmaceutical and Medical Devices, The Ministry of Health Republic of Indonesia, Pharmacoeconomic Analysis, InternshipGeneral Assignment x 39 pages 8 appendices Specific Assignment iv 13 pages 1 pictures, 1 tables Bibliography of General Assignment 2 2015 ndash 2017 Bibliography of Specific Assignment 4 2015 ndash 2017 "