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"Laboratorium Migas merupakan tempat kerja untuk melakukan pengujian, penelitian, dan pengembangan minyak mentah, produk sampingan, hingga produk jadi menggunakan peralatan dan bahan yang ada. Laboratorium memiliki banyak bahaya di dalamnya, tak terkecuali dengan bahaya kimia seperti benzene, toluene dan xylene (BTX). Oleh karena itu, diperlukan kajian risiko kesehatan di Laboratorium Migas untuk mengetahui seberapa besar tingkat risiko BTX terhadap pekerja laboratorium. Kajian risiko kesehatan ini akan mengacu pada CHRA DOSH Malaysia (2018) dimana data yang didapatkan dianalisis menggunakan IHSTAT. Kajian risiko kesehatan dilakukan menyesuaikan dengan SEG yang sudah ditentukan, yaitu unit Crude & Product Classification, unit Facility & Quality, unit Fuel, unit Analytical & Gas, serta unit Petrochemical. Hasil dari penelitian menunjukan bahwa terdapat tingkat risiko yang tinggi pada pajanan benzene melalui rute inhalasi serta rute dermal terhadap unit Fuel. Sementara itu, pajanan xylene dan toluene berada pada tingkat risiko yang rendah untuk rute pajanan inhalasi serta berada pada tingkat pajanan moderat pada rute pajanan dermal. Dari hasil penelitian terkait tingkat risiko keseharan pada pajanan benzene, toluene, dan xylene, diperlukan peningkatan kesadaran pekerja untuk menggunakan APD tambahan serta peningkatan sistem ventilasi di tempat kerja.

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The Oil and Gas Laboratory is a workplace for conducting testing, research and development on crude oil, by-products and finished products using existing equipment and materials. Laboratories have many dangers in them, including chemical hazards such as benzene, toluene and xylene (BTX). Therefore, it is necessary to study health risks in oil and gas laboratories to find out how big the risk level of BTX is to laboratory workers. This health risk study will refer to CHRA DOSH Malaysia (2018) where the data obtained was analyzed using IHSTAT. Health risk studies are carried out in accordance with the SEGs that have been determined, namely the Crude & Product Classification unit, Facility & Quality unit, Fuel unit, Analytical & Gas unit, and Petrochemical unit. The results of the study show that there is a high level of risk of exposure to benzene via the inhalation route and the dermal route on Fuel units. Meanwhile, exposure to xylene and toluene is at a low risk level for the inhalation exposure route and at a moderate exposure level for the dermal exposure route. From the results of research regarding the level of health risk from exposure to benzene, toluene and xylene, it is necessary to increase worker awareness to use additional PPE and improve the ventilation system in the workplace."

"Pekerja pada unit produksi minyak dan gas bumi berisiko terpajan berbagai bahaya kimia. Salah satu komponen bahan kimia dari minyak bumi adalah volatile organic compounds (VOC), dengan contoh bahan yang terkenal akan toksisitasnya adalah benzene, toluene dan xylene. Penelitian ini bertujuan untuk menganalisis risiko kesehatan terkait pajanan benzene, toluene dan xylene pekerja kilang minyak san gas di PT. X. Penelitian ini menganalisis data sekunder pajanan personal BTX melalui rute inhalasi menggunakan active sampler. Dengan menggunakan metode Chemical Health Risk Assessment (CHRA) dari Department of Safety and Health, Malaysia ditemukan bahwa risiko pajanan benzene pada SEG CDU (crude distillation unit) terkategori risiko sangat tinggi. Untuk pajanan toluene dan xylene berada pada tingkat risiko kesehatan rendah pada hampir seluruh SEG. Berdasarkan hasil penelitian, diperlukan pengendalian yang tepat untuk mengatasi pajanan benzene, toluene dan xylene. Salah satu pengendalian yang direkomendasikan adalah meningkatkan konsistensi penggunaan alat pelindung diri, monitoring pajanan secara kontinu, melaksanakan biomonitoring dan pemeriksaan sel darah tepi.

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Workers in oil and gas production units are at risk of exposure to various chemical hazards. One of the chemical components of petroleum is volatile organic compounds (VOC), with examples of materials known for their toxicity being benzene, toluene and xylene. This study aims to analyze health risks related to exposure to benzene, toluene and xylene of oil and gas refinery workers at PT. X. This study analyzes secondary data on personal exposure to BTX via the inhalation route using an active sampler. Using the Chemical Health Risk Assessment (CHRA) method from the Department of Safety and Health, Malaysia, it was found that the risk of benzene exposure in the SEG CDU (crude distillation unit) was categorized as very high risk. Exposure to toluene and xylene is at a low health risk level in almost all SEGs. Based on the research results, appropriate control is needed to overcome exposure to benzene, toluene and xylene. One of the recommended controls is increasing the consistent use of personal protective equipment, continuous monitoring of exposure, carrying out biomonitoring and examining peripheral blood cells."

"Sumber utama pencemaran perkotaan adalah transportasi. BTX (Benzene, Toluene dan Xylene) adalah merupakan agen pencemar polutan udara kegiatan transportasi yang berbahaya bagi kesehatan. Petugas pintu tol merupakan kelompok berisiko tinggi terpajan BTX. Penelitian ini menggunakan desain cross-sectional dengan pendekatan Analisis Risiko Kesehatan Lingkungan (ARKL) bertujuan untuk mengetahui besarnya risiko kesehatan akibat pajanan BTX pada petugas pintu tol kebun jeruk Jakarta barat. Hasil penelitian menunjukkan bahwa pada bagian gardu pintu tol rata-rata konsentrasi (mean+SD) benzena sebesar 0,00167+0,000056 mg/m3, Toluena sebesar 0,00124+0.000049 mg/m3 dan Xylena sebesar 0,00147+0,000063 mg/m3 sedangkan pada kantor administrasi konsentrasi tidak terdeteksi oleh alat (Method Detection Limit). Rata-rata RQ benzene 0,007, toluene 0,00003 dan xylene 0,002 pada petugas tol lebih tinggi dibandingkan dengan rata-rata RQ benzene 0,002, toluene 0,00001 dan xylene 0,007 petugas administrasi. Kesimpulan bahwa risiko nonkarsinogenik BTX semua pekerja memiliki RQ≤1. Risiko kesehatan nonkarsinogenik dan karsinogenik untuk seluruh pekerja di gerbang pintu tol kebun jeruk pada saat ini belum menunjukkan adanya risiko. Namun demikian, tindakan pencegahan tetap perlu dilakukan dalam rangka pengendalian risk agent tersebut di masa yang akan datang.

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The main sources of urban pollution is transportation. BTX (Benzene, Toluene and Xylene) is an air pollutant pollutant agent transport activities that are harmful to health. Worker in toll gate is high risk groups exposed to BTX.

Design of this study is cross-sectional with Environmental Health Risk Analysis approach to determine the magnitude of health risks due to exposure to benzene, toluene and xylene in the Kebun Jeruk toll gate, west Jakarta.

The results showed that at the toll collectors average concentration (mean+SD) was : benzene 0.00167+0.000056 mg/m3, toluene 0.00124+0.000049 mg/m3 and xylene 0.00147+0,000063 mg/m3. while at the administrative office was not detected (Minimum Detection Limit). The average RQ collector workers of benzene was 0.007, toluene was 0.00004, xylene was 0.002, & At administrative officer RQ of benzene was 0.002, toluene was 0.00001, xylene was 0.0006 lower than the average of worker toll gate.

In conclusion, the risk of all workers have the RQ ≤ 1. Noncarcinogenic and carcinogenic health risks to all workers at the kebun jeruk toll gate at this point have not shown any risk yet. Nevertheless, protections is needed in order to control the risk of the agent in the future."

"ABSTRAKTesis ini membahas Pajanan Penanganan Bahan Kimia Berbahaya Beracun (B3)Benzene dan xylene pada Divisi Industrial Chemical Specialties PT ClariantIndonesia. Tujuan Penelitian ini adalah untuk mengetahui pajanan Benzene danxylene serta untuk mengetahui upaya pengendalian yang sudah dilakukan.Penelitian ini adalah penelitian kualitatif dengan desain deskriptif. Datadikumpulkan dengan membagikan kuesioner terbuka dan melakukan pengukuranlangsung dengan metode personal active sampling untuk mengetahui kadarBenzene dan xylene di tempat kerja . Hasil penelitian menyarankan bahwakaryawan perlu meningkatkan kesadaran dalam menggunakan alat pelindung diripada saat bersinggungan dengan bahan kimia B3. Perusahaan perlu melakukanreview terhadap PPE management khususnya respirator. Perusahaan juga perlumeningkatkan program preventive maintenance terhadap sarana dan prasaranayang terkait dengan penanganan bahan kimia Benzene dan xylene.

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ABSTRACTThe focus of this study is the exposure assessment of handling Dangerous Goodsbenzene and xylene in Industrial Chemical Specialties Department at PTABCIndonesia. The purpose of this study is to analyze the exposure of benzeneand xylene also to evaluate the control programs of dangerous chemical exposure.This study is a qualitative research with descriptive interpretive. The data werecollected by open questionnaires and environment monitoring by personalsampling method to ensure the level of air quality. From the results, theresearcher suggests that workers need to increase awareness regarding personalprotective equipment used especially when handling dangerous goods chemicals.Company also has to improve management of personal protective equipmentwhich involved all workers who contact with dangerous chemicals. Company alsohas to improve preventive maintenance programs to equipments related withhandling benzene and xylene"

"Benzene bersifat toksik dan karsinogenik yang ditemukan dalam proses operasional Kilang Paraxylene di PT. X. Dalam proses kerjanya, pekerja terpajan benzene sehingga dilakukan analisa pajanan benzene terhadap pekerja. Desain penelitian adalah analisa kuantitatif dengan metode potong lintang dari data sekunder perusahaan. Variabel penelitian meliputi konsentrasi personal benzene, kadar SpMA, usia, masa kerja, status gizi, kebiasaan merokok, konsumsi alkohol, shift kerja, durasi pajanan per hari dan penggunaan APP dari 64 pekerja. Konsentrasi personal benzene diukur pada breathing zone pekerja berkisar antara 0,02 sd 0,44 ppm. Sebanyak 28 pekerja (43,75%) memiliki kadar SpMA melebihi IPB ACGIH 2021 (25 µg/g kreatinin), UCL 1,95% di semua SEG melebihi IPB, berarti ada ketidakyakinan sebesar 95% bahwa kadar SpMA pekerja Kilang Paraxylene tidak melebihi IPB. Uji korelasi pearson menunjukkan tidak terdapat hubungan yang signifikan antara konsentrasi personal benzene dengan kadar SpMA, p=0,195. Hasil uji statistic menemukan adanya hubungan signifikan antara kadar SpMA dengan masa kerja, p=0,04. Kadar SpMA hanya menggambarkan metabolit di tubuh namun tidak dapat memberikan rute pajanan. Penelitian lanjutan diperlukan untuk menganalisa dampak pajanan benzene pada pekerja yang melebihi durasi aman pajanan benzene pada PT. X.

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Benzene is presence in routine operational activities of Paraxylene Refinery Unit in PT. X. The process exposed the worker to benzene. Hence, the need to analyze its exposure to the workers. The study design was quantitative analysis with cross sectional design by analyzing secondary data. The variables studied were personal benzene, SpMA level, age, length of work, BMI, smoking habit, alcohol consumption, shift/non shift, length of exposure per day, and use of PPE from the sampel of 64 workers. The result showed personal benzene concentrations measured in the breathing zone are below the recommended exposure limit (NAB Permenaker No 5/2018: 0,5 ppm), 28 respondents (43,75%) had SpMA level above the value of BEI ACGIH 2021 (25 µg/g kreatinin ), UCL 1,95% of all SEG is higher than BEI meaning there is 95% inconfident that benzene concentrations in the breathing zones are below the standard. There is no correlation between personal benzene concentrations and SpMA p=0,195. There is a significant correlation between length of work with SpMA level, p=0,04. SpMA is useful in determining benzene exposure even in low level exposure however it does not recognize where benzene is coming from. Implementation of work rotation and benzene awareness need to be improved. Further study should be conducted to analyze risk of cancer to worker who has been exposed to benzene longer than the safe duration of exposure in PT. X."

"Pekerja kontraktor bahan kimia di perusahaan minyak dan gas bumi PT. XYZ merupakan populasi berisiko terhadap pajanan Benzena disebabkan oleh aktifitas dan kondisi lingkungan kerja yang memungkinkan terpajan oleh uap Benzena. Penelitian ini bertujuan untuk memperkirakan tingkat risiko nonkarsinogenik dan karsinogenik disertai dengan analisis kemungkinan ketidaknormalan kadar darah akibat pajanan Benzena, untuk kemudian ditentukan manajemen risiko yang harus dilakukan. Penelitian merupakan studi potong lintang dilakukan terhadap seluruh pekerja kontraktor bahan kimia di PT. XYZ yang berjumlah 22 orang ditambah dengan 22 orang sebagai pembanding dipilih dari karyawan perusahaan PT. XYZ pada lokasi yang sama.Hasil penelitian menunjukkan bahwa populasi pekerja bahan kimia di PT. XYZ berisiko terhadap pajanan Benzena nonkarsinogenik (RQ = 1,7442) dan karsinogenik (ECR = 1,76 x 10-4) pada durasi pajanan lifetime. Diketahui hubungan yang bermakna antara pajanan Benzena terhadap normalitas kadar hemoglobin (p = 0,015) dan eritrosit (p = 0,000). Risiko ketidaknormalan kadar hemoglobin dan eritrosit berturut-turut pada populasi terpajan adalah 6,92 kali (95% CI:1,28?37,29) dan 21,53 kali (95% CI:4,46?103,90) dibandingkan populasi tidak terpajan. Selain itu juga diketahui hubungan yang signifikan antara kenaikan jumlah asupan Benzena terhadap penurunan kadar haemoglobin (rs = -0,433; p = 0,044) dan eritrosit (rs = -0,474; p = 0,026).Disimpulkan bahwa risiko kesehatan nonkarsinogenik dan karsinogenik akibat pajanan Benzena pada populasi pekerja bahan kimia di perusahaan minyak dan gas PT. XYZ akan terjadi pada durasi pajanan lifetime. Terdapat hubungan antara pajanan Benzena dengan ketidaknormalan hemoglobin dan eritrosit.

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Chemical contractor worker at the oil and gas company PT. XYZ is a population at risk to Benzene exposure due to its activities and work environment condition that possibly exposed by Benzene vapour. This research is aimed to estimate noncarsinogenic and carsinogenic risk level, complemented with blood counts abnormality analysisdue to Benzene exposure, then determining risk management shall be done. The research is cross sectional study was done to all chemical contractor worker at PT. XYZ, consist of 22 person, and additional 22 person as a control was selected from employee of PT. XYZ working at the same location. The research yield that chemical worker population at PT. XYZ is at risk to the noncarsinogenic (RQ = 1.7442) and carsinogenic (ECR = 1.76 x 10-4) Benzene exposure at the lifetime exposure duration.Its known that there is a correlation between Benzene exposure with normality of haemoglobin (p = 0.015) and erythrocytes (p = 0.000). The risk of abnormality haemoglobin and erythrocytes counts is 6.92 times (95% CI:1.28?37.29) dan 21.53 times (95% CI:4.46?103.90) respectively compare to the non exposed population. In addition, its identified that there is a significant correlation between increased Benzene intake to the haemoglobin (rs = -0.433; p = 0.044) and erythrocytes (rs = -0.474; p = 0.026) counts reduction.In summary noncarcinogenic and carcinogenic health risk due to Benzene exposure in the population of chemical worker at the oil and gas company PT. XYZ will occure at the lifetime exposure duration. There is a correlation between Benzene exposure with abnormality of haemoglobin and erythrocytes."

"Penggunaan bahan kimia telah berkembang luas pada berbagai sektor industri baik formal maupun non-formal, termasuk industri mebel. Produk dengan bahan kimia dipakai untuk membantu meningkatkan kualitas dan keindahan produk mebel. Cat, thiner, dan pelitur adalah produk berbahan kimia yang biasa dipakai dalam pembuatan mebel. Toluene adalah komponen atau campuran bahan kimia utama yang terdapat dalam cat, thinner, dan pelitur. Penelitian ini bertujuan untuk Menganalisis tingkat risiko pajanan Toluene pada karyawan bengkel mebel X di Jatinegara. Untuk menentukan tingkat resiko, Sample toluene di udara diambil mengunakan Coconut Shell Charcoal lalu dianalisis dengan Gas Chromatography untuk mendapatkan nilai konsentrasi toluene. Konsentrasi toluene tertinggi berada di titik 5 yaitu area cat kursi sebesar 22.975 mg/m³. Berdasarkan perhitungan RQ pada 33 pekerja di bengkel mebel, didapatkan bahwa untuk pajanan realtime sebanyak 61% pekerja memiliki risiko kesehatan non karsinogenik karena nilai RQ > 1. Sedangkan menururt perhitungan RQ lifetime, didapatkan bahwa 88% dari 33 pekerja memiliki risiko kesehatan non karsinogenik karena nilai RQ > 1.

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Use of chemical has grown wider at various sectors in formal and non-formal including furniture industry. Those chemicals were used to improve the quality and beauty of furniture products. Paint, thiner, and varnish are the chemical product that commonly used in the furniture. Toluene is the major chemical contained in paint, thinner, and varnish.

This study attempts to analyze the risk levels of risk exposure on employees of furniture workshop ?X? in Jatinegara. To determine the risk levels, coconut shell charcoals were used in air sampling, and then were analyzed with gas chromatography to get toluene concentration. Highest toluene concentration was at painting area, 22.975 mg/m³.

Based on RQ realtime calculation, there were 61% of workers having non carcinogenic health risk because the value of RQ > 1. Acording to RQ lifetime calculation, got that 88% of 33 workers having non carcinogenic health risk because the value of RQ > 1."

"Laboratorium merupakan tempat kerja dengan potensi bahaya tinggi. Pekerja laboratorium dapat terpapar berbagai potensi bahaya faktor kimia berupa gas, uap, padatan dan cairan berbahaya, dan faktor bahaya lainnya seperti fisika, biologi, ergonomi dan psikologi. Kegiatan inti laboratorium terdiri dari pengujian, pengambilan contoh uji dan kalibrasi alat. PT X merupakan perusahaan yang bergerak di bidang jasa pengujian laboratorium lingkungan. PT X telah menerapkan identifikasi bahaya keselamatan kerja pada kegiatan intinya, namun belum mencakup bahaya terkait kesehatan. Terdapat 4 jenis Similar Group Exposure di PT X, yaitu Analis Laboratorium Kimia, Analis Laboratorium Mikrobiologi, Petugas Pengambil Contoh dan Petugas Administrasi. Identifikasi bahaya dan penilaian risiko terkait kesehatan dari stresor lingkungan kerja di Laboratorium Lingkungan PT X perlu dilakukan untuk mengetahui tingkat risiko agar dapat dikendalikan dengan tujuan pencegahan timbulnya penyakit akibat kerja. Hasil penilaian risiko pada keempat SEG tersebut menunjukkan bahwa terdapat berbagai aktivitas yang memiliki potensi bahaya fisika, kimia, biologi dan ergonomi dengan tingkat risiko tinggi, sedang dan juga rendah. PT X perlu segera melakukan tindakan pengendalian tambahan pada aktivitas dengan risiko tinggi, dan mempertimbangkan pengendalian tambahan pada aktivitas dengan risiko sedang. Pemantauan berkala juga diperlukan pada aktivitas dengan risiko rendah untuk memastikan kondisi tempat kerja aman dan sehat bagi pekerja.

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Laboratory is a workplace with high hazard potential. Laboratory workers can be exposed to various potential hazards of chemical factors such as dangerous gases, vapours, solids and liquids, and other hazardous factors such as physics, biology, ergonomics, and psychology. The core activities of the laboratory consist of testing, sampling, and calibration. PT X is an environmental laboratory testing service. PT X has implemented safety hazard identification in its core activities but has not yet included health-related hazards. There are 4 types of Similar Group Exposure at PT X, namely Chemical Laboratory Analysts, Microbiology Laboratory Analysts, Sampling Officers, and Administrative Officers. Hazard identification and risk assessment related to health from work environment stressors at the PT X Environmental Laboratory need to be carried out to determine the level of risk so that it can be controlled with the aim of preventing work-related diseases. The results of the risk assessment at the four SEGs show that there are various activities that have the potential for physical, chemical, biological, and ergonomic hazards with high, medium, and low levels of risk. PT X needs to immediately take additional control on high-risk activities and consider additional controls on moderate-risk activities. Periodic monitoring is also required for low-risk activities to ensure safe and healthy workplace conditions for workers."

"Sejak penggunaan benzena, ditemukan juga dampak kesehatan akibat pemajanan dengan bahan kimia ini. Petugas operator pada pengisian BBM adalah salah satu populasi pekerja yang memiliki tingkat resiko pajanan benzena yang tinggi, terutama melalui jalur inhalasi dalam waktu pajanan yang kontinyu. Metode yang digunakan adalah analisis risiko kesehatan lingkungan, yaitu menghitung besar risiko individu dan populasi. Pada estimasi risiko individu, seluruh karyawan belum berisiko efek nonkarsinogenik, tetapi pada pajanan 3 tahun terdapat 1 karyawan yang berisiko efek kanker dan pada pajanan lifetime seluruh karyawan berisiko efek kanker. Seluruh populasi karyawan belum berisiko efek nonkarsinogenik pada semua durasi pajanan. Populasi operator pompa BBM berisiko efek karsinogenik pada durasi pajanan lifetime. Populasi karyawan bagian administrasi belum berisiko efek karsinogenik pada semua durasi pajanan. Disarankan bekerja tidak lebih dari 3 tahun, bekerja selama maksimal 6 jam/hari atau penggunaan APD yang tepat agar terlindung dari risiko kanker.

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Since the use of benzene, was also found health effects due to exposure to these chemicals. Operators in charge of fuel is one of the working population who have high levels of benzene exposure is high risk, mainly through the inhalation pathway of exposure is continuous in time. The method used is the analysis of environmental health risks, namely large calculating individual and population risk. In the individual risk estimates, the employee has not at risk noncarsinogenic effect, but at 3 years of exposure there is an employee at risk of cancer and the effects on lifetime exposure to all employees at risk of cancer effects. The entire population of non-employee has not at risk of carcinogenic effects in all the duration of exposure. The population at risk of fuel pump operators carcinogenic effect on the duration of lifetime exposure. Populations at risk yet the administrative staff of a carcinogenic effect on all the duration of exposure. Advised to work no more than 3 years, working for a maximum of 6 hours / day or the use of appropriate PPE to protect them from the risk of cancer."

"Latar Belakang: Pria, 48 tahun, pekerja minyak dan gas bumi, didiagnosis dengan myelofibrosis, bagian dari myeloproliferatif neoplasma. Pasien bekerja sebagai operator selama 15 tahun, dimana salah satu hazardnya adalah paparan rendah benzen. Laporan kasus ini bertujuan untuk melihat hubungan antara paparan benzene dengan myeloproliferatif neoplasma pada pekerja minyak dan gas bumi. Metode:  Analisis PICO digunakan untuk memformula pertanyaan klinik laporan kasus ini, populasi: pekerja, intervensi/paparan: benzen, komparasi: tidak terpapar benzen, hasil: myeloproliferatif neoplasm. Strategi pencarian literatur untuk menjawab pertanyaan klinis menggunakan data basis leektronik pada PubMed, Google Scholar dan daftar pustaka. Kriteria inklusi adalah penelitian etiologik dengan kriteria eksklusi adalah leukemia myeloid kronik dan trombositopenia esensial. Penelitian yang terpilih kemudian dilakukan penilaian kritis untuk menentukan apakah penelitian ini valid, bermakna, dan dapat diaplikasikan terhadap pasien menggunakan kriteria relevansi dari Ofxord Centre untuk kedokteran berbasis bukti pada penelitian etiologik.Hasil: Terdapat satu peneliltian terpilih yaitu penelitian kasus kontrol dari Glass dkk, 2014 (n= 30 kasus dengan n=124 dengan matched controls), hasil dari penelitian ini paparan kumulatif benzene memiliki OR 1.57 (95% CI 0.55-2.78) terhadap myelofibrosis, paparan benzene 2-20 tahun p 0.49 dan OR 4.4 (95% CI 1.29-15). Setelah dilakukan penilaian kritis terhadap penelitian ini dengan hasil poenelitian valid, memiliki kualitas yang tinggi pada pengukuran paparan benzene pada pekerjaan individu. Meskipun terdapat limitasi berupa confounder data seperti tidak tersedianya informasi mengenai kebiasaan merokok, penggunaan alkohol, paparan radiasi dan atau kerentanan genetik. Kesimpulan: Berdasarkan analisis kasus 7 langkah diagnosis penyakit akibat kerja, dapat disimpulkan bahwa myelofibrosis dapat berhubungan dengan paparan benzen di tempat kerja.

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Background: A 48-years old male, oil and gas worker was diagnosed with myelofibrosis, part of myeloproliferative neoplasm. The patient worked as an operator for 15 years, where one of the hazards was low level of benzene exposure. Hence, this case report is aimed to find the association of benzene exposure with myeloproliferative neoplasm in oil and gas worker.

Method:  The following is PICO analysis to formulate clinical question from this case report; Population: worker, intervention/exposure: benzene, comparison: not exposed to benzene, outcomes: myeloproliferative neoplasm. Literature searching strategies for answering the clinical question used electronic database in PubMed, Google Scholar, and list of references. The inclusion criteria is etiologic research study, while the exclusion criteria are chronic myeloid leukaemia and essential thrombocythemia. The selected papers were then critically appraised to determine whether the article is valid, meaningful, and applicable to the patient using relevant criteria bye the Oxford Centre for Evidence-based Medicine for etiological study.

Result: Finally, one study was selected; a case control study by Glass et al, 2014 (n=30 cases with n=124 matched controls), the outcome of this study was OR of 1.57 (95% CI 0.55-2.78) for cumulative benzene exposure, p 0.49 and OR of 4.4 (95% CI 1.29-15) for a 2-20 years benzene exposure, p 0.018. After a critical appraisal, it was found that this article was valid, the study has high quality and precise benzene exposure metrics based on exposure of individual job. However, there were potential limitations on confounders data such as not available data on smoking habit, alcohol use, radiation exposure and/or genetic susceptibility.

Conclusion: Based on the case analysis through 7 (seven) steps of occupational disease diagnosis and journal critical appraisal, it can be concluded that the myelofibrosis may be related to exposure to benzene at the workplace."