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"Faktor karakteristik usia, stadium kanker, jenis terapi, dan dukungan suami diprediksi telah memengaruhi timbulnya beragam permasalahan psikoseksual pada pasien kanker ginekologi dan kanker payudara. Penelitian ini dilakukan untuk mengidentifikasi adanya hubungan karakteristik usia, stadium kanker, jenis terapi, dan dukungan suami dengan masalah psikoseksual pada pasien kanker ginekologi dan kanker payudara pasca terapi. Jenis penelitian yang digunakan yaitu cross sectional dengan desain penelitian korelatif dan dengan pendekatan analitis kategorik. Sebanyak 61 responden dipilih dengan menggunakan teknik consecutive sampling. Hasil penelitian menunjukkan bahwa ada hubungan signifikan antara jenis terapi dengan masalah psikoseksual (p= 0,049; α= 0,05). Namun, hasil menunjukkan tidak ada hubungan signifikan antara usia (p= 0,368; α= 0,05), stadium kanker (p= 0,636, α= 0,05), dan dukungan suami (p=0,172, α= 0,05) dengan masalah psikoseksual. Hasil penelitian menyarankan diperlukan pembahasan/penelitian dengan studi kohort lebih lanjut mengenai hubungan faktor karakteristik dengan masalah psikoseksual.

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Characteristic factors of age, cancer stage, types of treatment, and partner support has predicted influences psychosexual problems in patients with gynecological and breast cancer. This study aims to identify the assosiation of characteristics of age, stage of cancer, types of treatment, and partner support with psychosexual problems in post treatment gynecological and breast cancer patients. Cross-sectional study was used in this study. Study sample included 61 sample as respondents wich selected by consecutive sampling technique. The results showed that there was significant assosiation between types of treatment and psychosexual problem (p= 0.049; α= 0.05). But, there was no significant assosiation between age (p= 0.368, α = 0.05), cancer stage (p= 0.636, α= 0.05), and partner support (p= 0.172, α = 0.05) with psychosexual problem. Our findings suggest a need for cohort study to discusse later about the assosiation between the characteristics and psychosexual problems."

"Penatalaksanaan kanker payudara mungkin merupakan suatu hal yang amat kontrovesial dan telah mengalami perubahan luarbiasa dengan berjalannya waktu."

"This comprehensive guide delivers informed hope along with effective tools for reclaiming your vitality in the midst of cancer treatment, healing, and recovery.When you or a loved one is faced with a cancer diagnosis, the need for accurate and trusted medical information becomes urgent. Naturopathic physician Lise N. Alschuler and medical journalist Karolyn A. Gazella present an overview of what cancer is, its causes and preventative strategies, an in-depth approach to integrative treatment options, descriptions of key body functions, and discussions of more than twenty specific cancers. The Definitive Guide to Cancer, now in its third edition, encourages you to take an integrative approach that embraces both alternative and conventional therapies across the spectrum of cancer prevention, treatment, and healing."

"[Latar belakang : Angka ketahanan hidup dalam 5 tahun pasien penderitakeganasan kanker ovaeium rendah, karena > 70% kasus terlambat didiagnosis.CA125 asites merupakan metode untuk memprediksi kanker ovarium pra bedahsebelum dilakukan tindakan atau tatalaksanha selanjutnya. Tujuan : Penelitian ini bertujuan untuk menurunkan angka kematian akibatkanker ovarium stadium lanjut.Metode : Uji ini adalah uji diagnostik dengan desain potong lintang. Penelitianberlangsung dari Juli 2014 sampai Juni 2015 di Poli onkologi DepartemenObstetri dan Ginekologi RSUPN Dr Cipto Mangunkusumo sampel sebanyak 41kasus. Sampel diambil langsung dari pasien kanker ovarium dengan asites masif.Selanjutnya sampel di analisa nilai sensitivitas dan spesifitasnya. Hasil : Dari 41 orang subjek penelitian didapatkan nilai sensitivitas dan spesifitasyang cukup baik dalam mendiagnosis kanker ovarium, berturut ? turut nialisensitivitas dan spesifitasnya adalah 96% dan 100%. Pemeriksaan kadar CA125asites dapat dipertimbangkan untuk digunakan sebagai salah satu tumor markeruntuk mendiagnosis kanker ovarium dengan asites masif.Kesimpulan : Kadar CA125 asites memiliki nilai sensitivitas dan spesifitas 96% dan 100% untuk mendiagnosa kanker ovarium jenis sel epitel.;Background : Overall five-year survival rate of ovarian cancer is the lowest ofamongst gynecological malignancies, as it diagnosed in late stage diseases.Preoperative CA125 level in ascites fluid is one of the method to guide thesubsequent management. This research aimed to improve ovarian cancer survivalrate.Method :This study was a diagnostic study with cross-sectional review of CA125level in ascites fluid of 41 ovarian malignancy patients in Obstetrics andGynecology Department of RSUPN Dr. Cipto Mangunkusumo to analyze itssensitivity and specificity. Results :This research showed a good sensitivity and specificity of CA125 level,96 % and 100 % respectively. CA125 level in ascites fluid may consider as one ofthe tumour marker to diagnose ovarian malignancy with massive ascited fluid.Conclusion: CA125 level in ascites fluid had a good sensitivity and specificity to diagnose epithelial ovarian malignancy., Background : Overall five-year survival rate of ovarian cancer is the lowest ofamongst gynecological malignancies, as it diagnosed in late stage diseases.Preoperative CA125 level in ascites fluid is one of the method to guide thesubsequent management. This research aimed to improve ovarian cancer survivalrate.Method :This study was a diagnostic study with cross-sectional review of CA125level in ascites fluid of 41 ovarian malignancy patients in Obstetrics andGynecology Department of RSUPN Dr. Cipto Mangunkusumo to analyze itssensitivity and specificity. Results :This research showed a good sensitivity and specificity of CA125 level,96 % and 100 % respectively. CA125 level in ascites fluid may consider as one ofthe tumour marker to diagnose ovarian malignancy with massive ascited fluid.Conclusion: CA125 level in ascites fluid had a good sensitivity and specificity to diagnose epithelial ovarian malignancy.]"

"Latar Belakang: Proktitis radiasi merupakan komplikasi yang sering dijumpai akibat terapi radiasi pada pasien keganasan pelvis. Berbeda dengan proktitis radiasi akut yang umumnya self-limiting, proktitis radiasi kronik (PRK) dapat berdampak pada menurunnya kualitas hidup dan meningkatnya biaya kesehatan, morbiditas, dan bahkan mortalitas pasien. Tujuan: Mengevaluasi insidens dan faktor-faktor risiko terjadinya PRK pada pasien kanker leher rahim (KLR) yang mendapatkan terapi radiasi. Metode: Dilakukan analisis retrospektif pada pasien-pasien KLR yang mendapatkan terapi radiasi di Departemen Radioterapi Fakultas Kedokteran Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta selama kurun waktu 1 Januari 2010 sampai dengan 31 Desember 2010. Data mengenai pasien, faktor yang berhubungan dengan terapi radiasi, dan PRK akibat komplikasi lanjut dari terapi radiasi dikumpulkan dari catatan medik pasien. Hasil: Selama periode tersebut, terdapat 234 pasien yang memenuhi kriteria penelitian. Dengan median follow-up selama 30 bulan, didapatkan 12 pasien [5,1% (IK 95% 2,28-7,92%)] mengalami PRK (6 proktitis, 6 proktosigmoiditis). PRK terjadi pada 7-29 bulan setelah terapi radiasi selesai (median 14,5 bulan) dan 87% dari seluruh PRK terjadi dalam 24 bulan pertama setelah terapi radiasi. Dengan analisis multivariat Cox regresi, didapatkan hubungan bermakna antara dosis total radiasi yang diterima rektum >65 Gy (HR 7,96; IK 95% 2,30-27,50; p=0,001) dan usia ≥60 tahun (HR 5,42; IK 95% 1,65-17,86; p=0,005) dengan terjadinya PRK. Tidak didapatkan hubungan bermakna antara teknik radiasi 2 dimensional external radiation therapy (2D-XRT) (HR 1,36; IK 95% 0,41-4,51; p=0,616), riwayat histerektomi (HR 1,14; IK 95% 0,34-3,79; p=0,83), dan indeks massa tubuh (IMT) <18,5 kg/m2 (HR 2,34; IK 95% 0,51-10,70; p=0,265) dengan terjadinya PRK. Simpulan: Insidens kumulatif PRK selama 3 tahun pada pasien KLR yang mendapatkan terapi radiasi adalah 5,1% (IK 95% 2,28-7,92%). Dosis total radiasi yang diterima rektum >65 Gy dan usia ≥60 tahun merupakan faktor risiko potensial terjadinya PRK pada pasien KLR yang mendapatkan terapi radiasi. Teknik radiasi 2D-XRT, riwayat histerektomi, dan IMT <18,5 kg/m2 belum dapat dibuktikan sebagai faktor risiko terjadinya PRK pada pasien KLR yang mendapatkan terapi radiasi.

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Background: Radiation proctitis is frequently occured as a complication of radiotherapy for pelvic malignancies. Unlike acute radiation proctitis that is usually self-limiting, chronic radiation proctitis (CRP) can impact on quality of life and increase health cost, morbidity, and even mortality of the patients.

Aims: To evaluate the incidence and risk factors of CRP after radiotherapy in patients with cervical cancer (CC).

Methods: A detailed retrospective analysis was performed on CC patients who had radiotherapy at the Department of Radiotherapy Faculty of Medicine, The University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta from 1st January to 31st December 2010. Data on patient, treatment-related factors, as well as CRP as late complication of radiotherapy were collected from patients’ medical records.

Results: During that period of time, 234 patients met the criteria for this study. With a median follow-up of 30 months, 12 patients [5,1% (CI 95% 2,28-7,92%)] developed CRP (6 proctitis, 6 proctosigmoiditis). CRP occured 7-29 months after completion of radiotherapy (median 14,5 months) and 87% of all CRP occured within 24 months after radiotherapy. Multivariate Cox regression analysis demonstrated significant association between the total rectal-received dose >65 Gy (HR 7,96; CI 95% 2,30-27,50; p=0,001) and age ≥60 years (HR 5,42; CI 95% 1,65-17,86; p=0,005) and the occurrence of CRP. There was no significant association between 2 dimensional external radiation therapy (2D-XRT) technique (HR 1,36; CI 95% 0,41-4,51; p=0,616), history of hysterectomy (HR 1,14; CI 95% 0,34-3,79; p=0,83), and body mass index (BMI) <18,5 kg/m2 (HR 2,34; CI 95% 0,51-10,70; p=0,265) and the occurrence of CRP.

Conclusions: The 3 years cumulative incidence of CRP after radiotherapy in patients with CC is 5,1% (CI 95% 2,28-7,92%). The total rectal-received dose >65 Gy and age ≥60 years are the potential risk factors of CRP after radiotherapy in CC patients. The 2D-XRT technique, history of hysterectomy, and BMI <18,5 kg/m2 have not been proven as the risk factors of CRP after radiotherapy in CC patients."