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"Latar Belakang: Chronic limb threatening ischemia (CLTI) merupakan tahap akhir dari penyakit arteri perifer (PAP) yang menyebabkan morbiditas dan mortalitas yang tinggi. Penyakit arteri perifer dapat menjadi penanda aterotrombosis pada sistem vaskular lainnya. Peran mikrobiota usus dalam penyakit vaskular telah menjadi perhatian dalam penelitian terbaru. Perubahan komposisi mikrobiota usus dapat terjadi pada berbagai penyakit termasuk DM dan penyakit kardiovaskular. Short chain fatty acid (SCFA) adalah produk fermentasi mikrobiota usus dan dapat mempengaruhi kesehatan usus dan peradangan. SCFA dapat menghambat pembentukan foam cells dan mengurangi produksi sitokin pro-inflamasi oleh endotel. Deposit kalsium pada arteri adalah karakteristik dari proses aterosklerosis dan dapat dinilai menggunakan CT angiography. Tujuan dari penelitian ini adalah untuk mengevaluasi hubungan antara kadar SCFA dalam feses dengan tingkat kalsifikasi arteri pada pasien CLTI dengan DM.Metode: Penelitian desain potong lintang pada 30 subjek CLTI dengan DM tipe 2 yang dirawat di RSUPN Cipto Mangunkusumo. Pengukuran kadar SCFA dengan sampel feses. Analisis statistik menggunakan SPSS versi 25, nilai p<0.05 menunjukkan kemaknaan secara statistik.Hasil: Sebanyak 30 subjek penelitian CLTI dengan DM, didapatkan 17 subjek dengan diagnosis CLTI ekstremitas inferior sinistra dan 13 subjek dengan diagnosis CLTI ekstremitas inferior dekstra memiliki nilai kalsifikasi terberat pada regio right femoropopliteal dengan skor 449,46 ± 289,92 diikuti regio left femoropopliteal dengan skor 425 (0-6759). Didapatkan korelasi positif sedang antara persentase propionat dan skor LLAC regio left below knee (r=0,521; p= 0,032). Didapatkan korelasi positif lemah antara kadar HDL dengan aortoiliac score (r=0,371; p=0,043). Terdapat korelasi positif sedang pada kadar LDL dengan LLAC regio left below knee (r=0,535; p=0,027) serta korelasi positif kuat antara nilai kolestrol total dengan LLAC regio left below knee (r=0,671; p=0,003).Kesimpulan: Ekskresi SCFA pada feses yang tinggi dapat mencerminkan nilai LLAC yang tinggi terutama regio femoropopliteal pada subjek CLTI dengan diabetes melitus.

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Background: Chronic limb threatening ischemia (CLTI) is the end stage of peripheral artery disease (PAD) and is associated with high morbidity and mortality. Peripheral artery disease can serve as a marker of atherothrombosis in other vascular systems. The role of gut microbiota in vascular diseases has gained attention in recent research. Changes in gut microbiota composition have been observed in various diseases, including type 2 diabetes mellitus (DM) and cardiovascular diseases. Short chain fatty acids (SCFA), which are products of gut microbiota fermentation, can influence gut health and inflammation. SCFA can inhibit foam cell formation and reduce the production of pro-inflammatory cytokines by endothelial cells. Arterial calcification, assessed using CT angiography, is a characteristic feature of atherosclerosis. The aim of this study was to evaluate the relationship between fecal SCFA levels and arterial calcification in CLTI patients with DM.

Methods: A cross-sectional study was conducted on 30 CLTI subjects with type 2 DM who were treated at RSUPN Cipto Mangunkusumo. SCFA levels were measured using fecal samples. Statistical analysis was performed using SPSS version 25, with a significance level of p<0.05.

Results: the 30 CLTI subjects with DM, 17 had CLTI in the left lower extremity and 13 had CLTI in the right lower extremity. The highest calcification score was found in the right femoropopliteal region with a score of 449.46 ± 289.92, followed by the left femoropopliteal region with a score of 425 (0-6759). A moderate positive correlation was found between the percentage of propionate and the LLAC score in the left below knee region (r=0.521; p=0.032). A weak positive correlation was observed between HDL levels and the aortoiliac score (r=0.371; p=0.043). There was a moderate positive correlation between LDL levels and the LLAC score in the left below knee region (r=0.535; p=0.027), as well as a strong positive correlation between total cholesterol levels and the LLAC score in the left below knee region (r=0.671; p=0.003).

Conclusion: High fecal SCFA excretion may reflect high LLAC scores, particularly in the femoropopliteal region, in CLTI subjects with diabetes mellitus.

"

"Peningkatan kasus diabetes melitus tipe 2 (DMT2) dengan berbagai komplikasinya memberikan dampak gangguan fungsional seseorang dalam bentuk gangguan kognitif dan kapasitas fisik. Keduanya masih reversibel dan baru diketahui berhubungan sehingga disebut sebagai PhysioCognitive Decline Syndrome (PCDS). Kondisi PCDS baru dipelajari pada lansia dan belum spesifik pada penyandang DMT2.TujuanMengetahui korelasi antara kendali glikemik dengan komponen physiocognitive decline syndrome pada penyandang DMT2 dewasa usia pertengahan.Metode Studi potong lintang menggunakan consecutive sampling dari pasien di poliklinik metabolik endokrin dan poli jantung terpadu sejak Januari 2021 – November 2022. Subjek DMT2 berusia 40 – 59 tahun diinklusi. Pemeriksaan kekuatan genggam tangan, dan kecepatan berjalan 6-meter diperiksakan di ruangan standar. MoCA-Ina dilakukan oleh dokter yang telah dilatih. Data HbA1c subjek yang diperiksa adalah HbA1c 3 bulan terakhir. Analisis korelasi Pearson’s atau Spearman’s pada SPSS 20.0 dilakukan sesuai sebaran data.Hasil Sebanyak 133 subjek telah dianalisis. Usia median mencapai 53 tahun dengan proporsi laki-laki dan perempuan serta komplikasi pada masing-masing kateori kendali glikemik (batas HbA1c 7,0%) serupa. Subjek didominasi dengan pendidikan SMA dan Sarjana/Diploma. Median durasi terdiagnosisnya diabetes melitus mencapai 7 tahun dengan HbA1c median 7.6%. Nilai MoCA-Ina pada subjek mencapai nilai median 24 dengan kecepatan berjalan rerata 1.02 + 0.23 m/detik dan median kekuatan genggam tangan 24 kg. Terdapat korelasi bermakna hanya pada HbA1c dengan kekutan genggam tangan (r = -0.24, R2 = 0.06, p value <0.01), terutama pada perempuanKesimpulanTerdapat korelasi bermakna antara kendali glikemik dan kekuatan genggam tangan.

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Increasing cases of type 2 diabetes melitus (T2DM) including its complication have caused functional dysfunction consisted of cognitive decline and physical incapacity. Both cognitive decline and physical incapacity had been just known to be reversible and related to each other, so it is termed as PhysioCognitive Decline Syndrome (PCDS). However, it had been just evaluated in geriatric and not specific to T2DM patient.

To investigate the correlation between glycaemic correlation and component of physiocognitive decline syndrome in middle-aged adult with T2DM.

A cross sectional study with consecutive sampling in our metabolic and endocrine clinic and integrated heart centre in January 2021 – November 2022 had been conducted. Inclusion criteria was 40 – 59 years old subjects with T2DM. Measurement of HbA1c in the last 3 month were analysed, while hand grip strength and gait speed were done in standard room. MoCA-Ina had been conducted by trained doctor. Correlation analysis using Pearson’s or Spearman’s in SPSS 20.0 was done according to data distribution.

133 subjects were analysed. Median age was 53 years old with both sex and complication within each glycaemic control category (HbA1c 7,0% cut off) were similar. Subjects were dominated by high school and undergraduate/diploma education level. Most subjects were diagnosed in up to 7 years of T2DM. Median of HbA1c levels in our study was 7.6%. MoCA-Ina score was 24 in median with mean of gait speed was 1.02 + 0.23 m/s. Our median for hand grip was 24 kg. Significant correlation was only found in relationship of HbA1c and hand grip strength (r = -0.24, R2 = 0.06, p value <0.01).

There was significant correlation between glycaemic control and hand grip strength.

"

"Diabetes melitus (DM) merupakan kondisi yang mendorong perkembangan dan progresi penyakit arteri perifer (PAP). Short Chain Fatty Acid (SCFA) memiliki peran dalam modulasi sistem imun yang merupakan komponen penting dalam patogenesis dari aterosklerosis. Peran SCFA dalam regulasi kadar glukosa dan aterosklerosis memiliki kemungkinan penggunaan SCFA sebagai upaya mencegah PAP pada pasien DM Tipe 2. Oleh karena itu, penelitian ini bertujuan untuk mencari tahu hubungan antara SCFA dengan parameter ultrasonografi pada pasien diabetes melitus tipe 2 tanpa penyakit arteri perifer ekstremitas bawah Metode: Sebuah penelitian potong lintang pada pasien diabetes melitus tanpa PAP pada selama Februari 2023 s/d Mei 2023 di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo. Seluruh pasien dilakukan ultrasonografi pada ekstremitas bawah untuk menilai diameter, volume flow, peak systolic value, gelombang spektral, dan plak. Kemudian dialukan pemeriksaan SCFA dari feses Hasil: Terdapat 39 pasien yang diikutsertakan pada penelitian ini. Pada penelitian ini ditemukan korelasi positif sedang antara diameter SFA dengan propionat persen (r= 0,408; p= 0,025), terdapat korelasi negatif antara PSV CFA dengan total SCFA (p= 0,007), korelasi positif antara valerat persen dengan PSV PTA (r= 0,375; p= 0,041) dan PSV DPA (r= 0,379; p= 0,039), terdapat korelasi antara VF DPA dengan total SCFA (p =0.025), dan korelasi antara VF PTA dengan total SCFA (p=0,006) dan asetat absolut (p=0,038). Hasil ini dapat dipengaruhi oleh antropometri, jenis kelamin, kadar kolesterol, tekanan darah dan kadar gula darah pasien Kesimpulan: Terdapat potensi hubungan antara kadar SCFA dengan parameter ultrasonografi ekstremitas bawah. Perlu penelitian lebih lanjut dengan desain kohort dengan jumlah sampel yang lebih banyak untuk mengevaluasi efek sebab-akibat terkait hubungan SCFA dengan parameter-parameter klinis dan ultrasonografi pasien DM tanpa PAP.

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Diabetes mellitus (DM) is a condition that promotes the development and progression of peripheral arterial disease (PAD). Short Chain Fatty Acid (SCFA) has a role in modulating the immune system in the pathogenesis of atherosclerosis. The role of SCFA in the regulation of glucose levels and atherosclerosis has the possibility of using SCFA as an effort to prevent PAD in Type 2 DM patients. Therefore, this study aims to find out the relationship between SCFA and ultrasound parameters in type 2 DM patients without lower extremity peripheral artery disease. Methods: A cross-sectional study of DM patients without PAD from February 2023 to May 2023 at Cipto Mangunkusumo National Central General Hospital. All patients underwent ultrasonography of the lower extremities to assess diameter, volume flow, peak systolic value, spectral waves, and plaques. Then a SCFA examination of the stool is carried out Results: There were 39 patients included in this study. This study found a positive correlation between SFA diameter and propionate percent (r= 0,408; p= 0,025), there was a negative correlation between PSV CFA and total SCFA (p= 0,007), a positive correlation between valerate percent and PSV PTA (r= 0,375 ; p = 0,041) and PSV DPA (r = 0,379; p = 0,039), there is a correlation between VF DPA and total SCFA (p = 0,025), and a correlation between VF PTA and total SCFA (p = 0,006) and absolute acetate (p =0.038). These results can be influenced by anthropometry, gender, cholesterol levels, blood pressure and blood sugar levels of the patient. Conclusion: There is a potential relationship between SCFA levels and lower extremity ultrasound parameters. Further research is needed with a cohort design with a larger number of samples to evaluate the causal effect related to the relationship between SCFA and clinical and ultrasound parameters of DM patients without PAP."

"Diabetes mellitus merupakan penyakit kronik pada system endokrin yang paling banyak dijumpai dipelayanan kesehatan. Perawat dalam memberikan asuhan keperawatan dapat menggunakan berbagai metode pendekatan, salah satunya dengan model pendekatan Self Care Orem yang menggunakan pendekatan untuk memandirikan pasien diabetes melalui manajemen diabetes secara mandiri.Residensi keperawatan medikal bedah peminatan keperawatan endokrin bertujuan melakukan analisis terhadap penerapan model pendekatan Self Care Orem dalam melakukan kegiatan pemberian asuhan keperawatan. Selain itu juga dilakukan penerapan praktek berbasis bukti dengan pengkajian 3 menit kaki diabetesdi poliklinik penyakit dalam diharapkan dapat menjadi skrining terhadap pencegahan terjadinya ulkus diabetik. Selain penerapan Evidence Based Nursing Practice juga dilakukan penerapan inovasi promosi kesehatan dengan tujuan untuk memandirikan pasien dalam melakukan perawatan diri sehari-hari dalam mencegah terjadinya komplikasi diabeti yang dilakukan dipoliklinik penyakit dalam RS. Ciptomangunkusumo, Jakarta. Diharapkan dengan penerapan asuhan keperawatan dengan menggunakan pendekatan Self Care Orem, serta penerapan pengkajian 3 menit kaki diabetik dan promosi kesehatan dapat menjadi acuan dalam penerapan asuhan keperawatan yang komprehensif dan terintegrasi, sehingga pada akhirnya diharapkan dapat meningkatkan kulaitas asuhan keperawatan.

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Diabetes mellitus is a chronic disease in the endocrine system of the most prevalent in health care system. Nurses in providing nursing care can use various methods for approach , one of them with models of Orem Self Care approach.

That uses approach for diabetic patients through independent diabetes management. Nursing specialist of Medical-Surgical practice for endocrine conduct an analysis of the application models of Orem Self Care approach in the provision of nursing care activities. It also made the application of evidencebased practice with an assessment of the diabetic foot in 3 minutes in outpatient

with diabetic, with the aims to be screened foot problems for prevention of diabetic ulcers.

In addition to the application of evidence -based nursing practice is also carried

out the implementation of inovation prgramme health promotion. The purpose of

this programme is promote patient ability to be independent for perform daily

self-care and prevention from diabetic complication in Cipto Mangunkusumo

Hospital at Jakarta. The cxpectation of implementation of nursing care by using Orem Self Care Approach, 3 minutes diabetic foot assessment and health promotion can be a reference in the implementation of nursing care is comprehensive and integrated , which in turn is expected to improve the quality of nursing care ."

"[ABSTRAKDiabetic Kidney Disease DKD pada Diabetes Melitus Tipe 2 DMT2 merupakan komplikasi kronik yang dapat dicegah dan ditunda progresifitasnya dengan pengontrolan glikemik yang baik dan penatalaksanaan yang tepat dari komorbid lainnya Pengontrolan glikemik menjadi tanggung jawab bersama antara multidisiplin profesi kesehatan di ruang rawat dokter perawat dietisien farmasis dengan pasien serta keluarga Model Self care Orem sangat sesuai untuk diaplikasikan dan dikembangkan di ruangan pada asuhan keperawatan pasien dengan penyakit kronik Pasien dapat bersinergi secara aktif sesuai kemampuannya dalam mencapai tujuan dari setiap intervensi keperawatan Disamping itu pendekatan model self care Orem sesuai untuk mempersiapkan pasien dalam meningkatkan kemampuan self care untuk pasca rawat Pelaksanaan praktek berbasis pembuktian pengukuran suhu kaki dengan termometer infrared dapat menjadi perangkat tambahan untuk menilai adanya gejala inflamasi lokal sehingga upaya deteksi dini menjadi lebih komprehensif Pelaksanaan kegiatan inovasi pemantauan dan pemeriksaan kesehatan mandiri pada pasien DM dapat meningkatkan upaya promosi kesehatan pada pasien DM

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ABSTRACTDiabetic Kidney Disease DKD in Type 2 Diabetes Mellitus T2DM is a chronic complication that can be prevented and delayed its progresivity with a good glycemic control and appropriate treatments Glycemic control is a shared responsibility between the multidisciplinary health professions in the ward doctors nurses dietisien pharmacists and patients and families Orem rsquo s Self care model is appropriate to be applied and developed in the acute care of patients with chronic diseases Patients can actively work together within its capabilities in achieving the objectives of each nursing intervention Besides Orem rsquo s self care model approach appropriate to prepare the patient to improve the ability of self care for post hospitalization Implementation of evidence based practice the measurement of foot temperature with an infrared thermometer may be enhancements to assess the presence of local inflammatory symptoms so that early detection efforts become more comprehensive Implementation of innovation activity monitoring and self health assesment can improve health promotion efforts in diabetic patients ;Diabetic Kidney Disease DKD in Type 2 Diabetes Mellitus T2DM is a chronic complication that can be prevented and delayed its progresivity with a good glycemic control and appropriate treatments Glycemic control is a shared responsibility between the multidisciplinary health professions in the ward doctors nurses dietisien pharmacists and patients and families Orem rsquo s Self care model is appropriate to be applied and developed in the acute care of patients with chronic diseases Patients can actively work together within its capabilities in achieving the objectives of each nursing intervention Besides Orem rsquo s self care model approach appropriate to prepare the patient to improve the ability of self care for post hospitalization Implementation of evidence based practice the measurement of foot temperature with an infrared thermometer may be enhancements to assess the presence of local inflammatory symptoms so that early detection efforts become more comprehensive Implementation of innovation activity monitoring and self health assesment can improve health promotion efforts in diabetic patients ;Diabetic Kidney Disease DKD in Type 2 Diabetes Mellitus T2DM is a chronic complication that can be prevented and delayed its progresivity with a good glycemic control and appropriate treatments Glycemic control is a shared responsibility between the multidisciplinary health professions in the ward doctors nurses dietisien pharmacists and patients and families Orem rsquo s Self care model is appropriate to be applied and developed in the acute care of patients with chronic diseases Patients can actively work together within its capabilities in achieving the objectives of each nursing intervention Besides Orem rsquo s self care model approach appropriate to prepare the patient to improve the ability of self care for post hospitalization Implementation of evidence based practice the measurement of foot temperature with an infrared thermometer may be enhancements to assess the presence of local inflammatory symptoms so that early detection efforts become more comprehensive Implementation of innovation activity monitoring and self health assesment can improve health promotion efforts in diabetic patients ;Diabetic Kidney Disease DKD in Type 2 Diabetes Mellitus T2DM is a chronic complication that can be prevented and delayed its progresivity with a good glycemic control and appropriate treatments Glycemic control is a shared responsibility between the multidisciplinary health professions in the ward doctors nurses dietisien pharmacists and patients and families Orem rsquo s Self care model is appropriate to be applied and developed in the acute care of patients with chronic diseases Patients can actively work together within its capabilities in achieving the objectives of each nursing intervention Besides Orem rsquo s self care model approach appropriate to prepare the patient to improve the ability of self care for post hospitalization Implementation of evidence based practice the measurement of foot temperature with an infrared thermometer may be enhancements to assess the presence of local inflammatory symptoms so that early detection efforts become more comprehensive Implementation of innovation activity monitoring and self health assesment can improve health promotion efforts in diabetic patients , Diabetic Kidney Disease DKD in Type 2 Diabetes Mellitus T2DM is a chronic complication that can be prevented and delayed its progresivity with a good glycemic control and appropriate treatments Glycemic control is a shared responsibility between the multidisciplinary health professions in the ward doctors nurses dietisien pharmacists and patients and families Orem rsquo s Self care model is appropriate to be applied and developed in the acute care of patients with chronic diseases Patients can actively work together within its capabilities in achieving the objectives of each nursing intervention Besides Orem rsquo s self care model approach appropriate to prepare the patient to improve the ability of self care for post hospitalization Implementation of evidence based practice the measurement of foot temperature with an infrared thermometer may be enhancements to assess the presence of local inflammatory symptoms so that early detection efforts become more comprehensive Implementation of innovation activity monitoring and self health assesment can improve health promotion efforts in diabetic patients ]"

"Latar Belakang: Chronic limb threatening ischemia (CLTI) merupakan bentuk paling parah dari peripheral arterial disease (PAD). Sebanyak 25% pasien CLTI memiliki risiko amputasi tungkai mayor dan 25% lainnya akan meninggal karena penyakit kardiovaskular dalam 1 tahun. Risiko amputasi ini dapat diprediksi menggunakan sistem skoring Wound, Ischemia, and foot Infection (WIfI). Penelitian ini bertujuan untuk mendapatkan profil amputasi menggunakan skor Wound, Ischemia, foot Infection pada subjek chronic limb threatening ischemia di Rumah Sakit dr. Cipto Mangunkusumo (RSCM).Metode: Pengambilan data retrospektif dari data registrasi divisi bedah vaskular dan rekam medis pada subjek dengan CLTI di RSCM berupa profil subjek, skor WIfI, dan status amputasi mayor dalam 1 tahun pasca diagnosis CLTI ditegakkan. Data selanjutnya dimasukkan ke program SPSS, dan dilakukan analisa data. Hasil analisa lalu dipaparkan dalam bentuk narasi dan tabel.Hasil: Pada penelitian ini usia rerata subjek adalah 58,1 ± 12,9 tahun dengan predominasi jenis kelamin laki-laki (58,3%). Komorbid pada subjek dari yang tersering adalah diabetes (82,1%), hipertensi (67,9%), gagal ginjal kronis (51,3%), dan penyakit jantung (33%). Derajat skor WIfI dengan derajat sangat rendah, rendah, sedang, dan tinggi secara berurutan adalah 6,4%, 9,6%, 35,9%, dan 48,1%. Angka amputasi mayor yang sesungguhnya pada subjek CLTI di RSCM untuk skor WIfI derajat sangat rendah, rendah, sedang, dan tinggi adalah 5%, 7%, 35%, dan 70%, sedangkan pada kepustakaan adalah 3%, 8%, 25%, dan 50%.

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Background: Chronic limb threatening ischemia (CLTI) is the most severe form of peripheral arterial disease (PAD). As many as 25% of CLTI patients have a risk of major limb amputations and 25% will die due to cardiovascular event within 1 year. The risk of this major amputation can be predicted using the Wound, Ischemia, and foot Infection (WIfI) scoring system. This study aims to compare the amputation profile using Wound, Ischemia, foot Infection scores in chronic limb threatening ischemia patients at the RSCM.

Methods: Retrospective data collection from registry in vascular surgery division and medical records for patients with CLTI in RSCM were take, that is a patient profile, the comorbid disease, WIfI score, and the patient's major amputation status within 1 year after diagnosis of CLTI was established. The data then inputed to the SPSS program, and data analysis is performed. The results of the analysis are then presented in the form of narratives and tables.

Result: The mean age of the subjects in this study was 58,1 ± 12,9 years with male as gender predominance (58,3%). The comorbids in the subjects were diabetes (82,1%), hypertension (67,9%), chronic kidney failure (51,3%), heart disease (33%). The WIfI scores with very low, low, medium, and high degrees are 6,4%, 9,6%, 35,9%, and 48,1% respectively. The major amputation rates in for WIfI scores with very low, low, medium, and high degrees are 5%, 7%, 35%, and 70%, while in the literature are 3%, 8%, 25%, and 50%."

"Diabetes melitus merupakan faktor risiko berkembangnya disfungsi seksualitas pada wanita yang dapat mempengaruhi hasrat seksual, lubrikasi, dispareunia, dan menurunnya kemampuan mencapai orgasme. Masalah disfungsi seksualitas pada pasien diabetes melitus masih merupakan hal yang tabu untuk dibahas secara terbuka karena sulitnya pasien untuk mengungkapkan masalah seksualitasnya kepada petugas kesehatan. Tujuan penelitian adalah untuk mengeksplorasi pengalaman disfungsi seksualitas pasien wanita dengan diabetes melitus. Metode penelitian ini menggunakan desain kualitatif dengan pendekatan studi fenomenologi. Partisipan wanita sejumlah 6 orang dengan kriteria inklusi berusia 18-45 tahun, wanita diabetes melitus tipe 2 dengan disfungsi seksual, memiliki pasangan pernikahan yang masih hidup, yang diambil dengan menggunakan teknik purposive sampling. Pengumpulan data dilakukan dengan metode wawancara mendalam dan menggunakan catatan lapangan field note. Setiap partisipan diberikan kuesioner FSFI female sexual function index untuk menentukan status disfungsi seksualnya. Data dianalisa dengan metode konten analisis kualitatif. Tujuh tema yang ditemukan: 1 ketidaknyamanan fisik saat melakukan aktifitas seksual; 2 adanya penurunan hasrat seksual pada isteri usia lebih dari 30 tahun; 3 ketidakpuasan aktifitas seksual yang dilakukan; 4 keterpaksaan dalam mendiskusikan masalah seksual pada petugas kesehatan; 5 kurangnya informasi tentang aktifitas seksual; 6 ketidakberdayaan menjalani pengobatan masalah seksual; dan 7 penurunan peran seksual sebagai istri. Dapat disimpulkan bahwa disfungsi seksual pada wanita diabetes melitus tipe 2 ada dan mengganggu baik secara fisik maupun psikologis. Namun, masih terdapat keengganan bagi wanita untuk dapat mendiskusikan masalahnya secara terbuka. Oleh sebab itu, disarankan bagi perawat untuk memulai komunikasi secara terbuka mengani masalah seksualitas wanita dengan diabetes melitus tipe 2.

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Diabetes mellitus is a risk factor for developing female sexual dysfunction which affected sexual desire, lubrication, dispareunia sexual pain, and orgasm decreased. Sexual dysfunction problem in type 2 diabetic patients is still a taboo subject to be discussed because that was hard to be revealed to their healthcare personnel. The aim of the study was to explore sexual dysfunction experience of type 2 diabetes mellitus woman. A qualitative with a phenomenology design was used. This study was involved six women with type 2 diabetes mellitus who met the inclusion criterion ages 18 45 years, married, gathered using a purposive sampling method. Data were collected using an in depth interview and field notes. Each participant was screened using a FSFI quessionaire to determine sexual dysfunction status. Data were analyzed using qualitative content analysis. Seven themes emerged 1 physical discomfort while having sexual activities 2 presence of sexual desire decreased in spouse with ages more than 30 years old 3 dissatisfaction with sexual activity 4 hesitance feeling while discussing sexual problem with healthcare providers 5 lack of information about sexual activity 6 feeling powerlessness while undergone sexual problem treatment 7 decreased in sexual roles as a wife. In conclude that the sexual dysfunction among women with type 2 diabetes mellitus is existing and disturbing physically and psychology. But there has been hesitated of women to openly disccussed the problem. It is suggested for nurses to initiate open communication about sexual problem among women with type 2 diabetes mellitus."

"Latar Belakang: Peningkatan kadar high sensitivity C-reactive protein ( hsCRP ) dan kekakuan arteri berhubungan dengan peningkatan insiden kejadian kardiovaskular dan peningkatan mortalitas akibat penyakit jantung koroner pada pasien diabetes melitus tipe 2.Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara kadar hsCRP dan kekakuan arteri pada pasien diabetes melitus tipe 2.Metode : Melalui studi cross-sectional, dilakukan pemeriksaan kadar hsCRP dan derajat kekakuan arteri karotis pada 40 pasien dengan diabetes melitus tipe 2. Kekakuan arteri karotis kommunis diperiksa dengan doppler echotracking system untuk menentukan pulse wave velocity (PWV) atau kekakuan arteri karotis lokal (carotid-PWV).Hasil : Nilai median hsCRP pada penelitian ini adalah 4,5 (0,2 - 18,9) mg/L dan nilai rata-rata kekakuan arteri karotis adalah 8,8 ±1,7 m/detik. hsCRP berkorelasi kuat dengan karotid-PWV (r = 0,503, P = 0,001). Korelasi hsCRP dengan karotid-PWV ini tetap terlihat setelah dilakukan koreksi terhadap umur, indeks masa tubuh dan mean arterial pressure (r = 0,450, P = 0,005).Kesimpulan : Setelah dilakukan koreksi terhadap umur, indeks masa tubuh dan mean arterial pressure, hsCRP berkorelasi positif cukup kuat dengan kekakuan arteri pada pasien diabetes melitus tipe 2.

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Background: The elevated level of high-sensitivity C-reactive protein (hsCRP) and arterial stiffness are associated with higher incidences of cardiovascular events and with increased mortality from coronary heart disease in type 2 diabetic patients.

Aim: The aim of this study was to investigate the relationship between hsCRP and arterial stiffness in type 2 diabetic patients.

Methods: A cross-sectional study was conducted to assess the plasma levels of high sensitive C-reactive protein and carotid arterial stiffness among 40 patients with type 2 diabetes mellitus. The common carotid artery was studied by a doppler echotracking system to determine the local carotid pulse wave velocity (carotid-PWV).

Results: The median value of hsCRP in this study was 4.5 (0.2 to 18.9) mg/L and the average value of local carotid stiffness was 8.8 ± 1.7 m/sec. hsCRP showed a strong correlation with carotid-PWV (r = 0.503, P = 0.001). Levels of hsCRP were independently associated with carotid-PWV after adjusting for age, body mass index, and mean arterial pressure (r = 0,450, P = 0,005).

Conclusion: After adjusting for age, body mass index, and mean arterial pressure, hsCRP was strongly positively correlated with arterial stiffness in patients with type 2 diabets mellitus."

"Latar belakang: Hipomagnesemia berhubungan dengan kejadian pre-diabetes, konversi ke diabetes tipe 2 dan juga komplikasi kronik diabetes, termasuk albuminuria. Hasil studi hubungan antara kadar magnesium dengan kejadian albuminuria pada diabetes melitus tipe 2 masih kontroversial. Untuk itu perlu dilakukan penelitian hubungan tersebut. Metode: Potong lintang dengan consecutive sampling pada pasien DM tipe 2 yang sudah terdiagnosis nefropati diabetes. Dilakukan anamnesis faktor risiko, pemeriksaan fisik, kadar magnesium, albumine creatinine ratio dan A1C. Hasil: Tiga puluh delapan subjek ikut dalam penelitian yang sebagian besar berusia lebih 50 tahun dan memiliki kontrol glikemik yang buruk (81,6%). Pada subjek penelitian yang memiliki kadar Mg <1,7 mg/dl 80% mengalami albuminuria, sementara subjek yang memiliki kadar Mg ≥ 1,7 mg/dl didapat 63,6% subjek penelitian yang mengalami albuminuria. Pada penelitian ini didapatkan koefisien korelasi sebesar 0,006 yang menunjukkan hubungan yang lemah antara kadar magnesium dalam darah dengan albuminuria. Kesimpulan: Secara statistik tidak ditemukan korelasi antara kadar magnesium dengan albuminuria.

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Background: Hypomagnesemia associated with occurance of prediabetes, convertion to type 2 diabetes and also chronic complication of diabetes, including albuminuria. Studies that look for correlation magnesium concentration with albuminuria in type 2 diabetes still controvensial that?s why we need to do this research.

Method: Cross sectional study done in type 2 diabetes who have been diagnosed with nephropathy. Correlation Pearson test used to prove correlation between magnesium level with albuminuria.

Result: Thirty eight subjects follow this study, majority of them age more than 50 years old, mostly having bad glycemic control (81,6%).There are 80 % subject with hypomagnesemia (Mg <1,7 mg/dl) suffered from albuminuria while subject with normomagnesia (Mg ≥ 1.7 mg/dl) only 63.6% suffered from albuminuria. This study result in no correlation between magnesium level in type 2 diabetes.

Conclusion: No correlation between serum magnesium concentration with albuminuria."