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Ardian Sandhi Pramesti
Korelasi Persentase Lemak Tubuh Terhadap Kadar Vitamin D Serum Pada Populasi Obesitas di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo = Correlation between Fat Mass Percentage with Serum Vitamin D of Obese Adult Population in Dr Cipto Mangunkusumo Hospital
"Latar Belakang: Obesitas adalah masalah kesehatan masyarakat di seluruh dunia terutama di negara berkembang. Obesitas dapat mempengaruhi status vitamin D, salah satunya dikarenakan adanya peningkatan penyimpanan vitamin D di jaringan adiposa sehingga mengakibatkan rendahnya bioavailabilitas vitamin D. Selain itu, banyaknya jaringan lemak berkaitan dengan  inflamasi kronis tingkat rendah yang menyebabkan peningkatan penggunaan vitamin D pada sel imun sehingga menyebabkan rendahnya kadar vitamin D pada kasus obesitas. Penelitian ini bertujuan untuk melihat korelasi antara persentase massa lemak dengan kadar vitamin D serum pada populasi dewasa dengan penyandang obesitas.
Metode: Studi potong lintang ini dilakukan pada subjek dewasa dengan obesitas di Rumah Sakit Cipto Mangungkusumo, Pengukuran persentase massa lemak menggunakan bioelectrical impedance analysis (BIA) SECA mBCA 525. Pemeriksaan kadar vitamin D serum menggunakan kalsidiol serum dengan metode chemiluminescence immunoassay (CLIA).
Hasil: Sebanyak 90 subjek penelitian memiliki rerata usia 41 tahun dengan jumlah subjek terbanyak adalah perempuan (59%). Sebagian besar subjek tergolong status gizi obesitas derajat II. Median kadar vitamin D serum adalah 13,4 ng/dL dengan sebagian besar subjek tergolong defisiensi vitamin D. Rerata persentase massa lemak subjek adalah 37,2 ± 8,2. Terdapat korelasi negatif antara kadar vitamin D serum dengan persentase lemak tubuh pada pada dewasa penyandang obesitas (r=-0,378, p=0,000).
Kesimpulan: Terdapat korelasi bermakna berkekuatan sedang antara persentase massa lemak dengan kadar vitamin D serum pada subjek dewasa penyandang obesitas.
Background: Obesity is a global public health issue, especially in developing countries. Obesity can affect vitamin D status due to increased storage of vitamin D in adipose tissue. In addition, low bioavailability of vitamin D. Low levels of chronic inflammation is strongly associated with a large number of adipose tissue, which causes increased use of vitamin D in immune cells and causes low levels of vitamin D in obesity population. This study aims to see the correlation between the percentage of fat mass and serum vitamin D levels in the adult population with obesity.
Methods: This cross-sectional study was conducted on obese adult subjects at Cipto Mangunkusumo Hospital. First, the fat mass percentage was measured using bioelectrical impedance analysis (BIA) SECA mBCA 525. In addition, serum vitamin D levels were examined using serum calcidiol using the chemiluminescence immunoassay (CLIA) method.
Results: A total of 90 research subjects had an average age of 41; most were female. Most of the subjects were classified as obesity class II. The average serum vitamin D level was 13.4 ng/dL, with most of the subjects classified as deficient in vitamin D. The mean proportion of subjects in fat mass was 37.2 ± 8.2. There was a negative correlation between serum vitamin D levels and the proportion of body fat in obese adults (r=-0.378, p=0.000).
Conclusion: There was a significant medium correlation between fat mass percentage with serum vitamin D in the adult with obesity."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
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UI - Tugas Akhir  Universitas Indonesia Library
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Sarah Mahri
Korelasi kadar 25-hydroxy vitamin D serum dengan aktivitas penyakit pada pasien urtikaria kronik di poliklinik dermatologi dan venereologi, RSUPN Dr. Cipto Mangunkusumo = Correlation of serum 25-hydroxy vitamin-D levels with disease activity in chronic urticaria patients at dermatology and venereology outpatient, Dr. Cipto Mangunkusumo General Hospital
"Latar belakang: Saat ini, peran vitamin D dalam berbagai penyakit kronis banyak diteliti. Vitamin D dianggap memiliki efek imunomodulator sehingga diduga berkaitan dengan beberapa penyakit alergi dan autoimun, termasuk urtikaria kronik. Terdapat laporan kadar vitamin D yang rendah pada pasien urtikaria kronik dan suplementasi vitamin D terbukti memperbaiki gejala urtikaria kronik yang dinilai dengan kuesioner yang sudah tervalidasi Urticaria activity score 7 (UAS7). Namun, penelitian mengenai korelasi kadar vitamin D serum dengan aktivitas penyakit urtikaria masih terbatas, terutama di Indonesia.
Tujuan: Menganalisis korelasi kadar vitamin D (25[OH]D) serum dengan aktivitas penyakit pada pasien urtikaria kronik.
Metode: Penelitian deskriptif-analitik dengan desain potong lintang. Tiga puluh pasien urtikaria kronik usia 18–59 tahun yang memenuhi kriteria penerimaan dan penolakan direkrut dalam penelitian ini. Penilaian aktivitas penyakit menggunakan UAS7 dan dilakukan pengukuran kadar 25(OH)D serum. Korelasi kadar 25(OH)D serum dan aktivitas penyakit dilakukan dengan menggunakan analisis Spearman. Penelitian ini juga menilai kecukupan pajanan matahari menggunakan kuesioner pajanan matahari mingguan.
Hasil: Rerata skor UAS7 adalah 14,63±7,8, median durasi penyakit adalah 12 (2–120) bulan, median skor pajanan matahari mingguan adalah 8 (2–34), dan median kadar 25(OH)D serum adalah 12,10 ng/mL (6,85–29.87). Mayoritas subjek mengalami defisiensi vitamin D (80%). Tidak terdapat korelasi antara kadar 25(OH)D serum dengan aktivitas penyakit (r=0,151; p=0,425), tetapi didapatkan korelasi negatif kuat yang bermakna pada kelompok defisiensi vitamin D berat (r=-0,916; p=0,001). Terdapat korelasi positif sedang bermakna antara aktivitas penyakit dan durasi penyakit (r=0,391; p=0,033). Pada kuesioner pajanan sinar matahari mingguan, didapatkan perbedaan bermakna skor bagian tubuh yang terpajan matahari antar kelompok insufisiensi dan defisiensi vitamin D (p=0,031).
Kesimpulan: Tidak terdapat korelasi kadar 25(OH)D serum dengan aktivitas penyakit pasien urtikaria kronik, namun terdapat kecenderungan peningkatan aktivitas penyakit pada kelompok defisiensi berat vitamin D.
Background: Nowadays, the role of vitamin D in various chronic diseases is a matter of great interest. Vitamin D is thought to have an immunomodulatory effect so it is thought to be associated with several allergic and autoimmune diseases, including chronic urticaria. There have been reports of low vitamin D levels in patients with chronic urticaria and vitamin D supplementations has been shown to improve symptoms of chronic urticaria which was assessed by a validated questionnaire Urticaria activity score 7 (UAS7). However, data on the correlation between serum vitamin D levels and disease activity in chronic urticaria are still limited, especially in Indonesia.
Objective: To analyze the correlation between vitamin D (25[OH]D) serum and disease activity in chronic urticaria patients.
Methods:
This is an analytic-descriptive cross-sectional study. Thirty chronic urticaria patients age 18 – 59 years old who meet all inclusion and exclusion criterias were recruited in this study. Assessment of disease activity using UAS7 and measurement of 25(OH)D serum levels were performed. Correlation of 25(OH)D serum levels and disease activity was done using Spearman analysis. In this study, an assessment of sun exposure adequacy was carried out using a weekly sunlight exposure questionnaire.
Results: The mean of UAS7 was 14.63±7.8, median duration of illness was 12 (2 – 120) month, median weekly sunlight exposure score was 8 (2 – 34), and the median serum 25(OH)D was 12.10 ng/mL (6.85 – 29.87). The majority of subjects had vitamin D deficiency (80%). There was no correlations between serum 25(OH)D levels and disease activity (r=0.151; p=0.425). However, a significant negative correlation was found in severe deficiency vitamin D group (r=-0.916; p=0.001). There was also significant moderate correlation between disease activity and duration of illness (r=0.391; p=0.033). In weekly sunlight exposure questionnaire, we found that body surface area score was significantly different between insufficiency and deficiency vitamin D groups (p=0,031).
Conclusion: There was no correlation between serum 25(OH)D levels and disease activity in chronic urticaria patients, however there was a tendency of increasing disease activity in severe deficiency vitamin D group"
Depok: Fakultas Kedokteran Universitas Indonesia, 2021
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UI - Tesis Membership  Universitas Indonesia Library
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Audrey Haryanto
Korelasi antara kadar vitamin D serum dengan kadar hsCRP pada usia lanjut = Correlation between serum vitamin D level and hsCRP in elderly
"Prevalensi penyakit kardiovaskuler (PKV) meningkat seiring dengan proses penuaan. Aterosklerosis yang menyebabkan terjadinya inflamasi dan diikuti peningkatan kadar C-reactive protein (CRP). Vitamin D merupakan vitamin yang memiliki efek antiinflamasi dan dapat menurunkan kadar hsCRP. Penelitian ini merupakan penelitian dengan desain potong lintang yang bertujuan untuk mengetahui korelasi antara kadar vitamin D dengan kadar hsCRP pada usia lanjut (usila). Penelitian dilakukan di Pusat Santunan Keluarga (Pusaka) 12 di Tomang dan Pusaka 39 di Senen pada pertengahan bulan Desember 2012 sampai bulan Januari 2013. Pengambilan subyek dilakukan dengan cara cluster random sampling, dan didapatkan 71 orang subyek yang memenuhi kriteria penelitian. Data dikumpulkan melalui wawancara meliputi data usia, asupan vitamin D dengan metode Food Frequency Questionnaire (FFQ) semikuantitatif serta total skor pajanan sinar matahari mingguan. Pengukuran antropometri untuk menilai status gizi dan pemeriksaan laboratorium yang meliputi kadar vitamin D dan hsCRP. Didapatkan median usia 69 (60-85) tahun dan 80,3% subyek adalah perempuan. Malnutrisi terdapat pada 71,8 % subyek. Asupan vitamin D menunjukkan 98,6% subyek memiliki asupan vitamin D kurang dari Angka Kecukupan Gizi (AKG) Indonesia. Sebanyak 97,2% subyek memiliki skor pajanan sinar matahari rendah. Nilai rerata kadar vitamin D 38,02±12,94 nmol/L dan 78% subyek tergolong defisiensi vitamin D. Nilai median kadar hsCRP 1,5 (0,1-49,6) mg/L, dan 67,6% subyek tergolong risiko PKV sedang dan tinggi. Didapatkan korelasi positif tidak bermakna antara kadar vitamin D serum dengan kadar hsCRP pada usila (r=0,168, p=0,162).
The prevalence of cardiovascular disease (CVD) increases in the elderly. Atherosclerosis is a major cause of CVD which stimulate inflammation and followed by increase production of C-reactive protein (CRP). Vitamin D is a vitamin which has anti-inflammatory effects and may reduce level of hsCRP. The aim of this cross sectional study was to find the correlation between serum vitamin D level and hsCRP in elderly. Data collection was conducted during December 2012 to January 2013 on 2 selected Pusaka, Pusaka 12 (Tomang) and Pusaka 39 (Senen). Subjects were obtained using cluster random sampling method. A total of 71 elderly subjects had met the study criteria. Data were collected through interviews including age, vitamin D intake and weekly score of sunlight exposure. Anthropometry measurements to assess the nutritional status and laboratory examination i.e blood levels of vitamin D and hsCRP. Majority of the subjects were female (80,3%), median age was 69 (60-85) years. Malnutrition was occured in 71.8% of the subjects. Intake of vitamin D showed 98.6% of the subjects were less than recommended dietary allowances (RDA). Majority of the subjects had low score of sunlight exposure (97,2%). Mean of vitamin D levels 38,02±12,94 nmol/L, while 78% the of subjects were categorized as vitamin D deficiency. Median of hsCRP levels 1,5 (0,1-49,6) mg/L, while 67,6% subjects were at moderate and high risk of CVD. No significant correlation was found between serum vitamin D levels and hsCRP levels (r=0,168, p=0,162)."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
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UI - Tesis Membership  Universitas Indonesia Library
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Sri Utami Ningsih
Gambaran kadar vitamin D pada penggunaan obat anti epilepsi generasi pertama tunggal di Poli Neurologi Rumah Sakit Cipto Mangunkusumo = Profile of vitamin d in using first generation of anti epileptic drugs as monotherapy at Cipto Mangunkusumo Hospital Outpatient Clinic
"Kadar vitamin D dapat menurun pada penggunaan OAE lebih dari 6 bulan karena mengaktivasi pregnane x receptor (PXR) yang selanjutnya akan meningkatkan regulasi 24-hydroxylase. Hal ini dapat memicu perubahan vitamin D menjadi metabolit inaktif. Karbamazepin (CBZ), fenitoin (PHT), fenobarbital (PHB) dan asam valproat (VPA) merupakan jenis OAE generasi pertama yang banyak digunakan di RSCM. Tujuan penelitian ini adalah mengetahui gambaran kadar vitamin D dan faktor-faktor yang mempengaruhi penggunaan OAE generasi tunggal
Metode. Desain penelitian berupa studi potong lintang dengan pengambilan sampel secara konsekutif. Subyek penelitian adalah orang dengan epilepsi yang mengkonsumsi CBZ, PHT, PHB dan VPA minimal 6 bulan dan memenuhi kriteria inklusi dan eksklusi. Pada subyek dilakukan wawancara, pengisian kuesioner, pemeriksaan fisik, recall makanan dan pengambilan darah vena untuk pemeriksaan kadar vitamin D.
Hasil. Dari 59 subyek diperoleh subyek lelaki : perempuan (1,4:1). Sebagian besar subyek menggunakan karbamazepin (45,8%) dengan durasi penggunaan OAE berkisar 6 bulan – 35 tahun. Lebih banyak subyek yang mendapatkan paparan sinar matahari yang cukup lebih banyak dibandingkan yang kurang. Prevalensi kadar vitamin D rendah, yaitu, 30,5%. Median vitamin D yaitu, 36,9 ng/ml.
Kesimpulan. Kadar vitamin D pada penggunaan OAE generasi pertama tunggal lebih dari 6 bulan adalah normal. Kadar vitamin D tidak dipengaruhi oleh jenis OAE, durasi penggunaan OAE dan asupan vitamin D. Namun kadar vitamin D pada orang dengan epilpesi dipengaruhi oleh jumlah paparan sinar matahari.
Level of vitamin D can be decreased by first generation anti epileptic anti epileptic drugs (AEDs) due to pregnane x receptor (PXR) activated and increase of 24-hydroxylase regulation. Carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PHB) or valproic acid (VPA) are first generation AEDs that are common used at Cipto Mangunkusumo Hospital. Therefore, the aim of this study is knowing vitamin D level in patients that have been treated by those AEDs more than 6 months.
Method. This was a cross-sectional study with consecutive sampling. Subjects were people with epilepsy taking CBZ, PHT, PHB, or VPA for at least 6 months and fulfilled both inclusion and exclusion criteria. All subjects were interviewed, food recalled and underwent physical examination and measurements of vitamin D level.
Result. Among 59 subjects, male:female ratio is 1.4:1. Most subjects using carbamazepine (45.8%) with duration of OAE therapy is 6 months - 35 years. Prevalence of hipovitaminosis D is 30.5%. Median of vitamin D is 36.1 ng / ml.
Conclusion. Vitamin D level is normal among people with epilepsy (PWE) and not influenced by AEDs type, duration of medication and food intake. However, vitamin D level is influenced by sun exposure in PWE."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
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UI - Tesis Membership  Universitas Indonesia Library
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Yusi Deviana Nawawi
Korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di panti wreda = Correlation between vitamin D serum levels with physical performance among elderly individuals in nursing homes
"Usia lanjut berisiko tinggi mengalami defisiensi vitamin D, sedangkan vitamin D memiliki efek protektif terhadap massa otot. Penurunan massa otot dan fungsinya disebut dengan sarkopenia. Prevalensi sarkopenia sangat tinggi pada usia lanjut yang tinggal di panti wreda, kondisi ini disebabkan gaya hidup sedentari pada penghuni panti wreda. Deteksi dini sarkopenia dapat dilakukan dengan mengukur fungsi otot, salah satunya adalah mengukur performa fisik dengan tes short physical performance battery (SPPB). Penelitian potong lintang ini bertujuan untuk melihat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di lima panti wreda yang terdaftar di Kota Tangerang Selatan. Pengambilan subjek dilakukan dengan cara proportional random sampling, didapatkan 100 usila yang memenuhi kriteria penelitian. Pemeriksaan kadar vitamin D menggunakan kadar kalsidiol serum dengan metode chemiluminescence immunoassay (CLIA). Pemeriksaan massa otot menggunakan bioelectric impedance analysis Tanita SC-330. Analisis korelasi menggunakan uji nonparametrik. Didapatkan nilai tengah usia subjek adalah 74,89 tahun dan 72% subjek adalah perempuan. Terdapat  85% subjek memiliki asupan vitamin D yang kurang dan  94% subjek memiliki skor pajanan sinar matahari yang rendah, serta seluruh subjek masih memiliki massa otot yang normal. Nilai tengah kadar vitamin D serum  adalah 15,50(4-32) ng/mL, dengan 72% subjek mengalami defisiensi vitamin D. Nilai tengah performa fisik adalah 9(3-12) dan sebanyak 47% subjek mengalami performa fisik yang buruk. Hasil penelitian ini menunjukkan bahwa tidak terdapat korelasi antara kadar vitamin D serum dengan performa fisik pada usia lanjut di panti wreda (r=0,130; p=0,196).
Elderly individuals have a risk of vitamin D deficiency, whereas vitamin D has a protective effect on muscle mass. Decrease in muscle mass and function is called sarcopenia. The prevalence of sarcopenia is very high in the elderly who live in nursing homes, this condition is due to the sedentary lifestyle. Early detection of sarcopenia can be done by measuring physical performance with short physical performance battery (SPPB) test. This cross-sectional study aimed to explore the correlation between vitamin D serum levels with physical performance among elderly individuals in five nursing homes registered in South Tangerang. A hundred subjects who fulfilled study criteria gathered using proportional random sampling method. Examination of vitamin D levels using calcidiol serum with the chemiluminescence immunoassay (CLIA) method. Muscle mass was measured using bioelectric impedance analysis Tanita type SC-330. Nonparametric correlation was used for correlation analysis. Median age of subjects was 74.89 years old and 72% were female. Eighty-five percent of subjects had low vitamin D intake, 94% of subjects had low sun exposure score, and all subjects had normal muscle mass. Mean level of vitamin D serum was 15.50 (4-32) ng/mL, with 72% of subjects had vitamin D deficiency. Mean score of physical performance was 9(3-12) and 47% of subjects had low physical performance. This study showed that there was no correlation found between vitamin D serum levels with physical performance among elderly individuals in nursing homes (r=0.130; p=0.196)."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
T58914
UI - Tesis Membership  Universitas Indonesia Library
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Jonathan Darell Widjaja
Level Of Serum Vitamin D in Allergic Rhinitis Patients Compared to Healthy Controls in Rumah Sakit Cipto Mangunkusumo, Jakarta
"Background: Vitamin D role in immune system have been investigated due to the presence of VDR on immune cells. Based on this information deficient level of vitamin D could affect the progression of allergic rhinitis. Unfortunately the data regarding vitamin D status in the normal population and allergic rhinitis patient were very limited in Indonesia. This research was done to provide illustration regarding the status of vitamin D in healthy and allergic rhinitis patients in Jakarta and also to investigate the factor that might affect the level of vitamin D in allergie rhinitis. Methods: This research was an observational cross sectional research. There were 22 subjects used during this research all diagnosed with moderate-severe allergic rhinitis. The study used the Electrochemiluminescence Immunoassay (ECLIA) technique. The data then were analyzed with IBM® SPSS statistic version 22 Results: The difference between the mean vitamin D of patients suffering from allergic rhinitis with healthy controls (12.7±10.3 ng/mL to 15.1±8.1 ng/mL). There was no significant diference in mean vitamin D between the gender groups (Independent Sample T-test p= 0.62). There were no statistical difference between the vitamin D level in patient with different eosinophil count and IL-5 level (IL-5 group: one-way ANOVA: p= 0.897; eosinophil group: One Way ANOVA: p = 0.752). Conclusion: The mean level of vitamin D in allergic rhinitis patients compared to healthy controls showed no significant difference. Comparison studies about level of vitamin D between groups with different gender, IL-5 and eosinophil count showed no significant difference"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
S70303
UI - Skripsi Membership  Universitas Indonesia Library
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Nita Nurul Rachman
Korelasi Kadar Lemak Viseral dengan Kadar Vitamin D 25 (OH) pada Pasien Stroke Akut = Correlation Between Visceral Fat Levels and Vitamin D 25 (OH) Levels in Acute Stroke Patients
"Vitamin D memiliki efek mempertahankan fungsi endovaskular dan mengatur aktivitas inflamasi dalam dinding pembuluh darah. Lemak viseral, disebutkan sebagai prediktor risiko yang baik untuk penyakit vaskular karena berperan aktif secara metabolik serta bersifat meningkatkan pengeluaran sitokin proinflamasi Kedua hal ini berpengaruh dalam peningkatan risiko kejadian stroke akut. Sampai saat ini penelitian yang membahas korelasi antara kedua faktor tersebut masih inkosisten. Studi potong lintang dilakukan pada subyek berusia >18 tahun dengan stroke akut yang menjalani perawatan di RSUPN Dr. Cipto Mangunkusumo dan RS Universitas Indonesia. Pengukuran kadar lemak viseral menggunakan bioelectrical impedance analysis bedridden multifrekuensi. Penilaian kadar serum vitamin D (25 (OH)D) menggunakan metode chemiluminescent immunoassay. Terdapat total 73 subyek penelitian, sebanyak 55 subyek (75,3%) dengan insufisiensi dan 15 subyek (20,5%) mengalami defisiensi vitamin D, dengan nilai rerata di 17,08±7,85 ng/mL. Sejumlah 78,1% subyek memiliki kadar lemak viseral yang tinggi. Terdapat korelasi negatif (r= -0,271) yang signifikan (p <0,021) antara kadar lemak viseral dan kadar vitamin D serum pada stroke akut. Dilakukan analisis multivariat lanjutan, didapatkan kadar lemak viseral dan jenis pakaian (pakaian tertutup) menjadi faktor paling signifikan dalam menilai kadar vitamin D serum.Terdapat korelasi yang signifikan antara kadar lemak viseral dengan kadar vitamin D 25 (OH) pada pasien stroke akut.
Vitamin D has effects in maintaining endovascular function and regulating inflammatory activity in the vascular wall. Visceral fat is said to be a good risk predictor for vascular disease because it plays a metabolically active role and increases the release of pro-inflammatory cytokines, both of which are influential in increasing the risk of acute stroke events. Studies that discuss the correlation between these two factors are still inconsistent.  A cross-sectional study was conducted on subjects aged >18 years with acute stroke who underwent treatment at Dr. Cipto Mangunkusumo Hospital and University of Indonesia Hospital. Measurement of visceral fat levels using bioelectrical impedance analysis bedridden multifrequency. Assessment of serum vitamin D (25(OH)D) levels using chemiluminescent immunoassay method.  In a total of 73 subjects, 55 (75.3%) subjects had vitamin D insufficiency and 15 (20,5%) subject had deficiency, with mean values at 17.08±7.85 ng/mL. A total of 78.1% of subjects had high visceral fat levels. There was a significant (p<0.021) negative correlation (r= -0.271) between visceral fat and serum vitamin D levels in acute stroke. In a further multivariate analysis, visceral fat content and type of clothing (concealing clothing) was found to be the most significant factor in assessing serum vitamin D levels. There is a significant correlation between visceral fat levels and 25 (OH) vitamin D levels in acute stroke patients."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
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UI - Tesis Membership  Universitas Indonesia Library
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Nita Nurul Rachman
Korelasi kadar lemak viseral dengan kadar vitamin D 25 (OH) pada pasien stroke akut = Correlation between visceral fat levels and vitamin D 25 (OH) levels in acute stroke patients
"Latar Belakang: Vitamin D memiliki efek non-skeletal dalam mempertahankan fungsi endovaskular dan mengatur aktivitas inflamasi dalam dinding pembuluh darah. Lemak viseral, disebutkan sebagai prediktor risiko yang baik untuk penyakit vaskular karena berperan aktif secara metabolik serta bersifat meningkatkan pengeluaran sitokin proinflamasi Kedua hal ini berpengaruh dalam peningkatan risiko kejadian stroke akut. Sampai saat ini penelitian yang membahas korelasi antara kedua faktor tersebut masih inkosisten. Penelitian ini bertujuan untuk mengetahui korelasi antara kadar lemak viseral dan kadar vitamin D serum pada pasien stroke akut.
Metode: Studi potong lintang dilakukan pada subyek berusia >18 tahun dengan stroke akut yang menjalani perawatan di RSUPN Dr. Cipto Mangunkusumo dan RS Universitas Indonesia selama bulan November -Desember 2023. Pengukuran kadar lemak viseral menggunakan bioelectrical impedance analysis (BIA) bedridden multifrekuensi. Penilaian kadar serum vitamin D (25 (OH)D) menggunakan metode chemiluminescent immunoassay (CMIA). Analisis bivariat dan multivariat digunakan untuk menilai korelasi dan hubungan antara variable bebas dan terikat, serta mengidentifikasi faktor perancu lain yang berhubungan dengan kadar vitamin D serum.
Hasil: Terdapat total 73 subyek penelitian, sebanyak 55 subyek (75,3%) dengan insufisiensi dan 15 subyek (20,5%) mengalami defisiensi vitamin D, dengan nilai rerata di 17,08±7,85 ng/mL. Sejumlah 78,1% subyek memiliki kadar lemak viseral yang tinggi. Terdapat korelasi negatif (r= -0,271) yang signifikan (p <0,021) antara kadar lemak viseral dan kadar vitamin D serum pada stroke akut. Dilakukan analisis multivariat lanjutan dengan regresi linear untuk faktor perancu lain, hanya didapatkan kadar lemak viseral dan jenis pakaian (pakaian tertutup) yang menjadi faktor paling signifikan dalam menilai kadar vitamin D serum.
Kesimpulan: Terdapat korelasi yang signifikan antara kadar lemak viseral dengan kadar vitamin D 25 (OH) pada pasien stroke akut.
Background: Vitamin D has non-skeletal effects in maintaining endovascular function and regulating inflammatory activity in the vascular wall. Visceral fat is said to be a good risk predictor for vascular disease because it plays a metabolically active role and increases the release of pro-inflammatory cytokines, both of which are influential in increasing the risk of acute stroke events. Until now, studies that discuss the correlation between these two factors are still inconsistent. This study aims to determine the correlation between visceral fat levels and serum vitamin D levels in acute stroke patients.
Methods: A cross-sectional study was conducted on subjects aged >18 years with acute stroke who underwent treatment at Dr. Cipto Mangunkusumo Hospital and University of Indonesia Hospital during November - December 2023. Measurement of visceral fat levels using bioelectrical impedance analysis (BIA) bedridden multifrequency. Assessment of serum vitamin D (25(OH)D) levels using chemiluminescent immunoassay (CMIA) method. Bivariate and multivariate analyses were used to assess the correlation and relationship between independent and dependent variables, as well as identify other confounding factors associated with serum vitamin D levels.
Results: In a total of 73 subjects, 55 (75.3%) subjects had vitamin D insufficiency and 15 (20,5%) subject had deficiency, with mean values at 17.08±7.85 ng/mL. A total of 78.1% of subjects had high visceral fat levels. There was a significant (p<0.021) negative correlation (r= -0.271) between visceral fat and serum vitamin D levels in acute stroke. In a further multivariate analysis with linear regression for other confounding factors, only visceral fat content and type of clothing (concealing clothing) was found to be the most significant factor in assessing serum vitamin D levels.
Conclusion: There is a significant correlation between visceral fat levels and 25 (OH) vitamin D levels in acute stroke patients."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Isa Rosalia Ruslim
Korelasi antara asupan vitamin D dan skor paparan sinar matahari dengan kadar kalsidiol serum pada ibu hamil trimester 1 di Jakarta = Correlation between vitamin d intake and sun exposure score with serum calcidiol on first trimester pregnant women in Jakarta
"Hipovitaminosis D selama masa kehamilan dapat menimbulkan komplikasi selama kehamilan dan pada janin. Selain itu data mengenai status vitamin D pada ibu hamil terutama trimester 1 di Indonesia masih terbatas. Oleh karena itu penelitian ini dilakukan untuk mengetahui kadar kalsidiol serum pada ibu hamil trimester 1 dan korelasinya dengan asupan vitamin D dan skor paparan sinar matahari.
Penelitian ini menggunakan metode studi potong lintang pada ibu hamil sehat usia 20-35 tahun dengan usia kehamilan <12 minggu. Hasil penelitian menunjukkan rerata usia subyek 27,36+3,91 tahun dengan median usia kehamilan 9 minggu. Sebagian besar subyek berpendidikan tinggi (68,1%), status bekerja (70,2%) dengan pendapatan >UMP (59,6%) dan rerata IMT 23,74+3,83 kg/m2. Asupan lemak, protein, dan kalsium subyek
Median skor paparan sinar matahari adalah 14 (0-42) dengan median lama paparan 17,41 (0-85,71) menit. Terdapat perbedaan bermakna antara kadar kalsidiol serum dengan kelompok lama paparan sinar matahari 5-30 menit dan >30 menit (p=0,033). Rerata kadar kalsidiol serum 39,26+10,25 nmol/mL (insufisiensi) dengan 100% subyek memiliki kadar kalsidiol serum < 80 nmol/L yang menggambarkan keadaan hipovitaminosis D.
Tidak terdapat korelasi antara kadar kalsidiol serum dengan skor paparan sinar matahari (r=0,087; p=0,562), dan asupan vitamin D (r=-0,049; p=0,745). Kesimpulan yang didapatkan dari penelitian adalah seluruh ibu hamil trimester 1 di Jakarta mengalami hipovitaminosis D sehingga perlu segera diatasi melalui konseling dan edukasi gizi.
Vitamin D deficiency could be related to several complications to pregnancy`s outcomes, both for mother and fetus. Besides, there is limited data regarding to vitamin D status among pregnant women in Indonesia especially during the first trimester. Therefore this study was performed to determine serum calcidiol on the first trimester of pregnancy and its correlation to vitamin D intake and sun exposure score.
The methode in this study was cross-sectional study among healthy pregnant women aged 20-35 years old on their first trimester of pregnancy. Average age of the subjects was 27.36±3.91 years old with median gestational age of 9 weeks. Most of the subjects was well educated (68.1%), working (70.2%) with monthly income equal and more than the province minimum salary (59.6%), and with BMI average of 23.74±3.83 kg/m2. Mostly the subjects had fat, protein, and calcium intake below its RDA with the average intake of 44.49±22.22 g/day; 45.07±19.35 g/day; 661.93±405.91 mg/day, respectively. Vitamin D intake was mostly below its RDA with a median of 2.9 mcg/day and ranged from 0.3 to 15.6 mcg/day.
The median score of sun exposure score was 14 that ranged from zerro to 42, with a median for its duration of 17.41 minutes that ranged from zerro to 85.71 minutes. In this study, there was significant differences between serum calcidiol and sun exposure duration in 5-30 minutes and more than 30 minutes groups (p=0,033). As the main finding, it reveals that the average of serum calcidiol was 39.26±10.25 nmoL/mL or classified as insufficient where all of the subjects (100%) had serum calcidiol less than 80 nmol/L (hypovitaminosis D).
However, there were no significant correlations between serum calcidiol with sun exposure score and vitamin D intake (r=0.087 and p=0.562; r=-0,049 and p=0.745, respectively). In conclusion, all of the pregnant women in Jakarta, especially in their first trimester had low vitamin D status. Therefore, intervention is needed, i.e. through prenatal counselling and nutrition education regarding to natural sources of vitamin D."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
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UI - Tesis Membership  Universitas Indonesia Library
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Maggie Nathania
Korelasi massa lemak tubuh dan sensitivitas insulin pada pekerja Kantor Obesitas Di RSUPN Dr. Cipto Mangunkusumo = Correlation between body fat mass and insulin sensitivity among Obese Office workers at Dr. Cipto Mangunkusumo National Hospital
"Latar Belakang: Pegawai kantor dengan obesitas memiliki risiko tinggi mengalami diabetes melitus (DM) tipe 2. Pemeriksaan sensitivitas insulin jarang dilakukan karena kendala teknis dan biaya. Berbagai studi sebelumnya menunjukkan adanya hubungan negatif antara massa lemak tubuh dengan HOMA-IR, namun hasil penelitian di Indonesia menunjukkan hasil yang tidak konsisten. Indeks TyG disebut sebagai penanda resistensi insulin yang lebih akurat jika dibandingkan dengan HOMA-IR pada populasi Asia. Belum ada penelitian yang menilai hubungan massa lemak tubuh dengan Indeks TyG di Indonesia.
Metode: Studi potong lintang dilakukan pada 89 pekerja kantor dengan obesitas (IMT ≥25 kg/m2) tanpa riwayat DM di RSUPN Dr. Cipto Mangunkusumo, Jakarta, pada bulan Agustus hingga Oktober tahun 2022. Dilakukan pengambilan data demografis (usia, jenis kelamin, riwayat DM, kebiasaan merokok), antropometri, analisis asupan menggunakan 24-hour food recall 3x24 jam, serta penilaian tingkat aktivitas fisik berdasarkan Global Physical Activity Questionnaire Score. Pengukuran persentase lemak tubuh total dan massa lemak viseral menggunakan multi-frequency bioelectrical impedance analysis (BIA) SECA mBCA-525. Sensitivitas insulin dinilai menggunakan kadar HOMA-IR dan Indeks TyG serum. Analisis korelasi menggunakan uji Spearman dan dilakukan analisis multivariat untuk menilai faktor-faktor yang paling berhubungan dengan sensitivitas insulin.
Hasil: Didapatkan sebanyak 89 subjek dengan proporsi perempuan:laki-laki sekitar 2:1, median usia 40 (21-59) tahun, dan mayoritas memiliki tingkat aktivitas sedang, tidak memiliki riwayat DM pada keluarga, tidak merokok, serta memiliki persentase kecukupan asupan melebihi kebutuhan energi individual dengan persentase makronutrien masih masuk dalam rentang normal. Korelasi persentase lemak tubuh total dengan HOMA-IR menunjukkan korelasi positif lemah yang bermakna (r=0,262, p=0,013). Korelasi massa lemak viseral dengan Indeks TyG menunjukkan korelasi positif lemah yang bermakna (r=0,234, p=0,027). Hasil korelasi persentase lemak tubuh total dengan indeks TyG dan korelasi massa lemak viseral dengan HOMA-IR menunjukkan hasil yang tidak signifikan secara statistik. Persentase lemak tubuh total tidak berhubungan signifikan dengan HOMA-IR setelah disesuaikan dengan variabel jenis kelamin, tingkat aktivitas fisik, indeks massa tubuh, lemak viseral, trigliserida, HDL, lingkar pinggang, dan persentase asupan karbohidrat. Massa lemak viseral tidak berhubungan signifikan dengan Indeks TyG setelah disesuaikan dengan variabel usia, jenis kelamin, lemak viseral, persentase asupan protein, dan HDL.
Kesimpulan: Didapatkan korelasi positif lemah antara persentase lemak tubuh total dengan HOMA-IR dan korelasi positif lemah antara massa lemak viseral dengan Indeks TyG pada pegawai kantor obesitas di RSUPN Cipto Mangkunsumo.
Background: Obese office workers have a high risk of developing type 2 diabetes mellitus (DM). Insulin sensitivity tests are rarely performed due to technical and cost constraints. Previous studies have shown a negative relationship between body fat mass and HOMA-IR. However, the results of research in Indonesia have shown inconsistent results. No study has assessed the relationship between body fat mass and the TyG index in Indonesia. In contrast, some research showed that The TyG index is a more accurate marker of insulin resistance in Asian populations.
Methods: A cross-sectional study was conducted on 89 office workers with obesity (BMI ≥25 kg/m2) without a history of DM at RSUPN Dr. Cipto Mangunkusumo, Jakarta, on August-October 2022. Demographic data were collected (age, gender, history of DM, smoking habits), anthropometry, analysis of energy intake and macronutrients using a 3- days 24-hour food recall, as well as an assessment of the level of physical activity based on the Global Physical Activity Questionnaire Score. The total body fat percentage and visceral fat mass were measured using a multi-frequency bioelectrical impedance analysis (BIA) SECA mBCA-525. Insulin sensitivity was assessed using HOMA-IR levels and serum TyG Index. Correlation analysis used the Spearman test, and multivariate analysis was performed to assess the factors most related to insulin sensitivity.
Results: There were 89 subjects with a proportion of women: men around 2:1, the median age was 40 (21-59) years, and the majority had moderate activity levels, had no family history of DM, did not smoke, and had intakes exceeding individual energy needs with the percentage of macronutrients within normal range. The total body fat percentage correlation with HOMA-IR showed a significant positive correlation with weak strength (r=0.262, p=0.013). The correlation of visceral fat mass with the TyG index showed a significant positive correlation with weak strength (r=0.234, p=0.027). The results of the correlation of total body fat percentage with the TyG index and the correlation of visceral fat mass with HOMA-IR showed results that were not statistically significant. The total body fat percentage was not significantly related to HOMA-IR after adjusting for variables such as gender, level of physical activity, body mass index, visceral fat, triglycerides, HDL, waist circumference, and percentage of carbohydrate intake. Visceral fat mass did not have a significant relationship with the TyG index after adjusting for age, sex, visceral fat, percentage of protein intake, and HDL.
Conclusion: A weak positive correlation was found between the percentage of total body fat and HOMA-IR and a weak positive correlation between visceral fat mass and the TyG index in obese office workers at Cipto Mangkunsumo General Hospital."
Depok: Fakultas Kedokteran Universitas Indonesia, 2023
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UI - Tugas Akhir  Universitas Indonesia Library
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