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"The aim of this study was to investigate the effect of ant (hypertensive agents with different degrees of renal excretion lisinopril (L) eliminated in the kidney and fosinopril (F), only 50% of which is eliminated through the kidney on renal function in hypertension patients with mild to moderate renal failure.Materials and methods: Patients were divided into two groups. The first group was given F 10 mg/day and the second group was given L 10 mg/day. Groups were divided randomly, and drugs were given for 6 weeks each night at 8.00p.m. The hypertension status of each subject was determined from systolic blood pressureJ140 mmHg or diastolic blood pressure -f 90 mg/dl. Subjects were both male and female, with an age range of 18- 65 years old.Results: The results from the creatinine examination of the 10 mgF group was (3.06 ±0.97) mg/dl after drug use, which showed no decrease in renal function. The difference was insignificant (p=0.17). The 10 mgL group the creatinine level was (3.22 ±0.17), where as in the 10 mg L group the creatinine level was (3.22 ± 0.75) mg/dl before the use of the drug and (4.11 ± 2.14) mg/dl after the use of the drug respectively. There was no worsening of the renal function, which did not differ significantly (p=0.11). There was a significant difference (p < 0.05) in the creatinine level of the 10 mg F and 10 mg L groups. The serum creatinine level before and after treatment did show any significant changes at. 6 week. However, the serum creatinine profile over 6 week was more significant in the F group than in the L groups."

"Administration of a renal dose of dopamine in acute renal failure still attracts a lot of controversy, store there has not been a study that found a significant protective effect on the kidneys.Nevertheless, according to its ability to increase renal blood flow in laboratory animals and normal subjects, several parties still maintain its use, even though the required dose is very much individualized.The side effect of dopamine, such as tachycardia, arrhythmia, miocardiac ischemia, and intestinal ischemia due to precapilary vasoconstriction causing bacterial translo-caiionfrom the intestinal lumen to the systemic bloodstream, even though relatively rare, should receive adequate attention."

"The prevalence of chronic renal failure in Indonesia tends to increase in the lower age group (45–54 years). Chronic renal failure may lead to impaired sexual function. A descriptive phenomenology study with in-depth interviews was carried out with 12 participants, and thematic content analysis was applied. Six themes were revealed, as follows: 1) adaptation process to sexual dysfunction experienced, 2) sexual dysfunction experience, 3) importance of fulfilling sexuality needs, 4) behavior in dealing with sexual dysfunction, 5) perception of the cause of sexual dysfunction, and 6) participants’ expectation of health service related to sexual function. The experience of adapting to sexual dysfunction became a meaningful process through partner involvement. Similar research involving more heterogeneous samples would benefit further discourse."

"Empat puluh tiga kasus pasien gagal ginjal kronik ( GGK ) yang menjalani dialisis kronik di Divisi Ginjal Hipertensi, Fakultas Kedokteran Universitas Indonesia/Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Jakarta, selama bulan Oktober 2003 sampai dengan bulan Februari 2004, dilakukan pemeriksaan ekokardiografi untuk melihat fungsi diastolik ventrikel kiri dan penilaian indeks massa ventrikel kiri. Disfungsi diastolik ditemukan pada 58,1% pasien GGK yang menjalani dialisis kronik. Tidak terdapat perbedaan bermakna rerata massa ventrikel kiri pada kelompok dengan disfungsi diastolik dibandingkan kelompok tanpa disfungsi diastolik. (MedJIndones 2006; 15:105-8)

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Fourty three patients with chronic renal failure undergoing chronic hemodialysis in Division of Nephrology and Hypertension, Faculty of Medicine, University of Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, since October 2003 until February 2004, were examined for echocardiography ( 2-D, M-mode, Doppler imaging ). Diastolic dysfunction was found in 58.1% of chronic renal failure patients on hemodialysis. There was no significant difference between left ventricular mass in the group with or without left ventricular diastolic dysfunction. (MedJIndones 2006; 15:105-8)"

"Gagal ginjal kronik adalah suatu proses patofisiologis dengan etiologi yang beragam, mengakibatkan penurunan fungsi ginjal yang progresif. Klien yang mengalami gagal ginjal kronik memerlukan alternatif terapi untuk mengganti fungsi ginjal. Salah satu alterantif terapi tersebut adalah hemodialisa, yang pelaksanaannya memerlukan sarana arteri vena fistula/cimino. Pada saat menjalani hemodialisa kilen gagal ginjal kronik sering mengalami kecemasan.Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan tentang arteri vena fistula/cimino dan hemodialisa, karakteristik klien gagal ginjal kronik dengan tingkat kecemasan menjalani hemodialisa. Tehnik pengambilan sampel yang digunakan pada penelitian ini adalah accidental sampling. Pengumpulan data dilakukan dengan menggunakan kuesioner dari Halmilton Rating Scale for Anxiety (HRS-A) dan pengetahuan tentang arteri vena fistula/cimino dan hemodialisa. Analisis penelitian ini adalah univariat dan bivariat dengan uji chisquare.Analisis bivariat menjelaskan bahwa tidak ada hubungan antara tingkat pengetahuan dengan tingkat kecemasan (p= 0,11 α= >0,05). Hasil penelitian ini diharapkan perawat memberikan pendidikan kesehatan kepada klien dengan gagal ginjal kronik yang menjalani hemodialisa sehingga pengetahuan meningkat dan tingkat kecemasan menerun.

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Chronic renal failure (CRF) is a pathophysiological process with etiology,which cause decreasing in progressive kidney function. Clients with CRF need alternative therapy to replace the renal function. One of the alternative therapy is hemodialysis which needs arteriovenous fistula/cimino. During hemodialysis,clients with chronic renal failure often feel anxious.

This research aim to indentify the correlation between knowledge about arteriovenous fistula/cimino and hemodyalisis, the characteristics of clients with chronic renal failure with anxiety level during the hemodyalisis process. The technique used to collect the samples in this research was accidental sampling. Data was collect used Halmilton Rating Scale for Anxiety (HRS-A) questionnaires and questionnaire of knowledge about artery venous fistula/cimino and hemodyalisis.

The analysis of this research are univariat and bivariat with chi-square. Bivariat analysis explain that there was no correlation between knowledge level and anxiety level (p=0,39 α > 0,05). The result of this research expected the nurses to give education for patients with chronic renal failure which undergo hemodyalisis in order to increase their knowledge and decrease the anxiety level during hemodyalisis."

"Keluarga yang merawat anak dengan gagal ginjal kronik terutama yang mendapat terapi hemodialisis memiliki masalah. Penelitian ini bertujuan untuk mengeksplorasi pengalaman keluarga dalam merawat anak gagal ginjal kronik yang mendapat terapi hemodialisis. Metode penelitian ini menggunakan pendekatan fenomenologi deskriptif dengan cara wawancara mendalam kepada 7 partisipan. Partisipan adalah keluarga yang merawat anak selama minimal 1 bulan terakhir dan sedang menjalani terapi hemodialisis di RSUPN Cipto Mangunkusumo Jakarta. Data dianalisis dengan menggunakan teknik Collaizi dan menghasilkan 5 tema, yaitu 1) respon keluarga terhadap perawatan anak, 2) strategi koping yang dibangun keluarga, 3) dampak merawat anak bagi keluarga,, 4) upaya dukungan sosial yang diberikan keluarga, 5) perubahan pada anak yang menjalani terapi hemodialisis menurut persepsi keluarga. Hasil penelitian ini menunjukkan bahwa keluarga yang merawat anak memiliki permasalahan yang kompleks. Hasil penelitian ini diharapkan menjadi informasi dasar untuk mengembangkan program dalam menerapkan asuhan yang berpusat pada keluarga.

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Families who care for children with chronic renal failure who received therapy will have vulnerable occurrence problem. This study aim to explore the experience of families in caring for children with chronic renal failure receiving hemodialysis therapy. This research method is using descriptive phenomenological approach with in-depth interviews to 7 participants. Participants are families who care for the child for at least one month past is undergoing hemodialysis therapy in Cipto Mangunkusumo hospital. Data was analyzed by Collaizi so as to obtain 5 themes, namely the family's response to child care, family coping strategy, the impact of child care for families, family support and changes of children undergoing hemodialysis therapy related to family perception. These results indicate that the families who care for children have complex problems. This study endorse to develop program based on familycentered care."

"ABSTRAKXerostomia sering dialami pasien Gagal Ginjal Kronis. Masalah ini akan berdampak pada meningkatnya sensasi haus sehingga mempengaruhi pasien untuk meningkatkan asupan cairan yang menyebabkan peningkatan Interdialytic Weight Gain dan berujung pada penurunan Quality of Life pasien. Penelitian ini bertujuan mengetahui perbedaan pengaruh permen karet xylitol dan mouthwash terhadap xerostomia pada pasien gagal ginjal kronis. Desain yang digunakan adalah quasi eksperimen dengan melibatkan 30 orang responden yang dipilih dengan teknik consecutive sampling dan dibagi dalam dua kelompok. Hasil uji General Linear Model menunjukkan tidak ada perbedaan dalam empat pengukuran xerostomia pada kedua kelompok intervensi dengan p-value > 0,05. Disimpulkan bahwa penggunaan permen karet xylitol dan mouthwash memiliki efek yang sama dalam menurunkan keluhan xerostomia pasien gagal ginjal kronis. Hasil penelitan ini dapat direkomendasikan untuk diterapkan sebagai upaya mengatasi xerostomia pada pasien gagal ginjal kronis.

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ABSTRACTXerostomia is often experienced by patients with Chronic Renal Failure. This problem will have an impact on increasing thirst sensations that affect the patient to increase fluid intake that leads to an increase Interdialytic Weight Gain and lead to decreased Quality of Life patients. The aim of this research was to know the effect of chewing gum xylitol and mouthwash on xerostomia in chronic renal failure patients. The design was quasi experiment involving 30 respondents selected by consecutive sampling technique and divided into two groups. The results of General Linear Model test showed there was no differences in the four xerostomia measurements in both intervention groups with p-value> 0.05. The conclusion of this research was xylitol chewing gum and mouthwash had same effect to reduce xerostomia in patients with chronic renal failure. The results of this study can be recommended to be applied as an intervention to resolve xerostomia in chronic renal failure patients."

"Angka kejadian penyakit ginjal kronik semakin meningkat dengan tingkat kematian pertahun yang cukup tinggi yang menjadi masalah kesehatan serius di dunia karena mengalami peningkatan insidensi, berdampak pada morbiditas dan mortalitas serta sosial ekonomi dunia termasuk di Indonesia dengan mayoritas penduduk usia produktif angkatan kerja pada industri manufaktur. Oleh karena itu diperlukan deteksi dini penurunan fungsi ginjal dan faktor yang mempengaruhinya. Penelitian ini merupakan penelitian potong lintang analitik dengan pendekatan kuantitatif menggunakan data sekunder MCU PJK3 tahun 2022 dengan total data penelitian sebanyak 2.304 data. kemudian dilakukan analisis terhadap data-data yang telah dikumpulkan. data-data tersebutmencakup jenis kelamin, usia, sulit BAK, ISK, penyakit ginjal, BSK, inkontinensia urin, hipertensi, diabetes, klas alkohol, klas merokok, klas olahraga, klas TD, klas IMT, klas GDP, lemak, urinalisa, sindrom metabolik, jenis manufaktur, lama kerja, suhu panas, suhu dingin, beban kerja tidak sesuai dengan waktu dan jumlah pekerjaan, duduk lama >4 jam terus menerus, posisi tubuh tidak ergonomis, eLFG. Hasil penelitian didapatkan bahwa terjadi penurunan fungsi ginjal (Laju Filtrasi Glomerolus /LFG <90 ml /menit /1,73 m2) sebesar 33,8% dari total pekerja industri manufaktur di Jawa Barat pada tahun 2022. Penurunan eLFG dipengaruhi faktor risiko individu, klinis dan pekerjaan. Kesimpulannya faktor risiko yang berpengaruh terhadap kejadian penurunan fungsi ginjal pada pekerja industri manufaktur di Jawa Barat pada tahun 2022 adalah jenis kelamin laki-laki, usia lebih dari 40 tahun, kondisi hipertensi derajat I dan II, kondisi obesitas dan lama masa kerja lebih dari 19 tahun, dengan faktor berpengaruh yang paling dominan adalah jenis kelamin laki-laki.

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The incidence of chronic kidney disease is increasing with a fairly high annual death rate which is a serious health problem in the world because it has increase incidence, has an impact on morbidity and mortality as well as a serious socio-economic world including in Indonesia with the majority of the working age population in the manufacturing industry. Therefore an early detection of decreased kidney function and factors that influence it become necessity. This research is an analytical quantitative research with a cross sectional design using secondary data of MCU in PJK3 in 2022 with total 2.304 data. The data includes gender, age, UTI, renal disease, bladder stone,, incontinentia urine, hypertention, DM, alcohol class, smoking class, exercise class, BP class, BMI class, fasting glucose class, lipid, urinalysis, metabolic syndrome, manufacture type, working periodes, heat temperature, cold temperature, workload not matched the time and ammount of work, prolong seating >4 hours continuously, un ergonomic body position, eGFR. The result of the study suggest there was a decrease in kidney function (Glomerolar Filtration Rate /GFR <90 ml /minute /1,73 m2) of 33,8% of the total manufacturing industry workers in West Java in 2022. The decreased of eGFR are influenced by individual, clinical and occupational risk factors. The conclusion, risk factor that influence the incidence of renal impairment in manufacture industry workers in West Java in 2022 are male, age over 40 years old, condition of hypertention grade I and II, obesity and periodes of work of more than 19 years, with the most dominant influence factor is male gender."