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"Tujuan: mengetahui jumlah pelepasan Bispheno-A (BPA), yakni substansi yang memiliki efek sitotoksis pada Resin Adhesif Ortodonti, setelah perendaman larutan obat kumur Klorheksidin Glukonat dan saliva buatan. Metode Penelitian: 66 lempeng silindris Resin Adhesif Ortodontik direndam dalam dua larutan berbeda yaitu , (1) Klorheksidin Glukonat dan (2) Saliva buatan. Perendaman dilakukan pada beberapa waktu berbeda yaitu, 1 jam, 7 hari, dan 30 hari. Dihitung pelepasan BPA pada kedua kelompok menggunakan metode Liquid Chromathography-Mass Spectrometry (LC-MS/MS). Hasil: Diperoleh pelepasan BPA dari Resin Adhesif Ortodonti pada larutan obat kumur Klorheksidin Glukonat 1 jam: 0,21 ng/ml, 7 hari: 0,32 ng/ml, 30 hari: 0,78 ng/ml, sedangkan pada saliva buatan 1 jam: 0,19 ng/ml, 7 hari: 0,53 ng/ml, 30 hari: 1,41 ng/ml. Kesimpulan: Jumlah BPA yang terlepas dari Resin Adhesif Ortodonti pada perendaman larutan obat kumur Klorheksidin Glukonat dan saliva buatan selama 1 jam, 7 hari dan 30 hari, berada di bawah dosis toleransi harian BPA (< 1.52 ng/mL).

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Objective: to determine the amount of BPA, cytotoxic substance found in orthodontic adhesive resin, after immersion in a solution of chlorhexidine gluconate mouthwash and artificial saliva. Research Methods: 66 Orthodontic adhesive resin cylindrical plates were immersed in two different solutions: (1) Chlorhexidine Gluconate, (2) artificial saliva, for 1 hour, 7 days, 30 days. In each experimental group, the BPA release in the solution was calculated using LC- MS/MS. The release of BPA in both groups was calculated using the Liquid Chromathography-Mass Spectrometry (LC-MS/MS). Results: The release of BPA from Orthodontic Adhesive Resin was obtained in the Chlorhexidine Gluconate mouthwash solution, 1 hour: 0.21 ng/ml, 7 days: 0.32 ng/ml, 30 days: 0.78 ng/ml, while in artificial saliva, 1 hour: 0.19 ng/ml, 7 days: 0.53 ng/ml, 30 days: 1.41 ng/ml. Conclusion: The amount of BPA released from the Orthodontic Adhesive Resin by immersion in a solution of Chlorhexidine Gluconate mouthwash and artificial saliva for 1 hour, 7 days and 30 days, was below the daily tolerated dose of BPA (< 1.52 ng/mL)."

"Bisphenol A (BPA) merupakan senyawa kimia yang penggunaannya cukup luas, salah satunya dalam pembuatan plastik polikarbonat yang banyak digunakan untuk wadah makan dan minum. BPA diketahui dapat menginduksi stress oksidatif dalam tubuh melalui enzim sitokrom P450 dengan menghasilkan spesies oksigen reaktif (ROS). Keadaan stress oksidatif yang parah dapat menyebabkan beberapa masalah kesehatan, seperti risiko kanker dan penyakit degeneratif lainnya. Oleh karena itu, penelitian ini bertujuan untuk mendeteksi senyawa 8-OHdG sebagai indikasi adanya kerusakan oksidatif DNA. Penelitian dilakukan secara in vitro berdasarkan reaksi Fenton-like dengan menginkubasi 2’-dG, Cu(II), Zn(II), H₂O₂, dan BPA, yang kemudian hasilnya dianalisis menggunakan HPLC. Pada studi, diamati pengaruh waktu inkubasi, suhu, dan pH reaksi. Hasil analisis menunjukkan adanya penurunan 8-OHdG pada waktu inkubasi yang lebih lama dan pH yang lebih basa, serta memberikan kenaikan 8-OHdG pada suhu inkubasi yang lebih tinggi. Selain itu, adapun studi biomonitoring yang dilakukan pada urin balita pengguna botol susu plastik sebagai gambaran adanya paparan BPA. Biomonitoring dilakukan dengan mengumpulkan tiga urin balita sebagai kontrol dan tiga urin balita sebagai sampel terindikasi BPA. Sebelum dianalisis menggunakan LC-MS/MS, sampel urin diberikan enrichment melalui metode solid phase extraction (SPE) dan LC-MS/MS dilakukan validasi. Hasil analisis urin tersebut menunjukkan bahwa kadar 8-OHdG terdeteksi lebih tinggi pada sampel urin balita pengguna botol plastik terindikasi BPA.

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Bisphenol A (BPA) is a chemical compound that is widely used, such as in the manufacture of polycarbonate plastic which usually is used for food and drink containers. BPA is known to induce oxidative stress in the body through cytochrome P450 enzymes by producing reactive oxygen species (ROS). The state of severe oxidative stress will cause several health problems, such as the risk of cancer and other degenerative diseases. Therefore, this study aimed to detect 8-OHdG compounds as an indication of DNA oxidative damage. The study was conducted in vitro based on the Fenton-like reaction by incubating 2'-dG, Cu(II), Zn(II), H2O2, and BPA, then being analyzed with HPLC. This study also observed the effect of incubation time, temperature, and pH. The results of the analysis showed a decrease in 8-OHdG at a longer incubation time and a more alkaline pH, as well as an increase in 8-OHdG at a higher temperature. In addition, a biomonitoring study was also conducted on the urine of toddlers who used plastic milk bottles as a representation of BPA exposure. Biomonitoring was carried out by collecting three toddler urine as controls and three toddlers urine as samples indicated by BPA. Before being analyzed with LC-MS/MS, urine samples were given enrichment through the solid phase extraction (SPE) method and LC-MS/MS validation was performed. The results of the urine analysis showed that higher levels of 8-OHdG were detected in the urine samples of toddlers using plastic bottles indicated by BPA."

"Objectives: The objective of the study were to determine if there was any (bisphenol A) BPA release from three adhesive brands, to determine the differences of BPA release between three adhesive brands, to determine the genotoxicity from three adhesive brands, and to determine the correlation of BPA release and genotoxicity. Methods: Three branded adhesives materials were polimerized in mold and immersed in pH 7 and 4 artificial saliva from 24 to 720 hours. The artificial saliva was tested with spectrophotometry test to see BPA release at 24, 240, 480, and 720 hours, then freeze dried to get solid extract. Combination of the extract and lymphocite culture (male and female) then tested with in vitro cytokinesis-block micronucleus (MN) assay to see genotoxicity level of three adhesives at 24, 240, 480, and 720 hours as well. Results: The BPA release occured at 720 hours by Adhesive 1: 0.013μg/L; Adhesive 2: 0.11μg/L; Adhesive 3: 0.036μg/L. There was a statistically significant difference between BPA release with time (F = 505.98; p=0.00) and brands (F = 147.65; p = 0.00). Time and BPA release interaction also showed a statistically significant difference (F=13.35; p=0.00). Genotoxicity can be seen at 720 hours on Flowtain LV sample (MN frequency: male: 0.044; female: 0.053). Conclusion: The number of BPA release of all brand can be seen from the first 24 hours, and were increasing from 24 to 720 hours. Genotoxicity can be seen from one of the adhesive brand at 720 hours.There was correlation between BPA leaching and micronucleus frequency."

"ABSTRAKLatar Belakang: Saat ini pemakaian obat kumur di masyarakat cukup popular.Salah satu kandungan zat aktif obat kumur yang sering digunakan adalahklorheksidin glukonat. Pemakaian obat kumur yang berketerusan disampingmenyikat gigi tentunya akan mempengaruhi kondisi dalam rongga mulut, salahsatunya protein saliva. Tujuan: Untuk menganalisis pengaruh penggunaan obatkumur yang mengandung klorheksidin glukonat 0,2 % selama 1,2 dan 3 mingguterhadap profil protein saliva. Metode: Pengambilan sampel saliva dari 5 subyek saatsebelum berkumur dan 1, 2, 3 minggu setelah pemakaian obat kumur. Profil pitaprotein saliva diidentifikasi dengan metode SDS PAGE dengan Recom Blue WideRange Protein Marker. Hasil: Profil pita protein sebelum berkumur yangteridentifikasi antara 7-80 kDa. Setelah 1,2 dan 3 minggu berkumur teridentifikasijuga pita protein >100 kDa disamping pita protein <50 kDa Kesimpulan:Penggunaan obat kumur yang mengandung klorheksidin glukonat selama 1, 2 dan 3minggu mengakibatkan perubahan profil protein saliva dengan teridentifikasi pitaprotein yang sangat bervariasi.

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ABSTRACTBackground: Currently the use of mouthwash is quite popular. One of the activeingredients frequently used is chlorhexidine gluconate. The usage of mouthwashcontinuously besides brushing the teeth will surely affect conditions in the oralcavity, one of salivary proteins. Objective: To analyze the effect of mouthwashapplication containing chlorhexidine gluconate 0.2% for 1.2 and 3 weeks to salivaryprotein profiles. Methods: Sampling saliva of 5 subjects were collected beforerinsing and 1, 2, 3 weeks after the use of mouthwash. Salivary protein profile wereidentified using SDS-PAGE with Recom Blue Wide Range Protein Marker. Results:profile of protein bands before rinsing identified between 7-80 kDa. After usingmouthwash for 1,2 and 3 weeks also identified > 100 kDa protein band in addition to<50 kDa protein band. Conclusion: The use of mouthwash containing chlorhexidinegluconate for 1, 2 and 3 weeks resulted in changes of salivary protein profiles withhighly variable."

"Ketahanan ikatan resin komposit-dentin merupakan salah satu penentu keberhasilan restorasi resin komposit. Tujuan penelitian ini adalah menganalisis efek klorheksidin terhadap degradasi kekuatan ikat resin kompositdentin. Metode: Dua puluh empat sampel dentin yang diambil dari mahkota gigi premolar, dibagi menjadi tiga kelompok yang diberikan perlakuan berbeda. Kelompok I diberi perlakuan bahan bonding tanpa klorheksidin, kelompok II diberi perlakuan klorheksidin dan bonding, kelompok III diberi perlakuan bonding mengandung klorheksidin, pada tiap kelompok dibagi menjadi 2 sub-kelompok yaitu kelompok tanpa direndam dan kelompok yang direndam NaOCl 10% selama satu jam, sehingga didapat enam sub-kelompok. Kemudian seluruh kelompok di ukur kekuatan ikat gesernya menggunakan Universal Testing Machine. Satu sampel dari setiap sub-kelompok dilakukan Scanning Electron Microscope (SEM). Data dianalisa statistik dengan uji hipotesis Kruskal Wallis yang dilanjutkan dengan uji Mann-Whitney. Hasil: rerata kekuatan ikat geser sebelum perendaman NaOCl 10% tertinggi kelompok I sedangkan rerata kekuatan ikat geser setelah perendaman NaOCl 10% tertinggi pada kelompok III. Terdapat perbedaan bermakna antara kelompok I terhadap kelompok II dan antara kelompok II terhadap kelompok III. Kesimpulan: Klorheksidin mempunyai efek terhadap pengurangan degradasi kekuatan ikat geser resin komposit-dentin.

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Resilience of composite resin-dentin bonding known as one of success composite resin restoration determinants. The purpose of this study was to analyze the effect of chlorhexidine on reducing the degradation of composite resin-dentin shear bond strength.

Methods: Twenty-four premolar crowns were divided into three groups then given different treatments. Group I was treated material bonding without chlorhexidine, group II was treated with chlorhexidine and bonding, group III was treated with chlorhexidine-contained bonding. Each group was divided into two sub-groups: the group without immersion of NaOCl 10% and the group with immersion of NaOCl 10% for one hour, then it were obtained six sub-groups. After twenty-four hours, shear bond strengths measured using Universal Testing Machine. A sample of each group was photographed with Scanning Electron Microscope (SEM). Statistical analysis was done by Kruskal Wallis test, then followed by Mann Whitney test to determine significance between groups.

Results: The mean value of shear bond strength before immersion of NaOCl 10% was highest on Group I, while the mean value of shear bond strength after immersion of NaOCl 10% was highest on Group III. There are significant differences between Group I with Group II and between Group II with Group III.

Conclusion: Chlorhexidine have an effect on reducing the degradation of shear bond strength of resin-dentin bonding."

"ABSTRAKLatar belakang: Ketahanan ikatan resin komposit-dentin merupakan salah satupenentu keberhasilan restorasi resin komposit. Tujuan penelitian ini adalahmenganalisis efek klorheksidin terhadap degradasi kekuatan ikat resin kompositdentin.Metode: Dua puluh empat sampel dentin yang diambil dari mahkota gigipremolar, dibagi menjadi tiga kelompok yang diberikan perlakuan berbeda.Kelompok I diberi perlakuan bahan bonding tanpa klorheksidin, kelompok IIdiberi perlakuan klorheksidin dan bonding, kelompok III diberi perlakuan bondingmengandung klorheksidin, pada tiap kelompok dibagi menjadi 2 sub-kelompokyaitu kelompok tanpa direndam dan kelompok yang direndam NaOCl 10%selama satu jam, sehingga didapat enam sub-kelompok. Kemudian seluruhkelompok di ukur kekuatan ikat gesernya menggunakan Universal TestingMachine. Satu sampel dari setiap sub-kelompok dilakukan Scanning ElectronMicroscope (SEM). Data dianalisa statistik dengan uji hipotesis Kruskal Wallisyang dilanjutkan dengan uji Mann-Whitney. Hasil: rerata kekuatan ikat gesersebelum perendaman NaOCl 10% tertinggi kelompok I sedangkan rerata kekuatanikat geser setelah perendaman NaOCl 10% tertinggi pada kelompok III. Terdapatperbedaan bermakna antara kelompok I terhadap kelompok II dan antarakelompok II terhadap kelompok III. Kesimpulan: Klorheksidin mempunyai efekterhadap pengurangan degradasi kekuatan ikat geser resin komposit-dentin.

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ABSTRACTBackground: Resilience of composite resin-dentin bonding known as one ofsuccess composite resin restoration determinants. The purpose of this study was toanalyze the effect of chlorhexidine on reducing the degradation of compositeresin-dentin shear bond strength. Methods: Twenty-four premolar crowns weredivided into three groups then given different treatments. Group I was treatedmaterial bonding without chlorhexidine, group II was treated with chlorhexidineand bonding, group III was treated with chlorhexidine-contained bonding. Eachgroup was divided into two sub-groups: the group without immersion of NaOCl10% and the group with immersion of NaOCl 10% for one hour, then it wereobtained six sub-groups. After twenty-four hours, shear bond strengths measuredusing Universal Testing Machine. A sample of each group was photographed withScanning Electron Microscope (SEM). Statistical analysis was done by KruskalWallis test, then followed by Mann Whitney test to determine significancebetween groups. Results: The mean value of shear bond strength beforeimmersion of NaOCl 10% was highest on Group I, while the mean value of shearbond strength after immersion of NaOCl 10% was highest on Group III. There aresignificant differences between Group I with Group II and between Group II withGroup III. Conclusion: Chlorhexidine have an effect on reducing the degradationof shear bond strength of resin-dentin bonding"

"Penelitian ini dilakukan untuk mengetahui pengaruh penambahan bisphenol A BPA dan logam Cr VI terhadap pembentukan DNA adduct, 8-OHdG. Pembentukan senyawa 8-OHdG dilakukan dengan mereaksikan dG dengan BPA, penambahan reagen fenton-like, serta vitamin C. Senyawa 8-OHdG yang terbentuk dianalisis menggunakan HPLC kromatografi fasa terbalik dengan detektor UV/Vis pada panjang gelombang 254 nm. Variasi pada penelitian ini meliputi variasi pH 7,4 dan 8,4, suhu 37°C dan 60°C, dan waktu inkubasi 7 jam dan 12 jam . Senyawa 8-OHdG dianggap terdeteksi apabila nilai konsentrasi hasil analisis lebih besar atau sama dengan nilai LOD, yaitu sebesar 5,19 ppb, dan konsentrasi senyawa 8-OHdG dapat terkuantifikasi apabila nilai konsentrasi hasil analisis lebih besar atau sama dengan nilai LOQ, yaitu sebesar 17,29 ppb. Hasil penelitian ini menunjukkan bahwa penambahan BPA maupun logam Cr VI dapat meningkatkan konsentrasi senyawa 8-OHdG yang terbentuk dengan sebagian besar hasil analisis memiliki nilai konsentrasi diatas nilai LOD. Penambahan reagen fenton-like maupun vitamin C juga dapat meningkatkan konsentrasi senyawa 8-OHdG. Pada hampir seluruh sampel konsentrasi 8-OHdG yang terbentuk lebih tinggi untuk reaksi pada pH 7,4, suhu 60°C, dan waktu inkubasi 12 jam.

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This research was conducted to study the effect of bisphenol A BPA and Cr VI metal addition against the formation of DNA adduct, 8 OHdG. The formation of 8 OHdG compound was being done by reacting dG with bisphenol A with addition of fenton reagent and also vitamin C. 8 OHdG compounds were analyzed by using reversed phase HPLC with UV vis detector at 254 nm. Variations in this present study include the variations of pH 7.4 and 8.4, temperature 37°C and 60°C, and incubation time 7 hours and 12 hours. 8 OHdG compound considered to be detected if the concentration value from analysis result is above or the same as the LOD value, which is 5.19 ppb, and 8 OHdG concentration could be quantified if the concentration value from analysis result is above or the same as the LOQ value, which is 17.29 ppb. The results of this study indicate that addition of bisphenol A as well of Cr VI metal could increased 8 OHdG concentration that produced with most of the concentration value from analysis result is above the LOD value. The addition of fenton like reagent as well as vitamin C could also increased 8 OHdG concentration that produced. In most of the samples, higher 8 OHdG concentration was formed at reaction with pH 7.4, temperature 60°C, and 12 hours incubation time. "

"Background: Chlorhexidine (CHx) mouthrinse was the first choice for gingivitis. The loss of taste and tooth discolorisation was motivated the clinician to dilute CHx 0.2% to 1:1. Aims: To compare the effectiveness of CHx 0.2% and diluted CHx 1:1 as mouthrinse on gingivitis and evaluate tooth discoloration. Method: Ninety nine students with mild and moderate gingivitis at SMU Labs School jakarta age between 14-15 years had participated. The subjects were randomised selected and double-blind method was applied. The subjects were divided into 3 groups. The first group was instructed to rinse with CHx 0.2%, the second group rinsed with diluted CHx 1:1, and the third group as a control without rinsing. The first and the second groups were rinsing the regimen for one minute, twice a day in 7 days, in the morning and night. Plaque and bleeding were scored using Plaque Index (Loe and Silness), and modified Papilla Bleeding Index (Muhleman) on the first and seventh day of the study. The changes of scores (PII and PBI) before and after rinsing were analyzed using "paired t test". The differences of the effectivity of CHx 0.2%. CHx 1:1 and control groups using "ANOVA test" with 95% probability. Differences of tooth discolouration after rinsing were analyzed by "independen t test". Probabilities of less than 5 percents were taken to be statistically significant. Result: The results showed at day 7, not significant difference between CHx groups for plaque (CHx: 0.74, CHx 1:1: 0.66), and gingival bleeding (CHx: 1.02, CHx 1:1: 0.83). The proportion of tooth discolouration was not significant in the diluted CHx group (4.8%) and in the CHx group (7.3%). Conclusion: Diluted CHx 1:1 effectively on gingivitis. The clinician can be used in the clinic whereas the lost the taste were reduced. No differences significant of tooth discolourisation between rinsing regimens on seventh days."

"ABSTRAKHalitosis atau bau mulut adalah masalah kesehatan gigi dan mulut yang banyak dikeluhkan dan dapat menjadi persoalan kesehatan yang serius. Penyebab halitosis terutama dan terbanyak adalah bakteri yang hidup dalam rongga mulut terutama bakteri anaerob gram negatif yang menghasilkan sulfur. Keseluruhan senyawa sulfur yang dihasilkan disebut Volatile Sulfur Compounds (VSC) dan inilah yang menyebabkan bau pada mulut. Tujuan penelitian adalah untuk mengetahui perbandingan efektifitas oral hygiene menggunakan chlorhexidine dan normal saline terhadap skor halitosis. Metode dalam peneltian ini adalah quasi eksperimen dengan subjek penelitian pasien dengan penyakit kritis sebanyak 28 orang yang dibagi dalam dua kelompok, 14 responden dilakukan oral hygiene dengan menyikat gigi dan lidah dengan chlorhexidine glukonate 0,1% dan 14 responden dilakukan oral hygiene dengan menyikat gigi dan lidah dengan normal saline. Pengukuran skor halitosis dilakukan sebelum dan 15 menit sesudah oral hygiene. Gas VSC diukur menggunakan alat Tanita BreathChecker . Hasil menunjukkan terjadi penurunan skor halitosis sebelum dan sesudah oral hygiene dengan memperlihatkan perbedaan yang signifikan (p<0,05). Jumlah responden dengan nilai 0 pada skor halitosis sebanyak 10 responden (72%) pada kelompok pertama dan pada kelompok kedua sebanyak 4 responden (29%). Kesimpulan penggunaan chlorhexidine glukonate 0,1% lebih efektif terhadap penurunan skor halitosis dibandingkan menggunakan normal saline.

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ABSTRACTHalitosis or bad breath is a dental health problem that mainly complaint and can be a serious health problem. The cause of halitosis mainly and mostly bacterias which live in the oral cavity, especially anaerob negatif gram bacteria that produce sulfur. The whole sulfur component that was produced called Volatile Sulfur Compounds (VSC) and this is the cause of bad breath. The purpose of this study was to know the comparison of effectiveness oral hygiene using chlorhexidine and normal saline on halitosis score. This study used Quasy experiment with subjects consisted of 28 patients with critically ill, divided into two groups, 14 subjects conducted oral hygiene to brush their teeth and tongue with chlorhexidine glukonate 0,1% and 14 subjects conducted oral hygiene to brush their teeth and tongue with normal saline. The measurement of Volatile Sulfur Compounds level used Tanita BreathChecker, conducted before and 15 minutes after oral hygiene. The result showed significant differences in reducing VSC components in both groups (p<0,05). Number of subjects with score halitosis 0 by 10 subjects (72%) in first group and 4 subjects (29%) in second group. In conclusion, chlorhexidine glukonate 0,1% is more effective decreased score halitosis than normal saline on patients with critically ill."

"Konsumsi air minum dalam kemasan (AMDK) tak luput dari adanya risiko migrasi senyawa Bisfenol-A (BPA) dari kemasan polikarbonat yang digunakan, yang berpotensi menimbulkan risiko kesehatan signifikan seperti gangguan pada sistem kekebalan tubuh, proses reproduksi, dan saraf. Di Indonesia, masih terdapat kekosongan dalam regulasi mengenai risiko migrasi BPA pada AMDK, sehingga diperlukan peraturan yang dapat meningkatkan kesadaran masyarakat akan risiko tersebut. Menimbang hal tersebut, Badan Pengawas Obat dan Makanan (BPOM) sebagai badan regulator di bidang pangan, berinisiatif untuk merumuskan kebijakan pelabelan BPA pada AMDK dengan melalui revisi Peraturan Badan Pengawas Obat dan Makanan No.31/2018 tentang Label Olahan Pangan. Dalam perumusannya, diperlukan advokasi kebijakan untuk memastikan bahwa kebijakan tersebut dapat diimplementasikan dengan efektif dengan melibatkan berbagai aktor. Penelitian ini bertujuan untuk menganalisis advokasi kebijakan yang dilakukan dalam kebijakan pelabelan BPA pada AMDK dengan menggunakan teori Advocacy Strategy Framework oleh Coffman & Beer (2015). Penelitian ini menggunakan pendekatan post-positivist dan metode pengambilan data melalui wawancara mendalam dan studi kepustakaan. Hasil penelitian menunjukkan bahwa terdapat setidaknya empat dimensi dari Advocacy Strategy Framwork oleh Coffman & Beer (2015) yang perlu ditingkatkan dalam advokasi kebijakan pelabelan BPA pada AMDK yakni Dimensi Peningkatan Kapasitas Advokasi, Dimensi Peningkatan Kemauan atau Dukungan Publik, Dimensi Penguatan Koalisi, dan Dimensi Keberhasilan Mobilisasi Suara Publik. Rekomendasi yang diberikan oleh peneliti adalah untuk melakukan strategi peningkatan mobilisasi komunitas, peningkatan inklusivitas dalam proses perumusan kebijakan, penguatan koalisi, dan monitoring serta evaluasi berkala.

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The consumption of bottled drinking water has the risk of Bisphenol-A (BPA) migration from the polycarbonate packaging used, which can pose significant health risks such as immune system disorders, reproductive issues, and neurological effects. In Indonesia, there is still a regulatory gap concerning the risk of BPA migration in bottled water, necessitating regulations to raise public awareness of these risks. Considering this, the Indonesian Food and Drug Authority (BPOM), as the regulator in food sector, has taken the initiative to draft a BPA labelling policy for bottled water by revising Regulation of Indonesian Food and Drug Authority No.31/2018 on Processed Food Labels. Effective policy implementation requires advocacy efforts involving various stakeholders. This study aims to analyze the policy advocacy for BPA labelling on bottled water using the Advocacy Strategy Framework by Coffman & Beer (2015). The research employs a post- positivist approach with data collection methods including in-depth interviews and literature studies. The findings indicate that at least four dimensions of the Advocacy Strategy Framework by Coffman & Beer (2015) need enhancement in BPA labelling advocacy on bottled water: Increased Advocacy Capacity, Increased Public Will or Support, Stronger Coalitions, and Successful Mobilization of Public Voices. The recommendations provided by the researcher include strategies for community mobilization enhancement, increased inclusivity in policy formulation processes, coalition strengthening, and regular monitoring and evaluation."