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"ABSTRAKUntuk menciptakan penutupan sistem saluran akar yang adekuat diperlukan bahan siler yang berfungsi untuk mengisi celah diantara gutaperca dan dinding saluran akar.Pada pengisian saluran akar sering ditemukan kondisi siler yang keluar dari foramen sehingga berkontak dengan jaringan periapeks dalam waktu yang berkepanjangan.Untuk itu, salah satu persyaratan dari bahan siler saluran akar adalah harus bersifat biokompatibel terhadap jaringan periradikular.Genotoksisitas adalah salah satu faktor penting yang mempengaruhi biokompatibilitas bahan. Siler saluran akar yang digunakan saat ini merupakan bahan kimia yang dapat mengakibatkan kerusakan pada DNA apabila terpapar dalam waktu yang lama.Terdapat berbagai macam bahan siler seperti siler berbasis Resin, Silikon, atau Bioceramik yang masing-masing memiliki kandungan zat yang berpotensi genotoksik. Tujuan penelitian ini adalah untuk mengetahui dan membandingkan potensi genotoksisitas pada siler berbasis Resin, Silikon, dan Bioceramik terhadap DNA sel limfosit manusia dengan menggunakan uji genotoksisitas ?-H2AX selama 1, 3 dan 7 hari. Berdasarkan hasil penelitian diketahui bahwasiler berbasis Resin, Silikon, dan Bioceramik memiliki potensi genotoksik terhadap DNA sel limfosit manusia dengan nilai tertinggi terdapat pada siler berbasis resin, selanjutnya diikuti oleh siler berbasis Silikon dan Bioceramik.

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ABSTRACTTo create an adequate sealing on root canal system, it is requires a sealer that fill the gap between gutta percha and root canal wall. In root canal obturation, it is frequently found that sealer leak to foramen and in contact with periapex tissue in a prolonged time. For that reason, one property that requirement of root canal sealer material is biocompatible to periradicular tissue. Genotoxicity is one of the important factors that affecting the biocompatibility of the material. Root canal sealer used today are chemicals that can cause DNA damage when exposed for long periods of time. There are a wide range of sealers such as Resin based sealer, Silicone based, or Biaceramic based that each have a potentially genotoxic substance. The purpose of this study was to investigate and compare the potential genotoxicity of Resin based Silicone based, and Bioceramic based sealers against human DNA lymphocytes using H2AX assay for 1, 3, and 7 days. Based on the results, it is known that Resin based, Silicone based, and Bioceramic based sealers have genotoxic potential against human DNA lymphocytes with the highest value found in Resin based, followed by Silicone based and Bioceramic based sealers."

"Latar Belakang : Non-alcoholic fatty liver disease (NAFLD) adalah penyakit hati kronik yang ditandai dengan akumulasi lemak berlebihan di hati. Elastografi Transien (ET) dan metode Controlled Attenuation Parameter (CAP) merupakan metode pemeriksaan non-invasif untuk menilai derajat fibrosis dan steatosis, namun tidak tersedia di seluruh rumah sakit di Indonesia. Rasio Neutrofil Limfosit (RNL) merupakan penanda peradangan sederhana yang berpotensi memprediksi luaran penyakit. Tujuan : Mengetahui nilai diagnostik RNL sebagai indikator derajat keparahan steatosis dan fibrosis NAFLD. Metode : Penelitian ini adalah studi potong lintang menggunakan data sekunder dari data rekam medis tahun 2016-2018. Analisis statistik deskriptif dan analitik berupa uji korelasi, Receiver Operating Curve (ROC) dan Area Under The Curve (AUC) dipakai untuk mengetahui luaran studi. Hasil : Dari 106 subjek penelitian, kebanyakan pasien adalah perempuan (62,3%) berusia rata-rata 57,29 tahun dan menderita sindrom metabolik (77,4%). Sebagian besar pasien memiliki derajat steatosis sedang-berat (66%) dengan rerata ET 6,14 (2,8-18,2). Terdapat korelasi antara nilai CAP (r=0,648; p<0,001) dan ET (r=0,621; p<0,001) dengan RNL. Penggunaan RNL untuk menilai derajat steatosis sedang-berat memiliki titik potong 1,775 dengan sensitivitas, spesifisitas, NDP dan NDN sebesar 81,5%, 80,6%, 89,1%, dan 69,1%; titik potong 2,150 untuk menilai fibrosis signifikan dengan sensitivitas, spesifisitas, NDP dan NDN berurutan sebesar 92.3 %, 87.5%, 70.6%, dan 97.2%. Simpulan : RNL memiliki korelasi positif terhadap derajat steatosis dan fibrosis dengan sensitivitas dan spesifisitas yang tinggi.

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Introduction : Non-alcoholic fatty liver disease (NAFLD) is a chronic inflammatory disease with excessive fat accumulation in the liver. Transient Elastography (TE) with Controlled Attenuation Parameter (CAP) is a device and method to examine the degree of fibrosis and steatosis. However, this device is not widely available across Indonesia. Neutrophil and Lymphocyte Ratio (NLR) is a simple marker for inflammation which has a potency to predict disease outcome.

Objective : To know the diagnostic value of RNL as the indicator of steatosis and fibrosis severity.

Methods : This was a cross-sectional study using secondary data from the medical record, starting from 2016-2018 with the respective inclusion and exclusion criteria. A descriptive and analytic statistic, including correlation test, Receiver Operating Curve (ROC) and Area Under The Curve (AUC) were done to know the outcome of the study.

Result: Out of 106 subjects, 62.3% patients were women with aged mean 57.29 years old and 77.4% had metabolic syndrome. Most patients had average-severe steatosis degree (66%) with the mean of ET mean 6.14 (2.8-18.2). There was a positive correlation between CAP and TE compared with NLR with r = 0.647 (p<0.001) and r = 0.621 (p<0.001) respectively. The use of NLR to assess moderate-severe steatosis has a cutoff point of 1.775 with sensitivity, specificity, PPV and NPV of 81,5%, 80,6%, 89,1%, and 69,1%; cutoff point 2,150 to assess significant fibrosis with sensitivity, specificity, PPV and NPV of 92.3 %, 87.5%, 70.6%, 97.2% respectively.

Conclusion : NLR has a positive correlation with the degree of steatosis and fibrosis with high sensitivity and specificity."

"Latar belakang: Limfopenia merupakan manifestasi klinis yang sering terjadi pada pasien dengan LES serta mempunyai arti patologis yang bermakna. Patogenesis limfopenia saat ini masih belum jelas, namun beberapa penyebab yang diketahui adalah terdapatnya antibodi antilimfosit, penurunan CD 55 dan 59 dan apoptosis yang tidak terkontrol. Beberapa penelitian menunjukkan limfopenia berhubungan dengan aktivitas penyakit. Hal lain yang menjadi perhatian adalah pemberian terapi imunosupresan pada pasien LES dalam keadaan limfopenia dapat memperburuk limfopenia.Tujuan: Untuk mengetahui hubungan antara limfosit total dan aktivitas penyakit serta terapi imunosupresan pada pasien LES.Metode: Studi kohort retrospektif dengan penelusuran rekam medis pasien LES yang berobat ke RSUPN Cipto Mangunkusumo periode Januari 2020 – Desember 2020. Analisa bivariat menggunakan chi square dan fisher exact dilakukan untuk mengetahui hubungan limfopenia dengan aktivitas penyakit, serta analisa bivariat mann whitney dan wilcoxon digunakan untuk perbedaan rerata hitung limfosit dan terapi imunosupresan serta hubungan antara terapi imunosupresan terhadap limfosit total.Hasil: Sebanyak 214 subjek memenuhi kriteri inklusi. Didapatkan hubungan bermakna antara limfopenia terhadap Mex SLEDAI pada subjek LES dalam keadaan remisi di bulan ke-3 (RR: 0,490; 95% IK: 0,320-0,751; p = 0,001) dan bulan ke-6 (RR: 0,490; 95% IK: 0,322-0,769; p = 0,001). Pada subjek LES dalam keadaan aktif terdapat hubungan bermakna antara limfopenia terhadap Mex SLEDAI pada bulan ke-3 (RR: 2,46; 95% IK: 1,71-5,188; p = 0,009). Tidak didapatkan perbedaan median limfosit total pada pasien LES dalam terapi MMF dan tanpa terapi MMF baik pada bulan ke-0 (p = 0,822), bulan ke-3 (p = 0,916), dan bulan ke-6 (p = 0,560). Tidak didapatkan juga hubungan dari limfosit total pada pasien dalam terapi MMF selama 6 bulan (p = 0,084). Didapatkan perbedaan median limfosit total pada pasien LES dalam terapi AZA dibandingkan pasien LES tanpa terapi AZA di bulan ke-0 (p = 0,044) dan bulan ke-3 (p = 0,007). Terdapat penurunan limfosit total pada bulan ke-3 pada pasien LES dalam terapi AZA namun tidak signifikan (p = 0,844). Tidak didapatkan perbedaan median limfosit total pada subjek pasien LES dalam terapi MTX baik pada bulan ke-0, bulan ke-3 dan bulan ke-6 (p = 0,510), (p=0,977), (p=0,714). Tidak didapatkan hubungan bermakna antara terapi MTX terhadap limfosit total (p = 0,721).Kesimpulan: Terdapat hubungan bermakna antara limfopenia terhadap aktivitas penyakit pasien LES yang dihitung dengan Mex SLEDAI. Tidak terdapat hubungan bermakna antara terapi imunosupresan selama 6 bulan terhadap limfosit total pasien LES.

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Background: Lymphopenia is a clinical manifestations that frequently develops in SLE patients and has important pathological implications. Although the pathogenesis of lymphopenia is still unknown, antilymphocyte antibodies, diminished CD 55 and 59, and uncontrolled apoptosis are a few of the factors that can develop inside it. Numerous investigations have demonstrated a connection between lymphopenia and disease activity. Another issue is that administering immunosuppressant therapy to SLE patients who are already lymphopenic can make their condition worsen.

Objective: To investigate the association between total lymphocytes, disease activity, and immunosuppressive treatment in SLE patients.

Methods: Retrospective cohort study by tracing the medical records of SLE patients who visited Cipto Mangunkusumo General Hospital between January 2020 and December 2020. The relationship between lymphopenia and disease activity was investigated using bivariate analysis using chi square and fisher exact, and the relationship between immunosuppressant therapy and total lymphocytes and differences in mean lymphocyte count and immunosuppressant therapy were investigated using bivariate analysis using mann-Whitney and Wilcoxon.

Results: 214 subjects fulfilled the criteria for inclusion. Lymphopenia and Mex SLEDAI were shown to be significantly associated in SLE patients in remission at months 3 (RR: 0.490; 95% CI: 0.320-0.751; p = 0.001) and 6 (RR: 0.490; 95% CI: 0.322-0.769; p = 0.001). Lymphopenia and Mex SLEDAI were significantly associated at month 3 in patients with active SLE (RR: 2.46; 95% CI: 1.71-5.188; p = 0.009). At month 0 (p = 0.822), month 3 (p = 0.916), and month 6 (p = 0.560), there was no difference in the median total lymphocyte count between SLE patients receiving MMF therapy and those receiving no MMF medication. In addition, there was no association between total lymphocytes and MMF therapy in individuals treated for 6 months (p = 0.084). At month 0 (p = 0.044) and month 3 (p = 0.007), SLE patients receiving AZA therapy had median differences in total lymphocytes compared to SLE patients not receiving AZA therapy. Patients with SLE receiving AZA medication had a decrease in total lymphocytes in the third month, but it was not statistically significant (p = 0.844). At months 0, 3, and 6, there was no difference in the median total lymphocyte count among SLE patients receiving MTX therapy (p = 0.510), (p = 0.977), and (p = 0.714). Total lymphocytes and MTX treatment had no statistically significant relation (p = 0.721).

Conclusion: The lymphopenia and disease activity of SLE patients as determined by the Mex SLEDAI are related. Immunosuppressant therapy administered for six months had no significant impact on the total lymphocyte count in SLE patients."

"Latar Belakang: Siler saluran akar berfungsi untuk mengisi ruang antara gutaperca dengan dinding saluran akar dan harus bersifat biokompatibel terhadap jaringan periapeks. Siler saluran akar merupakan bahan kimia yang berpotensi menyebabkan mutasi yang dapat dilihat dari ekspresi protein sel tersebut. Tujuan: Mengetahui dan membandingkan potensi mutagenitas siler resin, silikon, dan biokeramik terhadap perubahan ekspresi protein sel limfosit manusia. Metode: Sembilan sampel dari setiap kelompok siler sebanyak 2 ml yang terdiri atas bahan siler dan darah diinkubasi selama 1, 3 dan 7 hari. Kemudian dilakukan isolasi sel limfosit dan pemisahan protein dengan metode elektroforesis. Profil pita protein diobservasi dan data dianalisis secara statistik dengan Kruskal-Wallis dan post-hoc Mann-Whitney. Hasil: Tidak terdapat perbedaan bermakna secara statistik terhadap pembentukan pita protein antara ketiga bahan siler berbahan dasar resin, silikon dan biokeramik. Namun, terdapat perbedaan bermakna antara kelompok siler resin dan silikon pada hari pertama dan ketiga, dan antara kelompok siler silikon dan biokeramik pada hari pertama. Kesimpulan: Terdapat perbedaan potensi mutagenik pada hari pertama, siler resin lebih berpotensi mutagenik diikuti oleh biokeramik kemudian siler silikon. Pada hari ketiga, biokeramik lebih berpotensi mutagenik diikuti oleh resin kemudian silikon. Pada hari ketujuh, biokeramik lebih berpotensi mutagenik diikuti oleh resin dan silikon......Background: Root canal sealers serves to fill the space between the gutta percha and canal wall must be biocompatible with periapical tissue. Root canal sealers are chemicals agent that potentially cause mutations that can be seen from the protein expression of the cells. Objective: To know and compare the potential mutagenicity of resin, silicone, and bioceramic sealers on expression of proteins of human lymphocyte cells. Methods: Nine samples from each group sealer as much as 2 ml of blood are incubated for 1, 3 and 7 days. Then the isolated lymphocytes are observed for protein separation by electrophoresis method. Profile of protein bands observed and data were analyzed statistically by Kruskal-Wallis and post-hoc Mann-Whitney. Results: there is no statistically differences in the formation of protein bands among the resin, silicone and bioceramic sealers. However, there is a statistically differences between the resin and silicone on the first and third, and between silicone and bioceramic on the first day. Conclusion: There were differences in the potential mutagenicity on the first day, resin is more potentially mutagenic followed by bioceramic then silicone. On the third day, bioceramic is more potentially mutagenic followed by resin then silicone. On the seventh day, bioceramic is more potentially mutagenic followed by resin and silicone sealers."

"ABSTRAK Latar Belakang: Biokeramik dan silikon merupakan material terbaru yang saat ini telah dipasarkan. Untuk melihat perbandingan antara material tersebut dibutuhkan uji sitogenetik dengan menggunakan resin metakrilat. Tujuan: Melihat perbandingan sitogenetik siler berbahan dasar biokeramik, silikon, dan resin metakrilat terhadap limfosit T. Metode: Menilai mikronukleus dalam 1000 sel binukleat yang terbentuk setelah pemaparan siler resin metakrilat, silikon, dan biokeramik terhadap limfosit T pada hari ke 1, 3 dan 7 hari. Hasil: Nilai mikronukleus siler biokeramik dan silikon lebih rendah dari siler resin metakrilat dengan nilai kemaknaan ABSTRACT Background Bioceramic and Silicone sealer are the latest material that widely commercialized nowadays. Cytogenetic test of bioceramic and silicone sealer need to be verified by testing with methacrylate resin. Purpose To observe cytogenetic of bioceramic, silicone, and methacrylate resin sealer on lymphocyte T. Methods Counting the number of micronuclei after the treats of bioceramic, silicone and metharylate resin sealer on lymphocyte T between 1,3 , adn 7 days. Results Micronuclei score of bioceramic and silicone lower than methacrylate resin with significance value p"

"ABSTRAKLatar belakang: Siler dapat meningkatkan sealing ability Tujuan: Menganalisis dan membandingkan sealing ability pengisian saluran akar dengan siler bioceramic dan resin metakrilat. Metode: Tiga puluh gigi dengan saluran akar tunggal, dipreparasi dengan ProTaper Next, dibagi dalam dua kelompok secara acak; Masing-masing grup diisi dengan gutaperca berlapis, untuk kelompok 1 menggunakan Siler Bioceramic SB dan kelompok 2 Siler Resin-Metakrilat SRM . Pengukuran kebocoran dengan tinta india pada daerah sepertiga apikal apeks yang dipotong secara melintang, kemudian dilihat dengan mikroskop stereo. Hasil: Kelompok siler bioceramic menunjukkan celah tepi yang lebih sedikit jika dibandingkan dengan siler resin-metakrilat. Kesimpulan: Sealing ability pengisian saluran akar menggunakan siler bioceramic SB lebih baik dibandingkan dengan siler resin-metakrilat SRM .

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ABSTRAKBackground Sealer may increase sealing ability. Purpose To compare and analyze sealability of obturation using the bioceramic sealer and methacrylate resin based sealer. Methods thirty single rooted teeth were prepared using ProTaper Next and divided randomly into two groups the first group was obturated with Bioceramic Sealer SB while the second group was obturated with methacrylate resin based sealer SRM . Each group used coated gutta percha as a core material. Apical third marginal adaptation was evaluated by observing the dye penetration between the obturation material and the root canal walls on cross sectioned samples. Results SB Showed the least microleakage in the apical third marginal adaptation, followed by SRM. Conclusion Obturation of root canal using bioceramic sealer has the best sealing ability at the apical third, compared to SRM."

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Latar Belakang: Siler kalsium silikat bersifat hidrofilik, berikatan secara kimia ke dentin,  membentuk hidroksiapatit, memiliki waktu kerja dan settingideal, dan tidak terjadi penyusutan. Siler resin epoksi yang banyak digunakan saat ini memiliki kekurangan berupa adanya penyusutan saat mengeras. Evaluasi adaptasi siler dapat menentukan kemampuan kerapatan suatu siler. Salah satu metode untuk mengevaluasi kemampuan kerapatan siler adalah dengan Scanning Electron Microscopy (SEM). Tujuan: Menganalisis perbedaan adaptasi siler pada sepertiga tengah dinding saluran akar antara siler berbahan dasar kalsium silikat dengan resin epoksi.Metode: Tiga puluh dua sampel gigi premolar mandibula dibagi menjadi dua kelompok, yaitu kelompok 1: siler resin epoksi dan kelompok 2: siler kalsium silikat. Sampel dipreparasi dan diobturasi dengan siler berbahan dasar kalsium silikat dan resin epoksi. Selanjutnya, gigi dipotong vertikal dan disiapkan untuk analisis adaptasi siler menggunakan SEM. Data tersebut dianalisis secara statistik dengan uji Chi-square. Hasil Penelitian: Tidak terdapat perbedaan bermakna antara adaptasi siler kalsium silikat dan resin epoksi secara statistik (p>0.05). Partikel resin epoksi secara keseluruhan tampak berukuran lebih besar dibandingkan dengan kalsium silikat. Kesimpulan: Tidak terdapat perbedaan adaptasi siler secara statistik antara siler berbahan dasar kalsium silikat dengan resin epoksi pada sepertiga tengah dinding saluran akar, namun secara klinis sampel siler kalsium silikat lebih sedikit menunjukkan gap/ celah dan lebih banyak yang berpenetrasi ke dalam tubuli dentin dinding saluran akar.

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Background: Calcium silicate sealer is hydrophilic, chemically bonded to dentin, forms hydroxyapatite, has an ideal working and setting time, and does not shrink. The epoxy resin sealer that is widely used today has the disadvantage of shrinkage when hardening. Evaluation of the adaptation of the sealer can determine the sealing ability of a sealer. One of the method for evaluating the sealing ability of a sealer is Scanning Electron Microscopy (SEM). Objective: To analyze differences in the adaptation of sealers in middle third of root canal wall between the calcium silicate and epoxy resin based sealer. Methods: Thirty-two mandibular premolar teeth samples were divided into two groups, that are group 1: epoxy resin sealer and group 2: calcium silicate sealer. Samples were prepared and obturated with calcium silicate and epoxy resin based sealer. Next, the teeth were cut vertically and prepared for analysis of the sealer adaptation using SEM. The data was analyzed statistically by Chi-square test. Results: There was no significant difference between the adaptation of calcium silicate and epoxy resin sealer statistically (p> 0.05). Overall epoxy resin’s particles appear larger than calcium silicate. Conclusion: There was no statistical difference in the adaptation of sealers between calcium silicate and epoxy resin based sealer in middle third of root canal wall, but clinically fewer calcium silicate sealer samples showed gaps and more penetrated into dentinal tubules of root canal wall.

 

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"Latar Belakang: Pengisian dengan kon gutaperca berlapis resin (GBR) dan siler resin metakrilat menciptakansuatu sistem monoblok tersier. Tujuan: menganalisis perbandingan kerapatan antara pengisian GBR dan gutaperca konvensional (GK) dengan siler resin metakrilat di daerah sepertiga apeks.Metode:Tiga puluh dua gigi insisif bawah, dibagi dua kelompok sama besar, yaitu kelompok GBR dan GK dengan masing-masing kelompok menggunakan siler resin metakrilat. Setelah pengisian saluran akar dengan tekniksingle-cone, sampel diinkubasi (370C, 24 jam), kemudian dibelah dua secara vertikal. Dilakukan pemeriksaan kerapatan sepertiga apeks berdasarkan celah mikro yang ada pada daerah 5mm dari apeks menggunakan SEM dan diberi skor. Analisis data menggunakan uji Kolmogorov-Smirnov. Hasil: Skor 0 terbanyak pada GBR 43.8%,skor 1 terbanyak pada GK 81,3%% (165), skor 2 0% dan skor 3 terbanyak pada GBR 12.5%.Kesimpulan: Kerapatan hasil pengisian dengan kon gutaperca berlapis dibanding gutaperca konvensional dengan masing-masing kelompok menggunakan siler resin metakrilat pada sepertiga apeks tidak ada perbedaan bermakna walaupun secara subtansi jumlah celah mikro pada kelompok gutaperca berlapis lebih sedikit didaerah sepertiga apeks

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Background:Resin-coatedguttapercha as aroot canal obturation material is the system of tertiary monoblock. Purpose: to compare sealability of obturation using methacrylate resin-based root canal sealer between GBR dan GK group. Methods: Thirty two human lower insisive was used as specimen.All specimen was prepared using REVO-S and divided randomly into two groups. First group, GBK was obturated with resin-coated guttapercha andmethacrylate resin-based root canal sealer; while GK group was obturated with conventional guttapercha with the same sealer.Afterobturation, the specimens were incubated (370C, 24 h), then the speciments was cut verticaly. The gap existance was measured using SEM and given score 0-3. Theresults were statistically analyzed with Kolmogorov Smirnov test. Results:Thelargest proportion distribution in GBR group was score 0 (43.8%), whilst the largestproportion distribution in GK group was score 1 (81.3%), both these groups has no score 2, and the largest proportion distribution in GBR was score 3(12.5%) Conclusion: Resin-coated guttapercha as an obturation material hadinsignificancy diffrence statisticaly than conventional guttapercha of sealing ability, despite resin-coated guttapercha showed better sealing ability substantially.

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"ABSTRAKLatar belakang: Salah satu sifat ideal suatu siler saluran akar adalah memiliki kemampuan penutupan yang baik terutama pada sepertiga apeks. Tujuan: Untuk mengevaluasi perbandingan kebocoran antara pengisian saluran akar dengan siler polidimetilsiloksan SP dan siler bioceramic SB . Metode: Tiga puluh enam gigi premolar rahang bawah, dibagi dua kelompok dan diisi dengan teknik kon tunggal menggunakan siler polidimetilsiloksan pada kelompok pertama, dan siler bioceramic pada kelompok ke-dua. Selanjutnya gigi diinkubasi 37?C, selama 24 jam , kemudian dilapisi dengan dua lapis cat kuku kecuali pada 2 mm dari apeks, dan direndam dalam tinta india 7 X 24 jam . Sampel didekalsifikasi, didehidrasi dan dibuat transparan sesuai dengan metode Robertson. Kedalaman penetrasi zat tinta dievaluasi dengan mikroskop stereo. Skor 0 untuk tidak bocor, skor 1 untuk penetrasi zat tinta le; 0,5 mm, skor 2 untuk penetrasi 0,51 ndash; 1 mm, dan skor 3 untuk penetrasi > 1 mm. Hasil: Distribusi proporsi kebocoran terbesar pada kelompok SP terdapat pada skor 2 44.4 , sedangkan pada kelompok SB terdapat pada skor 1 55.6 . Kesimpulan: Tingkat kebocoran pengisian saluran akar dengan siler bioceramic tidak berbeda dengan siler polidimetilsiloksan.

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ABSTRACTBackground One of the ideal properties of a root canal sealer is to have a good sealing ability, especially at the apical third of the root. Objective To evaluate the comparison of the apical leakage between obturation using bioceramic sealer SB and polydimethylsiloxane sealer SP . Methods Thirty six mandibular premolars were equally divided into two groups and was obturated with single cone technique. The sealer used for Group I and Group II were SP and SB respectively. After obturation, the samples were incubated 37 C, 24 h , sealed with two coats of nail polish except for 2 mm from the apex, immersed in the Indian ink for 7 days, decalcified, dehydrated and made transparent according to Robertson technique. Dye penetration were evaluated under stereomicroscope. Samples with no dye penetration were given score 0, le 0,5 mm dye penetration were given score 1, 0,051 ndash 1 mm were given score 2, and 1 mm were given score 3. Result The largest proportion distribution in SP group was at the score 2 44.4 , and in group SB was at the score 1 55.6 . Conclusion Bioceramic sealer showed similar apical leakage to polydimethylsiloxane sealer."

"Latar Belakang: Siler yang baik adalah yang memiliki tingkat kebocoran mikro yang rendah Penelitian ini bertujuan untuk menganalisis siler golongan resin SRE dan polidimetilsiloksan generasi baru SPGB Metode: Tiga puluh dua gigi premolar bawah dibagi dua kelompok sama besar yaitu kelompok SRE dan SPGB Setelah pengisian saluran akar dengan teknik kondensasi lateral sampel diinkubasi 370C 24 jam mahkota dipotong menyisakan bagian akar 15 mm dilapis cat kuku kecuali 1 mm dari apeks lalu direndam dalam tinta India selama 7 X 24 jam Lalu sampel didekalsifikasi dengan asam nitrat 5 didehidrasi berturut turut dengan alkohol 80 90 dan 100 dan dibuat transparan dengan metil salisilat 100 Kedalaman penetrasi tinta dievaluasi dengan mikroskop stereo Skor 1 untuk penetrasi tinta 0 0 5 mm skor 2 untuk penetrasi tinta 0 51 1 mm dan skor 3 untuk penetrasi tinta 1 mm Hasil: Distribusi proporsi kebocoran terbesar kelompok SRE terdapat pada skor 2 yaitu sebesar 56 3 Sedangkan distribusi proporsi kebocoran terbesar kelompok SPGB terdapat pada skor 1 yaitu sebesar 68 8 Dengan tes Kolmogorov Smirnov terdapat perbedaan bermakna antara kelompok SRE dan SPGB Kesimpulan: Kebocoran mikro pengisiansaluran akar pada sepertiga apeks dengan siler polidimetilsiloksan generasi baru lebih rendah dibandingkan dengan siler resin epoksi

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Background: An ideal root canal sealer should have good sealing ability The purpose of this study was to analyze the microleakage of obturation using epoxy resin based SRE and new generation polydimethylsiloxane based SPGB as root canal sealer

Methods: Thirty two mandibular first premolars were equally divided into two groups and obturated with lateral condensation technique The sealer used for Group I and Group II were SRE and SPGB respectively After obturation the specimens were incubated 370C 24 h decoronated sealed with nail polish except 1mm from apex immersed in Indian ink for 7 days decalcified with 5 nitric acid solution dehydrated with 80 90 and 100 alcohol consecutively and made transparent by immersing them in 100 methyl salicylate Dye penetration were evaluated under stereomicroscope and givenscore 1 3 Specimen with 0 0 5 mm dye penetration was given score 1 while 0 51 1 mm penetration was given score 2 and 1 mm was given score 3 The results were statistically analyzed with Kolmogorov Smirnov test

Results: The largest proportion distribution in SR group was score 2 56 3 whilst the largest proportion distribution in SPGB group was score 1 68 8 There was a significant difference between the microleakage of epoxy resin based and new generation polydimethylsiloxane based sealer observed from the one third apical leakage

Conclusion: The microleakage of new generation polydimethylsiloxanebasedsealer is lower than epoxy resin based sealer"