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"Artritis Reumatoid AR merupakan penyakit inflamasi sistemik kronik yang menyerang dan merusak sendi-sendi pada tungkai atas dan bawah. AR menyebabkan morbiditas dan disabilitas yang dapat menurunkan kualitas hidup Inflamasi kronis seiring dengan progresivitas penyakit menyebabkan penurunan indeks massa tubuh pada pasien AR. Titer Anti-CCP yang bersifat spesifik terhadap AR dapat menggambarkan progresivitas dan prediksi keparahan penyakit. Penelitian mengenai titer anti-CCP dan indeks massa tubuh belum dilakukan di Indonesia. Sehingga penelitian ini dilakukan dengan tujuan mengetahui korelasi antara titer anti-CCP dengan nilai indeks massa tubuh IMT di RSCM. Desain penelitian yang digunakan adalah cross-sectional dengan jumlah sampel sebanyak 42 rekam medis. Data mengenai titer anti-CCP, berat badan, tinggi badan, dan nilai indeks massa tubuh diperoleh dari rekam medis pasien. Hasil penelitian menunjukkan bahwa tidak terdapat korelasi antara titer anti-CCP dengan nilai indeks massa tubuh p>0.05; r-0.03.

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Rheumatoid arthritis is a chronic systemic inflammation that attacks and damages joints of upper and lower extremities. RA causes morbidity and disability, hence, affects the quality of life. Chronic inflammation, as the disease progressing, causes lowering of body mass index in RA patients. Titer of Anti CCP, which is specific for RA, indicates the progressivity and severity of the disease. Study about anti CCP titer and body mass index has not been done in Indonesia. Therefore, this study rsquo s done to understand the correlation between anti CCP titer and body mass index score in Rheumatoid Arthritis patients in RSCM. The design of this study is cross sectional study with 42 samples. The data including anti CCP titer, body weight, height, and body mass index are collected from patients rsquo medical records. The result of this study shows that there is no correlation between anti CCP titer and body mass index score in Rheumatoid Arthritis patients in RSCM p 0.05 r 0.03."

"Artritis Reumatoid AR merupakan salah satu penyakit yang berhubungan dengan sistem imun yang menyebabkan kerusakan sendi dan mengakibatkan terjadi penurunan kualitas hidup pasien. Nilai DAS28 CRP menggambarkan aktivitas penyakit AR. Titer Anti-CCP merupakan pemeriksaan yang sangat spesifik digunakan untuk memberikan gambaran prognosis penyakit pasien AR. Penelitian tentang korelasi titer Anti-CCP dengan nilai DAS28 CRP belum pernah dilakukan di Indonesia. Oleh karena itu, penelitian ini bertujuan untuk mengetahui korelasi antara titer Anti-CCP dengan nilai DAS28 CRP di RSCM. Pada peneltian ini desain penelitian yang digunakan adalah cross-sectional dengan sampel berjumlah 43 data. Data mengenai titer Anti-CCP dan DAS28 CRP didapatkan melalui rekam medis pasien. Hasil menyatakan bahwa tidak terdapat korelasi p=0,582 antara titer Anti-CCP dengan DAS28 CRP dengan nilai r yang menunjukkan korelasi sangat lemah r=0,086.

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Rheumatoid arthritis is one of a disease relating with immunity that causes destruction in joints which affects quality of life of its patients. DAS28 CRP score represents the activity of the disease. Anti CCP titer is a specific test to portray the prognosis for the patients. Study about correlation between DAS28 CRP score and Anti CCP titer has not been done in Indonesia. Therefore, this study rsquo s done to understand the correlation between DAS28 CRP score and Anti CCP titer in RSCM. The design of this study is cross sectional study with 43 samples. Data of Anti CCP score and DAS28 CRP score are collected from patients rsquo medical records. The result of this study shows that there is no correlation between Anti CCP titer and DAS 28 CRP score in Rheumatoid Arthritis patients in RSCM with a very low correlation p 0,582 r 0,086."

"Background. Rheumatoid Arthritis (RA) is one of the diseases associated with the immune system which causes joint damage and effect to the quality of patients life. DAS28 CRP value describes RA disease activity. The antiCCP titer is a very specific examination which provide an overview prognosis of RA patients illness. The research on the correlation of anti CCP Titers with DAS28 CRP values has never been done in Indonesia. Therefore, this research aims to determine the correlation between anti CCP Titer and DAS28 CRP value in RA patient in Cipto Mangunkusumo hospital with DAS28 CRP value in RSCM.Method. The research design is crosssectional with the sample amounted to 34. anti CCP and DAS28 CRP were obtained through patients medical records.Result. The result of this correlationstudy is (p = 0,582) and r = 0,086.Conclusion. In conclusion, there is no correlation between antiCCP and DAS28 in Cipto Mangunkusumo hospital."

"ABSTRACTArtritis Reumatoid AR merupakan penyakit inflamasi kronis sistemik yang ditandai dengan pembengkakan dan nyeri sendi, serta kerusakan dari membran sinovial pada persendian. Dalam memonitor penyakit ini, digunakan Disease Activity Score-28 DAS28 yang dapat menunjukkan aktivitas penyakit AR dari waktu ke waktu. DAS28 bermanfaat untuk mengevaluasi pengobatan serta menentukan keputusan klinis lainnya. DAS28 dapat dihitung menggunakan beberapa komponen seperti jumlah sendi yang nyeri, bengkak, nilai Visual Analogue Scale VAS , serta penanda inflamasi berupa nilai Laju Endap Darah LED atau C-Reactive Protein CRP . DAS28-LED dan DAS28-CRP digunakan secara luas dan keduanya ekuivalen. Namun, nilai LED dapat dipengaruhi berbagai faktor lain, seperti kejadian infeksi, yang angkanya cukup tinggi di Indonesia. Oleh karena itu, penelitian ini bertujuan untuk melihat apakah terdapat perbedaan antara nilai DAS28-CRP dengan DAS28-LED di Indonesia. Data ini belum diketahui sebelumnya. Data mengenai jenis kelamin, usia, jumlah sendi nyeri dan bengkak, nilai VAS, LED, dan CRP diperoleh dari 40 rekam medis pasien AR yang berobat di RSCM pada tahun 2015. Dari hasil penelitian, didapatkan bahwa terdapat perbedaan bermakna rerata antara nilai DAS28-CRP dan DAS28-LED sebesar 1,0107.

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ABSTRACTRheumatoid Arthritis RA is a systemic chronic inflammation disease marked by swollen and tender joint, also destruction of joint rsquo s synovial membrane. To monitoring this disease, Disease Activity Score 28 DAS28 used to show disease activity of RA in times to times. DAS28 is useful to evaluate disease rsquo s treatment and guide clinician to take a decision for the treatment itself. There are some component needed to count DAS28 score, they are number of tender and swollen joint, Visual Analogue Scale, and inflammatory marker such as Erythrocyte Sedimentation Rate ESR or C Reactive Protein CRP . Either DAS28 ESR or DAS28 CRP are used widely and are said to be equivalent to each other. Otherwise, ESR influenced by many other factors, one of them is infection disease, whose the incident number in Indonesia is relatively high. Therefore, the objective of this stuy is to know the comparison between DAS28 ESR and DAS28 CRP in Indonesia, which is still unknown. Data about gnder, age, number of tender and swollen joint, VAS, ESR, and CRP are obtained from 40 RSCM RA patients rsquo medical record in 2015. From this research known that there are significant mean difference between DAS28 CRP and DAS28 ESR which is 1,0107."

"ABSTRAKArtritis rematoid merupakan penyakit otoimun sistemik yang paling sering ditemukan di dunia pada berbagai populasi dan ras, ditandai oleh inflamasi menetap pada jaringan sendi yang meliputi sendi perifer, distribusi simetris, dengan atau tanpa kerusakan rawan sendi dan erosi tulang. Pemantauan aktivitas penyakit diperlukan untuk menentukan keberhasilan terapi. Selama ini, pemantauan aktivitas penyakit menggunakan Disease Activity Score 28 (DAS28), meskipun terdapat kekurangan berupa parameter klinis yang bersifat subjektif, menggunakan perhitungan yang rumit, dan terdapat ketidakseragaman nilai titik potong derajat aktivitas penyakit pada berbagai penelitian.Penelitian ini merupakan penelitian potong lintang untuk menilai korelasi antara kadar anti-CCP serum dan cairan sendi dengan aktivitas penyakit (DAS28) pada 30 subjek dengan artritis rematoid. Subjek yang memenuhi kriteria masukan dan tidak ada kriteria tolakan dilakukan penentuan skor DAS28 serta pemeriksaan anti-CCP serum dan cairan sendi.Median (rentang) kadar anti-CCP serum secara keseluruhan, pada tingkat aktivitas penyakit sedang, dan berat adalah 112.23 (1.02-1853.07), 70.98 (1.02-1224.07), dan 157.59 (1.07-1853.07) RU/mL. Median (rentang) kadar anti-CCP cairan sendi secara keseluruhan, pada tingkat aktivitas penyakit sedang dan berat adalah 85.54 (0.90-4150.58), 58.90 (1.03-2477.81), dan 110.23 (0.90-4150.58) RU/mL. Median (rentang) skor DAS28 pada keseluruhan subjek ditemukan 5.04 (4.04-7.10). Uji korelasi Spearman didapatkan korelasi positif lemah namun tidak bermakna secara statistik antara kadar anti-CCP serum dan DAS28 dengan rs = 0.296, p = 0.056, korelasi positif lemah yang bermakna secara statistik antara anti- CCP cairan sendi dan DAS28 dengan rs = 0.331, p = 0.037, sedangkan korelasi antara anti-CCP serum dengan cairan sendi ditemukan kuat yang bermakna secara statistik dengan rs = 0.907, p <0.01.Kami menyimpulkan kadar anti-CCP cairan sendi berkorelasi lemah dengan aktivitas penyakit (DAS28). Tidak ditemukan korelasi yang bermakna secara statistik antara kadar anti-CCP serum dengan aktivitas penyakit (DAS28). Terdapat korelasi kuat antara kadar anti-CCP serum dengan kadar anti-CCP dalam cairan sendi.

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ABSTRACTRheumatoid arhtritis is the most common chronic systemic autoimmune disease worldwide among many populations and races, characterized by persistent joint inflammation affecting peripheral joints, symmetrical distribution, with or without joint damage or bone erosion. Disease activity monitoring is needed to determine treatment response. Nowadays, Disease Activity Score 28 (DAS28) is used to monitor disease activity, although it uses subjective clinical parameter, complicated calculation, and ununiformity cut-off value for disease activity stages on various researches.This study was a cross sectional study to assess wheter there was any correlation between anti-CCP serum and synovial fluid concentration with disease activity (DAS28) in 30 rheumatoid arhtritis subject. Blood and synovial fluid specimen collection and DAS28 determination was performed on subjects who fulfill inclusion and exclusion criteria, followed by anti-CCP assay on each specimen.Median (range) anti-CCP serum concentration in overall, moderate, and severe disease activity were 112.23 (1.02-1853.07), 70.98 (1.02-1224.07), and 157.59 (1.07-1853.07) RU/mL, respectively. Median (range) anti-CCP synovial fluid concentration in overall, moderate, and severe disease activity were 85.54 (0.90-4150.58), 58.90 (1.03-2477.81), and 110.23 (0.90-4150.58) RU/mL, respectively. Median (range) of DAS28 were 5.04 (4.04-7.10). A weak but not statistically significant correlation was found between serum anti-CCP concentration and DAS28 with rs = 0.296 (p = 0.056). A weak and significant correlation was found between synovial fluid anti-CCP concentration and DAS28 with rs = 0.331 (p = 0.037). A strong and significant correlation are found between serum and synovial fluid anti-CCP concentration, with rs = 0.907 (p <0.01) using Spearman correlation test.We concluded that synovial fluid anti-CCP concentration weakly correlated with disease activity. No significant correlation was found between serum anti-CCP concentration with disease activity. Strong correlation was found between serum and synovial fluid anti-CCP concentration."

"Defisiensi besi selama kehamilan adalah salah satu defisiensi gizi yang prevalensinya tetap tinggi di dunia yaitu mencapai 70%. Berat badan kurang merupakan salah satu faktor risiko terjadinya defisiensi besi selama kehamilan. Feritin adalah protein cadangan zat besi yang disintesis oleh hati dan dapat meningkat selama peradangan. Penelitian ini bertujuan untuk mengetahui korelasi antara kadar feritin serum dengan indeks massa tubuh pada perempuan hamil trimester 1. Disain penelitian yang digunakan adalah studi potong lintang. Penelitian dilakukan di Pusat Kesehatan Masyarakat Kramat Jati, Jakarta selama bulan Oktober 2013. Pengambilan subyek dilakukan dengan cara consecutive sampling. Empat puluh tujuh perempuan hamil trimester 1 didapatkan memenuhi kriteria penelitian. Didapatkan rerata usia 27,79±4,85 tahun, diantara subyek penelitian 5 orang (10,6%) memiliki berat badan kurang, 25 orang (53,2%) berat badan normal dan 17 berat badan lebih (36,2%). Nilai tengah asupan zat besi 23,21 (8,4 ̶ 36,80) mg/hari. Asupan zat besi menunjukkan 66% subyek memiliki asupan zat besi kurang dari Angka Kecukupan Gizi (AKG) Indonesia. Nilai tengah kadar feritin serum 58,1 (4,9 ̶ 139,8) μg/L dan 6,4% subyek tergolong status feritin rendah. Hasil penelitian ini diperoleh korelasi positif tidak bermakna antara kadar feritin serum dengan indeks massa tubuh pada perempuan hamil trimester 1 (r=0,097, p=0,52).

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Iron deficiency during pregnancy is one of nutritional deficiency with high prevalence in the world, reaching up to 70%. Underweight is one of the main risk factors for iron deficiency during pregnancy. Ferritin is an iron storage protein which synthesized in the liver and can be increased during inflammation. The aim of this study was to find out the correlation between serum ferritin levels and body mass index (BMI) in pregnant woman in their first trimester. The design of the study is cross-sectional. Data collection was conducted at Kramat Jati Primary Health Care, Jakarta during October 2013. Subjects were obtained by consecutive sampling method. A total of 47 pregnant women in their first trimester subjects had met the sudy criteria. The mean of maternal age was 27,79±4,85 years, among them are 5 underweight (10,6%), 25 normal weight (53,2%) and 17 overweight (36,2%). Median of iron intake was 23,21 (8,4 ̶ 36,80) mg/day. Intake of iron showed 66% of the subjects had intake of iron less than Indonesian recomended dietary allowance (RDA). Median of serum ferritin levels was 58,1 (4,9 ̶ 139,8) μg/L, while 6,4% of the subjects were catagorized as low ferritin status. No significant correlation was found between serum ferritin levels and BMI in pregnant women in their first trimester (r=0,097, p=0,52)."

"ABSTRAKBackgrounds : There was a two-fold increase in cardiovascular-related mortality in rheumatoid arthritis (RA). Postprandial triglyceride (PPTG) related to increased risk of ischemic heart disease, myocardial infarction, ischemic stroke, mortality and elevated level of adhesion molecules. Increased endothelial adhesion molecules was a sign of endothelial activation, an early process in the development of atherosclerotic lesion. There was no study evaluating the role of NTG in cardiovascular risk assessment in RA patients. Aim : This study observed the relationship between PPTG and sICAM-1 and sE-selectin, as markers of endothelial activation. Methods : This was a cross-sectional study of fifty consecutively-recruited RA patients. Lipid profiles, sICAM-1, and sE-selectin were measured postprandially. Further analysis using multiple regression was performed. Results : There was no correlation found between PPTG and sICAM-1, nor NTG and sE-selectin. Level of sICAM-1 was influenced by HDL (R2=0,087) while sE-selectin was influenced by DAS-28 (R2=0,174), body mass index (R2=0,125), and postprandial glucose (R2=0,138). Conclusion : PPTG did not correlated with sICAM-1 and sE-selectin in RA patients.

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ABSTRACTBackgrounds : There was a two-fold increase in cardiovascular-related mortality in rheumatoid arthritis (RA). Postprandial triglyceride (PPTG) related to increased risk of ischemic heart disease, myocardial infarction, ischemic stroke, mortality and elevated level of adhesion molecules. Increased endothelial adhesion molecules was a sign of endothelial activation, an early process in the development of atherosclerotic lesion. There was no study evaluating the role of NTG in cardiovascular risk assessment in RA patients. Aim : This study observed the relationship between PPTG and sICAM-1 and sE-selectin, as markers of endothelial activation. Methods : This was a cross-sectional study of fifty consecutively-recruited RA patients. Lipid profiles, sICAM-1, and sE-selectin were measured postprandially. Further analysis using multiple regression was performed. Results : There was no correlation found between PPTG and sICAM-1, nor NTG and sE-selectin. Level of sICAM-1 was influenced by HDL (R2=0,087) while sE-selectin was influenced by DAS-28 (R2=0,174), body mass index (R2=0,125), and postprandial glucose (R2=0,138). Conclusion : PPTG did not correlated with sICAM-1 and sE-selectin in RA patients."

"Latar Belakang: Artritis Reumatoid (AR) adalah penyakit inflamasi kronik progresif, yang selain menyebabkan peningkatan morbiditas akibat kecacatan sendi, juga menyebabkan peningkatan mortalitas terkait kejadian kardiovaskular. Salah satu prediktor peningkatan risiko mortalitas kardiovaskular adalah kekakuan arteri (KA) lokal. Proses inflamasi pada AR yang dicerminkan oleh derajat aktivitas penyakit berupa disease activity score (DAS) 28, baik yang dinilai dengan c reactive protein (CRP) dan laju endap darah (LED) diduga memiliki hubungan terhadap KA. Penelitian ini dimaksudkan untuk mengetahui korelasi antara derajat aktivitas penyakit dengan kekakuan arteri pada penderita AR. Metode: Penelitian ini merupakan studi potong lintang pada penderita AR yang berobat di poliklinik Reumatologi RSCM dalam periode April-Mei 2014. Dilakukan pengukuran KA lokal dengan USG arteri karotis komunis menggunakan teknik rf-echotracking untuk mendapatkan nilai pulse wave velocity (PWV) serta penilaian DAS 28-CRP dan DAS 28-LED. Data penyerta yang juga dikumpulkan adalah data demografis, durasi dan jenis pengobatan, glukosa darah sewaktu, profil lemak darah, kreatinin, dan faktor risiko tradisional kejadian kardiovaskular. Hasil: Sebanyak 74 subjek diikutsertakan pada penelitian ini, dengan 68 (91,9%) adalah wanita. Rerata nilai KA (PWV) yaitu 7,89 (SB 1,92) m/detik yang termasuk dalam kategori kaku. Rerata nilai DAS 28-CRP 2,46 (SB 0,82) dan DAS 28-LED 3,49 (SB 0,91) yang masing-masing termasuk dalam kelompok aktivitas penyakit rendah dan sedang. Pada analisis bivariat didapatkan korelasi DAS 28-CRP dan DAS 28-LED terhadap KA, masing-masing dengan nilai r = 0,529 (p = 0,001) dan r = 0,493 (p = 0,001). Simpulan: Terdapat korelasi positif sedang yang bermakna antara derajat aktivitas penyakit (DAS 28-CRP dan DAS 28-LED) dengan kekakuan arteri (PWV).

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Background: Rheumatoid arthritis (RA) is a chronic progressive inflammatory disease related to increase in morbidity due to joint deformity and increase in mortality due to cardiovascular event. One of cardiovascular event predictor is local arterial stiffness (AS). Inflammatory process in RA that is reflected on disease activity score (DAS) 28 calculated by c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) suspect to be related with AS. This study was aimed to find correlation between disease activity score and arterial stiffness in RA patients.

Methods: a cross sectional study was conducted in Rheumatology outpatient clinic, Cipto Mangunkusumo Hospital between April-May 2014. Arterial stiffness was measured by carotid artery ultrasound using echotracking technic to get pulse wave velocity (PWV) value, also DAS 28-CRP and DAS 28-ESR measurement was done in every subject. Others data which also collected in this study are demographic profile, duration and drugs of treatment, random blood glucose, lipid profile, creatinin, and others cardiovascular risk factors.

Results: 74 subjects met the inclusion criteria, with 68 (91,9%) are women. Mean of AS (PWV) 7,89 (SD 1,92) m/second, which categorized in stiff artery. Mean of DAS 28-CRP 2,46 (SD 0,82) and DAS 28-ESR 3,49 (SD 0,91), each of them was categorized in low and moderate disease activity. In bivariate analysis we found correlation of DAS 28-CRP and DAS 28 ESR to AS (PWV) r = 0,529 (p= 0,001) and r = 0,493 (p = 0,001).

Conclusion: There was positive and significant correlation between disease activity score (DAS 28-CRP and DAS 28-ESR) with arterial stiffness (PWV)."

"Pada awal penyakit diagnosis Artritis reumatoid (AR) sering dikacaukan dengan Lupus eritematosus sistemik (LES). Persendian terutama pada tangan dapat terserang pada kedua penyakit, sehingga pasien LES sering salah diagnosis sebagai AR. Oleh karena hasil-akhir dari kedua penyakit ini sangat berbeda , maka dibutuhkan suatu marker serologik untuk membedakan keduanya pada saat awitan penyakit. Antibodi anti-citrullinated peptide (anti ?CCP) telah dilaporkan sangat spesifik pada AR. Tujuan penelitian ini untuk memastikan spesifitas antibodi anti-CCP pada AR dan kemungkinan antibodi ini dapat membedakan pasien RA dari SLE. Penelitian ini suatu studi potong-lintang pada pasien AR (n=27), LES dengan artritis (n=20). penyakit otoimun lain (non-reumatik, n=8) dan kontrol dewasa (n=20). Anti-CCP diperiksa dengan cara Elisa dan faktor-reumatoid (FR) dengan uji latex. Sensitivitas dan spesifitas anti-CCP untuk diagnosis RA adalah 63.0% dan 97.9%, dibandingkan dengan FR yang hanya sebesar 40.7% dan 85.4%. Hanya 1 dewasa sehat dengan anti-CCP+, tidak satupun pasien LES maupun pasien penyakit otoimun lain yang mempunyai anti-CCP+. Nilai rerata titer anti-CCP pada dewasa sehat, penyakit otoimun lain, LES dan AR berturut-turut sebesar 1.35 ± 2.04, 0.63 ± 0.59, 0.75 ± 0.59, and 38.17 ± 44.22 RU/ml. Terdapat perbedaan sangat bermakna di antara titer anti-CCP pada pasien AR dengan yang lainnya (p<0.001). Disimpulkan bahwa deteksi anti-CCP sangat berguna untuk diagnosis AR, dan untuk membedakan AR dari LES. (Med J Indones 2004; 13: 227-31)

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Diagnosis of Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) can be confused in their initial stages. The joints, especially the hands, are commonly affected in both disorders, many patients with SLE are initially misdiagnosed as having RA Given that the outcome for the two diseases is diverse, it would be helpful to have serological marker to distinguish between them at onset. Anti-citrullinated peptide antibodies (anti-CCP) have recently been described as highly specific for RA. The objective of this study is to confirm the specificity of anti-CCP antibodies and to determine whether they might distinguish patients with RA from those with SLE. This study is a cross sectional study on a group of patients with RA (n=27), SLE with arthritis (n=20), other autoimmune diseases (non-rheumatic diseases, n = 8), and healthy adults (n=20). Anti-CCP was determined by a commercial Elisa test and Rheumatoid factor (RF) was determined by the standard slide latex test. The sensitivity and specificity of anti-CCP for the diagnosis of RA was 63.0% and 97.9% respectively, comparing with RF for RA that was 40.7 % and 85.4 %. Only 1 healthy adult was anti-CCP+, no anti-CCP was detected from SLE and other autoimmune disease. The mean of titer anti CCP in normal healthy adult, other autoimmune diseases, SLE and RA was 1.35 ± 2.04, 0.63 ± 0.59, 0.75 ± 0.59, and 38.17 ± 44.22 RU/ml, respectively. There was a highly significant difference between the mean of titer anti CCP for RA with others diseases (p<0.001). We conclude that detection of anti-CCP is very useful for the diagnosis of RA and distinguishing RA from SLE. (Med J Indones 2004; 13: 227-31)."

"Insulin-like growth factor (IGF)-1 adalah salah satu hormon yang berperan pada pertumbuhan remaja perempuan. Kadarnya akan meningkat pada masa pubertas dan mulai menurun saat akhir pubertas. Kadar IGF-1 yang tinggi saat dewasa berhubungan dengan kejadian kanker payudara. Penelitian ini bertujuan untuk mengetahui korelasi antara IGF-1 dengan indeks massa tubuh (IMT) pada remaja perempuan usia 13-15 tahun di Jakarta. Studi potong lintang ini dilakukan sejak bulan April?Mei 2016 dengan menggunakan data primer dari serum darah tersimpan berupa kadar IGF-1 yang diperiksa dengan metode ELISA dan data sekunder dari penelitian berjudul ?Faktor Determinan Kadar Estradiol, IGF-1, dan Menarche Dini pada Remaja Putri Usia 13?15 tahun di Jakarta: Studi Epidemiologi Gizi Terkait Faktor Risiko Kanker Payudara? berupa data antropometri, asupan makanan, dan aktivitas fisik dari 178 subjek yang didapat dengan metode total population sampling. Indeks massa tubuh pada remaja perempuan usia 13?15 tahun diukur dengan menggunakan kurva WHO 2007 dan CDC 2000. Tidak didapatkan korelasi antara IGF-1 dengan IMT pada remaja perempuan, namun terdapat kecenderungan nilai IGF-1 akan meningkat pada status gizi overweight dan menurun pada obesitas. Hendaknya para remaja perempuan menjaga status gizi dengan menjaga pola makan, memilih jenis makanan yang tepat dan seimbang, serta meningkatkan aktivitas fisik.

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The insulin-like growth factor (IGF)-1 is one of hormone that plays a role in the growth of adolescent girls. Its level will rise at puberty and begin to decline at the end of puberty. High IGF-1 levels in adult associated with the incidence of breast cancer. This study aimed to determine the correlation between IGF-1 and body mass index (BMI) in 13-15-years-old girls in Jakarta. This cross-sectional study was conducted in April-May 2016 by using primary data from stored blood serum to measure IGF-1 level byELISA method and secondary data from a study entitled "Determinant Factors of Levels of Estradiol, IGF-1, and Early Menarche in Adolescents Girls Aged 13-15 in Jakarta: Nutritional Epidemiology Study Related to Breast Cancer Risk Factors" such as anthropometric data, dietary intake, and physical activity were obtained from 178 subjects with a total population sampling method. Body mass index in girls aged 13-15 years were measured using WHO 2007 and CDC 2000 curves. There were no correlation between IGF-1 with a BMI in adolescent girls, however, there is a tendency value of IGF-1 will increase in overweight and decrease in obesity. Thus adolescent girls should maintain their nutritional status by maintain a diet, choose the right and balanced foods, as well as increased physical activity."