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"Malnutrition and its related symptoms are both frequent and deleterious effects of cancer treatment. Despite the importance of targeted nutritional interventions in ameliorating these effects, however, publications providing up-to-date information on novel nutritional approaches and strategies are lacking. This book is intended to fill the void by describing and evaluating in detail the nutritional strategies that may be employed to alleviate a wide variety of cancer treatment effects. The guidance provided will help to improve the survival and quality of life of cancer patients, and has the potential to dramatically affect how evidence-based clinical practice is established and improved over the coming decade. "

"This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers."

"Wellness nutrition -- Personal and community nutrition -- Digestion, absorption, and metabolism -- Carbohydrates -- Fats -- Protein -- Vitamins -- Water and minerals -- Energy supply and fitness -- Management of body composition -- Life span health promotion : pregnancy, lactation, and infancy -- Life span health promotion : childhood and adolescence -- Life span health promotion : adulthood -- Nutrition in patient care -- Nutrition and metabolic stress -- Interactions: complementary and alternative medicine, dietary supplements, and medications -- Nutrition for disorders of the gastrointestinal tract -- Nutrition for disorders of the liver, gallbladder, and pancreas -- Nutrition for diabetes mellitus -- Nutrition for cardiovascular and respiratory diseases -- Nutrition for diseases of the kidneys -- Nutrition in cancer, aids, and other special problems."

"Latar Belakang: Sel punca mesenkimal SPM asal jaringan lemak ASCs dan tali pusat UCSCs merupakan sumber sel punca yang umum digunakan pada terapi seluler. SPM berkomunikasi dengan sel kanker diantaranya melalui berbagai faktor biologis aktif yang dinamakan sekretom. Lingkungan mikro kanker yang hipoksik dapat memberi pengaruh berbeda pada interaksi ini. Efek interaksi sekretom SPM terhadap agresivitas sel punca kanker payudara hingga kini belum banyak diketahui. Tujuan: Menganalisis berbagai penanda agresivitas yang berkaitan dengan pertumbuhan dan ketahanan hidup viabilitas, proliferasi, sifat pluripotensi OCT4 dan SOX2, tumorigenik MFU, progresif-agresif TGF-?1 dan T?R1, penanda kepuncaan dan kemampuan detoksifikasi ALDH1A1 dan ALDH1A3, serta sifat invasif MMP2 dari sel punca kanker payudara BCSCs ALDH paska interaksi dengan sekretom dari conditioned medium CM SPM asal tali pusat dan jaringan adiposa yang diproduksi dalam kondisi normoksia maupun hipoksia. Metode: Studi eksperimental in vitro menggunakan CM UCSCs dan ASCs normoksia dan hipoksia yang disuplementasikan pada medium asal DMEM-F12 dari sel punca kanker payudara BCSCs ALDH dengan konsentrasi 50 v/v selama 72 jam. Analisis uji viabilitas dan proliferasi, q-RT-PCR ekspresi mRNA ALDH1A1, ALDH1A3, OCT4, SOX2, MMP2, TGF-?1 dan T?R1 serta uji MFU dari BCSCs ALDH dilakukan untuk mengetahui efek dari sekretom dalam CM terhadap agresivitas BCSCs ALDH. Hasil: Sekretom dalam CM-UCSCs dapat meningkatkan agresivitas BCSCs melalui peningkatan penanda invasif ndash;agresif dan detoksifikasi. Sekretom dalam CM-ASCs dapat meningkatkan agresivitas BCSCs melalui peningkatan penanda pluripotensi, invasif dan detoksifikasi. Prekondisi hipoksia pada CM-SPM dapat meningkatkan potensi agresivitas lebih tinggi daripada CM normoksia. Perbedaan regulasi viabilitas dan proliferasi serta turunnya penanda tumorigenik BCSCs paska suplementasi CM perlu diinterpretasikan dengan hati-hati dan masih memerlukan verifikasi. Kesimpulan: Sekretom dalam CM UCSCs maupun ASCs dapat memberikan efek meningkatkan sifat agresif dari BCSCs ALDH. Preparasi hipoksia pada produksi CM cendrung lebih mendukung sifat agresif dari BCSCs ALDH dibandingkan CM normoksianya. Perbedaan regulasi viabilitas dan proliferasi serta turunnya penanda tumorigenik pada BCSCs paska suplementasi CM SPM masih membutuhkan penelitian lebih lanjut untuk menganalisis dasar molekuler yang menyebabkannya.

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Background: Adipose and umbilical cord tissue derived mesenchymal stem cells MSCs are the most common sources that are used in various cellular therapies. MSCs are known to communicate with cancer cells through their secretomes. The hypoxic microenvironment of cancer may cause different effects on this interaction. Effects of MSC secretomes against the aggressiveness of breast cancer stem cells BCSCs ALDH have not been widely investigated.

Aim: To analyze various markers of aggressiveness that are associated with growth and survival viability, proliferation, pluripotency OCT4 and SOX2, tumorigenic MFU, progressive aggressive TGF 1 and T R1, stemness and detoxification ALDH1A1 and ALDH1A3, as well as the invasive nature MMP2 of BCSCs ALDH post interaction with both normoxic and hypoxic MSC secretomes.

Methods: The in vitro experimental study using conditioned medium CM of MSCs produced in normoxic and hypoxic condition that were supplemented in medium of BCSCs ALDH with concentrations of 50 v v for 72 hours. Analysis of viability, proliferation, and q RT PCR of ALDH1A1, ALDH1A3, OCT4, SOX2, MMP2, TGF 1 and T R1 mRNA as well as MFU assay were performed to determine the effect of secretomes on the aggressiveness of BCSCs ALDH.

Results: Secretomes of UCSCs supported the aggressiveness by increasing invasive aggressive and detoxification markers, while secretomes of ASCs supported the aggressiveness by increased pluripotency, invasive and detoxification markers. Hypoxic preconditioning of MSC secretomes increased the potential for aggressiveness higher than normoxic secretomes. Differences in viability and proliferation regulation and the decrease in BCSCs tumorigenic post secretomes supplementation need to be interpreted carefully and further verification.

Conclusion: Supplementation of MSC secretomes increased the aggressive properties of BCSCs ALDH. The hypoxic secretomes tend to favor the aggressive nature of BCSCs ALDH compared to its counterpart. Differences in viability and proliferation regulation as well as the decrease in tumorigenic markers in BCSCs after MSC secretomes supplementation still need further research to analyze the molecular underlying basis."

"Status gizi seseorang menunjukkan seberapa besar kebutuhan fisiologis individu tersebut telah terpenuhi. Keseimbangan antara nutrisi yang masuk dan energi dikeluarkan untuk mencapai kesehatan optimal sangatlah penting, termasuk bagi seorang ibu yang sedang dalam masa menyusui. Faktor-faktor yang mempengaruhi status gizi ibu menyusui antara lain usia, genetik, status hormonal, tingkat pendidikan, penghasilan, morbiditas, praktek pemberian ASI eksklusif, dan asupan makanan. Dengan berubahnya faktor-faktor tersebut dapat membuat status gizi ibu menyusui menjadi kurang. Penelitian ini menggunakan metode cross-sectional dan dilakukan pada 86 ibu yang mempunyai bayi berusia 1,5 bulan atau lebih yang tinggal di beberapa RW/Posyandu terpilih di Jakarta Utara pada tahun 2009. Penelitian ini menggunakan data sekunder dari penelitian ”Survei Cepat Ibu Menyusui” pada beberapa Kelurahan di DKI Jakarta tahun 2005. Untuk status gizi, responden dibagi menjadi dua bagian berdasarkan indeks massa tubuh menjadi kurang dan tidak kurang dengan batasan 18,49 kg/m2. Lalu dilakukan uji statistik untuk menilai hubungan usia, tingkat pendidikan, penghasilan, morbiditas, praktek menyusui Asi secara eksklusif dengan status gizi ibu menyusui. Pasien memiliki IMT rerata 22.86 ± 3,79 kg/m2, terdiri dari ibu dengan IMT lebih 47,7%, IMT kurang 11,6%, dan IMT normal 40,7%. Dengan uji Chi-Square dan uji Fisher tidak didapatkan hubungan bermakna antara masingmasing variabel yang diteliti dengan status gizi ibu menyusui (p<0,05). Disimpulkan bahwa tidak terdapat hubungan yang bermakna antara antara status gizi subyek dengan usia, tingkat pendidikan, penghasilan, morbiditas, dan praktek pemberian ASI eksklusif di Jakarta Utara pada tahun 2009.

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The nutritional status of an individual shows how far the physiological needs have been fulfilled. The balance between the income nutrition and the outcome energy to achieve an optimum health is very important, including for a lactating woman. Factors contributing to the nutritional state of a lactating woman are the age, genetics, hormonal state, level of education, the mother’s income, the mother’s morbidity, the exclusive breastfeeding, and the intake of food. Changing those factors can lead the nutritional state of the lactating mother below the normal range. The design used was the cross-sectional study and had been done in 86 lactating mothers at North Jakarta in the year of 2009. This research uses the secondary data from the ”Quick Survey of Lactating Mother” rersearch at Jakarta in the year of 2005. For the nutritional state, all the respondents are divided into two groups acording to the body mass index, one is underweight group and the other is non-underweight group with the cut off point 18,49 kg/m2. We had been done the statistical test to assess the correlation of the age, level of education, the income, the morbidity, exclusive breastfeeding with the nutritional state of lactating mother. The result is, all the resopndents have a mean of BMI 22.86 ± 3,79 kg/m2, this includes the mothers within the overweight range 47,7%, the mothers within the underweight range 11,6%, and the mothers within the normoweight range 40,7%. With the Chi-Square test and the Fisher test, we did not find the significant relationship between those variables with the nutritional state of lactating mother (p<0,05). So we conclude that there is no significant relationship between the nutritional state of lactating mother with the age, level of education, the income, the morbidity, and the exclusive breastfeeding at North Jakarta in year 2009."

"Delivers comprehensive food and the nutrition care process information from educators and practitioners in the field. This title presents such recommendations as the MyPlate guide, the Dietary Guidelines for Americans 2010, and a variety of tables, boxes, and pathophysiology algorithms, providing need-to-know information with ease."

"The highly praised Nutritional health : strategies for disease prevention has been brought fully up to date to include all the new thinking and discoveries that have the greatest capacity to improve human health and nutritional advancement. About half the new edition will be revised and updated from the second edition while the other half will consist of major revisions of previous chapters or new subjects. Like the two previous editions the book will consist of general reviews on various topics in nutrition, especially those of much current interest.The authors provide extensive, in-depth chapters covering the most important aspects of the complex interactions between diet, its nutrient components, and their impacts on disease states, and on those health conditions that increase the risk of chronic dieases. "