Hasil Pencarian  ::  Simpan CSV :: Kembali

"Review of rheumatology is a synopsis of key areas of interest, making for an indispensable quick reference work. The material included reviews basic musculoskeletal anatomy, immunology, genetics, major rheumatic diseases and their pathophysiology, and major rheumatic therapeutics, as well as a unique chapter on the emerging autoinflammatory diseases. Review of rheumatology is a clear and concise review book written in an outline format. "

"Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg's Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics"

"Kualitas hidup merupakan aspek penting dalam tata laksana pasien anak dengan penyakit kronis, misalnya penyakit reumatik. Kualitas hidup pasien anak dengan penyakit reumatik dapat dinilai dengan kuesioner Pediatric Quality Of Life Inventory Rheumatology Module (PedsQL-RM) yang telah terbukti sahih dan andal. Akan tetapi, hingga saat ini belum terdapat kuesioner PedsQL-RM dalam bahasa Indonesia yang tervalidasi. Pada penelitian ini kuesioner asli diterjemahkan dan dilakukan adaptasi transkultural untuk menghasilkan kuesioner bahasa Indonesia. Kuesioner diujikan kepada 53 subyek berusia 2-18 tahun dengan diagnosis lupus eritematosus sistemik (LES) atau artritis reumatoid juvenil (AIJ) beserta orangtua. Berkaitan dengan jumlah subyek yang tidak terpenuhi, analisis data hanya dilakukan pada kelompok usia 8-18 tahun. Kesahihan kuesioner domain anak bervariasi dengan rentang korelasi cukup kuat hingga kuat (r 0,437-0,910), sedangkan domain orangtua bervariasi dengan rentang lemah hingga kuat (r 0,153-0,808). Kuesioner ini memiliki keandalan alpha cronbach 0,755-0,785. Kuesioner PedsQL-RM bahasa Indonesia terbukti sahih dan andal untuk menilai kualitas hidup pasien anak dengan penyakit reumatik usia 8-18 tahun. Perlu penelitian lebih lanjut untuk menilai kesahihan dan keandalan pada usia 2-7 tahun.

---

Quality of life is one important aspect in management of children with chronic condition, for example rheumatology disease. Quality of life of these children can be measured by Pediatric Quality Of Life Inventory Rheumatology Module (PedsQL-RM)questionnaire which was proven valid and reliable. A valid version of the questionnaire in Bahasa Indonesia has not yet available. We perform translation and transcultural adaptation to produce the Indonesian version. The questionnaire was answered by 53 children aged 2-18 years old with systemic lupus erythematosus (SLE) or juvenile idiopatic arthritis (JIA) and their respective parents. Due to lack of subject, analysis was only performed in age 8-18 years old group. The validity in children domain varied within range of good to strong (0,437-0,910), while the parents domain varied within range of weak to strong (0,153-0,808). The questionnaire is reliable with cronbach alpha of 0,755-0,785. In conclusion, the PedsQL-RM in Bahasa Indonesia is valid and reliable to assess the quality of life in children with rheumatology disease aged 8-18 years old. Further study needed to assess the validity and reliability for children aged 2-7 years old."

"Latar belakang. Lupus eritematosus sistemik (LES) dan artritis idiopatikjuvenil (AIJ) adalah penyakit reumatologi tersering pada anak. Penyakit ini memerlukan terapi dan tatalaksana yang cukup lama. Kualitas hidup adalah salah satu bagian penting dalam tatalaksana pasien anak dengan penyakit reumatologi. Hingga saat ini masih belum ada data kualitas hidup pasien remaja dengan penyakit reumatologi di Indonesia.Tujuan. Mengetahui kualitas hidup remaja dengan penyakit reumatologi, hubungan kualitas hidup dengan aktivitas penyakit dan lama sakit.Metode. Penelitian ini menggunakan desain potong lintang pada pasien remaja di Poliklinik Alergi Imunologi Departemen Kesehatan Anak Rumah Sakit Cipto Mengunkusumo sesuai dengan kriteria inklusi. Penilaian kualitas hidup menggunakan kuesioner PedsQL-RM. Pengambilan data menggunakan kuesioener yang dibagikan secara daring.Hasil. Didapatkan subyek pada penelitian ini 82 remaja dengan penyakit LES sebanyak 91,4% dan AIJ 8,6%. Sebanyak 65,9% pasien reumatologi memiliki kualitas hidup baik dengan 69,3% pasien LES memiliki kualitas hidup yang baik dan 47% memiliki aktivitas penyakit rendah-sedang. Sedangkan hanya 2/7 pasien AIJ memiliki kualitas hidup baik dan sebagian besar memiliki aktivitas penyakit tinggi (4/7 pasien). Tidak terbukti adanya hubungan antara aktivitas penyakit reumatologi terhadap kualitas hidup dari penilaian anak secara keseluruhan (p= 0,883). Aspek kekhawatiran dan komunikasi cukup rendah pada remaja dengan penyakit reumatologi. Durasi penyakit juga tidak memengaruhi kualitas hidup dari penilaian anak (p= 0,392).Kesimpulan. Kualitas hidup remaja dengan penyakit reumatologi (LES dan AIJ) baik. Tidak ditemukan hubungan antara aktivitas dan lama penyakit terhadap kualitas hidup menggunakan kuesioner PedsQL-RM.

---

Background. Systemic lupus erythematosus (SLE) and juvenile idiopathic arthritis (JIA) is the most reumatology diseases in children. These are chronic disease that needed prolonged treatment. Quality of life is the most important factor in treatment of rheumatology disease. Until now, there was no data of quality of life in rheumatology disease in adolescent in Indonesia.

Objectives: To assess the quality of life of adolescent with rheumatology disease and association with disease activity and duration.

Methods. A cross-sectional design was conducted on patients and parents/caregivers diagnosed SLE or JIA during August-November 2021 in Allergy and Immunology Policlinic Child Health Departement Cipto Mangunkusumo Hospital according to inclusion criteria. The quality of life were assess by PedsQL-RM questionnaire. Data were obtained from an online questionnaire.

Result. The subjects in this study were 82 adolescents with SLE is the most common in rheumatology disease (91.4%) and 8.6% were JIA. A total of 65.9% of rheumatology disease have a good quality of life that consist of 69.3% of SLE patients have a good quality of life and 47% have low-moderate disease activity. Meanwhile, only 2/7 of JIA patients have good quality of life and most of them have high disease activity (4/7 patients). There was no significant relationship between disease activity on quality of life from the overall assessment of children (p= 0.883). Worriness and communication aspects are quite low in adolescents with rheumatology disease. Illness duration did not affect the quality of life in children assessment (p= 0.392)."

"Latar belakang: Kriteria klasifikasi ACR 1997, SLICC 2012, dan EULAR/ACR 2019 telah banyak digunakan untuk membantu penegakan diagnosis LES. Sensitivitas dan spesifisitas masing-masing klasifikasi tersebut telah banyak dilaporkan pada populasi dewasa. Akan tetapi, penelitian performa diagnostik pada populasi anak masih sedikit. Penelitian ini bertujuan untuk membandingkan performa diagnostik ketiga kriteria klasifikasi tersebut pada LES anak.Metode: Rekam medis pasien yang tercatat sebagai penderita penyakit autoimun dengan hasil ANA positif pada periode Januari 2010-Mei 2021 diikutsertakan dalam penelitian. Rekam medis ini kemudian dinilai oleh dua orang konsultan alergi-imunologi untuk penentuan diagnosis LES atau bukan LES. Setiap kasus kemudian diekstrapolasi ke dalam ketiga kriteria klasifikasi, kemudian dinilai performa diagnostik.Hasil: Sebanyak 86 kasus LES (rerata usia saat diagnosis 12,73±2,97 tahun) dengan rasio perempuan : lelaki adalah 11:1 dan 44 kasus bukan LES (rerata usia saat diagnosis 8,86±4,78 tahun) dengan rasio perempuan : lelaki adalah 2:1. Kriteria klasifikasi EULAR/ACR 2019 memiliki sensitivitas tertinggi sebesar 100% dibandingkan dengan ACR 1997 (90%) dan SLICC 2012 (98%). Spesifisitas ACR 1997, SLICC 2012, dan EULAR/ACR 2019 masing-masing 90%, 86%, dan 68%. Nilai prediksi positif ACR 1997 tertinggi dibandingkan SLICC 2012 dan EULAR/ACR 2019 yaitu 94%, 91%, dan 86%. Sedangkan, nilai prediksi negatif EULAR/ACR 2019 tertinggi dibandingkan ACR 1997 dan SLICC 2012 masing-masing 100%, 83%, dan 95%.Simpulan: Kriteria klasifikasi EULAR/ACR 2019 memiliki sensitivitas tertinggi, sedangkan kriteria klasifikasi ACR 1997 memiliki spesifisitas yang paling baik dibandingkan dua kriteria klasifikasi lainnya.Background: The classification criteria of ACR 1997, SLICC 2012, and EULAR/ACR 2019 have been widely used to establish the diagnosis of childhood-onset SLE. The sensitivity and specificity of these classification criteria have been reported in the adult-onset SLE. However, only few studies have been conducted in the childhood-onset SLE. This study aims to compare the diagnostic performance of the three classification criteria in childhood-onset SLE.Methods: Medical records of patients diagnosed with autoimmune diseases who had positive ANA from January 2010 to May 2021 were reviewed.  Each record was assessed by two allergy-immunology consultants to determine the diagnosis of SLE or not SLE. Each subject data was extrapolated to fullfil classification criteria and was calculated of the diagnostic performance.Results: This study consisted of 86 cases of SLE (mean age at diagnosis 12.73±2.97 years), female to male ratio was 11:1. There were 44 subject non-SLE (mean age at diagnosis 8.86±4.78 years), female to male ratio was 2:1. The sensitivity of EULAR/ACR 2019 was 100% (the highest sensitivity) while SLICC 2012 was 98% and ACR 1997 was 90%. The specificity of ACR 1997, SLICC 2012, and EULAR/ACR 2019 were 90%, 86%, and 68%, respectively. The positive predictive value for 1997 ACR was the highest one compare to SLICC 2012 and EULAR/ACR 2019 (94%, 91%, and 86%, respectively).  Meanwhile, the negative predictive value for EULAR/ACR 2019, SLICC 2012, and ACR 1997 were 100%, 95%, and 83%, respectively.Conclusion: The classification criteria of EULAR/ACR 2019 has the highest sensitivity and ACR 1997 has the highest specificity than the other classification criteria."