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"Terapi kanker dengan menggunakan berkas neutron (BNCT) dari reaktor telah digunakan di beberapa negara maju seperti Amerika dan Eropa. Metode ini mula-mula menggunakan neutron termal, kemudian agar pada saat terapi tak perlu ada pembukaan batok kepala maka digunakan neutron epitermal. Umumnya, berkas neutron yang digunakan berasal dari reaktor nuklir sehingga kontribusi dari disiplin ilmu fisika reaktor sangat diperlukan. antara lain guna mendesain kolitnator untuk memperoleh berkas neutron epitermal, menentukan hcsarnya fluks neutron yang aman dikenakan pada pasien dan serta sinar gamma yang ditimbulkan serta durasinya. Pada inakalah ini hendak dijelaskan rincian kontribusi disiplin fisika reaktor untuk mengoperasikan fasilitas yang digunakan untuk terapi ini"

"Konduksi termal berkaitan erat dengan peristiwa Heat Flow (Aliran Termal). Konduksi panas suatu logam tertentu dapat diketahui dengan mengamati gradient temperatur pada saat kondisi Steady State (tunak). Pembuatan alat konduksi termal ini bertujuan untuk mengetahui karakter laju aliran panas (Heat flow) pada berbagai material logam,dan menghitung harga konduktivitas thermalnya. Pada penelitian ini dilakukan pengukuran perubahan temperatur terhadap waktu pada beberapa macam material logam, sehingga diperoleh informasi pada saat aliran panas mencapai keadaan tunak, dan pada akhirnya diperoleh informasi-informasi untuk perhitungan harga konduktivitas termalnya. Pada penelitian ini dipergunakan metode Angstrom yang menjadi acuan dasar teori penelitian, datadata yang akan diperlukan didalam metoda tersebut diperoleh melalui dua cara, yaitu metoda pulsa panas dan gelombang panas sebagai model aliran panasnya. Data-data yang diperoleh ini diamati oleh sistem instrumentasi berbasis mikrokontroller melalui sensor pengindra berupa sekumpulan deretan termistor. Data-data yang diperoleh selanjutnya diteruskan ke sistem komputer menggunakan aplikasi labview dan hasilnya berupa tampilan grafis yang menghasilkan data interpretasi dan diolah dengan menggunakan metode Angstrom.

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Thermal conduction is closely related to the events Heat Flow (Flow Thermal). Conduction heat of a certain metal can be determined by observing the temperature gradient at Steady State conditions (steady-state). Manufacture of thermal conduction device is intended to determine the character of the rate of heat flow (heat flow) on a variety of metal materials, and calculate the price of thermal conductivity. In this study measured the temperature changes with time on some sort of metal material, in order to obtain information on the current reached steady-state heat flow, and ultimately obtained the information for the calculation of thermal conductivity.

In this study, the method used is the reference Angstrom basic theory research, data that will be required in the method is derived in two ways, namely heat pulse method and heat waves as heat flow model. The data obtained was observed by the system microcontroller via the sensor-based instrumentation sensing thermistor in the form of a set of rows. The data obtained further transmitted to a computer system using labview application and the result is a graphical display that produces the data interpretation and processed using methods Angstrom."

"Beragam kebutuhan industri, membuat jenis-jenis proses pada industri pengolahan menjadi beragam dengan berberapa parameter input dan output, salah satunya adalah proses thermal mixing yang menggunakan sistem multi input multi output. Thermal mixing atau continuous stirred-tank reactor mengendalikan 2 aliran dengan temperatur berbeda kedalam tanki pencampur sehingga mendapat temperatur dan ketinggian tangki sesuai yang diinginkan. pada penelitian ini telah dirancang sistem pengendali berbasis logika fuzzy pada pengendalian temperatur dan level. Penelitian ini sistem logika fuzzy menngunakan 2 input dan 1 output unutk masing-masing parameter pengendalian. 2 input fuzzy set menggunakan nilai error dan change of error. Setiap fuzzy set menngunakan 7 membership function yaitu negative big (NB), negative medium (NM), negative small (NS), zero (Z), positive small (PS), positive medium (PM), dan positive big (PB). Sistem dapat melakukan pengendalian temperatur dan level sesuai yang diinginkan. Sistem ini menggunakan simulasi berbasis aplikasi MATLAB Simulink. Berdasarkan hasil simulasi, dapat disumpulkan bahwa pengendalian menggunakan fuzzy logic controller lebih baik dibandingkan pengendalian PID. Hasil pengendalian fuzzy memiliki rata-rata rise time dan settling time yang lebih cepat dan tidak memiliki overshoot.

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A variety of industrial needs, making the types of processes in the processing industry to be diverse with several input and output parameters, one of which is a thermal mixing process that uses a multi-input multi output system. Thermal mixing or continuous stirred-tank reactor controls 2 streams with different temperatures into the mixing tank so that the temperature and height of the tank are as desired. In this research a fuzzy logic based controller system has been designed for controlling temperature and level. This study uses a fuzzy logic system using 2 inputs and 1 output for each control parameter. 2 fuzzy input sets use error and change of error values. Each fuzzy set uses 7 membership functions, namely negative big (NB), negative medium (NM), negative small (NS), zero (Z), positive small (PS), positive medium (PM), and positive big (PB). The system can control the temperature and level as desired. This system uses a simulation based on the MATLAB Simulink application. Based on the simulation results, it can be concluded that the control using fuzzy logic controller is better than PID control. Fuzzy control results have a faster average rise time and settling time and do not have overshoot."

"Efektifitas ECCT Electrical Capacitive Cancer Tomography untuk terapi kanker paru diselidiki dalam penelitian ini ECCT merupakan teknik terapi kanker menggunakan medan listrik statis dengan frekuensi 100 kHz dari sumber arus listrik bolak balik. ECCT menggunakan tegangan input 3V dan menghasilkan tegangan output 20 Vpp Rekonstruksi citra 2D dilakukan menggunakan software MATLAB R2009a Simulasi dilakukan berdasarkan metode elemen berhingga dengan menggunakan software COMSOL Multiphysics 3 5 untuk mengetahui besar nilai medan listrik yang efektif untuk terapi kanker paru. Hasil penelitian menunjukkan bahwa alat ECCT efektif pada daerah permukaan kanker paru paru karena terjadi peningkatan rasio permitivitas yang signifikan pada daerah interface antara 2 medium dan dipengaruhi juga oleh perubahan frekuensi dan tegangan. Sehingga pembunuhan sel kanker paru dapat dimulai dari permukaan Kata kunci ECCT medan listrik frekuensi tegangan kanker paru.

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In this study the effectiveness of Electrical Capacitive Cancer Treatment ECCT in lung cancer therapy is being investigated ECCT is a technique of cancer treatment that uses electrostatic field from an AC current source with a frequency 100 kHz ECCT produces an AC output voltage of 20 Vpp from a DC input voltage of 3V 2D image reconstruction is done using MATLAB R2009a software. The simulation is carried out based on finite element method FEM using COMSOL Multyphysics 3 5 software to determine the optimal amount of electrical field for an effective lung cancer treatment. The simulation results show that ECCT device is effective at the surface area of lung cancer due to the significant increase of permittivity ratio at the interface between 2 medium and the change of frequency and voltage. So the killing of lung cancer cell can start from the surface of tissue Key words ECCT electric field frequency voltage lung cancer."

"Pendahuluan: Di Amerika Serikat kanker pada anak terjadi pada 2% dari seluruh kasus kanker. Setelah trauma, kanker merupakan penyebab kematian kedua terbanyak pada anak-anak usia lebih dari satu tahun. Beberapa tahun belakangan, kemajuan protokol terapi memberikan perbaikan yang signifikan terhadap prognosis pada pasien kanker anak. Selain itu juga menimbulkan permasalahan baru salah satunya adalah nyeri kanker. Studi klinis terbaru menunjukkan bahwa hampir 50% pasien kanker rawat jalan mengalami nyeri yang belum tertangani dengan baik. Efek samping dari nyeri yang tidak tertangani dengan baik seperti : menurunnya kualitas hidup, susah tidur, peningkatan sensitivitas terhadap nyeri, dan kesulitan dalam tindakan medis, hambatan dalam aktivitas sosial, dan berkembangnya masalah perilaku dan emosional. Akupunktur telah terbukti merupakan terapi tambahan yang efektif jika dilakukan bersama pengobatan farmakologi konvensional untuk mengatasi nyeri kanker dan dapat mengurangi dosis analgetik dan efek sampingnya. Tujuan dari penelitian ini adalah untuk mengetahui penggunaan obat analgetik, perubahan skor VAS intra kelompok, dan keberhasilan terapi pada kelompok akupunktur dan medikamentosa dan kelompok medikamentosa saja pada nyeri kanker anak.Metode: Penelitian ini menggunakan desain kohort retrospektif dengan mengambil data di RSUPN dr. Cipto Mangunkusumo (RSCM). Populasi terjangkau penelitian ini adalah pasien anak dengan nyeri kanker yang dirawat di Gedung Pusat Kesehatan Ibu Anak (PKIA) RSCM Kiara pada bulan Januari 2022- Juli 2023.Hasil: Kedua kelompok dapat menurunkan skor VAS dan terdapat beda signifikan. Akupunktur dan medikamentosa mempunyai peluang untuk dapat mengurangi penggunaan jenis obat analgetik, penggunaan ekstra obat dan pengurangan dosis total morfin harian, namun diperlukan penelitian lebih lanjut. Kedua kelompok memberikan hasil yang baik pada luaran keberhasilan terapiKesimpulan: Akupunktur dan medikamentosa mempunyai peluang untuk dapat mengurangi obat analgetik, mengurangi skor VAS, dan memberikan hasil yang baik untuk keberhasilan terapi, namun diperlukan penelitian lebih lanjut.

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Introduction: In the United States, childhood cancer occurs in 2% of all cancer cases. After trauma, cancer is the second leading cause of death in children over one year old. In recent years, advances in therapeutic protocols have provided significant improvements in the prognosis of pediatric cancer patients. Apart from that, it also creates new problems, one of which is cancer pain. Recent clinical studies show that nearly 50% of outpatient cancer patients have untreated pain. Side effects of pain that is not handled properly include: decreased quality of life, difficulty sleeping, increased sensitivity to pain, and difficulties in medical procedures, obstacles in social activities, and the development of behavioral and emotional problems. Acupuncture has been shown to be an effective adjunctive therapy when performed alongside conventional pharmacological treatment to treat cancer pain and can reduce analgesic doses and associated effects. The aim of this study was to determine the use of analgesic drugs, changes in intra-group VAS scores, and the success of therapy in the acupuncture and medication group and the medication alone group for childhood cancer pain.

Methode: This study used a retrospective cohort design by taking data at RSUPN dr. Cipto Mangunkusumo (RSCM). The reachable population for this study is children with cancer pain who are treated at the Pusat Kesehatan Ibu Anak (PKIA) RSCM Kiara in January 2022-July 2023.

Results: Both groups can reduce the VAS score and there is a significant difference. Acupuncture and medication have the opportunity to reduce analgesic drugs, reduce extra drug use and reduce the total daily dose of morphine, but further research is needed. Both groups gave good results in terms of therapeutic success.

Conclusion: Acupuncture and medication have the opportunity to reduce the use of analgesic drugs, reduce VAS scores, and provide good results for successful therapy, but further research is needed."

"Nanopartikel emas berpotensi dikembangkan sebagai nano medisin karena sifat nya yang mudah disintesa, mempunyai banyak kegunaan dan biokompatibel pada tubuh manusia. Dengan bantuan gom arab sebagai penstabil, vinkristin dikonjugasikan dengan nanopartikel emas. Penelitian ini berhasil mengembangkan sintesis dan karakterisasi nanopartikel emas berbasis gom arab terkonjugasi vinkristin dengan distribusi ukuran partikel rata rata dibawah 100 nm dengan menggunakan analisa ukuran partikel dan mikroskop transmisi elektron. Dilakukan uji sitotoksik dengan metode garam tetrazolium/ MTT [3-(4,5- dimethylthiazo-2-yl-)-2,5-diphenyl tetrazolium bromide] pada konjugat vinkristin-gom arab-nanopartikel emas menggunakan lini sel MCF-7 and CCRF. Hasil uji sitotoksisitas digambarkan dengan nilai IC50. Hasil uji pada 2 formula (vinkristin-gom arab-nanopartikel emas sebelum pemurnian dan sesudah pemurnian dengan kromatografi size exclusion) terhadap lini sel MCF-7 mempunyai IC50 berturut turut sebesar 3,59 and 3,10 μg/mL, sementara vinkristin murni sebagai pembanding menunjukkan IC50 yang lebih besar yaitu 125 μg/mL. Terhadap lini sel CCRF, konjugat sebelum pemurnian dan sesudah pemurnian nilai IC50 berturut turut adalah 1,026 μg/mL dan 2,607 ug/mL. Sementara berdasarkan data in vivo untuk melihat biodsitribusi konjugat pada hewan uji dan kemampuan sebagai agen pengontras pada Computed tomography (CT) termyata konjugat mampu terdistribusi di liver dan ginjal hewan uji dan dihasilkan nilai Haunsfield Unit (HU) pada uji dengan Computed tomography (CT) pada konjugat VCR-GA-AuNP lebih tinggi dibandingkan nilai HU pada Iodium sebagai pembanding. Dari hasil diatas dapat disimpulkan bahwa konjugat (Vinkristin-Gom Arab-Nanopartikel emas) mempunyai kemampuan untuk diteliti lebih lanjut dan dikembangkan sebagai bahan baru terapi obat kanker terarah.

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Gold nanoparticles (AuNP) are potentially developed as nano medicine because AuNP are easily synthesized, functionalized, and biocompatible. With gum arabic as stabilizer, vincristine was conjugated with gold nanoparticles. Gold nanoparticles (AuNP) coated with conjugated gum arabic (GA) and vincristine (VCR) were successfully synthesized and characterized. The conjugation of GAVCR and AuNP displayed a narrow hydrodynamic particle size distribution with average size < 100 nm by TEM and particle size analyser. We investigated cytotoxic activity of conjugated vincristine-gum arabic-gold nanoparticle by tetrazolium salt assay (MTT) using cancer cell line MCF-7 and CCRF. Cytotoxic activity of conjugated VCR-GA-AuNP before and after purification by Size Exclusion Chromatography (SEC), against leukemia cell line CCRF and breast cancer cell line MCF-7 was described by IC50 value. All formulation had a cytototoxic of activity with IC50 <20 μg/ml. The IC50 of the conjugate before and after purification againts MCF-7 cell line were 3.59 and 3.10 ug/mL, respectively. Meanwhile, the IC50 of vincristine was considerable larger (>125 ug/mL). The IC50 of samples againts CCRF cell line were 1,026 μg/mL dan 2,607 ug/mL, respectively. Based on in vivo data to evaluate the biodistribution and their capacity for a contras agent, conjugate could distributed in the liver and kidneys with the resulting of Hounsfield Unit (HU) value of VCR-GA-AuNP is higher than the HU value of Iodine as a comparison. In conclusion, conjugated VCR-GA-AuNP had a good prospect for further investigation and could be developed as materials for new targeted cancer drug therapy."

"[ABSTRAKKarya Ilmiah Akhir ini merupakan kumpulan dari laporan praktik residensi medikal bedah yang terdiri dari laporan kasus kelolaan, penerapan terapi musik berdasarkan evidenced based Nursing dan laporan inovasi tentang pelatihan pengkajian ESAS dan penatalaksanaannya. Praktik ini menerapkan asuhan keperawatan pada pasien kanker dengan menggunakan pendekatan The Corbin and Strauss Chronich Illness Trajectory Model. Fokus dari teori ini adalah menerapkan 9 fase perjalanan penyakit yaitu fase pretrajectory, trajectory, stable, unstable, crisis, acut, comeback, downward dan dying. Tujuan dari pendekatan teori ini adalah untuk mengetahui perjalanan penyakit kanker. Salah satu upaya untuk mengurangi kecemasan pada pasien kemoterapi adalah dengan terapi musik. Pelatihan perawat dapat meningkatkan kemampuan mengkaji ESAS dan memberikan penatalaksanaannya. The Corbin and Strauss Chronich Illness Trajectory Model, terapi musik dan pelatihan pengkajian ESAS dan penatalaksanaannya dapat diaplikasikan pada tatanan klinik untuk meningkatkan kualitas pelayanan keperawatan.

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ABSTRACTScientific work is a compilation of the final report medical surgical nursing practice ressidency wich consist of case report under management, the application of music therapy based on evidenced based nursing and innovation report on training of ESAS ( Edmonton Symptomp Assesment System) and it's tretment. This is implement nursing care to cancer patients using theorical approach The Corbin and Strauss Chronich Illness Trajectory Model. The focus of this theory is the apllication of nine phase of chronic illness, consist : pretrajectory, trajectory, stable, unstable, crisis, acut, comeback, downward and dying. The purpose of the theorical approach is to know the trajectory of disease especially cancer. One effort to reduce anxiety related chemotherapy of the patient was music therapy. Training of ESAS and it's treatment will increasing the skill of nurse to asses ESAS and it's treatment. The Corbin and Strauss Chronich Illness Trajectory Model, music therapy and assesment & treatment ESAS training can apllicated in clinical to increse quality of nursing., Scientific work is a compilation of the final report medical surgical nursing practice ressidency wich consist of case report under management, the application of music therapy based on evidenced based nursing and innovation report on training of ESAS ( Edmonton Symptomp Assesment System) and it's tretment. This is implement nursing care to cancer patients using theorical approach The Corbin and Strauss Chronich Illness Trajectory Model. The focus of this theory is the apllication of nine phase of chronic illness, consist : pretrajectory, trajectory, stable, unstable, crisis, acut, comeback, downward and dying. The purpose of the theorical approach is to know the trajectory of disease especially cancer. One effort to reduce anxiety related chemotherapy of the patient was music therapy. Training of ESAS and it's treatment will increasing the skill of nurse to asses ESAS and it's treatment. The Corbin and Strauss Chronich Illness Trajectory Model, music therapy and assesment & treatment ESAS training can apllicated in clinical to increse quality of nursing.]"

"ABSTRAK Peningkatan angka morbiditas dan mortalitas akibat penyakit kanker di Indonesia menunjukkan bahwa permasalahan kanker ini semakin besar dan kompleks Salah satunya adalah adanya keterlambatan pasien kanker untuk mendapatkan terapi definitif yang disebabkan oleh faktor faktor yang berasal dari pasien sendiri Penelitian ini merupakan studi analisis deskriptif menggunakan metode campuran kuantitatif dan kualitatif untuk mengetahui data insidens keterlambatan terapi karena keterlambatan pasien pada pasien kanker yang dirujuk ke Departemen Radioterapi RSUPN Dr Cipto Mangunkusmo pada bulan Mei Agustus 2015 serta mengevaluasi faktor faktor apa saja yang mempengaruhi keterlambatan pasien tersebut Terdapat 294 orang pasien yang diikutsertakan dalam penelitian ini setelah mendapatkan persetujuan tertulis Sebagian besar pasien 71 4 adalah perempuan dan 141 orang 48 bekerja sebagai ibu rumah tangga Rentang umur terbanyak adalah 36 50 tahun yaitu sebanyak 132 pasien 44 9 dan hampir seluruh pasien 91 8 telah menikah Keterlambatan terapi didapatkan pada 153 orang pasien 52 dan 67 orang di antaranya 43 8 memiliki riwayat pengobatan alternatif yang dilakukan dalam interval waktu setelah timbul keluhan pertama kali dan atau setelah pasien melakukan konsultasi medis pertama kali Analisis statistik menunjukkan adanya hubungan yang signifikan antara faktor usia p 0 047 pendidikan p 0 047 dan riwayat pengobatan alternatif p 0 0001 dengan keterlambatan terapi Adanya rasa takut untuk berobat secara medis atau menjalani tindakan medis menjadi alasan 51 orang pasien untuk memilih pengobatan alternatif Oleh karena itu diperlukan pengawasan dan evaluasi terhadap pengobatan alternatif terutama yang menyangkut kualitas efikasi dan keamanannya ABSTRACT Increased morbidity and mortality due to cancer in Indonesia showed that this problem has become more complex and significant One of the problems pointed out is regarding a delay in cancer patients to receive definitive therapy caused by factors derived from the patients themselves This study is a descriptive analysis using combination of quantitative and qualitative methods to determine the incidence of treatment delay due to patient delay in cancer patients who were referred to Radiotherapy Department Dr Cipto Mangunkusmo hospital during May August 2015 and to evaluate factors that influence the patient delay There are 294 patients enrolled in this study after obtaining a written consent Most of the patients 71 4 were women and 141 48 work as a housewife The largest age range was 36 50 years with 132 patients 44 9 and almost all patients 91 8 were married Delay in treatment obtained in 153 patients 52 and 67 of them 43 8 had a history of alternative medicine that is performed in a time interval after the patients experienced first complaints and or after patients had their first medical consultation Statistical analysis showed a significant relationship between age p 0 047 educational level p 0 047 and history of alternative medicine p 0 0001 with the treatment delay The fear of being treated medically or undergo a medical procedure has become the major reasons found in 51 patients to choose the alternative treatment Therefore it is necessary to conduct monitoring and evaluation of alternative medicine especially concerning the quality efficacy and its safety ;Increased morbidity and mortality due to cancer in Indonesia showed that this problem has become more complex and significant One of the problems pointed out is regarding a delay in cancer patients to receive definitive therapy caused by factors derived from the patients themselves This study is a descriptive analysis using combination of quantitative and qualitative methods to determine the incidence of treatment delay due to patient delay in cancer patients who were referred to Radiotherapy Department Dr Cipto Mangunkusmo hospital during May August 2015 and to evaluate factors that influence the patient delay There are 294 patients enrolled in this study after obtaining a written consent Most of the patients 71 4 were women and 141 48 work as a housewife The largest age range was 36 50 years with 132 patients 44 9 and almost all patients 91 8 were married Delay in treatment obtained in 153 patients 52 and 67 of them 43 8 had a history of alternative medicine that is performed in a time interval after the patients experienced first complaints and or after patients had their first medical consultation Statistical analysis showed a significant relationship between age p 0 047 educational level p 0 047 and history of alternative medicine p 0 0001 with the treatment delay The fear of being treated medically or undergo a medical procedure has become the major reasons found in 51 patients to choose the alternative treatment Therefore it is necessary to conduct monitoring and evaluation of alternative medicine especially concerning the quality efficacy and its safety ;Increased morbidity and mortality due to cancer in Indonesia showed that this problem has become more complex and significant One of the problems pointed out is regarding a delay in cancer patients to receive definitive therapy caused by factors derived from the patients themselves This study is a descriptive analysis using combination of quantitative and qualitative methods to determine the incidence of treatment delay due to patient delay in cancer patients who were referred to Radiotherapy Department Dr Cipto Mangunkusmo hospital during May August 2015 and to evaluate factors that influence the patient delay There are 294 patients enrolled in this study after obtaining a written consent Most of the patients 71 4 were women and 141 48 work as a housewife The largest age range was 36 50 years with 132 patients 44 9 and almost all patients 91 8 were married Delay in treatment obtained in 153 patients 52 and 67 of them 43 8 had a history of alternative medicine that is performed in a time interval after the patients experienced first complaints and or after patients had their first medical consultation Statistical analysis showed a significant relationship between age p 0 047 educational level p 0 047 and history of alternative medicine p 0 0001 with the treatment delay The fear of being treated medically or undergo a medical procedure has become the major reasons found in 51 patients to choose the alternative treatment Therefore it is necessary to conduct monitoring and evaluation of alternative medicine especially concerning the quality efficacy and its safety "

"Latar Belakang: Kanker payudara merupakan kanker yang paling sering terjadi di dunia dengan insidensi 25,1% dari semua jenis kanker. Pasien kanker payudara yang menjalani radiasi, umumnya tidak memenuhi kriteria malnutrisi pada skrining gizi namun kebanyakan pasien memiliki massa otot yang rendah, sehingga berpotensi mengalami penurunan kapasitas fungsional. Proses keganasan dan radiasi dapat menyebabkan peningkatan IL-6 yang berdampak pada penurunan kadar Hb. Kadar kolesterol LDL yang tinggi juga sering ditemukan pada pasien dengan obes/riwayat obes, peningkatan ini merugikan karena berdampak pada prognosis dan kesintasan pasien. Terapi medik gizi yang adekuat diperlukan pada pasien kanker payudara.Metode: Pasien kanker payudara berusia antara 36-79 tahun. Empat pasien telah menjalani mastektomi dan tiga di antaranya telah dikemoterapi. Pasien memiliki hasil skrining MST ≥2. Pemantauan yang dilakukan meliputi keluhan subjektif, kondisi klinis, tanda vital, pemeriksaan laboratorium, antropometri, komposisi tubuh, kapasitas fungsional dan analisis asupan 24 jam. Keempat pasien mendapatkan edukasi nutrisi, oral nutrition support (ONS), suplementasi vitamin dan mineral serta omega-3.Hasil: Dari hasil pemantauan diketahui bahwa pasien kanker payudara yang mendapatkan terapi medik gizi dapat meningkatkan asupan makanannya, berat badan, massa otot, kekuatan genggam tangan, kadar hemoglobin dan perbaikan kadar kolesterol LDL. Skor ECOG/Karnofsky Performance dari keempat pasien mengalami perbaikan bila dibandingkan dengan pemeriksaan awal.Kesimpulan: Terapi medik gizi dapat memperbaiki outcome klinis, kapasitas fungsional, antropometri, dan laboratorium pada semua pasien dalam serial kasus ini.

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Background: Breast cancer is the most common cancer in the world with an incidency 25.1% of all types of cancer. Generally, breast cancer patients who had undergoing radiation did not meet the criteria for malnutrition based on nutritional screening, but most patient had low muscle mass that reduce functional capacity. Malignancy and radiation cause an increase of IL-6 which result a decrease in Hb levels. High LDL cholesterol levels were also found in obesity or history of obesity which affected the prognostic and survival of breast cacer patient. The patients mostly had skeletal mass decreased. Adequate nutritional therapy is needed for breast cancer patients.Method: The case saries reported breast cancer patients aged between 36-79 years. Three patients had mastectomy and chemotherapy, while the other had only mastectomy. Patients had MST screening ≥ 2. Patiens were examined of subjective complaints, clinical conditions, vital signs, laboratory examination, anthropometry, body composition, functional capacity and 24-hour intake analysis. The four patients received nutritional education, oral nutrition support (ONS), vitamin and mineral supplement and omega-3.Results: Breast cancer patients who got adequate nutritional therapy had increased their food intake, body weight, skeletal mass, handgrip strength, hemoglobin levels and improvement of LDL cholesterol levels. The ECOG/Karnofsky Performance Score of the all patients showed improvement from the initial examination.Conclusion: Medical nutrition therapy improves the outcome, nutritional status, laboratory parameters and body composition in breast cancer patients."